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Box-Behnken Design响应面法优化银杏叶提取物醇提水沉工艺

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中国药业 2024年第7期33卷 59-64页

作者：毕艳艳姜佳峰孙绍明刘健郭田甜孙艳张兰郝大伟经方与现代中药融合创新全国重点实验室山东临沂276006 鲁南厚普制药有限公司山东临沂276006 鲁南制药集团股份有限公司山东临沂276006

目的优化银杏叶提取物的醇提水沉工艺。方法在单因素试验基础上,以总黄酮醇苷转移率、萜类内酯转移率及干物质得率为综合评价指标,通过Box-Behnken Design(BBD)响应面法对液料比、提取时间、提取次数、提取液浓缩倍数、加水倍数、冷沉... 详细信息

目的优化银杏叶提取物的醇提水沉工艺。方法在单因素试验基础上,以总黄酮醇苷转移率、萜类内酯转移率及干物质得率为综合评价指标,通过Box-Behnken Design(BBD)响应面法对液料比、提取时间、提取次数、提取液浓缩倍数、加水倍数、冷沉时间进行考察。结果醇提水沉最佳工艺为液料比8∶1(V/m),提取时间1.0 h,提取次数3次,浓缩倍数3倍,加水倍数3倍,冷沉时间28.0 h。结论BBD响应面法优化得到的银杏叶提取物醇提水沉工艺科学、合理、稳定、可行。

关键词：银杏叶提取物醇提水沉工艺 Box-Behnken Design响应面法总黄酮醇苷转移率萜类内酯转移率干物质得率

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A Wheeled Wall-Climbing Robot with Bio-Inspired Spine Mechanisms

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Journal of Bionic Engineering 2015年第1期12卷 17-28页

作者： Yanwei Liu shaoming sun Xuan Wu Tao Mei Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei 230026 China Institute of Advanced Manufacturing and Technology Hefei Institute of Physical Science Chinese Academy of Sciences Changzhou 213164 China

This paper presents a wheeled wall-climbing robot with the ability to climb concrete, brick walls using circular arrays of miniature spines located around the wheel. The robot consists of two driving wheels and a flexible tail, just like letter “T”, so it is called Tbot. The simple and effective structure of Tbot enables it to be steerable and to transition from horizontal to vertical surfaces rapidly and stably. Inspired by the structure and mechanics of the tarsal chain in the Serica orientalis Motschulsky, a compliant spine mechanism was developed. With the bio-inspired compliant spine mechanism, the climbing performance of Tbot was improved. It could climb on 100° （10° past vertical） brick walls at a speed of 10 cm·s^-1. A mechanical model is also presented to analyze the forces acting on spine during a climbing cycle as well as load share between multi-spines. The simu- lation and experiment results show that the mechanical model is suitable and useful in the optimum design of Tbot.

关键词： biologically-inspired robots climbing robots compliant spine mechanisms mechanical model wheeled robots

Incidence and Mortality of Cancers in Female Genital Organs—China,2022

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China CDC weekly 2024年第10期6卷 195-202,I0003,I0004页

作者： Kexin sun Bingfeng Han Hongmei Zeng shaoming Wang Li Li Ru Chen Rongshou Zheng Wenqiang Wei National Central Cancer Registry National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Introduction:This study presented the incidence and mortality rates of cancers affecting the female genital organs in China,along with their trends spanning from 2010 to ***:700 population-based cancer registries provided relevant cancer incidence and mortality data for the year *** these,106 registries had continuous monitoring data suitable for trend analysis from 2010 to *** focused specifically on cancers affecting female genital organs(ICD10=C51-C54,C56)and projected their incidences and mortalities in China for 2022 based on data from 2018 and the trends observed from 2010 to ***-standardized incidence rate(ASIR)and mortality rate(ASMR)were calculated using Segi’s world standard ***:In 2022,there were an estimated 296,300 new cases and 104,900 deaths from female cancers in *** for vulva(C51),vagina(C52),cervix uteri(C53),corpus uteri(C54),and ovary(C56)were 0.32,0.23,13.83,6.84,and 5.68 per 100,000 *** for corpus uteri and ovary cancers were higher in urban *** for vulva,vagina,cervix,corpus uteri,and ovary cancers were 0.14,0.08,4.54,1.05,and 2.64 per 100,000 population,*** for ovarian cancer was higher in urban *** and ASMRs for most female genital organ cancers increased from 2010 to 2018,although the rate of increase for vulvar and cervical cancers in rural areas has slowed ***:Tailored cancer prevention and control programs specific to each region are necessary to address the growing disease burden.

关键词： ICD10 mortality organs

A GTD model and state space approach based method for extracting the UWB scattering center of moving target

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Science China(Information Sciences) 2011年第1期54卷 182-196页

作者： WANG Jun,WEI shaoming,sun JinPing & MAO ShiYi School of Electronic and Information Engineering,Beihang University,Beijing 100191,China School of Electronic and Information Engineering Beihang University Beijing China

Movements of the scattering center on the condition of ultra-wideband(UWB)will impact the extraction of *** paper presents an approach for extracting the moving targets’UWB scattering center parameters based on the geometrical theory of diffraction(GTD)model and the state space approach. Firstly,the UWB GTD scattering model is transformed into state-space equations in order to estimate the range and range rate through the singular value ***,the type parameter in the whole bandwidth is indicated dimension-reducedly by orthonormalized basis and estimated by traversal algorithm and minimumnorm ***,the intensity of scattering center is worked out based on the least square *** paper provides the Cramer-Rao bound(CRB)for parameter *** effectiveness of the approach is verified by computer *** approach can estimate range,range rate,reflection intensity and type parameter simultaneously in order to improve the track of scattering centers and the target identification.

关键词： scattering center extraction GTD model state space approach ultra-wideband Doppler processing

Design of All-Fused-Ring Electron Acceptors with High Thermal,Chemical,and Photochemical Stability for Organic Photovoltaics

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CCS Chemistry 2021年第6期3卷 1070-1080页

作者： Xiaozhang Zhu Songjun Liu Qihui Yue Wuyue Liu shaoming sun Shengjie Xu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Sciences University of the Chinese Academy of SciencesBeijing 100190

High-performance donor-acceptor electron acceptors containing 2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile(INCN)-type terminals are labile toward photooxidation and basic conditions,and new molecular designs toward electron acceptors that can achieve both high power conversion efficiencies and high stability are urgently *** replacing the central benzene ring in the classical ladder-type n-type semiconductor,2,2′-(indeno[1,2-b]fluorene-6,12-diylidene)dimalononitrile,with the electron-rich 4,4,9,9-tetrahexyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b′]dithiophene,we report herein the design of 2,2′-(7,7,15,15-tetrahexyl-7,15-dihydro-sindaceno[1,2-b:5,6-b′]diindeno[1,2-d]thiophene-2,10(2H)-diylidene)dimalononitrile(ITYM),a new type of all-fused-ring electron acceptor(AFRA).A threestep reaction including a key Pd-catalyzed double C-H activation/intramolecular cyclization is established for the efficient synthesis of such type of electron *** is confirmed by singlecrystal X-ray analysis,which shows a planar nonacyclic structure with strongπ-π*** with the classical carbon-bridged INCN-type acceptors,ITYM exhibits extraordinary stability with very promising *** AFRA concept opens a new avenue toward high-efficiency and-stability organic photovoltaics(OPVs).

关键词： organic photovoltaics nonfullerene acceptor all-fused-ring design C-H activation stability

基于改进小波去噪和长短时记忆网络的肌肉疲劳识别模型研究

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生物医学工程学杂志 2022年第3期39卷 507-515页

作者：王君洪孙少明孙怡宁陈竟成彭伟李磊中国科学院合肥物质科学研究院智能机械研究所合肥230031 中国科学技术大学合肥230026

肌肉疲劳状态自动识别技术在运动学和康复医学领域具有广泛的应用。本文针对采集的表面肌电(sEMG)信号噪声干扰多、现有肌肉疲劳识别模型准确度不高等问题,基于sEMG信号开展循环抗阻训练过程中的下肢肌肉疲劳识别研究。首先,提出一种改... 详细信息

肌肉疲劳状态自动识别技术在运动学和康复医学领域具有广泛的应用。本文针对采集的表面肌电(sEMG)信号噪声干扰多、现有肌肉疲劳识别模型准确度不高等问题,基于sEMG信号开展循环抗阻训练过程中的下肢肌肉疲劳识别研究。首先,提出一种改进型小波阈值函数去噪算法对采集的sEMG信号进行处理;然后,基于长短时记忆神经网络(LSTM)构建肌肉疲劳状态识别模型,利用Holdout方法评估疲劳识别模型的性能;最后,将本研究提出的改进型小波阈值函数去噪方法的去噪效果与传统小波阈值去噪方法对比,将本文提出的肌肉疲劳识别模型的性能与粒子群优化支持向量机(PSO-SVM)和卷积神经网络(CNN)算法的识别性能进行对比。结果表明:新型小波阈值函数相比于硬、软阈值函数具有更好的去噪效果;在识别肌肉疲劳状态准确度方面LSTM网络模型分别比PSO-SVM和CNN识别分类算法高4.89%和2.47%。本文提出的sEMG信号去噪方法和肌肉疲劳识别模型对于康复训练和运动过程中的肌肉疲劳监测具有重要意义。

关键词：表面肌电信号肌肉疲劳小波去噪长短期记忆神经网络

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基于机器视觉的古籍修复装置设计

仪表技术 2023年第6期 28-31页

作者：王红孙少明孙根基阚涛中国科学院合肥物质科学研究院安徽合肥230031 中国科学技术大学安徽合肥230026 中科合肥技术创新工程院安徽合肥230088

为了提高当前纸质古籍修复的智能化程度,减少人力和物力的消耗,提出一种基于机器视觉的古籍修复装置。系统包括机械结构、硬件电路和软件开发3个部分,上位机以Qt和OpenCV视觉算法库为基础进行开发,下位机以STM32为控制核心,最终实现纸... 详细信息

为了提高当前纸质古籍修复的智能化程度,减少人力和物力的消耗,提出一种基于机器视觉的古籍修复装置。系统包括机械结构、硬件电路和软件开发3个部分,上位机以Qt和OpenCV视觉算法库为基础进行开发,下位机以STM32为控制核心,最终实现纸张破损识别和激光切纸等功能。结果表明,该系统运行稳定,识别与切割准确,以期为未来纸质古籍全自动修复机器人的开发提供基础条件。

关键词：机器视觉古籍修复装置单片机

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民航气象数据存储管理系统设计与应用

民航学报 2022年第1期6卷 65-68页

作者：杨乐朱国栋孙少明中国民用航空新疆空中交通管理局

随着气象技术的不断发展,传统的气象数据库系统在存储和管理各类新型数据上出现了可扩展性差、读写效率低的问题。为加强气象信息资料的存储、统计、分析功能,进一步挖掘气象信息的行业价值,本文以MySQL数据库结合智能化大容量文件存储... 详细信息

随着气象技术的不断发展,传统的气象数据库系统在存储和管理各类新型数据上出现了可扩展性差、读写效率低的问题。为加强气象信息资料的存储、统计、分析功能,进一步挖掘气象信息的行业价值,本文以MySQL数据库结合智能化大容量文件存储系统,设计实现了气象数据的存储统计和查询系统。通过实际业务运行,能够满足气象数据稳定存储与快速查询的要求,为复杂天气预报提供历史数据支撑。

关键词：民航气象数据库数据存储 MySQL

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乌鲁木齐机场一次低空颠簸天气分析

民航学报 2022年第6期6卷 88-93页

作者：张茜杨乐张亚莉孙少明中国民用航空新疆空中交通管理局

利用常规天气资料、微波辐射计资料、NCEP再分析资料及数值模拟资料，对乌鲁木齐2021年12月25～26日对飞行安全有较大影响的低空颠簸进行分析，结果表明局地性东南风层的形成造成水平方向上东南风与非东南风的切变和由于冬季乌鲁木齐上... 详细信息

利用常规天气资料、微波辐射计资料、NCEP再分析资料及数值模拟资料，对乌鲁木齐2021年12月25～26日对飞行安全有较大影响的低空颠簸进行分析，结果表明局地性东南风层的形成造成水平方向上东南风与非东南风的切变和由于冬季乌鲁木齐上空强逆温导致东南大风无法下传而引起的垂直方向上风向风速的骤变是造成乌鲁木齐机场低空颠簸的主要原因。通过数值模拟计算Dutton指数和L-P指数，对比发现Dutton指数对此次低空颠簸的预报效果比L-P指数更好。

关键词：东南大风数值模拟颠簸指数