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Study of Zero-Inflated Regression models in a Large-Scale Population Survey of Sub-Health Status and Its Influencing Factors

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Chinese Medical Sciences Journal 2017年第4期32卷 218-225页

作者： Tao Xu Guangjin Zhu shaomei Han Department of Epidemiology and Statistics Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College Beijing 100005 China Department of physiopathology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College Beijing 100005 China

Objective Sub-health status has progressively gained more attention from both medical professionals and the publics. Treating the number of sub-health symptoms as count data rather than dichotomous data helps to completely and accurately analyze findings in sub-healthy population. This study aims to compare the goodness of fit for count outcome models to identify the optimum model for sub-health *** The sample of the study derived from a large-scale population survey on physiological and psychological constants from 2007 to 2011 in 4 provinces and 2 autonomous regions in China. We constructed four count outcome models using SAS: Poisson model, negative binomial (NB) model, zero-inflated Poisson (ZIP) model and zero-inflated negative binomial (ZINB) model. The number of sub-health symptoms was used as the main outcome measure. The alpha dispersion parameter and O test were used to identify over-dispersed data, and Vuong test was used to evaluate the excessive zero count. The goodness of fit of regression models were determined by predictive probability curves and statistics of likelihood ratio *** Of all 78 307 respondents, 38.53% reported no sub-health symptoms. The mean number of sub-health symptoms was 2.98, and the standard deviation was 3.72. The statistic O in over-dispersion test was 720.995 (Pmodel and ZIP model; Vuong test statistic Z was 45.487. These results indicated over-dispersion of the data and excessive zero counts in this sub-health study. ZINB model had the largest log likelihood (-167 519), the smallest Akaike’s Information Criterion coefficient (335 112) and the smallest Bayesian information criterion coefficient (335455),indicating its best goodness of fit. The predictive probabilities for most counts in ZINB model fitted the observed counts best. The logit section of ZINB model analysis showed that age, sex, occupation, smoking, alcohol drinking, ethn

关键词： zero-inflated negative binomial regression sub-health population survey

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STOCHASTIC SIMPLIFIED BARDINA TURBULENT moDEL: EXISTENCE OF WEAK SOLUTION

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Acta Mathematica Scientia 2014年第4期34卷 1041-1054页

作者：邱华房少梅 Department of Applied Mathematics South China Agricultural University

In this paper, we consider the stochastic version of the 3D Bardina model arising from the turbulent flows of fluids. We obtain the existence of probabilistie weak solution for the model with the non-Lipschitz condition.

关键词： Bardina model probabilistie weak solution existence

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医院丙肝微消除模式的建立与应用成效

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现代医院 2024年第4期24卷 651-653页

作者：陆彦盟李仕雄向文耀蒙梦兰黄少美吕日英贵港市人民医院广西贵港537100

目的建立医院丙肝微消除模式并分析其在丙肝防治工作中的应用成效。方法以广西贵港市某三甲医院为例,通过部门分工、协调合作、能力建设多方面构建丙肝微消除模式,分析项目实施前(2021年)、项目实施后(2022年)两组抗-HCV筛查率、HCV RN... 详细信息

目的建立医院丙肝微消除模式并分析其在丙肝防治工作中的应用成效。方法以广西贵港市某三甲医院为例,通过部门分工、协调合作、能力建设多方面构建丙肝微消除模式,分析项目实施前(2021年)、项目实施后(2022年)两组抗-HCV筛查率、HCV RNA检测率、DAA治疗率、丙肝治愈人数的变化。结果2022年与2021年相比,抗-HCV筛查率由78.8%上升到81.2%,HCV RNA检测率由75.1%上升到97.8%,DAA治疗率由19.4%上升到57.3%,差异均具有统计学意义(P<0.05);丙肝治愈人数由61人上升到231人,成效明显。结论在医院建立丙肝微消除模式可显著提高抗-HCV筛查率、HCV RNA检测率、DAA治疗率,促进更多丙肝患者的治愈,有助于加快中国丙肝消除战略的进程,值得推广应用。

关键词：医院丙肝微消除应用成效

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Effects of realgar on stress proteins, inflammatory mediators, and complement in brain tissue and serum of rats with inflammatory brain injury

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Neural Regeneration Research 2008年第8期3卷 885-889页

作者： Yishan Tang Ningsheng Wang Yinqing Zhang shaomei Ye Weiping Ou Institute of Clinical Pharmacology Guangzhou University of Traditional Chinese Medicine Guangzhou 510405 Guangdong Province China

BACKGROUND：The Chinese herbal compound realgar exerts detoxification effects as an adjuvant. It is suggested that realgar exerts detoxification via the following pathways： in the pathological state, realgar corrects the oxidative stress state by increasing stress levels, activating some endogenous protective factors and antagonizing the excessive release of inflammatory factors, as well as inhibiting complement activation. OBJECTIVE： To observe the changes in stress proteins, inflammatory mediators, and complement in the brain tissue and serum of rats with inflammatory brain injury, which have been treated with the Chinese herbal compound Angong Niuhuang, and to compare the efficacy of Angong Niuhuang with that of realgar, to verify the mechanism of action of realgar. DESIGN, TIME AND SETTING： Randomized, controlled, cytological experiment, performed in the Institute of Clinical Pharmacology, Guangzhou University of Traditional Chinese Medicine in March 2006. MATERIALS： Thirty-six healthy, male, Sprague Dawley rats received 250 U/kg Bordetella pertussis via the common carotid artery within 15 seconds to induce inflammatory brain injury. Reagents and kits were as follows： Realgar and Angong Niuhuang powder （Foshan Second Pharmaceutical Factory, China）, Bordetella pertussis diagnostic antigen （National Institute for the Control of Pharmaceutical and Biological Products, China）, heat shock protein 70 （HSP70） enzyme-labeled immunosorbent assay （ELISA） kit （Stressgen, USA）, tumor necrosis factor-α （TNF-α） ELISA kit （Biosource, USA）, nitric oxide synthase （NOS） kit, Coomassie brilliant blue protein kit （Nanjing Jiancheng Bioengineering Co.,Ltd., China）, and complements C3 and C4 （Shanghai Kehua Dongling Diagnositic Products Co.,Ltd., China）. METHODS： Thirty-six rats were randomly and evenly divided into the following six groups： normal control, model, high-, middle-, and low-dose realgar-treated, and Angong Niuhuang-treated groups. At one hour prior to establishing the mo

关键词： realgar Angong Niuhuang powder stress protein inflammatory mediator complement inflammatory brain injury

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Direct transformation of FGD gypsum to calcium sulfate hemihydrate whiskers:Preparation,simulations,and process analysis

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Particuology 2015年第2期13卷 53-59页

作者： Miao Miao Xin Feng Gangling Wang shaomei Cao Wen Shi Liyi Shi Nano Science and Technology Research Center Shanghai University

Calcium sulfate hemihydrate （CSH） whiskers were synthesized by phase transition in CaCl2 solution under atmospheric pressure. Analytical-grade calcium sulfate dihydrate （AR CSD） was used as the raw material for the synthesis of CSH whiskers, according to orthogonal experiments. The effects of reaction tem- perature, AR CSD content, H2SO4 content, and reaction time were investigated, and the crystallization conditions were optimized. The as-prepared CSH whiskers displayed a regular morphology and a highly uniform size, with an aspect ratio of 105, A simulation system was also established by blending various sulfates with AR CSD, to evaluate the effects of impurities in flue gas desulfurization （FGD） gypsum. The main aim was to prepare CSH whiskers directly from FGD gypsum, without any purification, using the optimized conditions. This is a facile potential alternative process for large-scale production of CSH whiskers using abundant FGD gypsum as source materials.

关键词： FGD gypsum Calcium sulfate Whisker Direct transformation Simulation analysis

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桑叶免疫调节机制的网络药理学分析

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广西农学报 2024年第2期39卷 13-19页

作者：陈少梅胡湘云曹艳红李建庆曹植植卢俊求陆莹王新松广西农业职业技术大学广西南宁530007 南宁市农业综合行政执法支队广西南宁530001 南宁市兴宁区动物疫病预防控制中心广西南宁530021 南宁市动物疫病预防控制中心广西南宁530001

基于网络药理学分析桑叶调控免疫功能的作用机制。依托TCMSP数据库获得桑叶有效活性成分和相应作用靶点,构建有效成分——靶点网络图。结合Genecards、OMIM等数据库筛选桑叶免疫调节交集基因,利用STRING数据库构建蛋白相互作用网络(PPI)... 详细信息

基于网络药理学分析桑叶调控免疫功能的作用机制。依托TCMSP数据库获得桑叶有效活性成分和相应作用靶点,构建有效成分——靶点网络图。结合Genecards、OMIM等数据库筛选桑叶免疫调节交集基因,利用STRING数据库构建蛋白相互作用网络(PPI),并对核心靶点进行GO功能富集和KEGG通络分析。研究结果显示,桑叶的主要成分槲皮素、山柰酚、花生四烯酸、β-谷甾醇、四甲氧基木犀草素和豆甾醇等作用于TP53、AKT1、TNF、ESR1、IL6等关键靶点,参与癌症、糖尿病并发症AGE-RAGE信号通路、TNF信号通路、IL-17信号通路等,发挥了免疫调节作用。桑叶具有多成分、多靶点及多途径的特点,对免疫调节起到了良好的作用,为桑叶在畜禽养殖中的应用提供依据。

关键词：桑叶免疫调节网络药理学作用机制信号通路

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基于二次分解的风机齿轮箱油温预测模型

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华北电力大学学报（自然科学版） 2022年第1期49卷 118-126页

作者：杨少梅王廉茹华北电力大学经济与管理学院河北保定071003

齿轮箱作为风机的重要部件,其故障占风电机组停机故障的80%。风机齿轮箱油温预测研究是为了实现风电机组齿轮箱状态的实时检测,提高其故障预测准确度可有效减少维修费用,提高风机系统运行可靠性。风电机组的监控与采集系统的众多参数具... 详细信息

齿轮箱作为风机的重要部件,其故障占风电机组停机故障的80%。风机齿轮箱油温预测研究是为了实现风电机组齿轮箱状态的实时检测,提高其故障预测准确度可有效减少维修费用,提高风机系统运行可靠性。风电机组的监控与采集系统的众多参数具有高维度、非线性等特性。为解决上述问题,提出了一种基于二次分解、样本熵计算、序列重构和LSTM预测相结合的方法,首先利用EEMD对原始油温度数据进行预处理,得到多个子序列。然后计算各个子序列的样本熵,将样本熵最高的子序列用VMD进行二次分解。最后,利用LSTM对分解后的序列进行预测,得到最终的预测结果。通过对比不同分解方法、不同预测模型的预测结果与真实值之间的误差,证明了所提出分解方法与模型预测结果的可靠性。

关键词：风机齿轮箱聚类经验模态分解样本熵变分模态分解长短期记忆神经网络

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A Pseudo-Spectral Approximation for theSystem of Generalized Zakharov Equations

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Communications in Nonlinear Science and Numerical Simulation 1999年第3期4卷 3-5页

作者： shaomei FANG(Department of Mathematics, Shaoguan University, Shaoguan 512005, China)E-mail: bnlu@*** Department of Mathematics Shaoguan University Shaoguan 512005 China

IntroductionInthispaper,weareconcernedwiththetheoreticalanalysisofthefullydiscretepseudospectraJapproximationofthesystemofgenerajizedZakharovequationswithperiodicinitialconditionsbywherei=M,q(.)denotesacontinuousreal-... 详细信息

关键词： Zakharov equation pseudo-spectral approximation

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Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults,especially in obese individuals:a prospective cohort study

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Food Science and Human Wellness 2023年第1期12卷 295-302页

作者： Juanjuan Zhang Sabina Rayamajhi Amrish Thapa Ge Meng Qing Zhang Li Liu Hongmei Wu Yeqing Gu Shunming Zhang Tingjing Zhang Xuena Wang Zhixia Cao Jun Dong Xiaoxi Zheng Xu Zhang Xinrong Dong Xing Wang shaomei Sun Ming Zhou Qiyu Jia Kun Song Kaijun Niu Nutritional Epidemiology Institute and School of Public Health Tianjin Medical UniversityTianjin 300070China Department of Toxicology and Sanitary Chemistry School of Public HealthTianjin Medical UniversityTianjin 300070China Health Management Centre Tianjin Medical University General HospitalTianjin 300070China Nutrition and Radiation Epidemiology Research Center Institute of Radiation MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China Center for International Collaborative Research on Environment Nutrition and Public HealthTianjin 300070China

Background:Mushrooms are a good source of many nutrients which are potentially beneficial for chronic *** speculated that due to its abundant nutrients edible mushrooms might have a beneficial effect on the prevention of subclinical thyroid dysfunction(SCTD).Therefore,we designed a large-scale cohort study to examine whether mushrooms consumption is a protective factor for SCTD in ***:This prospective cohort study investigated 6631 participants(mean age:(45.0±10.2)years;55.1%men).Edible mushrooms consumption was measured at baseline using a validated food frequency *** was defined as abnormal serum thyroid-stimulating hormone levels and normal free *** proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident ***:During follow-up period,a total of 262 new cases of SCTD were identified,the incidence rate of subclinical hypothyroidism was 8.9/1000 person-years and subclinical hyperthyroidism was 7.2/1000 *** adjusting potential confounding factors,the multivariable hazard ratios(95%confidence intervals)for subclinical hypothyroidism were 1.00(reference)for almost never,0.53(0.29,0.97)for 1-3 times/week and 0.30(0.10,0.87)for≥4 times/week(P for trend=0.02).It also showed edible mushrooms consumption was inversely associated with subclinical hypothyroidism in obese individuals but not non-obese individuals,the final hazard ratios(95%confidence intervals)were 0.14(0.03,0.73)(P for trendmonstrated that higher edible mushrooms consumption was significantly associated with lower incidence of subclinical hypothyroidism among general adult population,especially in obese individuals.

关键词： Edible mushrooms Subclinical thyroid dysfunction Obese individuals Cohort study

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GLOBAL EXISTENCE AND POINTWISE ESTIMATES OF SOLUTIONS TO GENERALIZED KURAmoTO-SIVASHINSKY SYSTEM IN MULTI-DIMENSIONS

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Acta Mathematica Scientia 2019年第1期39卷 180-194页

作者：张颖妹李朗房少梅 Department of Mathematics South China Agricultural University

The Cauchy problem of the generalized Kuramoto-Sivashinsky equation in multidimensions(n ≥ 3) is considered. Based on Green's function method, some ingenious energy estimates are given. Then the global existence and pointwise convergence rates of the classical solutions are established. Furthermore, the L^p convergence rate of the solution is obtained.

关键词： Kuramoto-Sivashinsky equation global existence pointwise estimates Green’s function method energy method

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