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Contaminant removal from low-concentration polluted river water by the bio-rack wetlands

Journal of Environmental Sciences 2012年第6期24卷 1006-1013页

作者： Ji Wang Lanying Zhang shaoyong lu Xiangcan Jint Shu Gan Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun 130021China State Environmental Protection Key Laboratory for Lake Pollution Control Engineering and Technology Center of LakeResearch Center of Lake EnvironmentChinese Research Academy of Environment SciencesBeijing 100012China College of Resources and Environment Hunan Agriculture UniversityChangsha 410128China

The bio-rack is a new approach for treating low-concentration polluted river water in wetland systems.A comparative study of the efficiency of contaminant removal between four plant species in bio-rack wetlands and between a bio-rack system and control system was conducted on a small-scale （500 mm length × 400 mm width × 400 mm height） to evaluate the decontamination effects of four different wetland *** was generally a significant difference in the removal of total nitrogen （TN）,ammonia nitrogen （NH 3-N） and total phosphorus （TP）,but no significant difference in the removal of permanganate index （COD Mn） between the bio-rack wetland and control ***-rack wetland planted with Thalia dealbata had higher nutrient removal rates than wetlands planted with other *** fine-root （root diameter 3 mm） biomass rather than total plant biomass was related to nutrient removal *** study suggested that the nutrient removal rates are influenced by plant species,and high fine-root biomass is an important factor in selecting highly effective wetland plants for a bio-rack *** to the mass balance,the TN and TP removal were in the range of 61.03-73.27 g/m^2 and 4.14-5.20 g/m^2 in four bio-rack wetlands during the whole operational *** N and P removal by plant uptake constituted 34.9%-43.81% of the mass N removal and 62.05%-74.81% of the mass P *** study showed that the nitrification/denitrification process and plant uptake process are major removal pathways for TN,while plant uptake is an effective removal pathway for TP.

关键词： bio-rack constructed wetland fine-root biomass low-concentration polluted river water plants uptake

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Nitrogen removal from summer to winter in a field pilot-scale multistage constructed wetland-pond system

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Journal of Environmental Sciences 2022年第1期34卷 249-262页

作者： Tao Wang Liping Xiao Hongbin lu shaoyong lu Jiaxin Li Xiaochun Guo Xiaoliang Zhao National Engineering Laboratory for Lake Pollution Control and Ecological Restoration State Environmental Protection Scientific Observation and Research Station for Lake Dongtinghu(SEPSORSLD)State Environmental Protection Key Laboratory for Lake Pollution ControlState Key Laboratory of Environmental Criteria and Risk AssessmentChinese Research Academy of Environmental SciencesBeijing 100012China School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266033China College of Environmental Science and Engineering Liaoning Technical UniversityFuxin 123000China College of Water Sciences Beijing Normal UniversityBeying 100875China

A pilot-scale multistage constructed wetland-pond(MCWP)system with a"pre-ecological oxidation pond,two-stage horizontal subsurface flow constructed wetland(HSCW)and surface flow constructed wetland(SFCW)as the core and postsubmerged plant pond"as the process was used to treat actual polluted river water in the field,and the variation in nitrogen removal from summer to winter was *** results showed that the average total nitrogen(TN)removal efficiency in the MCWP was approximately 40.74%.The significant positive correlation between the daily highest temperature and the TN removal efficiency of the whole system was fitted with a nonlinear curve(R^(2)=0.7192).The TN removal load rate in the HSCWs was 2.7–3.7 times that in the *** SFCW,which had high-density plants(35 plants/m^(2)),increased the proportion of nitrogen removed by plant harvesting and microbial *** TN transformed by Iris pseudacorus *** for 54.53%in the ***,bacteria completed the nitrogen cycle in the SFCW through a variety of nitrogen removal *** research not only investigated the TN removal performance in an MCWP system but also made it possible to predict the TN removal efficiency according to the daily highest temperature from summer to winter in the field.

关键词： Multistage constructed wetland-pond Total nitrogen Air temperature change Emergent plants Polluted surface water

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Effects of overlying water aeration on phosphorus fractions and alkaline phosphatase activity in surface sediment

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Journal of Environmental Sciences 2011年第2期23卷 206-211页

作者： Jianjun Chen shaoyong lu Yikun Zhao Wei Wang Minsheng Huang School of Resource and Environmental Sciences East China Normal University Shanghai 200062 China State Environmental Protection Key Laboratory for Lake Pollution Control Research Center of Lake Environment Chinese Research Academy of Environmental Sciences Beijing 100012 China Civil and Environment Engineering School University of Science & Technology Beijing Beijing 100083 China

Microbial activity may influence phosphorus （P） deposit and release at the water sediment interface. The properties of DO （dissolved oxygen）, pH, P fractions （TE Ca-E Fe-R OE IP）, and APA （alkaline phospfiatase activity） at the water sediment interface were measured to investigate microbial activity variations in surface sediment under conditions of two-month intermittent aeration in overlying water. Results showed that DO and TP of overlying water increased rapidly in the first week and then decreased gradually after 15 day of intermittent aeration. Microorganism metabolism in surface sediment increased pH and decreased DO and TP in the overlying water. After two-month intermittent aeration, APA and OP from surface sediment （0-2 cm） were both significantly higher than those from bottom sediment （6-8 cm）（p 〈 0.05）, and surface sediment Fe-P was transferred to OP during the course of microorganism reproduction on the surface sediment. These results suggest that microbial activity and microorganism biomass from the surface sediment were higher than those from bottom sediment after two-month intermittent aeration in the overlying water.

关键词： aeration disturbance sediment phosphorus fractions alkaline phosphatase

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G protein-coupled receptors(GPCRs):advances in structures,mechanisms,and drug discovery

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1938-1980页

作者： Mingyang Zhang Ting Chen Xun lu Xiaobing Lan Ziqiang Chen shaoyong lu Key Laboratory of Protection Development and Utilization of Medicinal Resources in Liupanshan AreaMinistry of EducationPeptide&Protein Drug Research CenterSchool of PharmacyNingxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Cardiology Changzheng HospitalAffiliated to Naval Medical UniversityShanghai 200003China Department of Orthopedics Changhai HospitalAffiliated to Naval Medical UniversityShanghai 200433China

G protein-coupled receptors(GPCRs),the largest family of human membrane proteins and an important class of drug targets,play a role in maintaining numerous physiological *** or antagonist,orthosteric effects or allosteric effects,and biased signaling or balanced signaling,characterize the complexity of GPCR dynamic *** this study,we first review the structural advancements,activation mechanisms,and functional diversity of *** then focus on GPCR drug discovery by revealing the detailed drug-target interactions and the underlying mechanisms of orthosteric drugs approved by the US Food and Drug Administration in the past five ***,an up-to-date analysis is performed on available GPCR structures complexed with synthetic small-molecule allosteric modulators to elucidate key receptor-ligand interactions and allosteric ***,we highlight how the widespread GPCR-druggable allosteric sites can guide structure-or mechanism-based drug design and propose prospects of designing bitopic ligands for the future therapeutic potential of targeting this receptor family.

关键词： steric designing mechanisms

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Spatial distribution of phosphorus forms in sediments with different distances to the estuary of the Dianchi Lake,China

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Frontiers of Environmental Science & Engineering 2010年第3期4卷 295-300页

作者： shaoyong lu Xiangcan JIN Fengchang WU Jianning GUO Jing SI Research Center of Lake Eco-environment Chinese Research Academy of Environmental SciencesBeijing 100012China Department of Environmental Engineering Jilin Architectural and Civil Engineering InstituteChangchun 130021China

Effects of human activity on the distribution of phosphorus(P)forms were investigated for the sediments and porewaters in Daqinghe Estuary of Dianchi Lake,*** concentrations of total P(TP),inorganic-P(IP),and organic-P(Org-P),and the ratio of iron-bound P(Fe-P)/calcium-bound P(Ca-P)in the sediments decreased with the increasing distance from the sampling site to the *** is probably due to the flocculant materials,e.g.,ferric and aluminous salts,usually being added in the wastewater treatment *** concentration of ammonia in the sediment porewaters significantly decreased with the increasing distance from the sampling site to the *** concentrations of total nitrogen and nitrogen in the sediment porewaters decreased to some content with the increasing distance from the sampling site to the ***,the concentrations of nitrate,dissolved total P(DTP),and TP did not have strong relationship with the distances from the sampling sites to the *** load and water quantity also had an important influence on the concentrations of P in sediments and its interstitial water in estuary sedimentary area.

关键词： estuary sedimentary area phosphorus(P) spatial distribution human activity the Dianchi Lake

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Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1355-1361页

作者： shaoyong lu Yingyi Chen Jiacheng Wei Mingzhu Zhao Duan Ni Xinheng He Jian Zhang Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China State Key Laboratory of Oncogenes and Related Genes Renji HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200127China The Charles Perkins Centre University of SydneySydney NSW 2006Australia

The recent discovery of activator compounds binding to an allosteric site on the NAD+-dependent protein lysine deacetylase,sirtuin 6(SIRT6)has attracted interest and presents a pharmaceutical target for aging-related and cancer ***,the mechanism underlying allosteric activation of SIRT6 by the activator MDL-801 remains largely elusive because no major conformational changes are observed upon activator *** combining molecular dynamics simulations with biochemical and kinetic analyses of wild-type SIRT6 and its variant M136 A,we show that conformational rotation of 2-methyl-4-fluoro-5-bromo substituent on the right phenyl ring(R-ring)of MDL-801,which uncovers previously unseen hydrophobic interactions,contributes to increased activating deacetylation activity of *** hypothesis is further supported by the two newly synthesized MDL-801 derivatives through the removal of the 5-Br atom on the R-ring(MDL-801-D1)or the restraint of the rotation of the R-ring(MDL-801-D2).We further propose that the 5-Br atom serves as an allosteric driver that controls the ligand allosteric *** study highlights the effect of allosteric enzyme catalytic activity by activator binding and provides a rational approach for enhancing deacetylation activity.

关键词： Allosteric driver Allosteric sites Allosteric mechanisms Drug design Enzyme catalysis Protein dynamics

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Control concept and countermeasures for shallow lakes’eutrophication in China

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Frontiers of Environmental Science & Engineering 2008年第3期2卷 257-266页

作者： Xiangcan JIN shaoyong lu Xiaozhen HU Xia JIANG Fengchang WU State Environmental Protection Key Laboratory for Lake Pollution Control Research Center of Lake EnvironmentChinese Research Academy of Environmental SciencesBeijing 100012China

Research on lake eutrophication in China began in the early 1970s,and many lakes in China are now known to be in meso-eutrophic *** eutrophication has been showing a rapidly increasing trend since *** show that the main reasons for lake eutrophication include a fragile lake background environment,excessive nutrient loading into lakes,excessive human activities,ecological degeneration,weak environmental protection awareness,and lax lake *** mechanisms resulting from lake eutrophication include nutrient recycling imbalance,major changes in water chemistry(pH,oxygen,and carbon),lake ecosystem imbalance,and algal prevalence in *** concepts for controlling eutrophication should be persistently proposed,including lake catchment control,combination of pollutant source control with ecological restoration,protection of three important aspects(terrestrial ecology,lake coast zone,and submerged plant),and combination of lake management with *** to control lake eutrophication should include pollution source control(i.e.,optimize industrial structural adjustments in the lake catchment,reduce nitrogen and phosphorus emission amounts,and control endogenous pollution)and lake ecological restoration(*** a zone-lake buffer region and lakeside zone,protect regional vegetation,utilize hydrophytes in renovation technology);countermeasures for lake management should include implementing water quality management,identifying environmental and lake water goals,legislating and formulating laws and regulations to protect lakes,strengthening publicity and the education of people,increasing public awareness through participation in systems and mechanic innovations,establishing lake region management institutions,and ensuring implementation of governance and management measures.

关键词： China lake eutrophication control concept and countermeasures

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Targeting RAS phosphorylation in cancer therapy:Mechanisms and modulators

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3433-3446页

作者： Yuran Qiu Yuanhao Wang Zongtao Chai Duan Ni Xinyi Li Jun Pu Jie Chen Jian Zhang shaoyong lu Chuan Lv Mingfei Ji Department of Urology Changzheng HospitalNaval Military Medical UniversityShanghai 200003China Department of Pathophysiology Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of EducationShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China Department of Hepatic Surgery VI Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Department of Cardiology Renji HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200120China Department of Plastic Surgery Changhai HospitalNaval Military Medical UniversityShanghai 200438China

RAS,a member of the small GTPase family,functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded *** gain-of-function mutations are one of the leading causes in human oncogenesis,accounting for w19%of the global cancer *** a well-recognized target in malignancy,RAS has been intensively studied in the past *** the sustained efforts,many failures occurred in the earlier exploration and resulted in an‘undruggable’feature of RAS *** at several residues has been recently determined as regulators for wild-type and mutated RAS ***,the development of RAS inhibitors directly targeting the RAS mutants or towards upstream regulatory kinases supplies a novel direction for tackling the anti-RAS difficulties.A better understanding of RAS phosphorylation can contribute to future therapeutic *** this review,we comprehensively summarized the current advances in RAS phosphorylation and provided mechanistic insights into the signaling transduction of associated ***,the preclinical and clinical success in developing anti-RAS drugs targeting the upstream kinases and potential directions of harnessing allostery to target RAS phosphorylation sites were also discussed.

关键词： RAS Phosphorylation Undruggable Protein kinases Allostery

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Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1302-1316页

作者： Xinyuan Xu Qian Zhang Xufeng Wang Jing Jin Chengwei Wu Li Feng Xiuyan Yang Mingzhu Zhao Yingyi Chen shaoyong lu Zhen Zheng Xiaobing Lan Yi Wang Yan Zheng Xuefeng lu Qiufen Zhang Jian Zhang State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Medicinal Chemistry and BioinformaticsCenter Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230026China Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Pancreatic Surgery Shanghai General HospitalShanghai Key Laboratory of Pancreatic DiseaseInstitute of Pancreatic DiseaseShanghai Jiao Tong University School of MedicineShanghai 200080China

Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour ***6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic ***,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be ***,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/***,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/*** allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural ***,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver *** our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic *** not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.

关键词： SIRT6 Inhibitor Allosteric Selectivity Cocrystal Pancreatic cancer metastasis

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Poly(Ethylene Oxide) Mediated Synthesis of Sub-100-nm Aluminum Nanocrystals for Deep Ultraviolet Plasmonic Nanomaterials

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CCS Chemistry 2020年第4期2卷 516-526页

作者： Shuang Yang shaoyong lu Yang Li Hua Yu Linxia He Tianmeng Sun Bai Yang Kun Liu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012 The First Bethune Hospital and Institute of Immunology Jilin UniversityChangchun 130021 State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130012

Aluminum nanocrystals(Al NCs)are sustainable plasmonic nanomaterials with unique localized surface plasmonic resonance(LSPR)in the ultraviolet(UV)*** synthesis of sub-100-nm Al NCs remains a considerable challenge due to the lack of effective ligands to control their ***,we describe a precise size-controlled synthesis of small colloidal Al NCs(25–100 nm)with strong and tunable LSPR peak from 250 to 372 nmin the UV spectral region by the use of poly(ethylene oxide)(PEO)as a polydentate surface ligand.

关键词： aluminum nanocrystal UV plasmonics polymer ligands size-controlled synthesis poly (ethylene) oxide

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