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Quercetin regulates depression-like behavior in CUMS rat models via TLR4/NF-κB signaling

BIOCELL 2024年第5期48卷 731-744页

作者： YUANYUAN LI BITAO ZHANG ZILONG CUI PEIJIAN FAN shaoxian wang College of Basic Medicine Hebei University of Chinese MedicineShijiazhuang050200China Hebei Key Laboratory of Integrated Chinese and Western Medicine for Lung Disease Research Shijiazhuang050091China

Background:Depression is becoming increasingly prevalent around the world,imposing a substantial burden on individuals,families,as well as society.Quercetin is known to be highly effective in treating depression.However,additional research is needed to dissect the mechanisms of its anti-depressive effects.Methods:For this study,Sprague-Dawley(SD)rats were randomized into the control,model,quercetin,or fluoxetine group.The latter three groups were exposed to chronic unpredictable mild stress(CUMS)for 42 d.The first two groups received saline solution daily via oral gavage.Meanwhile,the quercetin group was orally administered a quercetin suspension(52.08 mg/kg)every day,while the fluoxetine group was orally administered a fluoxetine solution(2.08 mg/kg).Here,fluoxetine served as the positive control drug to compare the therapeutic effects of quercetin.The experimental period was 6 weeks.Depressive behaviors in rats were assessed through various physiological and behavioral measures.Additionally,pathological changes in hippocampal tissues were examined using Nissl staining.Serum cytokines were detected using an enzymelinked immunosorbent assay(ELISA),and immunohistochemistry was employed to quantify the levels and integral optical density(IOD)values of ionized calcium binding adaptor molecule-1(Iba-1)expression in the brain.Real-time fluorescence quantitative PCR(RT-qPCR)was utilized to evaluate the mRNA levels of inflammatory indicators as well as toll-like receptor 4(TLR4),and nuclear factor-κappa B P65(NF-κB P65)in hippocampus.Western blot(WB)technique was employed to observe the protein levels of TLR4,NF-κB P65,and phospho-NF-κB P65(p-NF-κB P65).Results:After 42 d of exposure to CUMS,rats exhibited a slow increase in body weight,a reduction in food intake,an abnormal preference for sugar water,and aberrant open-field behaviors.Pathological analysis revealed the disintegration,rupture,interruption,and disorganization of hippocampal neuronal cells after CUMS exposure,along with a decrease in Nissl bodies in the CA

关键词： Quercetin Chronic unpredictable mild stress Depression Microglia TLR4/NF-κB inflammatory pathway

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Vertically aligned montmorillonite aerogel-encapsulated polyethylene glycol with directional heat transfer paths for efficient solar thermal energy harvesting and storage

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 907-916页

作者： Qijing Guo Cong Guo Hao Yi Feifei Jia shaoxian Song Key Laboratory of Green Utilization of Critical Non-metallic Mineral Resources Ministry of EducationWuhan University of TechnologyWuhan 430070China School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China Hubei Key Laboratory of Mineral Resources Processing and Environment Wuhan University of TechnologyWuhan 430070China

The conversion and storage of photothermal energy using phase change materials(PCMs)represent an optimal approach for harnessing clean and sustainable solar energy.Herein,we encapsulated polyethylene glycol(PEG)in montmorillonite aerogels(3D-Mt)through vacuum impregnation to prepare 3D-Mt/PEG composite PCMs.When used as a support matrix,3D-Mt can effectively prevent PEG leakage and act as a flame-retardant barrier to reduce the flammability of PEG.Simultaneously,3D-Mt/PEG demonstrates outstanding shape retention,increased thermal energy storage density,and commendable thermal and chemical stability.The phase transition enthalpy of 3D-Mt/PEG can reach 167.53 J/g and remains stable even after 50 heating-cooling cycles.Furthermore,the vertical sheet-like structure of 3D-Mt establishes directional heat transport channels,facilitating efficient phonon transfer.This configuration results in highly anisotropic thermal conductivities that ensure swift thermal responses and efficient heat conduction.This study addresses the shortcomings of PCMs,including the issues of leakage and inadequate flame retardancy.It achieves the development and design of 3D-Mt/PEG with ultrahigh strength,superior flame retardancy,and directional heat transfer.Therefore,this work offers a design strategy for the preparation of high-performance composite PCMs.The 3D-Mt/PEG with vertically aligned and well-ordered array structure developed in this research shows great potential for thermal management and photothermal conversion applications.

关键词： montmorillonite aerogel polyethylene glycol phase change materials solar thermal energy storage flame retardant

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Doping engineering of lithium-aluminum layered double hydroxides for high-efficiency lithium extraction from salt lake brines

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Nano Research 2024年第3期17卷 1646-1654页

作者： Lingjie Zhang Tingting Zhang Yunliang Zhao Guangfeng Dong Shuaike Lv Songliang Ma shaoxian Song Mildred Quintana School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China School of Resources and Environmental Engineering Wuhan University of TechnologyWuhan 430070China Facultad de Ciencias Universidad Autonoma de San Luis PotosiAv.Parque Chapultepec 1570San Luis Potosi 78210Mexico Wuhan Clayene Technology Co. Ltd.Wuhan 430223China State Development Investment Xinjiang Lop Nur Potash Corporation Hami 839000China

Lithium-aluminum layered double hydroxides(LiAl-LDH)have been be successfully applied in commercial-scale for lithium extraction from salt lake brine,however,further advancement of their applications is hampered by suboptimal Li^(+)adsorption performance and ambiguous extraction process.Herein,a doping engineering strategy was developed to fabricate novel Zn^(2+)-doped LiAl-LDH(LiZnAl-LDH)with remarkable higher Li^(+)adsorption capacity(13.4 mg/g)and selectivity(separation factors of 213,834,171 for Li^(+)/K^(+),Li^(+)/Na^(+),Li^(+)/Mg^(2+),respectively),as well as lossless reusability in Luobupo brine compared to the pristine LiAl-LDH.Further,combining experiments and simulation calculations,it was revealed that the specific surface area,hydrophilic,and surface attraction for Li^(+)of LiZnAl-LDH were significantly improved,reducing the adsorption energy(Ead)and Gibbs free energy(ΔG),thus facilitating the transfer of Li^(+)from brine into interface followed by insertion into voids.Importantly,the intrinsic oxygen vacancies derived from Zn-doping depressed the diffusion energy barrier of Li^(+),which accelerated the diffusion process of Li^(+)in the internal bulk of LiZnAl-LDH.This work provides a general strategy to overcome the existing limitations of Li^(+)recovery and deepens the understanding of Li^(+)extraction on LiAl-LDH.

关键词： lithium extraction salt lake brines doping engineering lithium-aluminum layered double hydroxides density functional theory

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Neuropeptide Y and leptin receptor expression in the hypothalamus of rats with chronic immobilization stress

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Neural Regeneration Research 2013年第18期8卷 1721-1726页

作者： shaoxian wang Jiaxu Chen Guangxin Yue Minghua Bai Meijing Kou Zhongye Jin School of Pre-clinical Medicine Beijing University of Chinese Medicine Traditional Chinese Medicine College of Hebei Medical University Institute of Basic Theory in Chinese Medicine China Academy of Chinese Medical Sciences

In this study, Sprague-Dawley rats were immobilized to a frame for 3 hours a day for 21 days to establish a model of chronic immobilization stress. The body weight and food intake of rats subjected to chronic immobilization stress were significantly decreased compared with the control group. Dual-labeling immunofluorescence revealed that the expression of leptin receptor and the co-localization coeffient in these leptic receptor neurons in the arcuate nucleus of the hypothalamus were both upregulated, while the number of neuropeptide Y neurons was decreased. Chronic immobilization stress induced high expression of leptin receptor in the arcuate nucleus and suppressed the synthesis and secretion of neuropeptide Y, thereby disrupting the pathways in the arcuate nucleus that regulate feeding behavior, resulting in diminished food intake and reduced body weight.

关键词： neural regeneration chronic immobilization stress hypothalamus arcuate nucleus doubleimmunofluorescence neuropeptide Y leptin receptor feeding center body weight grants-supported paper neuroregeneration

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Changes in neuropeptides related to food intake in the rat arcuate nucleus after chronic immobilization stress and the effect of comfortable music exposure

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BIOCELL 2020年第3期44卷 421-429页

作者： HAO wang FANG FANG CHAOYI FANG RUNSHENG ZHAO shaoxian wang School of Preclinical Medicine Hebei University of Chinese MedicineShijiazhuangChina Department of Oncology Hebei Provincial Hospital of Traditional Chinese MedicineShijiazhuangChina

Stress is an inevitable interference factor that seriously affects health.Listening to music is an economical,noninvasive,and highly accepted tool for easing stress.However,physiological studies investigating the ability of music to reduce stress in daily life are limited.We established rat models of chronic immobilization stress(CIS)to observe changes in the hypothalamic arcuate nucleus(ARC)neurons involved in the regulation of food intake and the effect of comfortable classical music exposure.Twenty-one days of stress resulted in decreased food intake and delayed body weight gain,up-regulation of leptin receptor(Ob-R),cocaine-and amphetamine-regulated transcript(CART),proopiomelanocortin(POMC),and alpha-melanocyte-stimulating hormone(α-MSH)expression,and downregulation of neuropeptide Y(NPY)and agouti-related protein(AgRP)expression in the ARC.Thus,peripheral leptin entered the ARC under chronic stress conditions,bound to Ob-R,and affected downstream nerve pathways related to appetite,such as the NPY/AgRP and CART/POMC pathways.Gentle classical music played at 65 dB reversed the abnormal expression of Ob-R and NPY induced by chronic stress.Thus,listening to comfortable music improves changes in ARC neurons related to the regulation of food intake in CIS rats,and these results provide a reference for basic research regarding how music therapy alleviates stress and stress-related health issues.

关键词： Hypothalamic arcuate nucleus Neuropeptides Food intake Body weight Chronic immobilization stress Music exposure

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考虑刚度与强度劣化的洞室围岩弹塑性分析

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岩土工程学报 2024年第1期46卷 101-109页

作者：张帅王俊杰张海龙宋少贤吴岱峰重庆交通大学土木工程学院重庆400074 重庆交通大学材料科学与工程学院重庆400074 重庆文理学院土木工程学院重庆402160 重庆市市政设计研究院有限公司重庆400020 重庆市城投基础设施建设有限公司重庆400015

地下洞室锚固围岩进入塑性状态后其刚度与强度均会产生一定程度的劣化。将锚固围岩视为复合岩体并借助参数等效原则求出其刚度与强度参数后,基于D-P屈服准则得到了考虑劣化效应的深埋圆形洞室锚固围岩弹塑性解,借助FLAC-3D有限差分软件... 详细信息

地下洞室锚固围岩进入塑性状态后其刚度与强度均会产生一定程度的劣化。将锚固围岩视为复合岩体并借助参数等效原则求出其刚度与强度参数后,基于D-P屈服准则得到了考虑劣化效应的深埋圆形洞室锚固围岩弹塑性解,借助FLAC-3D有限差分软件验证了该方法的可靠性后对相关影响因素进行了具体分析。研究结果表明:①考虑锚固围岩的刚度与强度同时劣化后得到的围岩变形量更符合实际;②残余黏聚力c"、残余内摩擦角φ"、残余弹性模量E"的大小对锚固塑性残余区半径Rb、洞壁位移u具有控制性作用,当c",φ",E"取值越大时,Rb,u便会越小,反之Rp、Rb、u便会越大;③软化模量Mc、Mφ对塑性残余区半径Rb、洞壁位移u的影响较大,对塑性软化区半径Rp的影响可以忽略;④系统锚杆与支护阻力pi协调作用下可以有效控制塑性残余区范围及围岩变形。

关键词：洞室围岩刚度劣化强度劣化锚固效应 D-P准则

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440 MPa级高强钢焊条熔敷金属组织与低温冲击韧性研究

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焊接学报 2024年第3期45卷 120-128,I0010页

作者：曾道平郑韶先安同邦代海洋马成勇兰州交通大学兰州730070 钢铁研究总院焊接研究所北京100081

为满足440 MPa级高强钢对焊接材料的需求,研制了三种焊条,并进行了熔敷金属焊接试验,使用光学显微镜、扫描电镜和透射电镜等手段研究了熔敷金属组织与低温冲击韧性.结果表明,随着Mn,Ni,Cr和Cu含量的增大,熔敷金属的-40℃平均冲击吸收功... 详细信息

为满足440 MPa级高强钢对焊接材料的需求,研制了三种焊条,并进行了熔敷金属焊接试验,使用光学显微镜、扫描电镜和透射电镜等手段研究了熔敷金属组织与低温冲击韧性.结果表明,随着Mn,Ni,Cr和Cu含量的增大,熔敷金属的-40℃平均冲击吸收功从35.7 J逐渐增至96.3 J,低温冲击韧性逐渐提高;随着Mn,Ni,Cr和Cu含量的增大,虽然熔敷金属中M23C6型碳化物含量逐渐增大,但是熔敷金属的CCT曲线逐渐右移,相变温度逐渐降低,使得针状铁素体含量逐渐增加,铁素体板条尺寸逐渐减小和板条间交织状分布趋势逐渐增强,M-A组元含量及尺寸逐渐减小,是低温冲击韧性逐渐提高的主要原因;含Cu熔敷金属中夹杂物外层会形成CuS,针状铁素体形核更容易,有利于低温冲击韧性提高.

关键词： 440 MPa级高强钢熔敷金属针状铁素体 M-A组元低温冲击韧性

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表面波度对液体椭圆孔端面密封上游泵送特性的影响

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润滑与密封 2024年第1期49卷 149-154页

作者：顾广溪宋源森白少先新乡航空工业(集团)有限公司河南新乡453000 浙江工业大学机械工程学院浙江杭州310032

表面波度与端面几何型槽的耦合影响使得密封性能的变化规律更为复杂。基于粗糙和波度表面假设,建立空化效应下端面椭圆孔液体上游泵送密封的理论分析模型,对上游泵送端面密封的压力分布和泄漏率进行数值求解计算,分析周向表面波度幅值... 详细信息

表面波度与端面几何型槽的耦合影响使得密封性能的变化规律更为复杂。基于粗糙和波度表面假设,建立空化效应下端面椭圆孔液体上游泵送密封的理论分析模型,对上游泵送端面密封的压力分布和泄漏率进行数值求解计算,分析周向表面波度幅值、数量等几何参数和转速、密封压力等操作参数对开启力和泄漏率的影响规律。结果显示:表面波度使得密封端面产生更高的流体动压效果,并减弱上游泵送效果,容易导致密封介质的泄漏;随着波高和周向波数的增加,开启力略有增加;泄漏率随着波高的增加呈现正向增强趋势,但波数对泄漏率没有明显影响;在空化效应和表面波度的影响下,速度剪切产生的密封端面开启力可增加50%以上,并形成流体的完全上游泵送;密封压力和膜厚的增加,使得流体的上游泵送性能和密封性下降。

关键词：表面波度空化效应上游泵送椭圆孔液体端面密封

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440 MPa级高强钢焊缝金属的断裂韧性

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材料研究学报 2024年第2期38卷 151-160页

作者：曾道平安同邦郑韶先代海洋曹志龙马成勇钢铁研究总院焊接研究所北京100081 兰州交通大学材料科学与工程学院兰州730070

使用自研的Si-Mn-Ni气保护实心焊丝对440 MPa级高强钢进行MAG焊,并在系列温度下进行冲击试验、疲劳裂纹扩展速率试验和裂纹尖端张开位移试验,研究了焊缝金属的断裂韧性和显微组织对断裂韧性的影响。结果表明:焊缝金属的韧脆转变温度约为... 详细信息

使用自研的Si-Mn-Ni气保护实心焊丝对440 MPa级高强钢进行MAG焊,并在系列温度下进行冲击试验、疲劳裂纹扩展速率试验和裂纹尖端张开位移试验,研究了焊缝金属的断裂韧性和显微组织对断裂韧性的影响。结果表明:焊缝金属的韧脆转变温度约为-48.4℃;随着恒幅载荷(13~17 kN)的增大载荷循环次数N减小、疲劳寿命降低,且在应力强度因子范围ΔK相同的情况下疲劳裂纹扩展速率da/d N总体上随着恒幅载荷的增大而减小;焊缝金属的CTOD值δ为0.481~0.781 mm,有效特征值δ_(0.2BL)为0.5103 mm,CTOD值δ的离散系数仅为16.5%,表明焊缝金属的良好断裂韧性满足海洋工程的技术要求;阻碍裂纹扩展能力较强的针状铁素体使断裂韧性提高,而阻碍裂纹扩展能力较弱的准多边形铁素体和易诱发微裂纹的M-A组元使断裂韧性降低。

关键词：金属材料 440 MPa级高强钢焊缝金属断裂韧性显微组织

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基于TLR4/NF-κB信号通路研究逍遥散对慢性心理应激加重胶原诱导性关节炎大鼠病情的调节作用

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中华中医药杂志 2024年第5期39卷 2211-2218页

作者：李媛媛张碧涛崔子龙范培健王少贤河北中医药大学基础医学院石家庄050200 河北省中西医结合肺病研究重点实验室石家庄050091

目的:观察逍遥散对慢性心理应激加重胶原诱导性关节炎(CIA)大鼠病情的调节作用及可能机制。方法:40只Wistar大鼠适应性喂养1周后随机分为正常组(8只)与模型组(32只),正常组正常饲养4周,模型组大鼠在建立CIA动物模型基础上施加1周孤养与... 详细信息

目的:观察逍遥散对慢性心理应激加重胶原诱导性关节炎(CIA)大鼠病情的调节作用及可能机制。方法:40只Wistar大鼠适应性喂养1周后随机分为正常组(8只)与模型组(32只),正常组正常饲养4周,模型组大鼠在建立CIA动物模型基础上施加1周孤养与3周慢性不可预知温和应激(CUMS)建立类风湿关节炎伴发抑郁症(RAD)动物模型。通过比较第0天与第28天体质量、摄食量、糖水偏好率、旷场行为学变化及足趾容积、关节炎评分(AI)共同判断RAD模型大鼠是否制备成功。RAD模型大鼠全部成模并随机分为模型组、甲氨蝶呤组、逍遥散组、氟西汀组,每组8只。正常组与模型组每天灌胃0.9%氯化钠溶液,甲氨蝶呤组每周灌胃2次甲氨蝶呤水溶液(1 mg/kg),逍遥散组与氟西汀组除每周灌胃2次甲氨蝶呤水溶液(1 mg/kg)外,同时逍遥散组每天灌胃逍遥散水煎液(19.27 g/kg),氟西汀组每天灌胃氟西汀水溶液(2 mg/kg),给药持续6周。通过比较用药前后各组大鼠体质量、摄食量、糖水偏好率、旷场行为学及足趾容积、AI评分共同判断RAD大鼠抑郁与关节炎恢复程度;酶联免疫吸附法测定血清白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平;实时荧光定量PCR法测定海马IL-1β、TNF-α、IL-6、Toll样受体4(TLR4)、核转录因子-κB P65(NF-κB P65)mRNA表达;蛋白质印迹法(Western Blot)检测海马TLR4、NF-κB P65蛋白表达。结果:与正常组比较,模型组大鼠体质量增长缓慢,摄食量减少,糖水偏好率与旷场行为学异常,足趾容积与AI评分明显升高,兼具抑郁与关节炎外在表现,血清与海马组织中IL-1β、TNF-α、IL-6水平显著升高(P<0.01),海马组织中TLR4、NF-κB P65 mRNA与蛋白表达显著增加(P<0.01)。药物干预后,模型动物抑郁与关节炎表现得到有效改善,尤其加入抗抑郁药物逍遥散与氟西汀后效果更佳。同时,血清中IL-1β、TNF-α水平显著降低(P<0.05,P<0.01),海马组织IL-1β、TNF-α、IL-6 mRNA表达显著减少(P<0.05,P<0.01),海马组织中TLR4、NF-κB P65 mRNA与蛋白表达也显著减少(P<0.01)。结论:逍遥散可改善模型大鼠抑郁样行为同时减轻关节炎病情,其机制可能与调节TLR4/NF-κB信号通路,抑制炎症因子表达过多相关。

关键词：类风湿关节炎抑郁症胶原诱导性关节炎慢性心理应激逍遥散 TLR4/NF-κB信号通路

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