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Does an extended mediastinal lymphadenectomy improve outcome after R0 resection in lung cancer?

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Chinese Journal of Cancer Research 2014年第2期26卷 183-191页

作者： Nan Wu Shi Yan Chao Lv shaolei li Yuan Feng Yuzhao Wang Jia Wang Qingfeng Zheng Yue Yang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Thoracic Surgery II Peking University Cancer Hospital & Institute

Objective： This retrospective study was conducted to investigate the impact of more extended mediastinal lymphadenectomy on the outcome of lung cancer patients treated with R0 resection. Methods： During the investigation period, 325 lung cancer cases were enlisted and 278 cases entered the analysis. The patients were divided into Control group （n=116） and Research group （n=162） according to the different extents of mediastinal lymph node clearance at different time periods. Three major parameters were retrospectively assessed to compare the quality of surgical care： extent of lymph node clearance, resection volume, and postoperative recovery process and common complications. Comparison of the outcome between two groups was carried out. Results： Research group showed a significant quality improvement of lymphadenectomy, such as more mediastinal node stations investigated （more than 3 N2 stations investigated： Research group, 90.7% vs. Control group, 55.2%; P=0.001） and more nodes collection （total nodes 26.1±10.0 vs. 19.1±8.3, P=0.000; N2 nodes 15.5±7.2 vs. 9.8±5.6, P=0.000）. However, overall survival （OS） and disease-free survival （DFS） were not significantly different either between two groups （5-year OS： Control group, 56.4±4.6% vs. Research group, 62.6±4.3%; P=0.271） or between subgroups from stage I to IIIa. TNM stage and histology were significant factors associated with OS and DFS in multivariate analysis; extent of mediastinal lymphadenectomy was not associated with OS or DFS. Conclusions： More radical mediastinal lymphadenectomy may not lead to an improved oncological outcome for lung cancer treated with R0 resection.

关键词： Lung cancer lymphadenectomy outcome quality

植物m^(6)A修饰对转录本调控及影响机制的研究进展

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杭州师范大学学报（自然科学版） 2024年第5期23卷 512-522页

作者：唐银鞠李绍蕾冯泽地王慧中孟一君杭州师范大学生命与环境科学学院浙江杭州311121 浙江省药用植物种质改良与质量控制技术重点实验室浙江杭州311121

近年来植物中mRNA m^(6)A修饰及其对靶mRNA的调控研究备受关注.高通量测序、比色法及液相色谱质谱联用技术的发展加深了对m^(6)A修饰的分析.转录组范围内通过甲基转移酶、去甲基化酶和结合蛋白对mRNA修饰形成m^(6)A选择性标记,调控转录... 详细信息

近年来植物中mRNA m^(6)A修饰及其对靶mRNA的调控研究备受关注.高通量测序、比色法及液相色谱质谱联用技术的发展加深了对m^(6)A修饰的分析.转录组范围内通过甲基转移酶、去甲基化酶和结合蛋白对mRNA修饰形成m^(6)A选择性标记,调控转录本选择性剪接、稳定、翻译和衰变.m^(6)A修饰水平的变化对于维持植物毛状体形成、开花时间、胁迫响应和光合作用等生命活动也具有重要作用.文章综述近年来mRNA m^(6)A甲基化修饰类型,以及植物m^(6)A修饰在分子遗传和植物生长发育中的研究进展,尤其关注植物中m^(6)A修饰对mRNA命运和表达调控的不同作用.

关键词： m^(6)A mRNA修饰表观转录组学转录调控

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Adjuvant chemotherapy may improve outcome of patients with non-small-cell lung cancer with metastasis of intrapulmonary lymph nodes after systematic dissection of N1 nodes

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Chinese Journal of Cancer Research 2018年第6期30卷 588-595页

作者： Xing Wang Shi Yan Yaqi Wang Xiang li Chao Lyu Yuzhao Wang Jia Wang shaolei li lijian Zhang Yue Yang Nan Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Surgery IIPeking University Cancer Hospital&InstituteBeijing 100142China

Objective: Survival benefit of adjuvant chemotherapy(AC) of patients with intrapulmonary lymph node(IPLN)metastasis(level 12-14) needs *** evaluated the impact of AC on patients whose metastatic nodes were limited to intrapulmonary levels after systematic dissection of N1 ***: First,155 consective cases of lung cancer confirmed as pathologic N1 were collected and *** received systematic dissection of N2 and N1 *** patients with IPLN metastasis,survival outcomes were compared between those receiving AC and those not receiving ***: In this group,112 cases(72.3%) had IPLN metastasis and 55 cases(35.5%) had N1 involvement limited to level 13-14 without further disease spread to higher *** with IPLN involvement had a better prognosis than that of patients with hilar-interlobar *** the intrapulmonary N1 group(level 12-14-positive,level 10-11-negative or unknown,n=112),no survival benefit was found between the AC group and nonAC group [5-year overall survival(OS): 54.6±1.6 vs.50.4±2.4 months,P=0.177].However,76 of 112 cases for whom harvesting of level-10 and level-11 nodes was done did not show cancer involvement in pathology reports(level 12-14-positive,level 10-11 both negative),oncologic outcome was better for patients receiving AC than those not receiving AC in this subgroup(5-year OS: 57.3±1.5 vs.47.1±3.2 months,P=0.002).Conclusions: Oncologic outcome may be improved by AC for patients with involvement of N1 nodes limited to intrapulmonary levels after complete examination of N1 nodes.

关键词： Intrapulmonary lymph node metastasis adjuvant chemotherapy outcome

Hollow structured Fe@C nanorods for boosting dehydrogenation properties of α-AlH_(3)

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Nano Research 2024年第9期17卷 8184-8191页

作者： Yuan Zhao Qingshuang Wang Dongming Yin Xiaoli Wang Shouliang li Chunli Wang Long liang shaolei Zhao limin Wang Yong Cheng School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology College of Chemistry and Chemical EngineeringDezhou UniversityDezhou 253023China Henan Nayu New Material Co. Ltd.Xinxiang 453000China

α-AlH_(3)is regarded as one of the most promising hydrogen storage materials due to its high hydrogen storage capacity(10.1 wt.%,148 kg·m^(-3)).However,in practical applications,the associated hydrogen release temperature remains relatively *** effectively address this issue,hollow structured Fe@C nanorods derived from Fe-MOF are introduced as highly efficient catalyst to optimize the dehydrogenation properties ofα-AlH_(3).Comparatively,the initial hydrogen release temperature ofα-AlH_(3)+3 wt.%Fe@C is reduced to 94.2℃,which is significantly lower than that of pureα-AlH_(3)(137.8℃).At 100 and 120℃,it exhibits hydrogen capacities of 5.38 wt.%and 7.47 wt.%,respectively,whereas pureα-AlH_(3)only delivers hydrogen capacities of 0.24 wt.%and 5.94 wt.%under the same *** density functional theory(DFT)calculations further indicate that the existence of Fe@C catalyst can make the length of Al-H bond increase,which is more conducive to the release of *** results show that the synergistic effect of Fe and porous carbon in Fe@C nanorods can improve the hydrogen desorption kinetics ofα-AlH_(3),providing a good prospect for the application ofα-AlH_(3)in hydrogen storage fields.

关键词： Fe@C α-AlH_(3) dehydrogenation catalyst

Strengthening and toughening styrene-butadiene rubber by mechanically interlocked cross-links

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Science China Chemistry 2024年第10期67卷 3414-3422页

作者： Yuanhao Wang li Yang lin Cheng Jun Zhao Ruixue Bai Wenbin Wang shaolei Qu Zhaoming Zhang Wei Yu Xuzhou Yan School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Key Laboratory of Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China

Styrene-butadiene rubber(SBR)is an indispensable material in modern society,and the necessity for enhanced mechanical properties in SBR persists,particularly to withstand the rigors of challenging environmental *** surmount the limitations of conventional cross-linking modes,mechanical bonds stabilized by host-guest recognition are incorporated as the cross-linking points of SBR to form mechanically interlocked networks(MINs).Compared with covalently cross-linked network,the representative MIN exhibits superior mechanical performance in terms of elongation(1392%)and breaking strength(4.6 MPa),whose toughness has surged by 17 *** of host-guest recognition and subsequent sliding motion provide an effective energy dissipation mechanism,and the release of hidden length is also beneficial to enhance ***,the introduction of the rotaxane cross-links made the network more pliable and possess damping and elastic properties,which can return to initial state with one minute rest *** aspire that this direct introduction method can serve as a blueprint,offering valuable insights for the enhancement of mechanical properties in conventional commercial polymer materials.

关键词： mechanically interlocked molecules host-guest chemistry styrene-butadiene rubber mechanical properties dynamic materials

In-situ Generation of Hydroxyl Layers in Coo@FeSe_(2) Catalyst for High Selectivity Seawater Electrolysis

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Chinese Journal of Chemistry 2024年第1期42卷 48-54,I0004页

作者： Suyang Feng Peng Rao Xiao Wu Ke li Anyuan Qi Yanhui Yu Jing li Peilin Deng Yuliang Yuan shaolei Wang Xinlong Tian Zhenye Kang State Key Laboratoryof Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchoolof Chemical Engineering andTechnologyHainan UniversityHaikouHainan 570228China Key Laboraory of Polyoxmetalate andReticular Material Chemtry of Ministy of Education School of Chmistry Northeast NormalUniversity ChangchunJilin 130024China National Energy Group Ledong Power Generation Co. Ltd.LedongHainan 572539China

Seawater electrolysis holds great promise for hydrogen production in the future,while the development of anodic catalysts has been severely hampered by the side-reaction,chloride evolution *** this work,nano-flower-cluster structured Coo@FeSe_(2)/CF catalysts are synthesized via a scalable electrodeposition technique,and the performance is systematically *** oxygen evolution reaction(OER)overpotential of Co0@FeSe_(2)/CF is 267 mV at 100 ***^(-2),which is significantly lower than that of the IrO_(2) catalyst(435 mV).Additionally,the catalyst shows high selectivity for OER(97.9%)and almost no loss of activity after a durability test for 1100 *** impressive performance is attributed to the dense rod-like structure with abundant active centers after electrochemical activation and the in-situ generated CoOOH and FeOOH that improve the catalytic activity of the *** synergistic effect induced bythenon-uniform structureendows the catalyst with excellent stability.

关键词： Energy Transfer Seawat erelectrolysis Oxygen evolution reaction Electrodeposition method CoO@FeSe_(2)/CF catalyst Nano-flower-cluster structure Catalytic activity

基于输出误差模型的B-Dot传感器标定方法

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强激光与粒子束 2019年第10期31卷 79-84页

作者：王可段艳涛李炎新李少磊陆军工程大学电磁环境效应与光电工程重点实验室

B-dot传感器因其频带宽,体积小以及良好的稳定性而广泛应用于电磁脉冲(EMP)测量。任何理论模型与实际情况之间都存在差异,因此B-dot传感器必须在实验室环境下进行标定。针对传统的时域标定方法存在的弊端,提出一种基于输出误差(OE)模型... 详细信息

B-dot传感器因其频带宽,体积小以及良好的稳定性而广泛应用于电磁脉冲(EMP)测量。任何理论模型与实际情况之间都存在差异,因此B-dot传感器必须在实验室环境下进行标定。针对传统的时域标定方法存在的弊端,提出一种基于输出误差(OE)模型的频域标定方法。该方法利用单输入单输出的OE模型传递函数来表征B-dot传感器的频响特性,然后通过部分线性回归求得传感器实际工作的频率范围的灵敏度系数。经验证,该方法能够有效避免因阻抗突变引起的过冲或振铃现象对标定精度的影响。

关键词：电磁脉冲 B-dot传感器磁场频域标定 OE模型系统辨识

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外墙保温技术及房建节能材料应用分析

陶瓷 2022年第1期 141-143页

作者：李少磊中铁二十二局集团第二工程有限公司北京100041

随着近几年国家对环保问题的大力改革,政府与相关部门开始提出了创建环境友好型社会以及可持续发展战略,基于该背景下,社会经济发展过程中,最重要的一个原则就是要做到对资源进行节约。对于房屋建筑来说,在我国国民经济发展的过程中,是... 详细信息

随着近几年国家对环保问题的大力改革,政府与相关部门开始提出了创建环境友好型社会以及可持续发展战略,基于该背景下,社会经济发展过程中,最重要的一个原则就是要做到对资源进行节约。对于房屋建筑来说,在我国国民经济发展的过程中,是一项重要且不可缺少的建设工程,做好房屋建筑节能工作,是目前建设工程必不可少的一项重要工作内容。本文主要分析了外墙保温技术及房间节能材料的应用。

关键词：外墙保温节能材料应用

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计量供热系统特性及系统节能要点浅析

现代工业经济和信息化 2015年第6期5卷 72-74页

作者：李少雷李锐北京建筑大学北京100044

文章对计量供热系统与传统供热系统进行了对比分析,研究了热计量供热系统的特性,在此基础上进一步分析了计量供热系统节能的相关因素,并着重分析了系统节能首先要注重初调节,并配合变流量运行调节控制,克服系统水力失调,按需供热,实现... 详细信息

文章对计量供热系统与传统供热系统进行了对比分析,研究了热计量供热系统的特性,在此基础上进一步分析了计量供热系统节能的相关因素,并着重分析了系统节能首先要注重初调节,并配合变流量运行调节控制,克服系统水力失调,按需供热,实现节能目的。

关键词：热计量供热系统气候补偿系统节能