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学科交叉背景下研究生“高等数理统计”课程建设路径探析

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科教导刊 2024年第8期 68-70页

作者：李慧敏江绍萍覃文杰云南民族大学数学与计算机科学学院云南昆明650504

“高等数理统计”是概率论与数理统计专业研究生的一门核心基础课,其建设质量对研究生后续专业课程的学习和科研素养的提升具有重要意义。文章在学科交叉背景下对该课程的建设路径进行了分析和探索。首先分析了研究生“高等数理统计”... 详细信息

“高等数理统计”是概率论与数理统计专业研究生的一门核心基础课,其建设质量对研究生后续专业课程的学习和科研素养的提升具有重要意义。文章在学科交叉背景下对该课程的建设路径进行了分析和探索。首先分析了研究生“高等数理统计”课程教学现状,然后从优化教学内容、创新教学模式、强化过程性考核及加强课程思政教育四个维度提出了课程建设的路径,并将课程建设与研究生学术研究背景有机融合,为提升研究生教学质量和培养研究生科研素养提供参考。

关键词：高等数理统计研究生学科交叉课程建设

Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment

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Cellular & Molecular Immunology 2024年第1期21卷 47-59页

作者： Yu Zheng Haihui jiang Naixue Yang shaoping Shen Daosheng Huang Lemei Jia Jing Ling Longchen Xu Mingxiao Li Kefu Yu Xiaohui Ren Yong Cui Xun Lan Song Lin Xin Lin Institute for Immunology and School of Medicine Tsinghua UniversityBeijing100084China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityChina.National Clinical Research Center for Neurological DiseasesCenter of Brain TumorBeijing Institute for Brain Disorders and Beijing Key Laboratory of Brain TumorBeijing100070China Department of Neurosurgery Peking University Third HospitalPeking UniversityBeijing100191China Tsinghua-Peking Center for Life Sciences Beijing100084China

A highly immunosuppressive tumor microenvironment(TME)and the presence of the blood‒brain barrier are the two major obstacles to eliciting an effective immune response in patients with high-grade glioma(HGG).Here,we tried to enhance the local innate immune response in relapsed HGG by intracranially injecting poly(I:C)to establish a robust antitumor immune response in this registered clinical trial(NCT03392545).During the follow-up,12/27(44.4%)patients who achieved tumor control concomitant with survival benefit were regarded as responders in our *** found that the T-cell receptor(TCR)repertoire in the TME was reshaped after poly(I:C)*** on the RNA-seq analysis of tumor samples,the expression of annexin A1(ANXA1)was significantly upregulated in the tumor cells of nonresponders,which was further validated at the protein *** vitro and in vivo experiments showed that ANXA1 could induce the production of M2-like macrophages and microglia via its surface receptor formyl peptide receptor 1(FPR1)to establish a Treg cell-driven immunosuppressive TME and suppress the antitumor immune response facilitated by poly(I:C).The ANXA1/FPR1 signaling axis can inhibit the innate immune response of glioma patients by promoting an anti-inflammatory and Treg-driven ***,ANXA1 could serve as a reliable predictor of response to poly(I:C),with a notable predictive accuracy rate of 92.3%.In light of these notable findings,this study unveils a new perspective of immunotherapy for gliomas.

关键词： glioma ANXA1 TLR3 poly(I:C) immunotherapy

A case of transcatheter closure of aortopulmonary window using modified double-disk occluder

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Journal of Medical Colleges of PLA(China) 2011年第3期26卷 174-178页

作者： Chen shaoping Zhao Xianxian jiang Dong Qin Yongwen Department of Cardiology Changhai Hospital Second Military Medical University Shanghai 200433 China

Aortopuimonary window is a rare congenital cardiac malformation,which is previously repaired using cardiopulmonary ***,some cases were reported to repair the aortopuimonary septal defect by transcatheter *** we present a 30 year-old woman with a 7-mm aortopuimonary window,who was successfully treated using a modified double-disk PmVSD occluder.

关键词：肺动脉封堵器窗口封闭磁盘改性导管体外循环

课程思政教育背景下“概率论与数理统计”课堂教学改革研究

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科教导刊 2022年第1期 59-61页

作者：江绍萍张靠民云南民族大学数学与计算机科学学院云南昆明650500 昆明理工大学民航与航空学院云南昆明650500

本文在高校课程思政教育的背景下,剖析了“概率论与数理统计”课程教学现状,结合“概率论与数理统计”课程的教学内容,挖掘了几个与教学内容相关的思政教学案例,希望为其他数学类课程的思政教育提供有价值的借鉴与参考。

关键词：课程思政概率论与数理统计教学改革

RESEARCH ON IMPROVEMENT OF RELIABILITY INDEX BASED ON SAMPLING POINTS ON LIMIT STATE SURFACE

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RESEARCH ON IMPROVEMENT OF RELIABILITY INDEX BASED ON SAMPLI...

Chinese Society of Cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis

The International Symposium on Innovation & Sustainability of Structures in Civil Engineering

作者： Jian Feng Youbao jiang and shaoping Meng College of Civil Engineering Southeast University Nanjing 210096 China

＜正＞The analysis result is less accurate with the first order reliability method （FORM） when the limit state surface is highly nonlinear. The second order reliability method （SORM） can provide some accuracy, but its analysis precision is sensitive to the design point *** practical structural reliability analysis a certain function model is chosen to restructure the performance function since it is implicit. So the approximate design point will lessen the analysis accuracy with the second order reliability method. In this paper a method is proposed with the sampling point on the real limit state surface to improve reliability index based on the second order reliability method. It considers the feature of the limit state surface and approximate accuracy. Numerical examples show that the method is of high precision.

关键词： Reliability limit state surface response surface sampling point

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Science China(Life Sciences) 2024年第5期67卷 913-939页

作者： Chinese Society of Cardiology,Chinese Medical Association,Writing Group jiangang jiang Hongyang Shu Dao Wen Wang Rutai Hui Chenze Li Xiao Ran Hong Wang Jing Zhang shaoping Nie Guanglin Cui Dingcheng Xiang Qun Shao Shengyong Xu Discussion experts:Ning Zhou Yuming Li Wei Gao Yuguo Chen Yuan Bian Guoping Wang Liming Xia Yan Wang Chunxia Zhao Zhiren Zhang Yuhua Zhao Jianan Wang Shaoliang Chen Hong jiang Jing Chen Xianjin Du Mao Chen Yinxian Sun Sheng Li Hu Ding Xueping Ma Hesong Zeng Li Lin Shenghua Zhou Likun Ma Ling Tao Juan Chen Yiwu Zhou Xiaomei Guo 不详 Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Fuwai Hospital National Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Zhongnan Hospital of Wuhan University Wuhan 430062China Fuwai Huazhong Cardiovascular Hospital Zhengzhou 450003China Beijing Anzhen Hospital Capital Medical UniversityBeijing 100029China Guangzhou General Hospital of Guangzhou Military Command Guangzhou 510010China Harbin Medical University Cancer Hospital Harbin 150081China Union Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Taida Hospital Tianjin 300457China Peking University Third Hospital Beijing 100191China Qilu Hospital of Shandong University Jinan 250012China Kanghua Hospital DongguanGuangzhou 523080China Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003China Nanjing First Hospital Nanjing Medical UniversityNanjing 210006China Renmin Hospital of Wuhan University Wuhan 430060Wuhan West China Hospital Sichuan UniversityChengdu 610044China First Hospital of China Medical University Shenyang 110002China General Hospital of Ningxia Medical University Yinchuan 750003China The Second Xiangya Hospital Central South UniversityChangsha 410012China The First Affiliated Hospital of USTC University of Science and Technology of ChinaHefei 230002China The First Affiliated Hospital of Air Force Medical University Xi’an 710032China Central Hospital of Wuhan City Wuhan 430014China Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030China

Fulminant myocarditis is an acute diffuse inflammatory disease of *** is characterized by acute onset,rapid progress and high risk of *** pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory *** to China’s practical experience,the adoption of the“life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core)can significantly improve the survival rate and long-term *** emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.

关键词： fulminant myocarditis guidelines life support-based comprehensive treatment regimen diagnosis treatment cytokine storm overactivation of immunity

工作能力强化训练对手外伤患者术后功能恢复、心理状态及日常生活活动能力的影响

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中外医学研究 2020年第23期18卷 173-175页

作者：江少平佛山市中医院广东佛山528000

目的:探究工作能力强化训练对手外伤患者术后功能恢复、心理状态及日常生活活动能力的影响。方法:选取2018年10月-2019年12月笔者所在医院收治的40例手外伤术后患者为受试对象,按照随机数表法均分为研究组与对照组,各20例。对照组采取... 详细信息

目的:探究工作能力强化训练对手外伤患者术后功能恢复、心理状态及日常生活活动能力的影响。方法:选取2018年10月-2019年12月笔者所在医院收治的40例手外伤术后患者为受试对象,按照随机数表法均分为研究组与对照组,各20例。对照组采取常规康复治疗,研究组在对照组基础上给予工作能力强化训练。观察治疗前及治疗3个月后两组上肢功能[肌腱总主动活动度(MMDT)、普渡手精细运动评定(PPT)]、日常生活活动能力(Barthel指数)及心理状态[状态焦虑问卷(S-AI)]变化。结果:治疗3个月后,两组MMDT均低于治疗前,PPT均高于治疗前,且研究组MMDT、PPT均优于对照组,差异均有统计学意义(P<0.05);治疗3个月后,两组Barthel指数均高于治疗前,且研究组Barthel指数高于对照组,差异均有统计学意义(P<0.05);治疗3个月后,两组正性情绪评分均高于治疗前,负性情绪评分均低于治疗前,且研究组评分均优于对照组,差异均有统计学意义(P<0.05)。结论:工作能力强化训练可显著提高手外伤术后患者上肢功能及日常生活活动能力,改善患者心理状态。

关键词：工作能力强化训练运动功能生活能力心理状态

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链路时延波动对光纤时间传递稳定性的影响

激光与光电子学进展 2016年第4期53卷 45-51页

作者：江少平张浩姜文宁吴龟灵陈建平上海交通大学区域光纤通信网与新型光通信系统国家重点实验室上海200240 上海交通大学上海市北斗导航与位置服务重点实验室上海200240

环境温度和激光器输出波长变化引起的光纤链路时延波动直接影响光纤时间传递的稳定性。采用链路分段处理方法推导了长距离光纤时间传递的稳定性与激光器输出波长及链路温度变化之间的关系;通过分析实测的激光器波长波动数据,建立了激光... 详细信息

环境温度和激光器输出波长变化引起的光纤链路时延波动直接影响光纤时间传递的稳定性。采用链路分段处理方法推导了长距离光纤时间传递的稳定性与激光器输出波长及链路温度变化之间的关系;通过分析实测的激光器波长波动数据,建立了激光器波长波动模型。基于实际温度数据构造了3000 km光纤链路,分析了波长波动和链路铺设深度等对双向时分复用(BTDM)和波分复用(WDM)光纤时间传递稳定性的影响。结果表明:光纤链路温度变化主要影响光纤时间传递的长期稳定性,且这种影响与光纤链路铺设深度和时间传递工作季节有关;激光器波长的随机抖动主要影响光纤时间传递的短期稳定性,而波长漂移主要影响漂移周期对应时间尺度上的时间传递稳定性。当两端激光器波长随机抖动标准差从(0.07,0.05)pm变化为(0.27,0.25)pm时,3000 km光纤时间传递的稳定度由3 ps/s恶化为12 ps/s。

关键词：光纤光学长距离时间传递时间稳定性时延波动

大级差塔式起重机超重构件85m超远吊装施工技术

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施工技术 2016年第3期45卷 107-110页

作者：徐健江少平郭好新中建一局集团总承包公司北京100073

青岛国际航运中心项目钢结构外框柱安装过程中,构件最大水平吊装距离达85m,就位点超出塔式起重机吊重范围,且局部楼层外框柱无法分节,限于塔式起重机工况,局部外框柱无法正常起吊就位。通过利用现场已有资源,以大型动臂式塔式起重机L50... 详细信息

青岛国际航运中心项目钢结构外框柱安装过程中,构件最大水平吊装距离达85m,就位点超出塔式起重机吊重范围,且局部楼层外框柱无法分节,限于塔式起重机工况,局部外框柱无法正常起吊就位。通过利用现场已有资源,以大型动臂式塔式起重机L500为主,平臂式塔式起重机TC6010为辅助,利用倒链及缆风绳牵引,安全顺利地完成抬吊任务。对现场施工条件以及大级差塔式起重机抬吊难点进行分析,详细阐述施工可行性方案及安全控制要点。

关键词：安装工程钢结构塔式起重机大级差施工技术