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Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang shaolei Wang Junyi Yin Ming Yang Xuxu Chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

Correction: A systemic and molecular study of subcellular localization of SARS-CoV-2 proteins

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1931-1931页

作者： Jing Zhang Ruth Cruz-cosme Meng-Wei Zhuang Dongxiao Liu Yuan Liu shaolei teng Pei-Hui Wang Qiyi Tang Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute Cheeloo College of Medicine Shandong University Jinan Shandong 250012 China Howard University College of Medicine 520 W Street NW Washington DC 20059 USA Weill Institute for Cell and Molecular Biology Cornell University Ithaca NY USA Department of Biology Howard University 415 College St. NW Washington DC 20059 USA

Fe_3Al/ZrO_2复合材料海水腐蚀电化学行为

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中国腐蚀与防护学报 2007年第5期27卷 263-268页

作者：刘涛常雪婷滕少磊杜建波李嘉尹衍升中国海洋大学材料研究院青岛266003 山东大学材料学院济南250061 济南大学材料学院济南250001

用电化学阻抗、极化曲线、扫描电镜等测试手段研究单相Fe3Al和Fe3Al/ZrO2复合材料的耐海水腐蚀性能。结果表明:浸蚀初期,材料的抗局部腐蚀能力由强到弱依次为单相Fe3Al>Fe3Al(75 vol%)/ZrO2>Fe3Al(50 vol%)/ZrO2,但随着浸蚀时间的延长,F... 详细信息

用电化学阻抗、极化曲线、扫描电镜等测试手段研究单相Fe3Al和Fe3Al/ZrO2复合材料的耐海水腐蚀性能。结果表明:浸蚀初期,材料的抗局部腐蚀能力由强到弱依次为单相Fe3Al>Fe3Al(75 vol%)/ZrO2>Fe3Al(50 vol%)/ZrO2,但随着浸蚀时间的延长,Fe3Al(50 vol%)/ZrO2复合材料的腐蚀速率下降较快;浸蚀30 d后,其抗海水腐蚀性最好。

关键词： Fe3Al/ZrO2复合材料电化学阻抗海水腐蚀

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有机封装基板常见失效模式与制程控制

电子与封装 2024年第2期24卷 62-71页

作者：周帅林孟凡义张领李国有滕少磊清河电子科技(山东)有限责任公司济南250000

随着封装技术的迅速发展,集成电路封装需要具备微型化、多功能化、高频、高速、高性能以及低成本等特点。为了满足先进封装的需求,有机封装基板朝着小孔径、高布线密度、小尺寸等方向发展,这一发展趋势对基板的机械稳固性、散热性和电... 详细信息

随着封装技术的迅速发展,集成电路封装需要具备微型化、多功能化、高频、高速、高性能以及低成本等特点。为了满足先进封装的需求,有机封装基板朝着小孔径、高布线密度、小尺寸等方向发展,这一发展趋势对基板的机械稳固性、散热性和电学性能提出了更高的要求,对内部互连可靠性、离子迁移以及焊点牢固性的控制带来很大挑战。研究了孔底开裂、离子迁移、焊点开裂等失效模式,分析其失效机理,总结失效模式的影响因素,有针对性地提出了有效的基板制程控制措施。

关键词：孔底开裂离子迁移焊点开裂失效模式制程控制

An approach to visual analysis for task flow management

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Science China(Information Sciences) 2013年第5期56卷 91-102页

作者： teng DongXing SONG shaolei YANG HaiYan MA CuiXia WANG HongAn DAI GuoZhong Beijing Key Laboratory of Human-Computer Interaction Institute of SoftwareChinese Academy of Sciences Graduate University of Chinese Academy of Sciences

Efficient management of task flow plays an important role in prediction,planning,control and optimization of *** this paper,according to major indicators to evaluate during task flow management such as time performance,resource allocation efficiency and executory costs we establish a task flow management oriented business model and analyze important operations performed in evaluation,analysis,and optimization of task *** on the business model,in the view of problems from multi-source and heterogeneous data without standardized description,we define a unified data model to give a description for the massive and heterogeneous task flow *** we further demonstrate a complex task flow oriented visualization morphology design,with corresponding layout algorithm,and introduce the Focus + Context technique to assist users in analyzing task flows and making accurate ***,we develop a task flow management oriented visual analysis prototype system,and apply it into medical process *** results show that this system can effectively support analysis and evaluation of execution progress,time performance,resource utilization,cost,etc.,which can improve efficiency of the task flow management and contribute to quick and accurate decision-making.

关键词： process management information visualization visual analytics human-computer interaction

Merging daily sea surface temperature data from multiple satellites using a Bayesian maximum entropy method

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Frontiers of Earth Science 2015年第4期9卷 722-731页

作者： shaolei TANG Xiaofeng YANG Di DONG Ziwei LI State Key Laboratory of Remote Sensing Science Institute of Remote Sensing and Digital Earth Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Sea surface temperature （SST） is an important variable for understanding interactions between the ocean and the atmosphere. SST fusion is crucial for acquiring SST products of high spatial resolution and coverage. This study introduces a Bayesian maximum entropy （BME） method for blending daily SSTs from multiple satellite sensors. A new spatiotemporal covariance model of an SST field is built to integrate not only single-day SSTs but also time-adjacent SSTs. In addition, AVHRR 30-year SST climatology data are introduced as soft data at the estimation points to improve the accuracy of blended results within the BME framework. The merged SSTs, with a spatial resolution of 4 km and a temporal resolution of 24 hours, are produced in the Western Pacific Ocean region to demonstrate and evaluate the proposed metho- dology. Comparisons with in situ drifting buoy observations show that the merged SSTs are accurate and the bias and root-mean-square errors for the comparison are 0.15℃ and 0.72℃, respectively.

关键词： sea surface temperature (SST) Bayesian maximum entropy (BME) remote sensing data fusion

Differentiation of embryonic versus adult rat neural stem cells into dopaminergic neurons in vitro

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Neural Regeneration Research 2008年第8期3卷 832-836页

作者： Chunlong Ke Baili Chen shaolei Guo Chao Yang Department of Neurosurgery First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 Guangdong Province China Department of Gastroenterology First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 Guangdong Province China

BACKGROUND：It has been reported that the conversion of neural stem cells into dopaminergic neurons in vitro can be increased through specific cytokine combinations. Such neural stem cell-derived dopaminergic neurons could be used for the treatment of Parkinson’s disease. However, little is known about the differences in dopaminergic differentiation between neural stem cells derived from adult and embryonic rats. OBJECTIVE： To study the ability of rat adult and embryonic-derived neural stem cells to differentiate into dopaminergic neurons in vitro. DESIGN： Randomized grouping design. SETTING： Department of Neurosurgery in the First Affiliated Hospital of Sun Yat-sen University. MATERIALS： This experiment was performed at the Surgical Laboratory in the First Affiliated Hospital of Sun Yat-sen University （Guangzhou, Guangdong, China） from June to December 2007. Eight, adult, male, Sprague Dawley rats and eight, pregnant, Sprague Dawley rats （embryonic day 14 or 15） were provided by the Experimental Animal Center of Sun Yat-sen University. METHODS： Neural stem cells derived from adult and embryonic rats were respectively cultivated in serum-free culture medium containing epidermal growth factor and basic fibroblast growth factor. After passaging, neural stem cells were differentiated in medium containing interleukin-1α, interleukin-11, human leukemia inhibition factor, and glial cell line-derived neurotrophic factor. Six days later, cells were analyzed by immunocytochemistry and flow cytometry. MAIN OUTCOME MEASURES： Alterations in cellular morphology after differentiation of neural stem cells derived from adult and embryonic rats; and percentage of tyrosine hydroxylase-positive neurons in the differentiated cells. RESULTS： Neural stem cells derived from adult and embryonic rats were cultivated in differentiation medium. Six days later, differentiated cells were immunoreactive for tyrosine hydroxylase. The percentage of tyrosine hydroxylase positive neurons was （5.6 ± 2

关键词： neural stem cells differentiation dopaminergic neurons

Distinct Evolution of the SST Anomalies in the Far Eastern Pacific between the 1997/98 and 2015/16 Extreme El Niños

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Advances in Atmospheric Sciences 2022年第6期39卷 927-942页

作者： shaolei TANG Jing-Jia LUO Lin CHEN Yongqiang YU Institute for Climate and Application Research(ICAR) Nanjing University of Information Science and TechnologyNanjing 210044China Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/ILCEC/CIC-FEMDNanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

The 2015/16 El Niño displayed a distinct feature in the SST anomalies over the far eastern Pacific(FEP)compared to the 1997/98 extreme *** contrast to the strong warm SST anomalies in the FEP in the 1997/98 event,the FEP warm SST anomalies in the 2015/16 El Niño were modest and accompanied by strong southeasterly wind anomalies in the southeastern *** possible underlying causes of this distinct difference in the FEP may improve understanding of the diversity of extreme El Niñ***,we employ observational analyses and numerical model experiments to tackle this ***-layer heat budget analysis suggests that compared to the 1997/98 event,the modest FEP SST warming in the 2015/16 event was closely related to strong vertical upwelling,strong westward current,and enhanced surface evaporation,which were caused by the strong southeasterly wind anomalies in the southeastern *** strong southeasterly wind anomalies were initially triggered by the combined effects of warm SST anomalies in the equatorial central and eastern Pacific(CEP)and cold SST anomalies in the southeastern subtropical Pacific in the antecedent winter,and then sustained by the warm SST anomalies over the northeastern subtropical Pacific and *** contrast,southeasterly wind anomalies in the 1997/98 El Niño were partly restrained by strong anomalously negative sea level pressure and northwesterlies in the northeast flank of the related anomalous cyclone in the subtropical South *** addition,the strong southeasterly wind and modest SST anomalies in the 2015/16 El Niño may also have been partly related to decadal climate variability.

关键词： El Nño-Southern Oscillation extreme El Niño El Niño diversity far eastern Pacific decadal climate variability

Absorption behavior of lattice oxygen in Ce_(0.8)Y_(0.2)O_(2-δ) at intermediate temperature

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Journal of Rare Earths 2018年第6期36卷 630-634页

作者： Chencen Sun Guanzhong He Liangchao Gao shaolei Song Rong Li Qiang Zhen Nano Science and Technology Research Center Shanghai University School of Materials Science and Engineering Shanghai University

The absorption behavior of lattice oxygen for Ce0.8Y0.2O2-δ(YDC) crystal was investigated. Combined with TG-DSC, XRD, Raman and XPS characterization, lattice oxygen absorption occurs at intermediate temperature(from 500 to 800 ℃),which is related to the oxygen vacancies consumption,and no phase change is observed in this process. In electric conductivity relaxation(ECR) experiment, prolonged oxygen diffusion process is observed above 600 ℃, which may be caused by oxygen absorption process. And through ECR experiments,the bulk diffusion coefficient Dchemand surface exchange coefficient Kexfor YDC dense sample are measured as 6,5×10-5-2×10-4cm2/s and Kex=2×10-4-9×10-4cm/s at intermediate temperature range.

关键词： Y doped CeO_2 ECR XPS Oxygen vacancies Oxygen absorption Rare earths