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Nd@C3N4-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines

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Chinese Chemical Letters 2025年第2期36卷 412-416页

作者： Hong-Tao Ji Yu-Han Lu yan-Ting Liu Yu-Lin Huang Jiang-Feng Tian Feng Liu yan-yan Zeng Hai-yan yang Yong-Hong Zhang Wei-Min He Department of Ophthalmology The Affiliated Nanhua Hospital Hengyang Medical School University of South China School of Chemistry and Chemical Engineering University of South China Department of Lung Cancer and Gastroenterology Hunan Cancer Hospital The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University

The first example of Nd@C3N4-photoredox/chlorine dual catalyzed alkylation with unactivated alkanes as the alkyl sources has been developed,which allows for the synthesis of various 4-alkylated cyclic sulfonyl *** this process,chlorine functions as both a redox and hydrogen atom transfer *** synergism of the reversible Nd2+/Nd3+and Clˉ/Cl˙redox pairs significantly enhances overall photocatalytic *** in vitro anticancer activity of 4-alkylated products was evaluated by using the CCK8assay against both human choroidal melanoma （MUM-2B） and lung cancer （A549） *** 3da showed approximately triple the potency of 5-fluorouracil.

关键词： Chlorine Dual catalysis Hydrogen atom transfer Redox catalyst Semiconductor

Temperature-sensitive Micelles as Artificial Chaperones for Insulin Protection

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Chinese Journal of Polymer Science 2025年第2期43卷 350-359页

作者： Jia-Wen Chen yan Xiao Mei-Dong Lang Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China

Insulin is an essential and versatile protein taking part in the control of blood glucose levels and protein ***,under prolonged storage or high temperature stress,insulin tends to unfold and aggregate into toxic amyloid fibrils,leading to loss of physiological *** by natural chaperones,a series of temperature-sensitive polycaprolactone-based micelles were designed to prevent insulin from *** micelles were fabricated through the self-assembly of amphiphilic copolymers of methoxy poly(ethylene glycol)-poly(4-diethylformamide caprolactone-co-caprolactone)(mPEG_(17)-P(DECL-co-CL)),which had a regular spherical morphology with particle sizes of about 100 *** addition,the lower critical solution temperature(LCST)of the micelles could be tuned to 9 and 29℃by changing the ratio of DECL to *** from the temperature-sensitivity of DECL segment,the binding ability of micelles to insulin could be modulated by changing the *** LCST,micelles effectively inhibited insulin aggregation and protected it from thermal inactivation due to the strong binding ability between the hydrophobic segment DECL and *** LCST,DECL segment returned to hydrophilic and bound weakly with insulin,leading to the release of insulin and assisting in its recovery of secondary ***,these temperature-sensitive micelles provided an effective strategy for insulin protection.

关键词： Temperature-sensitive Insulin Micelles Chaperones

Axial emission characteristics of an ionic liquid electrospray thruster with a circular emitter

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Chinese Journal of Aeronautics 2025年第1期38卷 297-305页

作者： Cheng yanG Jiawei LUO Xiangbei WU yan SHEN School of Aeronautics and Astronautics Sun Yat-sen UniversityShenzhen 518107China Shenzhen Key Laboratory of Intelligent Microsatellite Constellation Shenzhen 518107China

Ionic Liquid Electrospray Thrusters(ILETs)are well suited for micro-nano satellite applications due to their small size,low power consumption,and high specific ***,the limited thrust of a single-emitter ILET restricts its use in space *** optimize the performance of ILETs and make them suitable for a wider range of space missions,we designed a Circular-emitter ILET(CILET)to convert a one-dimensional(point)emission into a twodimensional(line)*** CILET can self-organize multiple Taylor cones *** cones were photographed and the axial emission currents were measured under different voltage and pressure difference conditions with a CILET experimental *** emission can be divided into two stable states and one unstable state based on the flow and current *** current in Stable state Ⅰ increases non-linearly with the voltage,while that in Stable state Ⅱ is nearly linear with respect to the *** number of cones increases with the voltage in stable states,while the cones become short and crowded under high-voltage *** variation law of the number of cones can be explained with the self-organization *** variation in the current exhibits a good correlation with the number of *** study demonstrates the feasibility of circular emitters and experimentally indicates that the emission current is improved by approximately two orders of magnitude compared to that of a single capillary.

关键词： Electrospray Ionic liquid thruster Self-organize Emitter Taylor cone

基于ZigBee技术的图书馆智能消防监控系统

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电子技术（上海） 2013年第2期40卷 52-54页

作者：王丽娟闫绍敏曲阜师范大学日照校区图书馆曲阜师范大学电气信息与自动化学院

为加强图书馆消防安全,文章提出基于ZigBee技术的图书馆智能消防监控系统设计方案。该设计由数据采集系统、数据通讯系统、执行机构和后台监控系统等四部分构成。其中数据采集系统采用单片机技术实现对现场环境数据的采集和发送功能;数... 详细信息

为加强图书馆消防安全,文章提出基于ZigBee技术的图书馆智能消防监控系统设计方案。该设计由数据采集系统、数据通讯系统、执行机构和后台监控系统等四部分构成。其中数据采集系统采用单片机技术实现对现场环境数据的采集和发送功能;数据通讯系统采用ZigBee组网技术将各个Zigbee节点上传的环境数据进行集中处理,并通过GPRS/GSM无线通讯传送到后台监控系统;后台监控系统采用LabVIEW技术进行设计,实现了多个现场的环境监控。实验结果表明,该系统具有高性能、安全、便捷、智能的特点,具有广阔的应用前景。

关键词：消防监控系统 ZigBee 智能化 GPRS GSM

经络推拿联合益气舒筋汤治疗颈肩腰腿痛患者的疗效研究

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中国实用乡村医生杂志 2023年第6期30卷 29-31,35页

作者：刘凤萍颜少敏泉州永春蓬壶中心卫生院福建泉州362609 泉州永春县中医院

目的探究经络推拿联合益气舒筋汤治疗颈肩腰腿痛对患者疼痛程度的改善作用。方法选择2021年1月—2022年12月泉州永春蓬壶中心卫生院收治的颈肩腰腿痛患者300例,随机分为对照组和观察组各150例。对照组给予经络推拿治疗,观察组在对照组... 详细信息

目的探究经络推拿联合益气舒筋汤治疗颈肩腰腿痛对患者疼痛程度的改善作用。方法选择2021年1月—2022年12月泉州永春蓬壶中心卫生院收治的颈肩腰腿痛患者300例,随机分为对照组和观察组各150例。对照组给予经络推拿治疗,观察组在对照组基础上口服益气舒筋汤,均治疗1个月,比较两组西医症状指标、中医症候评分和SF-36量表评分。结果治疗后,观察组总有效率高于对照组,差异有统计学意义(P<0.05);观察组中医症候脉络淤血、局部刺痛、麻木肿胀、僵硬和皮下瘀斑评分低于对照组,差异有统计学意义(P<0.05);观察组SF-36量表各项评分高于对照组,差异有统计学意义(P<0.05)。结论在治疗颈肩腰腿痛时,经络推拿联合益气舒筋汤可减轻患者中西医症状,提高生活质量。

关键词：经络推拿益气舒筋汤颈肩腰腿痛中西医症状生活质量

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan Chen Hongxia Deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

Manufacture the conducting polymer with light

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Science China Chemistry 2025年第1期68卷 8-9页

作者： yang Li Tianyu Li yan Ji Baoguang Liu College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&TelecommunicationsNanjing 210023China

Poly(3,4-ethylenedioxythiophene)(PEDOT),heralded as the“king”of conducting polymers,is esteemed in bioelectronics for its mixed electronic and ionic conductivity,mechanical properties compatible with biological tissues,tunable healing ability and stability in diverse environments^([1]).Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics,the construction of intricate electrode-neural implantations,and the development of smart brain-computer-interfaces^([2]).

关键词： conducting implantation additive

Eukaryotic translation initiation factor OseIF5A4 negatively regulates rice immunity against blast and bacterial blight diseases

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Crop Journal 2025年第1期13卷 79-91页

作者： Wang, Hui yan, Yuqing Bi, yan Li, Dayong Song, Fengming National Key Laboratory for Rice Biology and Breeding Institute of Biotechnology Zhejiang University Zhejiang Hangzhou 310058 China Ministry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insect Pests Institute of Biotechnology Zhejiang University Zhejiang Hangzhou 310058 China Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province Institute of Biotechnology Zhejiang University Zhejiang Hangzhou 310058 China

The RING-type E3 ligase OsBBI1 regulates rice resistance against Magnaporthe oryzae through modifying cell wall defenses. In this study, we report the function of an OsBBI1 substrate, eukaryotic translation initiation factor OseIF5A4, in rice immunity. OsBBI1 interacts with OseIF5A4 and other four members of the OseIF5A family. The RING domain in OsBBI1 and the eIF-5a domain in OseIF5A4 are critical for the OsBBI1-OseIF5A4 interaction. OsBBI1 ubiquitinates OseIF5A4 and mediates its degradation in vitro and in vivo. Moreover, the expression of OseIF5A4 was upregulated during early stage of compatible interaction but downregulated in incompatible interaction between rice and M. oryzae. Knockout of OseIF5A4 enhances rice immunity against M. oryzae and Xanthomonas oryzae pv. oryzae, boosts pattern-triggered immune responses, and strengthens pathogen-induced defense responses (e.g., expression of defense genes, accumulation of reactive oxygen species and reinforcement of cell wall). However, overexpression of OseIF5A4 attenuates rice immunity and immune responses. These results demonstrate that OseIF5A4, a substrate of the immunity-associated E3 ligase OsBBI1, negatively regulates rice immunity against M. oryzae and X. oryzae pv. oryzae through modulating pathogen-induced defense responses, highlighting the importance of the protein translational machinery in rice immunity. © 2025 Crop Science Society of China and Institute of Crop Science, CAAS

关键词： Magnaporthe oryzae OsBBI1 OseIF5A Rice immunity Xanthomonas oryzae pv. oryzae