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Rheological properties and concentration evolution of thickened tailings under the coupling effect of compression and shear

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 862-876页

作者： Aixiang Wu Zhenqi wang Zhuen Ruan Raimund Bürger shaoyong wang Yi Mo Key Laboratory of the Ministry of Education of China for High-efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China Shunde Innovation School University of Science and Technology BeijingFoshan 528399China CI2MA and Departamento de Ingeniería Matemática Facultad de Ciencias Físicas y MatemáticasUniversidad de ConcepciónCasilla 160-CConcepciónChile School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China China Railway Construction Tongguan Investment Co. Ltd.Tongling 244000China

Cemented paste backfill(CPB)is a key technology for green mining in metal mines,in which tailings thickening comprises the primary link of CPB technology.However,difficult flocculation and substandard concentrations of thickened tailings often occur.The rheological properties and concentration evolution in the thickened tailings remain unclear.Moreover,traditional indoor thickening experiments have yet to quantitatively characterize their rheological properties.An experiment of flocculation condition optimization based on the Box-Behnken design(BBD)was performed in the study,and the two response values were investigated:concentration and the mean weighted chord length(MWCL)of flocs.Thus,optimal flocculation conditions were obtained.In addition,the rheological properties and concentration evolution of different flocculant dosages and ultrafine tailing contents under shear,compression,and compression-shear coupling experimental conditions were tested and compared.The results show that the shear yield stress under compression and compression-shear coupling increases with the growth of compressive yield stress,while the shear yield stress increases slightly under shear.The order of shear yield stress from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Under compression and compression-shear coupling,the concentration first rapidly increases with the growth of compressive yield stress and then slowly increases,while concentration increases slightly under shear.The order of concentration from low to high under different thickening conditions is shear,compression,and compression-shear coupling.Finally,the evolution mechanism of the flocs and drainage channels during the thickening of the thickened tailings under different experimental conditions was revealed.

关键词： thickened tailings compression-shear coupling compressive yield stress shear yield stress concentration

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Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1302-1316页

作者： Xinyuan Xu Qian Zhang Xufeng wang Jing Jin Chengwei Wu Li Feng Xiuyan Yang Mingzhu Zhao Yingyi Chen shaoyong Lu Zhen Zheng Xiaobing Lan Yi wang Yan Zheng Xuefeng Lu Qiufen Zhang Jian Zhang State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Medicinal Chemistry and BioinformaticsCenter Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230026China Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Pancreatic Surgery Shanghai General HospitalShanghai Key Laboratory of Pancreatic DiseaseInstitute of Pancreatic DiseaseShanghai Jiao Tong University School of MedicineShanghai 200080China

Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour metastasis.SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic cancer.However,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be discovered.Here,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/L.Moreover,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/L.The allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural analyses.Importantly,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver metastasis.To our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic cancer.It not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.

关键词： SIRT6 Inhibitor Allosteric Selectivity Cocrystal Pancreatic cancer metastasis

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New advances in the assessment of tight oil resource in China

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Petroleum Research 2017年第1期2卷 1-12页

作者： Shejiao wang Yuanjiang Yu Qiulin Guo shaoyong wang Xiaozhi Wu PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China

The research on tight oil becomes another hotspot in the field of unconventional oil and gas after the boom of shale gas.The global recoverable resources of tight oil are estimated to be around 47.3×10^(9)t.In recent years,significant progress has been made in the technologies of tight oil exploration and development in North America,thus stimulating the dramatic increase of tight oil production.Meanwhile,China has also acquired remarkable achievements in tight oil exploration.Mature assessment methods have been established for tight oil resources by the US,generally dominated by analogy and statistical methods with their own advantages and disadvantages as well as applicable conditions.In China,improvement of resource evaluation techniques becomes an urgent issue in increasing tight oil reserve and production.This study mainly discusses the resource evaluation methods and resource enrichment characteristics of tight oil.Seven kinds of assessment methods in three categories(i.e.,analogy,statistical and genetic method)and evaluation parameters have been preliminary established,and are specifically applied in the Sichuan,Ordos,Songliao,Junggar,Bohai Bay and other tight oil basins through the newly hierarchical resource abundance analogy method,the estimated ultimate recovery(EUR)analogy method and the small-cell volumetric method.The preliminary evaluation results reveal that China has great potential in tight oil resource,and the geological resources amount to 20×10^(9)t,providing a resource base for large-scale development.

关键词： Unconventional oil and gas Resource assessment method Resource potential Resource enrichment characteristics Tight oil

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Formation characteristics and resource potential of Jurassic tight oil in Sichuan Basin

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Petroleum Research 2017年第4期2卷 301-314页

作者： Denghua Li Jianzhong Li Bin Zhang Jiajing Yang shaoyong wang Strategic Research Center of Oil and Gas Resources Ministry of Land and ResourcesBeijing 100034China PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China Institute of Exploration and Development PetroChina Southwest Oil and Gas Field CompanyChengdu 610041China

Through test analysis of large amount of cores,rock fragments and crude oil samples,and in combination with dynamic data of production from 456 oil wells,hydrocarbon generation potentials of four major source rocks and accumulation characteristics of three major pay layers in the Jurassic of Sichun Basin were well investigated.Results indicated that source rocks in the Lianggaoshan Formation,the Da'anzhai Member and the Dongyuemiao Member mainly generated oil,and those in the Zhenzhuchong Member dominantly generated gas;the organic-rich source rocks controlled distribution of sweet spots of tight oil,and most industrial oil wells were located at the area with high-quality source rocks(TOC>1.2%);and micron-sized pore throats were effective storage space,and fractures played a key role in initial high yield.Jurassic tight oil in the Sichuan Basin was characterized by light oil,high gas-oil ratio and abnormal high pressure,which were favorable for tight oil flow and output.Four methods(i.e.,small bin method,resource abundance analogy method,EUR analogy method and total organic carbon method)were used to estimate Jurassic oil in-place in the Sichuan Basin which ranged from 2×10^(9) to 3×10^(9) t.Through analysis of main controlling factors of resource enrichment,the grading criteria were established for the evaluation of oil in-place in the Sichuan Basin.Through the small bin method,the oil in-place of Type I,Type II and Type III was 1.611×10^(9)t,0.477×10^(9)t and 0.289×10^(9)t,respectively.It was predicted that the largest exploration potential of the Da'anzhai Member was in the Nanchong-Suining area and the east of Liangping area,the most favorable exploration area of the Lianggaoshan Formation was in the Guang'anNanchong-Suining-Yilong area,and the good exploration prospect of the Dongyuemiao Member was in the south of the Guang'an-Suining area.

关键词： Tight oil High-quality source rock Preservation condition Pore throat Sweet spot Resource evaluation Jurassic Sichuan Baisn

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高原富营养化湖泊杞麓湖微囊藻毒素分布特征、相关因子及其健康风险分析

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湖泊科学 2024年第1期36卷 52-63页

作者：王永强国晓春卢少勇宋迪蒋昀耕杨莉园云南省生态环境科学研究院云南省高原湖泊流域污染过程与管理重点实验室昆明650034 中国环境科学研究院湖泊水污染治理与生态修复技术国家工程实验室北京100012

杞麓湖作为典型的富营养化高原湖泊,其藻华暴发引发的微囊藻毒素(microcystins,MCs)污染问题会危害水生态安全并造成人体健康风险。为了评估杞麓湖流域MCs的秋冬季节污染现状以及健康风险情况,对湖内和7条主要入湖河流入湖口的表层水进... 详细信息

杞麓湖作为典型的富营养化高原湖泊,其藻华暴发引发的微囊藻毒素(microcystins,MCs)污染问题会危害水生态安全并造成人体健康风险。为了评估杞麓湖流域MCs的秋冬季节污染现状以及健康风险情况,对湖内和7条主要入湖河流入湖口的表层水进行采样检测,分析MCs主要异构体的时空分布特征,研究MCs与水质和浮游植物等环境因子的关系,并通过人体非致癌健康风险评价MCs的风险等级。结果发现,MCs浓度自秋季到冬季呈下降趋势,秋季湖内胞内MCs(IMCs)占比超过99%,冬季IMCs与胞外MCs(EMCs)浓度接近。MC-RR和MC-LR是主要的MCs异构体类型,其中MC-RR在秋季浓度占比高于MC-LR和MC-YR,而冬季MC-LR最高。MCs与微囊藻密度等生物因子呈极显著正相关关系,与TN、TP和NH_(3)-N营养盐呈显著负相关关系。杞麓湖EMCs污染的风险指数范围为0.004~0.110,处于极低或低风险,冬季风险略高于秋季,因南岸入湖EMCs污染以及湖内IMCs释放带来的风险需要进一步关注。

关键词：微囊藻毒素杞麓湖环境因子时空分布健康风险

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分布式集群秩亏约束协同导航方法研究

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航天控制 2024年第2期42卷 42-47页

作者：秦峰王璞胡少勇薛书棋上海机电工程研究所上海201109

针对卫星导航拒止环境、分布式集群纯惯导误差快速发散问题,提出了一种适用于所有节点均为纯惯导的分布式集群的协同导航方法,设计了秩亏约束卡尔曼滤波器,在量测量数量少于状态量数量导致滤波方程秩亏时,仍可以实现分布式集群协同导航... 详细信息

针对卫星导航拒止环境、分布式集群纯惯导误差快速发散问题,提出了一种适用于所有节点均为纯惯导的分布式集群的协同导航方法,设计了秩亏约束卡尔曼滤波器,在量测量数量少于状态量数量导致滤波方程秩亏时,仍可以实现分布式集群协同导航,减小惯导误差。构建了无人机飞行试验平台,飞行试验验证结果表明,组网内无高精度节点,协同导航修正后位置和速度精度可提升两倍左右;组网内有一个高精度节点,协同导航修正后位置和速度精度可提升10~20倍左右。

关键词：协同导航无人机卡尔曼滤波分布式集群

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改进DTW下界约束的Granger多元时序LSTM预测模型

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计算机应用与软件 2024年第5期41卷 233-239页

作者：许凤魁孙士保贾少勇王静河南科技大学信息工程学院河南洛阳471023

多元时序的因果预测研究是探讨复杂网络响应关系的热点问题。提出一种通过DTW的下界约束组合并改进的层级过滤器,与格兰杰因果验证法相结合验证其因果统计量,挖掘出有效信息实现有效降维,进一步输入LSTM预测模型进行因果预测。仿真实验... 详细信息

多元时序的因果预测研究是探讨复杂网络响应关系的热点问题。提出一种通过DTW的下界约束组合并改进的层级过滤器,与格兰杰因果验证法相结合验证其因果统计量,挖掘出有效信息实现有效降维,进一步输入LSTM预测模型进行因果预测。仿真实验利用开源的空气质量数据集进行定量和定性对比验证,该方法的损失函数训练曲线和测试曲线有较好的拟合度,表明该因果预测法是可行且有效的。

关键词：动态时间弯曲长短时记忆网络格兰杰因果关系层级过滤器

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Connotation analysis, source-reservoir assemblage types and development potential of unconventional hydrocarbons in China

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Petroleum Research 2016年第2期1卷 135-148页

作者： Jianzhong Li Min Zhen Xiaoming Chen Denghua Li shaoyong wang Tao Song PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China

Through analysis of the connotation of unconventional hydrocarbons,the source-reservoir assemblages of unconventional hydrocarbons are divided into three types,i.e.,source-reservoir neighboring type,source-reservoir integration type,and source-reservoir separation type.The source-reservoir neighboring type resources mainly include tight oil and tight gas with the following formation conditions and characteristics:(1)efficient near-source accumulation close to high-quality source rocks with the pressure difference between source and reservoir as the dynamic force;(2)large-area tight reservoirs with certain porosity,dominated by micro-nanopores of inorganic origin;(3)distributed in depressions and slopes with large hydrocarbon-bearing area and great resource quantity,low abundance and local development of“sweet spots”;(4)weak tectonism.The source-reservoir integration type resources mainly include coalbed methane,shale gas,shale oil and oil shale.The formation conditions and characteristics are:(1)high abundance of organic matter,different types of organic matter and thermal evolution grades leading to formation of different resources types;(2)organic-rich sections are distributed continuously in the reservoiring space which is dominated by nanometer organic pores,interparticle pores and microfissures;(3)hydrocarbons mainly occur in free or adsorbed state,varying much with resource type;(4)the resources are self-conserved,and enriched in depressions and slopes,the conservation conditions are controlled by tectonics,temperature and pressure;(5)the production per well can be enhanced by volume fracturing,which increases the permeability of the reservoirs.The source-reservoir separation type resources are more special,mainly including(1)transformed conventional resources such as oil sand and heavy oil;(2)unsteady resources formed under special conditions of temperature and pressure,among which natural gas hydrate is a representative.These three types of resources in China are different in both development prospect and

关键词： Unconventional hydrocarbons connotation source-reservoir assemblage source-reservoir neighboring type source-reservoir integration type source-reservoir separation type development potential

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醋酸奥曲肽联合王氏保赤丸治疗急性胰腺炎的效果

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世界复合医学 2024年第3期10卷 113-115,139页

作者：郭少勇阜宁县人民医院消化内科江苏阜宁224400

目的探究醋酸奥曲肽联合王氏保赤丸治疗急性胰腺炎的临床效果。方法随机选取2017年1月—2023年11月阜宁县人民医院消化内科治疗的60例急性胰腺炎患者作为研究对象,经抛硬币法分为对照组和观察组,各30例。对照组单用醋酸奥曲肽治疗,观察... 详细信息

目的探究醋酸奥曲肽联合王氏保赤丸治疗急性胰腺炎的临床效果。方法随机选取2017年1月—2023年11月阜宁县人民医院消化内科治疗的60例急性胰腺炎患者作为研究对象,经抛硬币法分为对照组和观察组,各30例。对照组单用醋酸奥曲肽治疗,观察组在对照组基础上加用王氏保赤丸治疗。比较两组治疗的有效性、不良反应以及炎症状态。结果观察组治疗总有效率为93.33%,高于对照组的73.33%,差异有统计学意义(χ^(2)=4.320,P=0.038)。观察组用药不良反应发生率低于对照组,差异有统计学意义(P<0.05)。观察组治疗后C反应蛋白、外周血白细胞计数、降钙素原水平均低于对照组,差异有统计学意义(P均<0.05)。结论醋酸奥曲肽+王氏保赤丸用于急性胰腺炎的临床效果确切,有助于改善机体炎症状态,用药不良反应少,可确保患者安全用药。

关键词：醋酸奥曲肽王氏保赤丸急性胰腺炎治疗效果不良反应炎症水平

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广域空间感知敏感器光学系统设计

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光子学报 2024年第3期53卷 219-231页

作者：杜伟峰王燕清郑循江孙少勇毛晓楠曲耀斌吴泽鹏上海航天控制技术研究所上海201109 上海卫星工程研究所上海201109

根据空间感知任务的特殊应用需求,开展了光电系统技术指标论证,完成了光学系统设计和性能测试。光学系统全视场设计值为60°,F数为3.0,主光线在像面的入射角为8°。光学系统采用低灵敏公差优化设计方案,并在公差分析时提出以离焦方式补... 详细信息

根据空间感知任务的特殊应用需求,开展了光电系统技术指标论证,完成了光学系统设计和性能测试。光学系统全视场设计值为60°,F数为3.0,主光线在像面的入射角为8°。光学系统采用低灵敏公差优化设计方案,并在公差分析时提出以离焦方式补偿点目标与面目标的MTF,使之在50 lp/mm处不小于0.4。采用传函仪对装配后的镜头进行指标检测:13.5μm弥散斑直径内星点能量集中度达到90%以上;点目标MTF在50 lp/mm处不小于0.55,15 m处的面目标在同样的分辨率处MTF不小于0.48;视场边缘相对中心的照度达到72%;全视场的畸变小于-0.58%;倍率色差绝对值为1.53μm。外场观星测试表明,光机系统测试灵敏度为6.4 Mv,单独头部测角精度均值为0.7″,3σ置信区间为2″~3″。

关键词：电子轰击有源像素传感器光学设计低灵敏度公差优化镜头检测

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