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Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions： finding of 18F-FDG PET/CT

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Frontiers of Medicine 2017年第3期11卷 440-444页

作者： Zhan Su Fengyu wu Weiyu Hu Xiaodan Liu shaoling wu Xianqi Feng Zhongguang Cui Jie Yang Zhenguang Wang Hongzai Guan Hongguo Zhao Wei Wang Chunting Zhao Jun Peng Department of Haematology Qilu Hospital Shandong University Jinan 250012 China Department of Haematology The Affiliated Hospital of Qingdao University Qingdao 266000 China PET/CT Center The Affiliated Hospital of Qingdao University Qingdao 266000China Department of Hepatobiliary Surgery The Affiliated Hospital of Qingdao University Qingdao 266000 China Department of Haematology Qingdao University Medical College Qingdao 266071 China

Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia. As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lyric lesions. In this paper, we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain, fever, fatigue, emaciation, and splenomegaly. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography （18F-FDG PET/CT） result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion, multiple soft tissue neoplasms with high 18F-FDG uptake, and lyric bone lesions. Bone marrow smear and biopsy detected aberrant blast cells expressing myeloid rather than lymphoid immunophenotype marker. For the existence of Philadelphia chromosome and BCR-ABL1 fusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive acute myeloid leukemia was made, although the type （de novo or blast crisis） remained unclear.

关键词： Philadelphia chromosome acute myeloid leukemia mass osteolysis positron emission tomography

Combined metabolic phenotypes and gene expression profiles revealed the formation of terpene and ester volatiles during white tea withering process

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Beverage Plant Research 2023年第1期3卷 188-198页

作者： Xuming Deng Jun wu Tao Wang Haomin Dai Jiajia Chen Bo Song shaoling wu Chenxi Gao Yan Huang Weilong Kong Weijiang Sun College of Horticulture Fujian Agriculture and Forestry University15 Shangxiadian RoadFuzhou 350002China Ministerial and Provincial Joint Innovation Centre for Safety Production of Cross-Strait Crops Fujian Agriculture and Forestry UniversityFuzhou 350002China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120China

Withering is a critical process to form the unique aroma of high-quality white *** study the mechanism underlying aroma changes during the white withering,we herein conducted volatile metabolomics and transcriptomics of the young leaves from the'Fuding Dahaocha'tea *** the withering time extended,the content of major aroma components increased significantly,score of sensory evaluation and Owuor's flavor index(OFI)also *** aromatic substances that accumulated during white tea withering were mainly volatile terpenes and *** change trends were largely consistent with the gene expression of theα-linolenic acid metabolic pathways,while the correlation between the trends in volatiles and the gene expression of the terpenoid biosynthesis pathways was more complex and induced by the jasmonic acid(JA)signaling ***,we also explored the regulation pattern of key genes in the signaling pathway by related transcription *** coexpression networks strongly correlated to the variation of volatile component content during withering were identified by weighted gene coexpression network analysis(WGCNA).Our results provide a new perspective on the processing mechanism and quality improvement of white tea.

关键词： white volatile process

Efficacy and Safety of Iron Isomaltoside Compared with an Oral Iron Supplement in the Management of Patients with Iron Deficiency Anemia

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Open Journal of Blood Diseases 2024年第1期14卷 17-30页

作者： Zhimin wu Chunxiao Zhou Chunyan wu Qiao Song Shilyu Chen Wen Zhang shaoling wu Department of Medicine Qingdao University Qingdao China Department of Hematology The Affiliated Hospital of Qingdao University Qingdao China

Objective: To evaluate the treatment outcome of iron isomaltoside compared with an oral iron supplement in the management of iron deficiency anemia (IDA). Methods: The study included patients with IDA who visited the Outpatient Clinic of the Department of Hematology, the Affiliated Hospital of Qingdao University from October 2021 to August 2022 and met the inclusion and exclusion criteria. According to the actual application of iron supplementation, the patients were divided into two groups: iron isomaltoside treatment group and oral iron treatment group. Baseline measurements were collected before the start of treatment, and measurements were collected subsequently at intervals of 1 week, 1 month, and 3 months. The hematological parameters analyzed included Hemoglobin (Hb), Mean corpuscular hemoglobin (MCH), Mean Hemoglobin content (MCH), Mean corpuscular Hemoglobin concentration (MCHC), and Platelet (Plt). Safety data and adverse event profiles were recorded. Results: Intra-group comparisons: After 1 month of treatment, the Hb significantly improved (P 0.05). Inter-group comparisons: The biochemical parameters were significantly improved (P 0.05) in the iron isomaltoside group compared with those in the oral iron group after 1 month of iron supplementation in patients with mild and moderate anemia. Adverse reactions were tolerable for the patients in both iron isomaltoside group and oral iron group. Only 1 patient in iron isomaltoside group developed anaphylactic shock during medication and recovered after aggressive rescue. Conclusions: Iron isomaltoside which increases Hb more rapidly compared with the oral iron supplementation has few adverse reactions and good acceptance.

关键词： Anemia Iron-Deficiency Drug Therapy Iron Isomaltoside 1000 Treatment Outcome

基于TCN和注意力机制的异常检测和定位算法

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信息网络安全 2021年第11期21卷 85-94页

作者：吴佳洁吴绍岭王伟华东师范大学数据科学与工程学院上海200062 同济大学计算机科学与技术系上海201804

随着云计算时代的到来,应用上云已经成为主流的系统部署方案。为了满足业务需求,很多系统都在混合云环境采用微服务架构。系统本身的复杂性和运行环境的复杂性使得实时监控和运维数据处理、异常检测及定位都变得困难。文章设计了一个面... 详细信息

随着云计算时代的到来,应用上云已经成为主流的系统部署方案。为了满足业务需求,很多系统都在混合云环境采用微服务架构。系统本身的复杂性和运行环境的复杂性使得实时监控和运维数据处理、异常检测及定位都变得困难。文章设计了一个面向复杂云系统的实时监控和数据处理框架,同时提出了一种基于TCN和注意力机制的异常检测算法(TCN-AT)□前者可在复杂云环境的微>务系统中运行,后者用于时间序列数据中的点异常和窗口异常检测。文章在仿真数据、真实的微服务系统数据和开源的比赛数据上进行了大量实验,结果表明TCN-AT的性能优于其他前沿算法。

关键词： TCN 异常检测异常定位微服务系统

Transcriptome characterization for genome annotation and functional genomics in Pyrus spp.

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Transcriptome characterization for genome annotation and fun...

一种最大化内存共享与最小化运行时环境的超轻量级容器

第十三届全国植物基因组学大会

作者： Jun wu,Shutian Tao,Kaijie Qi,Juyou wu,shaoling Zhang~* Department of Horticulture,Nanjing Agricultural University,Nanjing 210095,P.R.China

Pear(Pyrus spp.) is one of the leading cultivated temperate fruit crops and grown in different countries around the *** ranks second after apple,as a deciduous tree fruit species,in commercial production(over 20 million tons per year).Pear belongs to the subfamily Pomoideae of Rosaceae,and has at least 22 well-recognized

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计算机研究与发展 2019年第7期56卷 1545-1555页

作者：张礼庆郭栋吴绍岭崔海波王伟同济大学计算机科学与技术系上海200092 嵌入式系统与服务计算教育部重点实验室(同济大学) 上海200092 湖北大学计算机与信息工程学院武汉430062 湖北省教育信息化工程技术研究中心(湖北大学) 武汉430062

容器技术的兴起带来了数据中心的深刻变化,大量软件转为微服务方式部署与交付.如何优化海量用户环境下大规模容器的启动、运行与维护问题具有广泛的现实意义.目前以Docker为代表的主流容器技术已经取得较大成功,但在镜像体积、资源共享... 详细信息

容器技术的兴起带来了数据中心的深刻变化,大量软件转为微服务方式部署与交付.如何优化海量用户环境下大规模容器的启动、运行与维护问题具有广泛的现实意义.目前以Docker为代表的主流容器技术已经取得较大成功,但在镜像体积、资源共享等方面仍有较大改进空间.梳理了虚拟化技术的发展过程,阐明轻量级的虚拟化技术是未来的研究方向,对数据敏感型应用至关重要.通过建立库文件共享模型,探究了库文件的共享程度对容器最大启动数量的影响.给出了一种超轻量级的容器设计方案,通过细化可操作资源的粒度,使得支撑应用程序运行的容器运行时环境最小化;将依赖库文件与可执行二进制文件单独抽取成层,实现了容器对主机内存资源的最大化共享.根据上述方案实现了一种超轻量级容器管理引擎:REG(runtime environment generation),并定义了一套基于REG的工作流.在镜像体积、启动速度、内存占用、容器启动风暴等方面进行对比实验,验证了所提方法在大规模容器环境下的有效性.

关键词：容器云件轻量级运行时环境资源共享

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高校公共机房管理模式探讨

无线互联科技 2017年第8期14卷 129-130页

作者：吴少苓广东肇庆学院教育技术与计算机中心广东肇庆526061

在计算机应用技术水平提高后,高校开始广泛运用计算机,所以公共机房已成为高校教学中重要的教学环境。公共机房的用途是比较广的,可以用来开展基础课、专业课、课程设计、毕业设计、考试等任务。因此,公共机房的管理是比较重要的。当前... 详细信息

在计算机应用技术水平提高后,高校开始广泛运用计算机,所以公共机房已成为高校教学中重要的教学环境。公共机房的用途是比较广的,可以用来开展基础课、专业课、课程设计、毕业设计、考试等任务。因此,公共机房的管理是比较重要的。当前一些高校的公共机房管理存在的问题比较多,影响了公共机房的使用率,只有解决这些问题,才能更好地发挥公共机房在教学的作用。

关键词：高校公共机房管理模式

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“汽车销售实务”课程思政建设路径与创新

福建农机 2023年第3期 46-50页

作者：武少玲湖北汽车工业学院经济管理学院湖北十堰4420022

“汽车销售实务”课程组在梳理我国多所高校汽车营销、车辆工程、汽车服务等专业人才培养方案与汽车销售顾问职业素养的基础上,立足湖北汽车工业学院进行了学情分析,充分挖掘课程思政元素,将其融入专业课程教学目标与课程定位,不断完善... 详细信息

“汽车销售实务”课程组在梳理我国多所高校汽车营销、车辆工程、汽车服务等专业人才培养方案与汽车销售顾问职业素养的基础上,立足湖北汽车工业学院进行了学情分析,充分挖掘课程思政元素,将其融入专业课程教学目标与课程定位,不断完善课程内容、教学方法,修订第三版国家规划教材,改革考核方案,将思想政治工作贯穿教育教学及人才培养的全过程,探索专业课程和课程思政如何同频共振,全方位、多角度使学生具备相应的岗位职业能力,实现汽车销售顾问的职业素质和自我管理,努力培养营销专业学生成为冠军级营销人员。

关键词：汽车销售实务课程思政建设路径创新方法

同方期刊数据库博看期刊评论

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超声引导兔髋关节腔准确注射的可行性

中国组织工程研究 2022年第5期26卷 657-662页

作者：王少玲汪衍雪郑耀超余少君马超伍少玲中山大学孙逸仙纪念医院康复医学科广东省广州市510120

背景:以往引导髋关节注射的首选是透视引导,近年来由于超声具有便携、无辐射、成本低、准确度高等优点,其在关节腔注射的应用越来越普遍。目的:比较超声引导与透视引导兔髋关节腔内注射的准确性,探讨超声引导注射的可行性。方法:成年新... 详细信息

背景:以往引导髋关节注射的首选是透视引导,近年来由于超声具有便携、无辐射、成本低、准确度高等优点,其在关节腔注射的应用越来越普遍。目的:比较超声引导与透视引导兔髋关节腔内注射的准确性,探讨超声引导注射的可行性。方法:成年新西兰兔16只(64个髋关节),分两轮进行髋关节注射,每轮注射前将兔随机分为2组:超声引导组采用高分辨率超声引导注射;透视引导组采用配备无线传输平板探测器的X射线机进行透视引导注射。两组注射后均通过计算机断层扫描检测碘海醇在关节腔内的分布情况,比较两种不同方法的注射准确率、穿刺尝试次数和注射操作花费时间。实验经中山大学动物实验伦理委员会批准。结果与结论:(1)两组各注射32个髋关节,超声引导组中有29个关节(90.6%)注射成功,透视引导组有21个关节(65.6%)注射成功;超声引导组注射准确率显著高于透视引导组(P <0.05);(2)超声引导组平均尝试次数显著少于透视引导组(P <0.05);(3)两组注射平均花费时间差异无显著性意义;(4)结果说明,超声引导兔髋关节注射较透视引导注射具有较高的准确性,且尝试穿刺次数少,无辐射,是一种简易可行的引导注射的方法。

关键词：超声兔髋关节关节内注射准确性