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An ultra low-input method for global RNA structure probing uncovers Regnase-1-mediated regulation in macrophages

Fundamental Research 2022年第1期2卷 2-13页

作者： Meiling Piao Pan Li Xiaomin Zeng Xi-Wen Wang Lan Kang Jinsong Zhang Yifan Wei shaojun zhangas Lei Tang Jianghui Zhu Chun Kit Kwok Xiaoyu Hu Qiangfeng Cliff Zhang MOE Key Laboratory of Bioinformatics Center for Synthetic and Systems BiologySchool of Life SciencesTsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Structural Biology&Frontier Research Center for Biological Structure School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China Institute for Immunology and School of Medicine Tsinghua UniversityBeijingChina Beijing Key Laboratory for Immunological Research on Chronic Diseases Tsinghua-Peking Center for Life SciencesTsinghua UniversityBeijingChina department of Chemistry City University of Hong KongTat Chee AvenueKowloon TongHong KongChina Shenzhen Research Institute of City University of Hong Kong ShenzhenChina

To enable diverse functions and precise regulation,an RNA sequence often folds into complex yet distinct structures in different cellular *** RNA in its native environment is essential to uncovering RNA structures of biological ***,current methods generally require large amounts of input RNA and are challenging for physiologically relevant ***,we report smartSHAPE,a new RNA structure probing method that requires very low amounts of RNA input due to the largely reduced artefact of probing signals and increased efficiency of library *** smartSHAPE,we showcased the profiling of the RNA structure landscape of mouse intestinal macrophages upon inflammation,and provided evidence that RNA conformational changes regulate immune *** results demonstrate that smartSHAPE can greatly expand the scope of RNA structure-based investigations in practical biological systems,and also provide a research paradigm for the study of post-transcriptional regulation.

关键词： RNA structure probing method Low-input RNA structure element Macrophage RNA structure RNA structurome

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