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Asian Journal of Pharmaceutical Sciences 2020年第3期15卷 365-373页

作者： shaoning wang Chunxiu Liu Cunyang wang Jia Ma Hui Xu Jianbo Guo Yihui Deng School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityBenxi 117004China School of Pharmacy Shenyang Pharmaceutical UniversityChina Shanxi Institute for Food and Drug Control Xi’an 710065China

In this study, arsenic trioxide(ATO) was encapsulated in liposomes via copper acetate(Cu(OAc)2) gradients and high entrapment efficiency of over 80% was obtained. The average particle size and the zeta-potential of the liposomes were detected to be 115.1 ± 29.1 nm and-21.97 ± 0.6 m V, respectively. The TEM images showed rod-like precipitates in the inner aqueous phase, which was supposed be due to the formation of insoluble ATO–Cu complex.The in vitro drug release of ATO–Cu liposomes exhibited a sustained release over 72 h, and the release rates decreased with the increase of the p H of release media. Pharmacokinetic and tissue distribution studies of ATO liposomes showed significantly reduced plasma clearance rate, increased AUC0–12h and T1/2, and improved tumor distribution of As compared to iv administration of ATO solution. The anti-tumor effect of ATO loaded liposomes to S180 tumor-bearing mice was significantly improved with a tumor inhibition rate of 61.2%,meanwhile the toxicity of encapsulated ATO was greatly decreased. In conclusion, ATO can be effectively encapsulated into liposomes by remote loading method via Cu(OAc)2 gradients;the co-administration of ATO and Cu(Ⅱ) via liposomal formulation may find wide applications in the treatment of various tumors.

关键词： Arsenic trioxide Liposomes Copper acetate gradient Pharmacokinetics Tissue distribution Antitumor activity

Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats

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Asian Journal of Pharmaceutical Sciences 2017年第1期12卷 28-36页

作者： Yuqing Su Wenya Tang Yanzhi Song Chunling wang Qingjing Tian Xuling wang Jingjing Quan Buoqun Li shaoning wang Yihui Deng School of Pharmacy Shenyang Pharmaceutical University103Wenhua RoadShenyang 110016China Beijing Sihuan-Pharm Company China School of Pharmaceutical Engineering Shenyang Pharmaceutical University103Wenhua RoadShenyang 110016China

The accelerated blood clearance(ABC) phenomenon which is induced by repeated injection of poly(ethylene glycol)(PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response.A novel 4-arm poly(ethylene glycol-5000)4-cholesteryl methyl amide(4-arm PEG5000-CHMA)has been synthesized. The structure of 4-arm PEG5000-CHMA was confirmed by IR and 1H-NMR spectrum. The pharmacokinetics of the tocopheryl nicotinate(TN)-loaded nanoemulsions modified with 4-arm PEG5000-CHMA or/and 1, 2-distearoyl-Sn-glycero-3-phosphoethanolamine-n-[methoxy(poly-ethyleneglycol)-2000](mPEG2000-DSPE) have been studied. Furthermore, the ABC phenomenon has been detailed investigated in rats by TN-loaded nanoemulsions modified with 4-arm PEG5000-CHMA and mPEG2000-DSPE(CPNE). The plasma levels of TN and anti-PEG IgM antibody were determined by HPLC and ELISA, respectively.The circulation time of the CPNEs were comparable to the mPEG2000-DSPE coated nanoemulsions. Moreover, the ABC phenomenon can be decreased by CPNEs. This study designs a method to decrease the ABC phenomenon and develops a clinical promising nanoemulsion for therapeutic or imaging purpose.

关键词： Accelerated blood clearance(ABC) phenomenon Repeated administration 4-arm PEG5000-CHMA Anti-PEG IgM

Extended tacrolimus release via the combination of lipid-based solid dispersion and HPMC hydrogel matrix tablets

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Asian Journal of Pharmaceutical Sciences 2019年第4期14卷 445-454页

作者： Hui Xu Li Liu Xuehui Li Junyuan Ma Rui Liu shaoning wang School of Pharmacy Shenyang Pharmaceutical UniversityBenxi 117004China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityBenxi 117004China

The objective of this study is to evaluate the feasibility of obtaining extended release of tacrolimus by a novel combination of lipid-based solid dispersion and matrix-type extended release tablet techniques. Tacrolimus solid dispersion was prepared using glycerylbehenate(Compritol~?ATO888) and Pluronic F127 as the carrier materials with hot-melt method, which was then blended with hydrogel matrix materials, such as HPMC and lactose, the powders were directly compressed into tablets. In vitro drug release tests were carried out to evaluate the performance of the solid dispersions and the tablets. The dissolution rate of tacrolimus was significantly improved by the lipid-based solid dispersion, and the incorporation of HPC into the solid dispersion obviously improved its stability after storage. Extended release tablets loaded with tacrolimus solid dispersion showed prolonged drug release patterns over 24 h, the release patterns of the tablets can be tailored by the compositions of the matrix materials, including the types and content of HPMCs. A modified processing method that directly mixed the melted solid dispersion with HPMC powders improved the uniformity of the solid dispersion inside the tablet matrix and release profile. The release data of the extended release tablet fitted well to the Korsmeyer–Peppas model with n value of 0.85, which suggested diffusion-and erosion-controlled release mechanism. The combination of lipid-based solid dispersion and HPMC hydrogel matrix may find wide applications in the extended release dosage forms of high potent, water-insoluble drugs.

关键词： Tacrolimus Solid dispersion Lipid Extended-release tablet

Improved dissolution and oral absorption by co-grinding active drug probucol and ternary stabilizers mixtures with planetary beads-milling method

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 649-657页

作者： Fang Li Linsen Li shaoning wang Yan Yang Jia Li Dongchun Liu Sijie Zhang Siling wang Hui Xu School of Pharmacy Shenyang Pharmaceutical UniversityBenxi 117004China Shenyang Medical College Shenyang 110031China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityBenxi 117004China School of Traditional Chinese Medicine Shenyang Pharmaceutical UniversityBenxi 117004China

The objective of this work is to construct a nanosuspension drug delivery system of probucol,a BCS II drug,in order to improve its dissolution and oral bioavailability.The wet milling procedure using planetary beads-milling equipment was utilized to grind the raw probucol to ultrafine nanoparticle/nanocrystal aqueous suspension that was further solidified by freeze-drying process.Cellulose derivatives of different substitution groups and molecular weights,including HPMC,HPC,and MC,were evaluated as the primary stabilizer of probucol nanosuspension.Ternary stabilizers system composed of a primary stabilizer(cellulose derivative,i.e.HPC),a nonionic surfactant(Pluronic R F68),and an anionic surfactant(SDS)was employed to obtain probucol nanosuspension of finer particle size and enhanced dissolution in aqueous media.The probucol nanosuspension with good physical stability showed no obvious change of particle size even after storing over 7 d at 4°C or 25°C.The solidified probucol nanosuspension with trehalose as the cryoprotectant showed the highest dissolution rate(>60%at 2 h)compared to other cryoprotectant.The in vivo pharmacokinetic evaluation indicated about 15-folds higher AUC value of the probucol nanosuspension compared to that of coarse probucol suspension after oral administration to rats.The probucol nanosuspension prepared by wet-milling and ternary stabilizers system may find wide applications for improving the dissolution and oral absorption of water-insoluble drugs.

关键词： Probucol Nanosuspension Ternary stabilizers systems Planetary beads-milling Bioavailability

Fe203-CeO2-Bi203/y-AI203 catalyst in the catalytic wet air oxidation （CWAO） of cationic red GTL under mild reaction conditions

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Frontiers of Environmental Science & Engineering 2018年第1期12卷 105-112页

作者： Pan Gaol Yuan Song shaoning wang Claude Descorme Shaoxia Yang

The Fe203-CeO2-Bi203/-A1203 catalyst, a novel environmental-friendly material, was used to investigate the catalytic wet air oxidation （CWAO） of cationic red GTL under mild operating conditions in a batch reactor. The catalyst was prepared by wet impregnation, and characterized by special surface area （BET measurement）, X-ray diffraction （XRD） and X-ray photoelectron spectroscopy （XPS）. The Fe203-CeO2-]]i203/qt-A1203 catalyst exhibited good catalytic activity and stability in the CWAO under atmosphere pressure. The effect of the reaction conditions （catalyst loading, degradation temperature, solution concentration and initial solution pH value） was studied. The result showed that the decolorization efficiency of cationic red GTL was improved with increasing the initial solution pH value and the degradation temperature. The apparent activation energy for the reaction was 79 kJ. mo1-1. Hydroperoxy radicals （HO2.） and superoxide radicals （O2-） appeared as the main reactive species upon the CWAO of cationic red GTL.

关键词： Catalytic wet air oxidation （CWAO）Advanced oxidation processes （AOPs）Iron oxide catalystIndustrial wastewater

Optimum Design of Tilt Angle and Horizontal Direction of Solar Collectors under Obstacle’s Shadow for Building Applications

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Journal of Building Construction and Planning Research 2015年第2期3卷 60-67页

作者： shaoning wang Bo Hong Department of BIM Center China Architecture Design Institute Co. Ltd. Beijing China College of Landscape Architecture and Arts Northwest A&F University Yangling China

Solar collectors can provide clean, renewable, and domestic energy. The tilt angle and horizontal direction of solar collectors significantly affect its efficiency. There are many good methods to search the optimum tilt angle and horizontal direction to realize the maximum total radiation on the solar collector within a particular day or a specific period. However, it is hard to realize it when solar collectors are placed under obstacle’s shadows;especially when some obstacles, such as trees, have irregular shapes. This paper presents algorithms to achieve the best tilt angle and horizontal direction for solar collector’s performance under the free-form surfaces 3D obstacle’s shadow. The solution process is composed of 4 steps. First, it creates a 3D scene, in which a unique color is given to the solar collector. Second, it employs orthographic projection from the point of view to get an image of the scene. Third, the number of pixels is used to represent the efficiency of the solar collector by counting the pixels of the unique color. Fourth, the efficiency of solar collector in each direction in a period of time is calculated with many images to further select the best direction.

关键词： Solar Collector Tilt Angle Horizontal Direction Solar Radiation Optimum Design Orthographic Projection

Spatial distribution of laser energy and its influence on the stability of extreme narrow keyholes during ultra-high power laser welding

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Science China(Technological Sciences) 2022年第9期65卷 2079-2088页

作者： wang YiLin JIANG Ping GENG shaoning SHU LeShi SHAO XinYu The State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science&TechnologyWuhan 430074China

The instability of extremely narrow keyholes is the main challenge in high-power laser welding.In this work,the spatial energy distribution and its influence on the stability of extremely narrow keyholes during ultra-high power laser welding are studied.A multiphase flow model that considers the vapor plume impact and the multiple scattering of laser radiation is built to simulate the topology and downstream wave flow on the keyhole wall.Drastic keyhole fluctuation is due to excessive energy accumulation,which arises from the abnormal wrinkle structures that form on the front keyhole wall.Suppressing the periodic cutting phenomena on the keyhole opening and the hump accumulation effect on the solid-liquid interface help smooth the keyhole surface.Optimized welding processes are obtained,producing fine,closed,and evenly distributed wrinkle structures,and the keyhole stability is correspondingly improved.The simulation results agree well with the experiment.

关键词： ultra-high power laser welding extreme narrow keyhole spatial energy distribution keyhole stability

Manipulating oxygenate adsorption on N-doped carbon by coupling with CoSn alloy for bifunctional oxygen electrocatalyst

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Green Energy & Environment 2023年第5期8卷 1417-1428页

作者： Chenlong Dong Xilin Zhang shaoning Zhang Siwei Zhao Xueyu Lin Xin wang Yajing Zhang Fuqiang Huang Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science and EngineeringTianjin University of TechnologyTianjin300384China Beijing National Laboratory for Molecular Sciences and State Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China School of Physics Henan Normal UniversityXinxiang453007China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China College of Chemistry Zhengzhou UniversityZhengzhou450001China

Highly active bifunctional oxygen electrocatalysts accelerate the development of high-performance Zn-air battery,but suffer from the mismatched activities of oxygen evolution reaction(OER)and oxygen reduced reaction(ORR).Herein,highly integrated bifunctional oxygen electrocatalysts,cobalt-tin alloys coated by nitrogen doped carbon(CoSn@NC)are prepared by MOFs-derived method.In this hybrid catalyst,the binary CoSn nanoalloys mainly contribute to highly active OER process while the Co(or Sn)-N-C serves as ORR active sites.Rational interaction between CoSn and NC donates more rapid reaction kinetics than Pt/C(ORR)and IrO_(2)(OER).Such CoSn@NC holds a promise as air-cathode electrocatalyst in Zn-air battery,superior to Pt/C+IrO_(2)catalyst.First-principles calculations predict that CoSn alloys can upgrade charge redistribution on NC and promote the transfer to reactants,thus optimizing the adsorption strength of oxygen-containing intermediates to boost the overall reactivity.The tuning of oxygenate adsorption by interactions between alloy and heteroatom-doped carbon can guide the design of bifunctional oxygen electrocatalysts.

关键词： CoSn alloy Oxygenate adsorption Nitrogen-doped carbon Bifunctional catalyst Zn-air battery

新工科背景下车辆工程专业课程思政教学体系构建研究

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汽车实用技术 2024年第9期49卷 177-180页

作者：崔立堃施绍宁王金元陕西理工大学机械工程学院陕西汉中723001

根据新时代背景下车辆工程专业的特点和行业需求,提出培养具有良好思想道德素养和时代精神的人才是思政教育的主要目标。因此,文章给出了基于成果导向教育(OBE)理念构建车辆工程专业课程思政教学体系的方法,通过打造新工科背景下的课程... 详细信息

根据新时代背景下车辆工程专业的特点和行业需求,提出培养具有良好思想道德素养和时代精神的人才是思政教育的主要目标。因此,文章给出了基于成果导向教育(OBE)理念构建车辆工程专业课程思政教学体系的方法,通过打造新工科背景下的课程思政人才培养体系、多方面多维度协同开展课程思政内容建设、加强教师队伍建设以及打造融合课程思政的校企合作育人模式等措施,在各个层面上将思政教育元素有机地融入车辆工程专业教学,以实现专业课程思政的有效提升。

关键词：新工科车辆工程 OBE 专业课程思政

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B-PesNet: Smoothly Propagating Semantics for Robust and Reliable Multi-Scale Object Detection for Secure Systems

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Computer Modeling in Engineering & Sciences 2022年第9期132卷 1039-1054页

作者： Yunbo Rao Hongyu Mu Zeyu Yang Weibin Zheng Faxin wang Jiansu Pu shaoning Zeng School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu610054China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313000China

Multi-scale object detection is a research hotspot,and it has critical applications in many secure systems.Although the object detection algorithms have constantly been progressing recently,how to perform highly accurate and reliable multi-class object detection is still a challenging task due to the influence of many factors,such as the deformation and occlusion of the object in the actual scene.The more interference factors,the more complicated the semantic information,so we need a deeper network to extract deep information.However,deep neural networks often suffer from network degradation.To prevent the occurrence of degradation on deep neural networks,we put forth a new model using a newly-designed Pre-ReLU,which inserts a ReLU layer before the convolution layer for the sake of preventing network degradation and ensuring the performance of deep networks.This structure can transfer the semantic information more smoothly from the shallow to the deep layer.However,the deep networks will encounter not only degradation,but also a decline in efficiency.Therefore,to speed up the two-stage detector,we divide the feature map into many groups so as to diminish the number of parameters.Correspondingly,calculation speed has been enhanced,achieving a balance between speed and accuracy.Through mathematical demonstration,a Balanced Loss(BL)is proposed by a balance factor to decrease the weight of the negative sample during the training phase to balance the positives and negatives.Finally,our detector demonstrates rosy results in a range of experiments and gains an mAP of 73.38 on PASCAL VOC2007,which approaches the requirement of many security systems.

关键词： Object detection Pre-ReLU CNN Balanced loss