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Oncology Research 2024年第4期32卷 691-702页

作者： JIJIE XIAO HONG XIAO YUJUN CAI JIANWEI liAO JUE liU liN YAO shaolin li Department of Radiology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai510900China Department of Ultrasound The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou528405China PCFM Lab of Ministry of Education School of Materials Science and EngineeringGuangzhou510275China

Osteosarcoma is a malignant tumor originating from bone tissue that progresses rapidly and has a poor patient prognosis.Immunotherapy has shown great potential in the treatment of osteosarcoma.However,the immunosuppressive microenvironment severely limits the efficacy of osteosarcoma treatment.The dual pH-sensitive nanocarrier has emerged as an effective antitumor drug delivery system that can selectively release drugs into the acidic tumor microenvironment.Here,we prepared a dual pH-sensitive nanocarrier,loaded with the photosensitizer Chlorin e6(Ce6)and CD47 monoclonal antibodies(aCD47),to deliver synergistic photodynamic and immunotherapy of osteosarcoma.On laser irradiation,Ce6 can generate reactive oxygen species(ROS)to kill cancer cells directly and induces immunogenic tumor cell death(ICD),which further facilitates the dendritic cell maturation induced by blockade of CD47 by aCD47.Moreover,both calreticulin released during ICD and CD47 blockade can accelerate phagocytosis of tumor cells by macrophages,promote antigen presentation,and eventually induce T lymphocyte-mediated antitumor immunity.Overall,the dual pH-sensitive nanodrug loaded with Ce6 and aCD47 showed excellent immune-activating and anti-tumor effects in osteosarcoma,which may lay the theoretical foundation for a novel combination model of osteosarcoma treatment.

关键词： Immunotherapy Osteosarcoma Nanodrug Photodynamic therapy CD47

Microbes team with nanoscale zero-valent iron: A robust route for degradation of recalcitrant pollutants

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Journal of Environmental Sciences 2022年第8期34卷 140-146页

作者： Nuo liu Jing liu Hong Wang shaolin li Wei-xian Zhang State Key Laboratory for Pollution Control and Resource Reuse School of Environmental Science and EngineeringTongji UniversityShanghai 200092China

Integrating nanoscale zero-valent iron(nZVI) with biological treatment processes holds the promise of inheriting significant advantages from both environmental nano-and biotechnologies. nZVI and microbes can perform in coalition in direct contact and act simultaneously, or be maintained in separate reactors and operated sequentially. Both modes can generate enhanced performance for wastewater treatment and environmental remediation. nZVI scavenges and eliminates toxic metals, and enhances biodegradability of some recalcitrant contaminants while bioprocesses serve to mineralize organic compounds and further remove impurities from wastewater. This has been demonstrated in a number of recent works that nZVI can substantially augment the performance of conventional biological treatment for wastewaters from textile and nonferrous metal industries. Our recent laboratory and field tests show that COD of the industrial effluents can be reduced to a record-low of 50 ppm. Recent literature on the theory and applications of the nZVI-bio system is highlighted in this mini review.

关键词： Environmental microbiology Nanoscale zero-valent iron(nZVI) Remediation Wastewater nZVI-bio system

Recent Advances in Mn,Fe,Co,and Ni-Catalyzed Organic Reactions

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CCS Chemistry 2024年第3期6卷 537-584页

作者： Lu-Jie li Yuli He Yunhui Yang Jun Guo Zhan Lu Congyang Wang shaolin Zhu Shou-Fei Zhu College of Chemistry Nankai UniversityTianjin 300071 School of Chemistry and Chemical Engineering Nanjing UniversityNanjingJiangsu Province 210093 Institute of Chemistry Chinese Academy of Sciences and University of Chinese Academy of SciencesBeijing 100190 Department of Chemistry Zhejiang UniversityHangzhouZhejiang Province 310058

This paper reviewed the recent research progress of organic reactions catalyzed by four typical earthabundant and 3d metal catalysts:Mn,Fe,Co,and Ni complexes and mainly focused on the reactions in which these 3d metal catalysts exhibited obvious advantages over other catalysts.The mechanism that makes these 3d metal catalysts show unusual properties is another focus of this paper.An outlook on 3d metal complexes-catalyzed organic reactions was also considered.

关键词： Earth-abundant metal catalysts sustainable organic synthesis structure-function relationships organometallic intermediates hydrocarbon transformations

风电网源波动对并网点等值阻抗估计影响及电网阻抗在线辨识

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电网技术 2024年第6期48卷 2376-2384,I0037页

作者：李春彦李少林王伟胜秦世耀李庆可再生能源并网全国重点实验室(中国电力科学研究院有限公司) 北京市海淀区100192

风电等新能源发电并网性能对电网强度较为敏感,作为衡量新能源场站接入点电网强度的重要指标,风电场并网点电网侧的戴维南等值阻抗在线辨识对风电稳定运行风险评估及策略优化意义重大。首先介绍了戴维南等值阻抗估计原理,揭示了网源两... 详细信息

风电等新能源发电并网性能对电网强度较为敏感,作为衡量新能源场站接入点电网强度的重要指标,风电场并网点电网侧的戴维南等值阻抗在线辨识对风电稳定运行风险评估及策略优化意义重大。首先介绍了戴维南等值阻抗估计原理,揭示了网源两侧波动对等值阻抗辨识精度的影响与变化规律,明确了实现等值阻抗准确辨识及在线应用的波动数据筛选原则。在此基础上,设计了测量点电压相量和功率波动信息相融合的数据筛选指标,提出了网源数据波动特征筛选与等值阻抗线性关系描述相结合的电网阻抗的在线辨识方法,有效克服了复杂网源条件下等值阻抗辨识误差大的问题。最后通过仿真和现场实测数据证明了理论分析与所提方法的准确性与有效性。

关键词：风电并网点戴维南等值阻抗辨识

Interfacial failure behavior of PyC-C_f/AZ91D composite fabricated by LSEVI

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Journal of Materials Science & Technology 2018年第9期34卷 1602-1608页

作者： shaolin li Lehua Qi Ting Zhang Jiming Zhou Hejun li State Key Laboratory of Solidification Processing Carbon/Carbon Composites Research Center Northwestern Polytechnical University School of Mechanical Engineering Northwestern Polytechnical University

Carbon fiber reinforced AZ91 D matrix composites with pyrolytic（PyC） coating deposited on fiber surface（PyC-Cf/AZ91 D composites） have been fabricated by liquid-solid extrusion following vacuum pressure infiltration technique（LSEVI）. Interfacial microstructure and failure behavior of the composites were investigated. Instead of interfacial reaction products, block-shaped interfacial precipitates Mg（17） Al（12） were detected at the interface, which indicates that interfacial reaction was restrained by LSEVI and PyC coating. Nano-MgO was detected at the interface. Interfacial failure behavior of the PyC-Cf/AZ91 D composites,which was the failure between PyC coating and AZ91 D alloy due to the mismatch of thermal expansion and relatively poor bonding, was proposed. Fracture surface of the PyC-Cf/AZ91 D composites was characterized by fibers pulling-out tests. PyC coating served not only as protection to the fibers, but also an adjustment of the interface of the composites.

关键词： MMCs Interface Carbon fiber Failure

Microstructure and tensile behavior of 2D-C_f/AZ91D composites fabricated by liquid–solid extrusion and vacuum pressure infiltration

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Journal of Materials Science & Technology 2017年第6期33卷 541-546页

作者： shaolin li Lehua Qi Ting Zhang Jiming Zhou Hejun li State Key Laboratory of Solidification Processing Carbon/Carbon Composites Research Center Northwestern Polytechnical University School of Mechatronic Engineering Northwestern Polytechnical University

2D carbon fiber reinforced AZ91 D matrix composites（2D-C_f/AZ91 D composites） were fabricated by liquid–solid extrusion and vacuum pressure infiltration technique（LSEVI）. In order to modify the interface between fibers and matrix and protect the fiber, pyrolytic carbon（Py C） coating was deposited on the surface of T700 carbon fiber by chemical vapor deposition（CVD）. Microstructure observation of the composites revealed that the composites were well fabricated by LSEVI. The segregation of aluminum at fiber surface led to the formation of Mg_（17）Al_（12） precipitates at the interface. The aluminum improved the infiltration of the alloy and Py C coating protected the fibers effectively. The ultimate tensile strength of 2D-C_f/AZ91 D composites was about 400 MPa. The fracture process of 2D-C_f/AZ91 D composites was transverse fiber interface cracking–matrix transferring load–longitudinal fibers bearing load–longitudinal fibers breaking.

关键词： Magnesium matrix composites Microstructure Tensile properties Fracture behavior

Dynamic parametric modeling-based model updating strategy of aeroengine casings

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Chinese Journal of Aeronautics 2021年第12期34卷 145-157页

作者： Chengwei FEI Haotian liU shaolin li Huan li liqiang AN Cheng LU Department of Aeronautics and Astronautics Fudan UniversityShanghai 200433China School of Energy and Power Engineering Beihang UniversityBeijing 100083China Beijing Key Laboratory of Aero-Engine Structure and Strength Beijing 100083China Department of Mechanical Engineering North China Electric Power UniversityBaoding 071003China

For accurate Finite Element(FE)modeling for the structural dynamics of aeroengine casings,Parametric Modeling-based Model Updating Strategy(PM-MUS)is proposed based on efficient FE parametric modeling and model updating techniques regarding uncorrelated/correlated mode shapes.Casings structure is parametrically modeled by simplifying initial structural FE model and equivalently simulating mechanical characteristics.Uncorrelated modes between FE model and experiment are reasonably handled by adopting an objective function to recognize correct correlated modes pairs.The parametrized FE model is updated to effectively describe structural dynamic characteristics in respect of testing data.The model updating technology is firstly validated by the detailed FE model updating of one fixed–fixed beam structure in light of correlated/uncorrelated mode shapes and measured mode data.The PM-MUS is applied to the FE parametrized model updating of an aeroengine stator system(casings)which is constructed by the proposed parametric modeling approach.As revealed in this study,(A)the updated models by the proposed updating strategy and dynamic test data is accurate,and(B)the uncorrelated modes like close modes can be effectively handled and precisely identify the FE model mode associated the corresponding experimental mode,and(C)parametric modeling can enhance the dynamic modeling updating of complex structure in the accuracy of mode matching.The efforts of this study provide an efficient dynamic model updating strategy(PM-MUS)for aeroengine casings by parametric modeling and experimental test data regarding uncorrelated modes.

关键词： Aeroengine casings Correlated mode pair Model updating Parametric modeling Structural dynamics Uncorrelated modes

基于逐元和轴对称谱元的混合方法及远震波场模拟

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地球物理学报 2024年第5期67卷 1819-1831页

作者：李昊臻刘少林董兴朋蒙伟娟杨顶辉清华大学数学科学系北京100084 应急管理部国家自然灾害防治研究院北京100085 中国地震局地质研究所北京100029

远震波形成像是研究地球内部结构和动力学过程的重要手段.然而,由于巨大的计算需求,当前在全球尺度(包含震源-台站)数值模拟高频(频率到2 Hz)地震波传播并不现实.谱元法是一种高有效性的数值模拟算法,具有高精度和网格剖分灵活的优点,... 详细信息

远震波形成像是研究地球内部结构和动力学过程的重要手段.然而,由于巨大的计算需求,当前在全球尺度(包含震源-台站)数值模拟高频(频率到2 Hz)地震波传播并不现实.谱元法是一种高有效性的数值模拟算法,具有高精度和网格剖分灵活的优点,并且已经成功应用于弹性波方程求解中.但缺点是求解远震问题时计算量和存储量较大.为了克服上述难题,本文发展了一种基于逐元并行谱元法与轴对称谱元法相结合的混合方法:即在全球尺度层状模型下使用具有快速计算效率的轴对称谱元法模拟远震背景波场,而在研究区域内使用逐元并行谱元法精确计算非均匀介质中远震波场传播.该方法减少了非均匀介质中远震波场模拟的计算量与存储量,并保持了逐元并行谱元法高精度、低存储量、易并行的优点.数值实验验证了该混合方法的可行性和精确性,并有望进一步应用于实际地震数据远震波形成像研究中.

关键词：弹性波方程混合方法逐元谱元法轴对称谱元法远震波场模拟

飞秒激光直写三维光波导的应用与挑战(特邀)

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中国激光 2024年第4期51卷 296-315页

作者：李泽政郭帅鹏蒋闯柯少林田振男吉林大学电子科学与工程学院集成光电子学国家重点实验室吉林长春130012 武汉工程大学光学信息与模式识别湖北省重点实验室湖北武汉430205

得益于飞秒激光直写技术的穿透式真三维改性加工能力,多种介质内任意三维路径及截面形状的光波导得以实现并得到了重要应用。本文围绕飞秒激光直写光波导的机理及基本类型,综述了三维光波导器件在光通信、集成量子光学、拓扑光子学、天... 详细信息

得益于飞秒激光直写技术的穿透式真三维改性加工能力,多种介质内任意三维路径及截面形状的光波导得以实现并得到了重要应用。本文围绕飞秒激光直写光波导的机理及基本类型,综述了三维光波导器件在光通信、集成量子光学、拓扑光子学、天文光子学以及光学传感等领域的应用。从三维光子芯片的应用需求入手,总结了飞秒激光直写技术在低损耗、任意截面、大纵深直写和可重构三维波导制备中面临的挑战,并展望了飞秒激光直写三维光波导的未来发展趋势。

关键词：集成光学光子集成芯片飞秒激光直写三维光波导

Study on grid adaptability testing methodology for wind turbines

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Journal of Modern Power Systems and Clean Energy 2013年第1期1卷 81-87页

作者： shaolin li Shiyao QIN Ruiming WANG Qing li Chen CHEN China Electric Power Research Institute Beijing 100192China

The use of wind power has grown rapidly in recent years.Wind power is a clean source of energy,but can have negative impacts on the distribution grid.The influence of large-scale wind power integration on the safe and stable operation of a power system cannot be ignored.It is necessary and urgent to achieve grid adaptability for wind turbines in China.Using a 35 kV/6 MVA grid simulator,the performance of a grid is investigated by simulation.Typical grid disturbances such as voltage deviation,frequency fluctuation,voltage unbalance,and distortion can be simulated.A grid adaptability testing methodology was developed and applied to a doubly fed wind turbine with a focus on analyzing real test data to ascertain its three-phase voltage unbalance adaptability,which was successfully demonstrated.The methodology can also be used to guide other grid adaptability tests.

关键词： Wind turbines Grid simulator Grid adaptability testing