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表观转录元件溴结构域蛋白4抑制剂减轻心肌梗死后心脏损伤

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心肺血管病杂志 2024年第3期43卷 306-311页

作者：郭昱瑄乔博康王媛舒绍坤杜杰首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所 100029 北京大学肿瘤医院

目的:探究溴结构域蛋白4(bromodomain-containing protein 4,BRD4)在心肌梗死后心脏损伤中的作用。方法:通过分析公共数据,明确心肌梗死小鼠心脏组织中BRD4在整体和以及各细胞群中的表达变化。构建心肌梗死小鼠模型,设立空白对照组(WT... 详细信息

目的:探究溴结构域蛋白4(bromodomain-containing protein 4,BRD4)在心肌梗死后心脏损伤中的作用。方法:通过分析公共数据,明确心肌梗死小鼠心脏组织中BRD4在整体和以及各细胞群中的表达变化。构建心肌梗死小鼠模型,设立空白对照组(WT组),心肌梗死组(MI组),药物组(JQ1组,ABBV-744组),术后第6天腹腔注射BRD4抑制剂JQ1或灌胃二代抑制剂ABBV-744,持续22天。MI术后4周,小动物超声影像系统检测小鼠心功能,检测小鼠质量、心脏质量与胫骨长度,天狼星红染色评估梗死区纤维化程度,WGA染色检测心肌细胞横截面积。结果:与心肌梗死组相比,BRD4抑制剂组能够显著改善术后心功能障碍(P<0.01)。转录组学数据表明,BRD4在心肌梗死损伤区域持续高表达。单细胞数据显示,心肌梗死后,成纤维细胞中BRD4阳性细胞比例显著增加,并且在心肌梗死后7、14、30d的成纤维细胞中,BRD4表达持续上调。与心肌梗死组相比,BRD4抑制剂组显著减轻心脏纤维化(P <0.01)。与一代药物组相比,二代药物组心脏纤维化程度显著降低(P<0.01)。结论:抑制表观转录因子BRD4可减轻心肌梗死后心脏损伤,抑制心脏纤维化,并改善心功能。

关键词：溴结构域蛋白4 表观调控心脏成纤维细胞心肌梗死

Therapy of Primary Liver Cancer

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The Innovation 2020年第2期1卷 97-115页

作者： Mei Feng Yisheng Pan Ruirui Kong shaokun shu Translational Cancer Research Center Peking University First HospitalBeijing 100034China Department of Biomedical Engineering Peking UniversityBeijing 100871China Peking University Cancer Hospital Beijing 100142China Department of General Surgery Peking University First HospitalBeijing 100034China

Primary liver cancer(PLC)is a fatal disease that affects millions of lives *** is the leading cause of cancer-related deaths and the incidence rate is predicted to rise in the coming *** can be categorized into three major histological subtypes:hepatocellular carcinoma(HCC),intrahepatic cholangiocarcinoma(ICC),and combined *** subtypes are distinct with respect to epidemiology,clinicopathological features,genetic alterations,and clinical managements,which are thoroughly summarized in this *** state of treatment strategies for each subtype,including the currently approved drugs and the potential novel therapies,are also discussed.

关键词： PRIMARY LIVER CANCER HEPATOCELLULAR CARCINOMA INTRAHEPATIC CHOLANGIOCARCINOMA COMBINED HCCICC PLC THERAPY

A low-frequency pure metal metamaterial absorber with continuously tunable stiffness

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1209-1224页

作者： Xingzhong WANG Shiteng RUI shaokun YANG Weiquan ZHANG Fuyin MA School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an710049China Xi’an Precision Machinery Research Institute Xi’an710077China

To address the incompatibility between high environmental adaptability and deep subwavelength characteristics in conventional local resonance metamaterials,and overcome the deficiencies in the stability of existing active control techniques for band gaps,this paper proposes a design method of pure metal vibration damping metamaterial with continuously tunable stiffness for wideband elastic wave *** design a dual-helix narrow-slit pure metal metamaterial unit,which possesses the triple advantage of high spatial compactness,low stiffness characteristics,and high structural stability,enabling the opening of elastic flexural band gaps in the low-frequency *** to the principle of a sliding rheostat,the introduction of continuously sliding plug-ins into the helical slits enables the continuous variation of the stiffness of the metamaterial unit,achieving a continuously tunable band gap *** successfully extends the effective band gap by more than ten *** experimental results indicate that this metamaterial unit can be used as an additional vibration absorber to absorb the low-frequency vibration energy ***,it advances the metamaterial absorbers from a purely passive narrowband design to a wideband tunable *** pure metal double-helix metamaterials retain the subwavelength properties of metamaterials and are suitable for deployment in harsh ***,by adjusting its stiffness,it substantially broadens the effective band gap range,presenting promising potential applications in various mechanical equipment operating under adverse conditions.

关键词： elastic metamaterial absorber continuously tunable stiffness low-frequency vibration damping variable stiffness design pure metal structure

Impact of Blade-Flapping Vibration on Aerodynamic Characteristics of Wind Turbines under Yaw Conditions

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Energy Engineering 2024年第8期121卷 2213-2229页

作者： shaokun Liu Zhiying Gao Rina Su Mengmeng Yan Jianwen Wang College of Energy and Power Engineering Inner Mongolia University of TechnologyHohhot010051China Key Laboratory of Wind and Solar Energy Utilization Technology Ministry of EducationHohhot010051China

Although the aerodynamic loading of wind turbine blades under various conditions has been widely studied,the radial distribution of load along the blade under various yaw conditions and with blade flapping phenomena is poorly *** study aims to investigate the effects of second-order flapwise vibration on the mean and fluctuation characteristics of the torque and axial thrust of wind turbines under yaw conditions using computational fluid dynamics(CFD).In the CFD model,the blades are segmented radially to comprehensively analyze the distribution patterns of torque,axial load,and tangential *** following results are obtained.(i)After applying flapwise vibration,the torque and axial thrust of wind turbines decrease in relation to those of the rigid model,with significantly increased fluctuations.(ii)Flapwise vibration causes the blades to reciprocate along the axial direction,altering the local angle of attack and velocity of the blades relative to the incoming wind *** results in the contraction of the torque region from a circular shape to a complex“gear”shape,which is accompanied by evident oscillations.(iii)Compared to the tangential load,the axial load on the blades is more sensitive to flapwise vibration although both exhibit significantly enhanced *** study not only reveals the impact of flapwise vibration on wind turbine blade performance,including the reduction of torque and axial thrust and increased operational fluctuations,but also clarifies the radial distribution patterns of blade aerodynamic characteristics,which is of great significance for optimizing wind turbine blade design and reducing fatigue risks.

关键词： Wind turbine CFD numerical simulation aerodynamic characteristics yaw flapping vibration

Coupling of reduced inorganic fertilizer with plant-based organic fertilizer as a promising fertilizer management strategy for colored rice in tropical regions

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Journal of Integrative Agriculture 2024年第1期23卷 93-107页

作者： Tingcheng Zhao Aibin He Mohammad Nauman Khan Qi Yin shaokun Song Lixiao Nie Research Center for Physiology and Ecology and Green Cultivation of Tropical Crops School of Breeding and Multiplication(Sanya Institute of Breeding and Multiplication)Hainan UniversitySanya 572000China

Colored rice is a type of high-quality,high-added-value rice that has attracted increasing attention in recent *** use of large amounts of inorganic nitrogen fertilizer in rice fields results in low fertilizer use efficiency and high environmental *** fertilizer is a promising way to improve soil quality and sustain high ***,most studies focus on the effect of animal-based organic *** effects of different ratios of plantbased organic fertilizer and inorganic fertilizer on the grain yield and quality of colored rice have rarely been ***,a two-year field experiment was conducted in 2020 and 2021 to study the effects of replacing inorganic N fertilizers with plant-based organic fertilizers on the yield,nitrogen use efficiency(NUE),and anthocyanin content of two colored rice varieties in a tropical region in *** experimental treatments included no nitrogen fertilization(T1),100% inorganic nitrogen fertilizer(T2),30%inorganic nitrogen fertilizer substitution with plant-based organic fertilizer(T3),60%inorganic nitrogen fertilizer substitution with plant-based organic fertilizer(T4),and 100% plantbased organic fertilizer(T5).The total nitrogen provided to all the treatments except T1 was the same at 120 kg *** results showed that the T3 treatment enhanced the grain yield and anthocyanin content of colored rice by increasing nitrogen use efficiency compared with *** average,grain yields were increased by 9 and 8%,while the anthocyanin content increased by 16 and 10% in the two colored rice varieties under T3 across the two years,respectively,as compared with *** study of the residual effect of partial substitution of inorganic fertilizers showed that the substitution of inorganic fertilizer with plant-based organic fertilizer improved the soil physiochemical properties,and thus increased the rice grain yield,in the subsequent *** highest grain yield of the subsequent rice crop was observe

关键词： colored rice organic fertilizer soil quality grain yield anthocyanin

A Magnetic-Multiplier-Enabled Hybrid Generator with Frequency Division Operation and High Energy Utilization Efficiency

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Research 2024年第1期2023卷 561-570页

作者： Jie Chen Kangjie Wu shaokun Gong Jianchao Wang Ke Wang Hengyu Guo College of Physics and Electronic Engineering Chongqing Key Laboratory Photo-electric Functional MaterialsChongqing Normal UniversityChongqing 401331China State Key Laboratory of Mechanical Transmission College of Mechanical and Vehicle EngineeringChongqing UniversityChongqing 400044China School of Physics Chongqing UniversityChongqing 400044China

The hybrid electromagnetic-triboelectric generator(HETG)is a prevalent device for mechanical energy ***,the energy utilization efficiency of the electromagnetic generator(EMG)is inferior to that of the triboelectric nanogenerator(TENG)at low driving frequencies,which limits the overall efficacy of the *** tackle this issue,a layered hybrid generator consisting of a rotating disk TENG,a magnetic multiplier,and a coil panel is *** magnetic multiplier not only forms the EMG part with its high-speed rotor and the coil panel but also facilitates the EMG to operate at a higher frequency than the TENG through frequency division *** systematic parameter optimization of the hybrid generator reveals that the energy utilization efficiency of EMG can be elevated to that of rotating disk *** a power management circuit,the HETG assumes the responsibility for monitoring the water quality and fishing conditions by collecting low-frequency mechanical *** magneticmultiplier-enabled hybrid generator demonstrated in this work offers a universal frequency division approach to improve the overall outputs of any hybrid generator that collects rotational energy,expanding its practical applications in diverse multifunctional self-powered systems.

关键词： generator rotating assume

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平台规则效力判定标准的重构

法学评论 2024年第3期42卷 110-120页

作者：黄绍坤武汉大学法学院

平台规则是平台治理的依托,通过对其效力的控制,可以有效保障用户利益,优化平台生态。现有立法和司法实践关于平台规则效力的判定标准存在认知错误,难以应对网络新问题和实现平台治理优化,需要予以重构。在数字空间,受平台公共属性强化... 详细信息

平台规则是平台治理的依托,通过对其效力的控制,可以有效保障用户利益,优化平台生态。现有立法和司法实践关于平台规则效力的判定标准存在认知错误,难以应对网络新问题和实现平台治理优化,需要予以重构。在数字空间,受平台公共属性强化、平台组织化、社会关系与平台规则相互嵌入、平台规则具备强制履行性等因素影响,平台规则已经成为嵌入算法的新型规则,处于合同与法律的过渡地带,特征更趋向规范性文件。平台规则的效力判断不能直接套用格式条款效力判断规范,而应有限借鉴行政规范性文件等的效力判断标准,从主体权限、程序、实体内容三方面加以考察。当平台规则“权限”越位,违反制定、修改、提示程序,或内容违反强制性法律规定、赋权均衡原则、比例原则、非歧视原则时,相应条款应属无效。

关键词：平台规则效力判断格式条款私权力司法审查

同方期刊数据库博看期刊评论

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铋铒共掺光纤实现C+L+U波段超宽带放大

中国激光 2024年第14期51卷 210-216页

作者：刘少坤褚应波戴能利李进延华中科技大学武汉光电国家研究中心湖北武汉430074

传统掺铒(Er)光纤放大器的增益带宽已无法满足日益增长的通信带宽需求。为了对现有通信系统进行升级扩容,迫切需要开发出可实现多波段同时放大的光纤放大器。然而,国内尚未成功研制出能够实现多波段同时放大的增益光纤。基于改进的化学... 详细信息

传统掺铒(Er)光纤放大器的增益带宽已无法满足日益增长的通信带宽需求。为了对现有通信系统进行升级扩容,迫切需要开发出可实现多波段同时放大的光纤放大器。然而,国内尚未成功研制出能够实现多波段同时放大的增益光纤。基于改进的化学气相沉积技术,成功制备了可实现C+L+U波段同时放大的铋(Bi)铒共掺光纤,通过比较不同Bi、Er掺杂浓度对增益谱的影响,分析了其影响机制。讨论了不同泵浦方式(前向泵浦、后向泵浦和双向泵浦)和不同泵浦波长(1460 nm和1480 nm)对增益谱的影响。结果显示,基于双向泵浦结构,当输入信号功率为-25 dBm时,采用自制铋铒共掺光纤搭建的放大器在1530~1670 nm范围内实现了11.8 dB以上的增益,噪声指数为6.3 dB~9.3 dB。

关键词：铋铒共掺光纤改进的化学气相沉积 C+L+U波段放大器

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磷硅酸盐掺铋光纤实现O+E波段放大

中国激光 2024年第2期51卷 106-110页

作者：殷晓科何乐刘少坤褚应波戴能利李进延华中科技大学武汉光电国家研究中心湖北武汉430074

由于数据流量需求的逐年增加,现有光纤放大器的传输带宽已很难应对光纤通信系统的容量危机,实现扩展波段的光放大被认为是一种解决容量危机的有效方案。不同基质的掺铋光纤的发光范围可以覆盖大部分的传输窗口,因此具有重要的研究意义... 详细信息

由于数据流量需求的逐年增加,现有光纤放大器的传输带宽已很难应对光纤通信系统的容量危机,实现扩展波段的光放大被认为是一种解决容量危机的有效方案。不同基质的掺铋光纤的发光范围可以覆盖大部分的传输窗口,因此具有重要的研究意义和广阔的应用前景。报道了一种基于改进的化学气相沉积技术制备的磷硅酸盐掺铋光纤,并测试了其基本参数及放大性能。该掺铋光纤在1550 nm处的背景损耗为21 dB/km,在1240 nm处的吸收系数达0.58 dB/m,非饱和损耗占比为13.6%。通过搭建单级前向泵浦结构测试了该掺铋光纤的放大性能,当输入信号功率为-15 dBm时,采用泵浦功率为460 mW的1240 nm半导体激光器进行泵浦,将光纤长度优化至140 m,实现了O+E波段(1270~1480 nm)的净增益,并在1340 nm处得到了最大增益(21.2 dB),其3 dB带宽约为55 nm(1310~1365 nm)。

关键词：光纤光学掺铋光纤宽带放大 O波段 E波段