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Microstructure and mechanical properties of Mg-3Sn-1Ca reinforced with AlN nano-particles

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Journal of Magnesium and Alloys 2023年第1期11卷 259-269页

作者： Shaozhu Wang Yuanding Huang Lixiang Yang Ying Zeng Yaozeng Hu Xiao Zhang Qiang Sun shaojun shi Guangyao Meng Norbert Hort School of Mechanical&Automotive Engineering Qingdao University of TechnologyTsingtao 266520PR China MagIC-Magnesium Innovation Center Helmholtz-Zentrum GeesthachtMax-Planck-Strasse 1Geesthacht 21502Germany Linyi Institute of Industrial Technology Linyi 276000PR China Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming and State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240PR China Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Material Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031PR China Shandong Yinguang Yuyuan Light Metal Precise Forming Co. LtdShandong 273400PR China

Microstructural evolution and strengthening mechanisms of Mg-3Sn-1Ca based alloys with additions of different amounts of Al N nanoparticles were *** was found that with increasing the amount of AlN nano-particles the grain size decreases *** existence of AlN nano-particles could refine the primary crystal phases CaMgSn,which provided more heterogeneous nucleation sites for the formation of ***,such nano-particles could also restrict the grain growth during *** adding AlN nano-particles,both the tensile properties at room temperature and high temperature 250℃and the hardness are largely *** improvement of strength is attributed to grain refinement and second phase refinement.

关键词： Mg-Sn-Ca alloy AlN nano-particles Microstructure Strengthening mechanisms Grain refinement

One-step constructing advanced N-doped carbon@metal nitride as ultra-stable electrocatalysts via urea plasma under room temperature

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Chinese Chemical Letters 2024年第11期35卷 486-491页

作者： Tao Tang Chen Li Sipu Li Zhong Qiu Tianqi Yang Beirong Ye shaojun shi Chunyang Wu Feng Cao Xinhui Xia Minghua Chen Xinqi Liang Xinping He Xin Liu Yongqi Zhang Institute of Fundamental and Frontier Science University of Electronic Science and Technology of ChinaChengdu 611731China Department of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China College of Materials Science&Engineering Zhejiang University of TechnologyHangzhou 310014China School of Chemistry and Materials Engineering Changshu Institute of TechnologyChangshu 215500China State Key Laboratory of Electronic Thin Film and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 611731China Department of Engineering Technology Huzhou CollegeHuzhou 313000China Key Laboratory of Engineering Dielectric and Applications(Ministry of Education) School of Electrical and Electronic EngineeringHarbin University of Science and TechnologyHarbin 150080China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China

Highly active transition metal nitrides are desirable for electrocatalytic reactions,but their long-term stability is still unsatisfactory and thus limiting commercial ***,for the first time,we report a unique and universal room-temperature urea plasma method for controllable synthesis of N-doped carbon coated metal(Fe,Co,Ni,etc.)nitrides arrays *** preformed metal oxides arrays can be successfully converted into metal nitrides arrays with preserved nanostructures and a thin layer of N-doped carbon(N-C)via one-step urea ***,as a representative case,N-C@CoN nanowire arrays are illustrated and corresponding formation mechanism by plasma is ***,the designed N-C@Co N catalysts deliver excellent electrocatalytic activity and long-term stability both in oxygen evolution reaction(OER)and urea oxidation reaction(UOR).For OER,a low overpotential(264 mV at 10 mA/cm^(2))and high stability(>50 h at 20 mA/cm^(2))are *** UOR,a current density of100 m A/cm^(2) is achieved at only 1.39 V and maintain over 100 *** calculations reveal that the synergetic coupling effect of CoN and N-C can significantly facilitate the charge-transfer process,optimize adsorbed intermediates binding strength and further greatly decrease the energy *** strategy provides a novel method for fabrication of N-C@metal nitrides as highly active and stable catalysts.

关键词： Urea plasma Metal nitrides Carbon shell Oxygen evolution reaction Urea oxidation reaction

芍药苷通过激活LKB1/AMPK信号通路对急性脑梗死大鼠神经损伤的保护作用

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中国实验动物学报 2022年第5期30卷 671-678页

作者：赵霞薛娣师少军南阳医学高等专科学校河南南阳473000 河南省安阳市中医院神经外科河南安阳455000

目的探讨芍药苷通过激活肝激酶B1(LKB1)/5’-磷酸腺苷激活的蛋白激酶(AMPK)信号通路对急性脑梗死大鼠神经损伤的保护作用。方法通过线栓闭塞大鼠大脑中动脉建立急性脑梗死模型,随机分为模型组、芍药苷(10 mg/kg)组、AMPK抑制剂CC(0.2 mg... 详细信息

目的探讨芍药苷通过激活肝激酶B1(LKB1)/5’-磷酸腺苷激活的蛋白激酶(AMPK)信号通路对急性脑梗死大鼠神经损伤的保护作用。方法通过线栓闭塞大鼠大脑中动脉建立急性脑梗死模型,随机分为模型组、芍药苷(10 mg/kg)组、AMPK抑制剂CC(0.2 mg/kg)组、芍药苷(10 mg/kg)+CC(0.2 mg/kg)组,每组12只,另取12只大鼠仅分离出颈总动脉与颈外动脉,不插线栓,设为假手术组,分组给药处理后,采用Morris水迷宫实验评测大鼠认知功能;采用三苯基氯化四氮唑(TTC)染色检测各组大鼠脑梗死情况;采用TUNEL染色测定各组大鼠海马神经元凋亡率;采用试剂盒测量各组大鼠血清炎性因子诱导型一氧化氮合酶(iNOS)与白细胞介素-1β(IL-1β)水平、脑组织过氧化氢酶(CAT)、活性氧(ROS)与丙二醛(MDA)含量;采用蛋白免疫印迹法检测各组大鼠脑组织凋亡相关蛋白B淋巴细胞瘤-2(Bcl-2)、BCL2相关X蛋白(Bax)与LKB1/AMPK通路相关蛋白(p-LKB1/LKB1、p-AMPK/AMPK)表达状况。结果与假手术组相比,模型组大鼠跨越原平台次数、原平台象限内停留时间、脑组织CAT含量、p-LKB1/LKB1、p-AMPK/AMPK、Bcl-2表达水平显著降低(P<0.05),脑梗死面积、海马神经元凋亡率、血清iNOS与IL-1β水平、脑组织ROS与MDA含量、Bax表达水平显著升高(P<0.05)。与模型组相比,芍药苷组大鼠跨越原平台次数、原平台象限内停留时间、脑组织CAT含量、p-LKB1/LKB1、p-AMPK/AMPK、Bcl-2表达水平显著升高(P<0.05),脑梗死面积、海马神经元凋亡率、血清iNOS与IL-1β水平、脑组织ROS与MDA含量、Bax表达水平显著降低(P<0.05)。CC可减轻芍药苷对大鼠脑梗死的保护作用。结论芍药苷可能通过激活LKB1/AMPK信号通路,而阻止炎症发生发展,降低氧化应激水平,减轻大鼠脑组织梗死及海马神经元凋亡,改善其认知功能,起到保护神经的作用。CC可减轻芍药苷对大鼠脑梗死的保护作用。

关键词：芍药苷肝激酶B1/5’-磷酸腺苷激活的蛋白激酶急性脑梗死神经损伤保护作用

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生物制剂和生物仿制药的特殊性及其风险管理

药学服务与研究 2012年第5期12卷 326-329,386页

作者：师少军陈东生华中科技大学同济医学院附属协和医院药学部武汉430022

近年来,生物制剂发展迅速,临床广泛用于类风湿性关节炎、强直性脊柱炎、炎性肠病、银屑病关节炎和系统性红斑狼疮等炎症疾病的治疗。作为一类新型药物,生物制剂具有某些特殊的风险(如免疫原性),并可引发一些严重感染、结核和机会性感染... 详细信息

近年来,生物制剂发展迅速,临床广泛用于类风湿性关节炎、强直性脊柱炎、炎性肠病、银屑病关节炎和系统性红斑狼疮等炎症疾病的治疗。作为一类新型药物,生物制剂具有某些特殊的风险(如免疫原性),并可引发一些严重感染、结核和机会性感染。最近几年,欧洲药品管理局(EMA)、世界卫生组织(WHO)和美国食品药品监督管理局(FDA)均颁布了有关生物制剂及生物仿制药临床试验和上市的相应法规与审批程序。本文分析了生物制剂和生物仿制药面临的用药风险及其特殊性。我国应借鉴欧美国家的经验,进一步规范生物制剂和生物仿制药的审批和评价体系,加强该类药物的用药风险监管。

关键词：生物制剂生物仿制药免疫原性特殊性风险管理

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消化系统肿瘤外周血循环肿瘤细胞的研究进展

胃肠病学 2016年第2期21卷 107-110页

作者：施少军薛峰上海交通大学医学院附属仁济医院肝脏外科 200127

近年来,外周血循环肿瘤细胞(CTCs)检测已作为一项"液相活检"技术应用于临床实践。CTCs的肿瘤自我播种机制为探索恶性肿瘤的生长机制以及开发相应的肿瘤靶向治疗提供了新思路。10年前美国食品与药品管理局(FDA)即已批准将计数分析CTCs的C... 详细信息

近年来,外周血循环肿瘤细胞(CTCs)检测已作为一项"液相活检"技术应用于临床实践。CTCs的肿瘤自我播种机制为探索恶性肿瘤的生长机制以及开发相应的肿瘤靶向治疗提供了新思路。10年前美国食品与药品管理局(FDA)即已批准将计数分析CTCs的CellSearch系统应用于临床监控乳腺癌、前列腺癌和结直肠癌根治术后肿瘤复发。尽管近年来CTCs分离和检测技术得到了显著提升,然而在消化系统肿瘤领域,检测CTCs的临床意义尚在研究中。本文就消化系统肿瘤外周血CTCs的研究进展作一综述。

关键词：肿瘤细胞,循环消化系统肿瘤肿瘤转移预后

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国际国内双循环新发展格局构造特征研究

中国软科学 2023年第9期 214-224页

作者：朱灏史昭君朱泊翰中南大学数学与统计学院湖南长沙410075 中南大学自动化学院湖南长沙410083

基于经济循环理论,该文依据经济运行特征按规范方法,研究双循环发展格局下的循环逻辑结构、分类资源特性及配置规律、典型经济运行前提,以及典型经济之间交换的不平等性。依据驱动力的差异,划分出资源—劳力型经济和知识—资本型经济,... 详细信息

基于经济循环理论,该文依据经济运行特征按规范方法,研究双循环发展格局下的循环逻辑结构、分类资源特性及配置规律、典型经济运行前提,以及典型经济之间交换的不平等性。依据驱动力的差异,划分出资源—劳力型经济和知识—资本型经济,据此讨论双循环的本质含义、促进因素、阻碍因素、教育科技体制改革需求、国际国内影响以及决策条件制约。研究认为,驱动双循环的是知识和资本,我国走向双循环既是必要的也是必然的。通过创新驱动发展,让中国经济走向可持续、高质量、循环增强的发展道路,让中国增强独立性、自主性,让中国人增强向心力、自信心,让世界多极化竞争进步、缩小贫富差距。

关键词：国家战略经济战略决策逻辑模型双循环循环增强

Study on the Pharmacokinetics and Relative Bioavailability of Irbesartan Capsules in Healthy Volunteers

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第1期22卷 14-16页

作者：顾世芬陈汇邱应海师少军曾繁典 Institute of Clinical Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Institute of Medicine of Zhuhai Mintong Zhuhai 519041

The pharmacokinetics and relative bioavailability were studied in 18 healthy volunteers. A single oral dose of 150 mg irbesartan capsule (test) or tablet (reference) was given to each volunteer according to a randomized 2 way crossover study. The concentrations in plasma were determined by HPLC UV method. The main parameters of irbesartan capsules were: C max : 1.502±0.295 μg/ml, t max : 1.44±0.34 h, t 1/2 : 20.21±14.71 h, AUC 0 t : 11.087±3.443 μg/ml -1 ·h. The relative bioavailability of capsule to tablet was (101.4±28.9) %. The results of statistical analysis showed that two formulations were bioequivalent.

关键词： irbesartan pharmacokinetics bioavailability HPLC

Study of Inhibitory Effects of Quercetin and its Major Metabolite Q3GA on Human UDP-glucuronosyltransferase 1A Isoforms by Liquid Chromatography-tandem Mass Spectrometry

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Study of Inhibitory Effects of Quercetin and its Major Metab...

Al_2O_3/Cu复合材料的微动摩擦学特性

2019中国中西医结合学会临床药理与毒理专业委员会第三届学术研讨会

作者： Rui Zhang Ye Wei Tingyu Yang Xixi Huang Jinping Zhou Chunxiao Yang Jiani Zhou Yani Liu shaojun shi Department of Pharmacy Union Hospital Tongji Medical College Huazhong University of Science and Technology

Quercetin is a flavonoid compound that is widely present in plant-derived ***?3?O?β?D?glucoside(Q3 GA) is a predominant metabolite of quercetin in animal and human plasma. The inhibitory effect of UDP-glucuronosyltransferase enzymes(UGTs) by herbal components might be a key factor for clinical herb-drug interaction. In this paper, we aim at investigating the inhibition profile of quercetin and Q3 GA on recombinant UGT1 A isoforms in vitro through the use of nonspecific substrate 4-methylumbelliferone(4-MU) and liquid chromatography-tandem mass spectrometry(LC-MS/MS). Preliminary screening experiment showed that both quercetin and Q3 GA exhibited strong inhibition on UGT1 A1, UGT1 A3, UGT1 A6 and UGT1 A9 except for the weak inhibitory effect of Q3 GA on UGT1 A9. Kinetic experiments were also performed to characterize the inhibition of quercetin and Q3 GA towards these UGT isoforms. Quercetin exerted the noncompetitive inhibition towards UGT1 A1, UGT1 A6, with a half maximal inhibitory concentration(IC50) value of 7.47 and 7.07 μM, and an inhibition kinetic parameter(Ki) value of 2.18 and 28.87 μM, respectively. It also showed mixed inhibition towards UGT1 A3 with an IC50 value of 10.58 μM and a Ki value of 1.60 μM, and competitive inhibition towards UGT1 A9 with an IC50 value of 2.81 μM and a Ki value of 0.51 μM. While Q3 GA displayed negligible inhibition towards UGT1 A1, UGT1 A3 and UGT1 A6 with an IC50 value of 45.21, 106.5 and 51.37 μM, respectively. In this study, we found that the inhibitory ability of quercetin on UGT1 A1, 1 A3, 1 A6, 1 A9 were widely more potent than that of Q3 GA, and herb-drug interaction might occur when quercetin was co-administered with drugs that mainly are metabolized by UGT1 A1, UGT1 A3, UGT1 A6 and UGT1 A9.

关键词： quercetin Q3GA UGT1As LC-MS/MS

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润滑与密封 2008年第4期33卷 78-80,55页

作者：章跃刘义发史邵军淮阴工学院机械工程系江苏淮安223003 江苏大学材料学院江苏镇江212016

以纳米Al2O3为增强相,用粉末冶金法制备了铜基复合材料,研究了Al2O3的比例、载荷等对复合材料摩擦因数和磨损量的影响,并和纯铜的性能作了比较。结果表明,Al2O3的质量分数不宜超过4%,以2%为最佳;纯铜的摩擦因数随着载荷的增加而轻微上升... 详细信息

以纳米Al2O3为增强相,用粉末冶金法制备了铜基复合材料,研究了Al2O3的比例、载荷等对复合材料摩擦因数和磨损量的影响,并和纯铜的性能作了比较。结果表明,Al2O3的质量分数不宜超过4%,以2%为最佳;纯铜的摩擦因数随着载荷的增加而轻微上升,但Cu/Al2O3复合材料的摩擦因数随着载荷的增加变化幅度较大,呈先上升后下降的趋势,且在极小和较大的载荷下,复合材料的摩擦因数均比纯铜低,但复合材料的磨损量始终比纯铜的低,相对耐磨性最高可达1.55,呈现出良好的耐磨性。

关键词：摩擦因数耐磨性弥散强化铜基复合材料