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Controls of strike-slip fault on fractures:Insight from 3D discrete element simulation

Science China Earth Sciences 2024年第1期67卷 146-164页

作者： Lianbo ZENG Zhe MAO Guoping LIU He TIAN Yingtao YAO Kewei ZU shaoqun DONG Mehdi OSTADHASSAN State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing 102249China College of Geosciences China University of Petroleum(Beijing)Beijing 102249China Institute of Energy Peking UniversityBeijing 100871China Exploration and Development Research Institute Zhongyuan Oilfield Branch CompanySINOPECZhengzhou 457001China Northeast Petroleum University Daqing 163318China

The fracture-cave reservoirs controlled by strike-slip faults are the main targets for oil and gas exploration of ultradeep carbonate in the Tarim Basin.It is of great significance to clarify the distribution rules of fractures related to strike-slip faults for guiding the exploration and development of ultra-deep oil and gas.In this study,six groups of strike-slip fault 3D models based on discrete element numerical simulation method have been created to investigate characteristics of fault-related fracture development and distribution law.In addition,we compared the modeling results to the measurement of fractures from the outcrop of a strike-slip fault in the Northern Tarim Basin to verify their validity.The results show that the stress environment is stable in the simple strike-slip section,and fractures intersecting with the strike-slip direction at a small angle are the principal fracture.In the releasing stepover and double-bend sections,the maximum principal stress changes from horizontal to vertical during the formation of pull-apart zones,where the principal fractures intersect the strike-slip direction at a large angle.The maximum principal stress in the restraining stepover and double-bend section remains horizontal,but their strikes change significantly with the increment of fault displacement.Thus,fractures intersecting the strike-slip direction at a small angle will become principal fractures early on,while those parallel to or anti-intersecting the strike-slip direction at a small angle will become principal fractures later.There are obvious differences in the development of fractures in different structural positions of strike-slip faults.Fractures are mainly concentrated in the fault tips,connections,and fault plane,and the magnitude of the fault damage zone is relatively larger in the first two.Compared with fault displacement,the principal damage zone(PDZ)shows stronger control on the distribution and development intensity of fractures.With the increment of fault displacement,the width of the f

关键词： Strike-slip fault Fault-related fracture Stepover Double-bend Discrete element method

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The multi-omics basis of potato heterosis

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Journal of Integrative Plant Biology 2022年第3期64卷 671-687页

作者： Dawei Li Xiaoyue Lu Yanhui Zhu Jun Pan shaoqun zhou Xinyan Zhang Guangtao Zhu Yi Shang Sanwen Huang Chunzhi Zhang Guangdong Laboratory of Lingnan Modern Agriculture Genome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Synthetic Biology CenterAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518172China Yunnan Key Laboratory of Potato Biology The AGISCAAS-YNNU Joint Academy of Potato SciencesYunnan Normal UniversityKunming 650500China

Heterosis is a fundamental biological phenomenon characterized by the superior performance of hybrids over their parents.Although tremendous progress has been reported in seed crops,the molecular mechanisms underlying heterosis in clonally propagated crops are largely unknown.Potato(Solanum tuberosum L.)is the most important tuber crop and an ongoing revolution is transforming potato from a clonally propagated tetraploid crop into a seed-propagated diploidhybrid potato.In our previous study,we developed the first generation of highly homozygous inbred lines of potato and hybrids with strong heterosis.Here,we integrated transcriptome,metabolome,and DNA methylation data to explore the genetic and molecular basis of potato heterosis at three developmental stages.We found that the initial establishment of heterosis in diploid potato was mainly due to dominant complementation.Flower color,male fertility,and starch and sucrose metabolism showed obvious gene dominant complementation in hybrids,and hybrids devoted more energy to primary metabolism for rapid growth.In addition,we identified~2700 allele-specific expression genes at each stage,which likely function in potato heterosis and might be regulated by CHH allele-specific methylation level.Our multi-omics analysis provides insight into heterosis in potato and facilitates the exploitation of heterosis in potato breeding.

关键词： allele-specific expression dominance DNA methylation heterosis metabolome multi-omics potato transcriptome

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Functional diversity and metabolic engineering of plantspecialized metabolites

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Life Metabolism 2022年第2期1卷 109-121页

作者： shaoqun zhou Yongshuo Ma Yi Shang Xiaoquan Qi Sanwen Huang Jiayang Li Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518120China Department of Chemical Engineering Massachusetts Institute of TechnologyCambridgeMA 02142USA Yunnan Key Laboratory of Potato Biology The CAAS-YNNU-YINMORE Joint Academy of Potato SciencesYunnan Normal UniversityKunmingYunan 650500China Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China State Key Laboratory of Plant Genomics National Center for Plant Gene ResearchInstitute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China

Plants are talented biochemists that produce a broad diversity of small molecules.These so-called specialized metabolites(SMs)play critical roles in the adaptive evolution of plants to defend against biotic and abiotic stresses,attract pollinators,and modulate soil microbiota for their own benefits.Many plant SMs have been used as nutrition and flavor compounds in our daily food,as well as drugs for treatment of human diseases.Current multi-omics tools have significantly accelerated the process of biosynthetic pathway elucidation in plants through correlation analyses,genetic mapping,and de novo biosynthetic gene cluster predictions.Understanding the biosynthesis of plant SMs has enabled reconstitution of naturally occurring specialized metabolic pathways in microbial hosts,providing a sustainable supply of these high-value molecules.In this review,we illustrate the general functions of several typical plant SMs in natural ecosystems and for human societies.We then provide an overview of current methods elucidating the biosynthetic pathways of plant SMs,and synthetic biology strategies that optimize the efficiency of heterologous biosynthetic pathways in microbial hosts.Moving forward,dissection of the functions and application of plant SMs by using current multidiscipline approaches would be greatly benefit to the scientific community and human societies.

关键词： plant specialized metabolites metabolic engineering

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Cell type-specific proteomics uncovers a RAF15-SnRK2.6/OST1 kinase cascade in guard cells

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植物学报:英文版 2023年第9期65卷 2122-2137页

作者： Hongliang Wang Yubei Wang Tian Sang Zhen Lin Rongxia Li Weiwei Ren Xin Shen Bing Zhao Xiao Wang Xuebin Zhang shaoqun zhou Shaojun Dai Honghong Hu Chun-Peng Song Pengcheng Wang Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China Institute of Advanced Biotechnology and School of Life Sciences Southern University of Science and TechnologyShenzhen 518055China Shanghai Bioprofile Technology Company Ltd Shanghai 200241China Center of Plant Germplasm Resources College of Life SciencesShanghai Normal UniversityShanghai 200234China National Key Laboratory of Crop Genetic Improvement College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Crop Stress Adaptation and Improvement College of Life SciencesCollege of AgricultureAcademy for Advanced Interdisciplinary StudiesHenan UniversityKaifeng 475004China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China

Multicellular organisms such as plants contain various cell types with specialized functions.Analyzing the characteristics of each cell type reveals specific cell functions and enhances our understanding of organization and function at the organismal level.Guard cells(GCs)are specialized epidermal cells that regulate the movement of the stomata and gaseous exchange,and provide a model genetic system for analyzing cell fate,signaling,and function.Several proteomics analyses of GC are available,but these are limited in depth.Here we used enzymatic isolation and flow cytometry to enrich GC and mesophyll cell protoplasts and perform in-depth proteomics in these two major cell types in Arabidopsis leaves.We identified approximately 3,000 proteins not previously found in the GC proteome and more than600 proteins that may be specific to GC.The depth of our proteomics enabled us to uncover a guard cell-specific kinase cascade whereby Raf15and Snf1-related kinase2.6(SnRK2.6)/OST1(open stomata 1)mediate abscisic acid(ABA)-induced stomatal closure.RAF15 directly phosphorylated SnRK2.6/OST1 at the conserved Ser175 residue in its activation loop and was sufficient to reactivate the inactive form of SnRK2.6/OST1.ABAtriggered SnRK2.6/OST1 activation and stomatal closure was impaired in raf15 mutants.We also showed enrichment of enzymes and flavone metabolism in GC,and consistent,dramatic accumulation of flavone metabolites.Our study answers the long-standing question of how ABA activates SnRK2.6/OST1 in GCs and represents a resource potentially providing further insights into the molecular basis of GC and mesophyll cell development,metabolism,structure,and function.

关键词： abscisic acid guard cell metabolomics phosphorylation proteomics signaling

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基于GNSS浮标数据的PPP和PPK方法解算海面高精度对比分析

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北京测绘 2024年第1期38卷 102-106页

作者：潘少群江西省地质局地理信息工程大队江西南昌330001

全球导航卫星系统(GNSS)浮标技术的广泛应用为海面高测量提供了一种新的思路和方法。使用直径为2 m的GNSS浮标采集了5 d的GNSS观测数据,通过精密单点定位(PPP)和事后处理动态相对定位(PPK)方法对数据进行解算,得到海面高,并对解算的海... 详细信息

全球导航卫星系统(GNSS)浮标技术的广泛应用为海面高测量提供了一种新的思路和方法。使用直径为2 m的GNSS浮标采集了5 d的GNSS观测数据,通过精密单点定位(PPP)和事后处理动态相对定位(PPK)方法对数据进行解算,得到海面高,并对解算的海面高进行低通滤波,将滤波前后的海面高数据与压力计观测的海面高进行对比分析。结果显示:PPP和PPK方法的解算精度(内符合精度)相当;与压力计的对比结果表明,PPK方法的解算精度略高于PPP方法,其与压力计数据的差值整体上较小,但精度相差不大;在滤波后,PPP和PPK方法的定位精度都得到了提高,滤波处理有助于提高海面高观测精度。

关键词：海面高精密单点定位事后处理动态相对定位滤波

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淮北地区辣椒雄性不育三系育种技术

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长江蔬菜 2024年第14期 65-67页

作者：周少群花娟娟朱珠刘春淮北市农业科学研究院安徽淮北235099 淮北师范大学生命科学学院

利用辣椒雄性不育三系育种,大大节省人工费用,种子产量可增加5%~8%,整个种子生产成本可降低30%左右,从而降低了种子价格,减少种植户的生产成本。此外,利用雄性不育系制种避免了自交种、假杂种的存在,保证了种子纯度。

关键词：淮北地区辣椒雄性不育三系育种技术

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定位与非定位颈椎旋转手法对不同程度粥样硬化颈内动脉拉伸力学性能的影响

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中国组织工程研究 2024年第30期28卷 4788-4794页

作者：张少群郑川江刘佳富蒋顺琬广州中医药大学第四临床医学院深圳市中医院广东省深圳市518033

背景:颈椎旋转手法被广泛应用于颈部疾病的治疗且疗效明确,但临床发现其存在一定风险。作者前期研究发现颈椎旋转手法会降低粥样硬化颈动脉的拉伸力学性能,但尚不明确不同颈椎旋转手法(定位/非定位)及不同程度(轻/中/重度)粥样硬化对颈... 详细信息

背景:颈椎旋转手法被广泛应用于颈部疾病的治疗且疗效明确,但临床发现其存在一定风险。作者前期研究发现颈椎旋转手法会降低粥样硬化颈动脉的拉伸力学性能,但尚不明确不同颈椎旋转手法(定位/非定位)及不同程度(轻/中/重度)粥样硬化对颈动脉拉伸力学性能的影响。目的:探索不同颈椎旋转手法及不同程度粥样硬化对颈内动脉拉伸力学性能的影响。方法:120只雄性新西兰兔根据不同程度粥样硬化及不同颈椎旋转手法干预随机分为重度粥样硬化+定位/非定位颈椎旋转手法、中度粥样硬化+定位/非定位颈椎旋转手法、轻度粥样硬化+定位/非定位颈椎旋转手法、正常兔+定位/非定位颈椎旋转手法共8个实验组,以及轻/中/重度粥样硬化+无手法干预共3个模型对照组和1个空白对照组。采用两因素方差分析探索不同颈椎旋转手法及不同程度粥样硬化对颈内动脉拉伸力学性能的主效应及交互效应,并用单因素方差分析探索同一程度粥样硬化情况下,不同手法干预对颈内动脉拉伸力学性能的影响。结果与结论:①“不同颈椎旋转手法”与“不同程度粥样硬化”均是影响颈内动脉拉伸力学性能的主效应因素;②对于轻度及重度粥样硬化,定位颈椎旋转手法及非定位颈椎旋转手法均会降低颈内动脉的最大应力(P0.05);⑤结果提示,定位颈椎旋转手法及非定位颈椎旋转手法均可能会增加动脉粥样硬化颈内动脉的刚度,使其弹性降低、脆性增加;因此定位颈椎旋转手法及非定位颈椎旋转手法均会增加轻/中/重度颈内动脉粥样硬化家兔出现心血管事件的风险,且粥样硬化程度越重,定位/非定位颈椎旋转手法风险均越大,但定位颈椎旋转手法的风险并未比非定位颈椎旋转手法低。

关键词：动脉粥样硬化定位颈椎旋转手法非定位颈椎旋转手法拉伸力学性能因素分析

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免疫亲和柱净化-超高效液相色谱串联质谱法同时测定火锅底料中的5种真菌毒素

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食品科技 2024年第2期49卷 334-339页

作者：孟春杨吴玉田邹璐钟雪杨绍群刘文政周贻兵贵州省疾病预防控制中心贵州贵阳550004

目的:建立复合免疫亲和柱净化、超高效液相色谱串联质谱检测火锅底料中的黄曲霉毒素B_(1)(Aflatoxins B_(1),AFB_(1))、黄曲霉毒素B_(2)(Aflatoxins B_(2),AFB_(2))、黄曲霉毒素G_(1)(Aflatoxins G_(1),AFG_(1))、黄曲霉毒素G_(2)(Aflatoxins G_(2),AFG_(2))、赭曲霉毒素A(Ochratoxin A,OTA)的方法。方法:样品提取后,经复合免疫亲和柱净化,以0.1%甲酸水和甲醇为流动相梯度洗脱,用Agilent EclipsePlus C_(18)RRHD色谱柱分离,ESI+进行多反应监测,内标法定量。结果:5种真菌毒素的线性范围在0.1~10.0 ng/mL,相关系数(r)>0.999,检出限0.1μg/kg,定量限0.3μg/kg。3个加标水平下(0.2、5.0、10.0μg/kg)的回收率在81.38%~97.87%之间,相对标准偏差为0.79%~6.18%。结论:该方法快速准确,可用于火锅底料中5种真菌毒素的定性、定量检测。

关键词：免疫亲和柱超高效液相色谱串联质谱火锅底料真菌毒素

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张吉怀铁路酉水大桥非对称拱桥钢拱肋架设技术研究

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高速铁路技术 2024年第2期15卷 102-107,118页

作者：孙凤祥左少群李江中铁大桥局集团第五工程有限公司江西九江332001

张吉怀铁路酉水大桥主桥为主跨292 m的非对称上承式钢管混凝土拱桥,其钢拱肋采用斜拉扣挂法进行节段悬臂架设施工。本文结合张吉怀铁路酉水大桥工程,针对高速铁路非对称拱桥钢拱肋安装施工技术展开研究,主要包括:复杂地形条件下的施工技... 详细信息

张吉怀铁路酉水大桥主桥为主跨292 m的非对称上承式钢管混凝土拱桥,其钢拱肋采用斜拉扣挂法进行节段悬臂架设施工。本文结合张吉怀铁路酉水大桥工程,针对高速铁路非对称拱桥钢拱肋安装施工技术展开研究,主要包括:复杂地形条件下的施工技术,因地制宜地进行缆索起重机的设计及安装,钢管拱整节段拼装和架设,合龙装置和技术等。该施工技术保障了钢拱肋架设的精度和质量,钢拱肋的成拱线形与设计值较为吻合。该桥运营以来,各结构性能指标均满足设计要求。

关键词：张吉怀铁路酉水大桥非对称钢管混凝土拱桥钢拱肋斜拉扣挂法施工技术

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再程放疗联合CDK4/6抑制剂治疗儿童复发弥漫内生型脑桥胶质瘤的真实世界研究

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临床小儿外科杂志 2024年第5期23卷 440-445页

作者：赖名耀李少群李娟胡清军周江芬艾茹玉黄丽君苏一博于晓军蔡林波广东三九脑科医院肿瘤综合诊疗科广州暨南大学附属第一医院影像中心广州

目的分析儿童复发弥漫内生型脑桥胶质瘤(diffuse intrinsic pontine glioma, DIPG)再程放疗的疗效, 初步探讨再程放疗同步联合瑞博西尼对DIPG患儿预后的影响。方法本研究为回顾性研究, 以2021年5月至2023年5月广东三九脑科医院肿瘤科接... 详细信息

目的分析儿童复发弥漫内生型脑桥胶质瘤(diffuse intrinsic pontine glioma, DIPG)再程放疗的疗效, 初步探讨再程放疗同步联合瑞博西尼对DIPG患儿预后的影响。方法本研究为回顾性研究, 以2021年5月至2023年5月广东三九脑科医院肿瘤科接受再程放疗联合(或不联合)瑞博西尼治疗的复发DIPG患儿为研究对象, 根据国际肿瘤化疗药物通用不良反应术语标准(Common Terminology Criteria for Adverse Events, CTCAE)4.0版, 评价再程放疗联合瑞博西尼治疗的疗效及不良反应。采用Kaplan-Meier法计算患儿生存时间, 采用Log-rank检验比较再程放疗联合或不联合瑞博西尼患儿的生存情况差异。结果共纳入18例DIPG患儿, 男5例、女13例, 中位年龄7.0岁, 其中7例采用再程放疗同步瑞博西尼治疗。首程放疗与再程放疗的中位间隔时间为9.0个月。再程放疗后64.3%(9/14)肢体乏力、62.5%(5/8)言语不清、50%(3/6)行走不稳症状改善。再程放疗后77.8%(14/18)的患儿肿瘤体积缩小。18例患儿再程放疗后中位生存期为4.7个月, 中位总生存期为18.6个月。再程放疗联合瑞博西尼组与未联合瑞博西尼组的总中位生存期(17.2个月比18.9个月)、再程放疗后中位生存期(6.2个月比5.4个月)差异均无统计学意义(P值分别为0.714、0.390)。7例接受瑞博西尼同步治疗的患儿中, 3例(42.9%)出现血液系统不良反应, 分别为CTCAE 1、2、3级。结论再程放疗可改善儿童复发DIPG的临床症状, 延长生存时间。同步瑞博西尼治疗并不能改善患儿生存时间, 且增加治疗毒性。

关键词：弥漫内生型脑桥胶质瘤再程放疗瑞博西尼外科手术儿童

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