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Ti_(3)C_(2)T_(x)-TiSe_(2) analogous heterostructure for flexible zinc ion battery

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Journal of Materials Science & Technology 2023年第19期150卷 225-232页

作者： Li Wen Junjie shi Qixiang Zhang Fei Wang Siliang Wang shaojun Zhang Qiang Wang Ke Mao Fei Long Yihua Gao Center for Nanoscale Characterization&Devices(CNCD) School of Physics and Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and Technology(HUST)Wuhan 430074China Information Materials and Intelligent Sensing Laboratory of Anhui Province School of Integrated CircuitsAnhui UniversityHefei 230601China College of Materials Science and Engineering Guangxi Key Laboratory of Optical and Electronic Materials and DevicesGuilin University of TechnologyGuilin 541004China

Exploring zinc-free anode materials is one of the effective strategies to get the zinc dendrites problem of flexible zinc ion battery(ZIB)*** this work,an analogous heterostructure(AHS)is constructed from the excellent MXene(Ti_(3)C_(2)T_(x))and TiSe_(2) *** AHS not only possesses numerous diffu-sion paths and Zn^(2+)storage sites but also possesses a stable conductive network to accelerate charge transfer in the *** a collaborative advantage,electrochemical measurement results show that MXene/TiSe_(2) electrodes display an excellent specific capacity of 177.9 mAh g^(-1) at 0.10 A g^(-1) and a long-term cycling stability of 77.4%capacity retention after 400 *** computations further demon-strate the excellent performance of MXene/TiSe_(2) electrodes including desirable electronic conductivity and low Zn^(2+)migration *** assembled flexible ZIB not only delivers a good specific capacity of 42.2μAh cm^(-2) at 0.20 mA cm^(-2) and a competitive energy density of 37.4μWh cm^(-2) but also exhibits excellent flexibility and ***,after 400 cycles at 0.60 A g^(-1),flexible ZIB shows a capacity retention of 73.8%.This work gives a successful attempt to design 2D layered materials as Zn metal-free anode for flexible ZIB.

关键词： Flexible zinc ion battery Analogous heterostructure Zinc dendrite Zinc free metal anode MXene flakes TiSe_(2)nanosheets

Rapid sterilisation and diabetic cutaneous regeneration using cascade bio-heterojunctions through glucose oxidase-primed therapy

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Bioactive Materials 2023年第7期25卷 748-765页

作者： Yi Deng Xumei Ouyang Jiyu Sun Xiuyuan shi Yunfei Li Yau Kei Chan Weizhong Yang shaojun Peng College of Biomedical Engineering School of Chemical EngineeringSichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China Zhuhai Institute of Translational Medicine Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)ZhuhaiGuangdong519000China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China Department of Materials Imperial College LondonSW72AZLondonUnited Kingdom Department of Biomedical Engineering The City College of the City University of New YorkNew YorkUnited States Department of Mechanical Engineering The University of Hong KongHong KongChina Department of Ophthalmology The University of Hong KongHong KongChina

The cutaneous wound in diabetic patients frequently encounters intractable pathogenic infections due to the hyperglycemia micromilieu which is conducive to bacterial growth and *** the extensive clinical use of antibiotics to treat bacterial infections,the emergence of drug-resistant and super pathogens as well as the potential side effects of antibiotics have elicited alarming challenges to public *** address this daunting concern,we devise and develop a photo-activated cascade bio-heterojunctions(C-bio-HJs)for rapid sterilization and diabetic cutaneous *** the designed C-bio-HJs,photo-generated electron-hole pairs of graphite-phase carbon nitride(g-C_(3)N_(4))are effectively separated with the marriage of molybdenum disulfide(MoS_(2)),which achieves the augmented photodynamic antibacterial ***,glucose oxidase(GOx)tethered on the bio-HJs catalyzes glucose into hydrogen peroxide(H_(2)O_(2))in diabetic wounds for starvation ***,Mo4+enables the catalysis of H_(2)O_(2)into a highly effective hydroxyl radical(⋅OH)for chemodynamic-photothermal combined antibacterial *** in vitro and in vivo results authenticate the cascading antibacterial properties and skin regeneration-promoting effects of the C-bio-HJs,which provide a facile strategy to combat diabetic wound healing through the synergistic GOx-primed dynamic therapies.

关键词： Antibacterial therapy Bio-heterojunction g-C_(3)N_(4) Rapid sterilization Tissue regeneration

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基于绩效考核的处方点评模式与效果

中国药师 2016年第12期19卷 2280-2283页

作者：陈晨师少军吴永剑程叔彪周海威万元胜黄怡菲华中科技大学同济医学院附属协和医院药学部武汉430022

目的:探讨基于绩效考核的适合本院院情的处方点评模式及其效果。方法:通过改进处方点评制度和流程,建立奖惩制度,采用回顾性分析方法,比较改进前后处方的合格率、医生接受率等指标变化。结果:采用新的处方点评模式之后,本院2015年下半... 详细信息

目的:探讨基于绩效考核的适合本院院情的处方点评模式及其效果。方法:通过改进处方点评制度和流程,建立奖惩制度,采用回顾性分析方法,比较改进前后处方的合格率、医生接受率等指标变化。结果:采用新的处方点评模式之后,本院2015年下半年处方合格率(72.95%)和医生接受率(95.08%)均高于2015年上半年(59.67%,71.49%),差异有统计学意义(P<0.05)。结论:该模式具有可行性和操作性,最大限度地对门诊不合理用药进行主动干预,切实提高医院合理用药水平,同时增加临床接受度和认可度。

关键词：处方点评模式绩效考核合理用药门急诊处方

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国产辛伐他汀片与原研制剂的生物等效性研究

中国药师 2014年第8期17卷 1288-1291页

作者：付琴琴尹丽华刘海鑫干国平刘亚妮师少军吴健鸿湖北中医药大学药学院武汉430065 武汉药品医疗器械检验所华中科技大学同济医学院附属协和医院

目的：考察国产辛伐他汀片与原研制剂的的人体生物利用度,评价两制剂在健康人体的生物等效性.方法：18名健康成年男性志愿者采用随机自身交叉对照试验设计,单剂量口服辛伐他汀片40 mg,用LC-MS/MS法测定血浆中辛伐他汀浓度,采用DAS 3.2.... 详细信息

目的：考察国产辛伐他汀片与原研制剂的的人体生物利用度,评价两制剂在健康人体的生物等效性.方法：18名健康成年男性志愿者采用随机自身交叉对照试验设计,单剂量口服辛伐他汀片40 mg,用LC-MS/MS法测定血浆中辛伐他汀浓度,采用DAS 3.2.2程序拟合药动学参数,并进行生物等效性评价.结果：单剂量口服40 mg辛伐他汀试验制剂（国产）和参比制剂后,两药的主要药动学参数分别为tmax（4.54±5.35）和（2.32±1.72） h;Cmax：（5.63±4.03）和（7.29±3.84） ng·ml-1;t1/2：（6.31±4.99）和（4.67±3.07） h;AUC（0-t）：（38.75 ±29.55）和（35.54±30.12）ng·h·ml-1;AUC（∞）：（67.31±60.25）和（40.36±34.78）ng·h·ml-1.试验制剂与参比制剂比较,相对生物利用度为117.2％.受试制剂的AUC0→t 90％可信限为89.5％～ 153.5％,AUC0→ 90％可信限为118.1％～198.7％,落在参比制剂对应参数80％～ 125％范围外.结论：两制剂的吸收程度有差异,不等效.

关键词：辛伐他汀片液相色谱-串联质谱法相对生物利用度生物等效性

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烤烟上部叶成熟度对烟叶品质的影响

现代农业科技 2024年第8期 13-16页

作者：王鹏陈炬廷石刚叶协锋吴明吴少军付龙吴勇湖北中烟工业有限责任公司武汉卷烟厂湖北武汉430040 河南农业大学烟草学院/国家烟草栽培生理生化研究基地/烟草行业烟草栽培重点实验室河南郑州450002 四川省烟草公司广元市公司剑阁县公司四川剑阁628300

为探究四川省广元产区上部烟叶适宜的采收成熟度,以云烟87为试验材料,设置4个成熟度处理,测定不同处理烤后烟外观质量、化学成分、感官质量及经济效益。结果表明:2021年较常规采收时间推迟3 d采收,上部烟叶烤后外观质量最好,化学成分较... 详细信息

为探究四川省广元产区上部烟叶适宜的采收成熟度,以云烟87为试验材料,设置4个成熟度处理,测定不同处理烤后烟外观质量、化学成分、感官质量及经济效益。结果表明:2021年较常规采收时间推迟3 d采收,上部烟叶烤后外观质量最好,化学成分较为协调,但还原糖和总糖含量稍低于优质烟叶目标;2022年较常规采收时间推迟3 d采收,上部烟叶烤后外观质量、感官质量及经济效益均最好。综合来看,建议较常规采收时间推迟3 d,此时可达到广元烟区上部烟叶采收的最佳成熟度。

关键词：上部烟叶成熟度外观质量感官质量经济效益

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Comparison of diploid and triploid Carassius auratus provides insights into adaptation to environmental change

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Science China(Life Sciences) 2018年第11期61卷 1407-1419页

作者： Li Ren Xin Gao Conghui Yang Hui Tan Jialin Cui shi Wang Wuhui Li Chun Zhang Min Tao Qinbo Qin shaojun Liu State Key Laboratory of Developmental Biology of Freshwater Fish Hunan Normal University College of Life Sciences Hunan Normal University

Focusing on adaptation of aquatic organisms, especially fish, can help elucidate complex dynamics in freshwater ecology. The differences in genetic and epigenetic regulation between diploid and triploid Carassius auratus affect survival under eutrophication. To identify the underlying mechanisms that lead to better adaption of triploids than diploids, we compared mRNA and microRNA(miRNA) expressions in liver tissue of diploid and triploid individuals obtained from the Dongting lake water system in central China. Differential expression analysis revealed that 566 transcripts were significantly up-regulated, whereas758 were down-regulated in triploids; of these differentially expressed transcripts, 33 transcripts including cacna1 d, nfkb2, hspa1 and fgfr4 were involved in the MAPK signaling pathway, and eight transcripts were determined to be regulated by seven miRNAs. Additionally, four of 25 differential expressed(DE) transcripts(mhc1, irf7, nfkb2 and pik3 c) involving the viral carcinogenesis pathway were regulated by four miRNAs. Furthermore, genetic polymorphisms analysis showed that more heterozygous mutations were detected in triploids than diploids. The d N/d S results revealed that 21 genes were under positive selection(d N/d S>1) in C. auratus complex. We hypothesize that these changes related to genetic and epigenetic regulation may be caused by abiotic stresses, and facilitate adaptation to environmental changes.

关键词： triploid adapting positive selection differential expression

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基于MPC的插秧机路径跟踪控制算法研究

中国农机化学报 2022年第7期43卷 173-178页

作者：王玉亮李汉卿陈兆英石绍军陈国防王金星山东农业大学机械与电子工程学院山东泰安271018 山东省园艺机械与装备重点实验室山东泰安271018

针对国内自动驾驶插秧机路径跟踪精度不高的现象,提出一种基于线性时变模型预测控制的路径跟踪方法。将建立的非线性插秧机运动学模型进行线性化和离散化处理,并基于此模型进行模型预测路径跟踪控制;建立以控制增量为状态量的目标函数;... 详细信息

针对国内自动驾驶插秧机路径跟踪精度不高的现象,提出一种基于线性时变模型预测控制的路径跟踪方法。将建立的非线性插秧机运动学模型进行线性化和离散化处理,并基于此模型进行模型预测路径跟踪控制;建立以控制增量为状态量的目标函数;考虑系统控制量和控制增量的约束条件,将目标函数求解转为带约束的二次规划问题;采用内点法进行求解,将所得控制序列第一个元素作用于系统,并且不断重复以上过程实现最优控制。在MATLAB/Simulink环境下,搭建上述模型预测控制器系统仿真,并与路径跟踪效果良好的Stanley控制算法对比,结果表明,上述模型预测控制器优于Stanley控制算法。采用卫星信号接收机、电动方向盘和转角传感器,改造井关PZ60型插秧机,搭建插秧机自动驾驶试验平台,进行田间试验,试验结果表明,基于线性时变模型预测控制器能够使自动驾驶插秧机车速1 m/s时,有效进行路径跟踪,直线段跟踪误差最大2.02 cm,满足插秧机自动驾驶路径跟踪精度要求。

关键词：插秧机自动驾驶模型预测控制 MATLAB/Simulink 路径跟踪

低温熔融盐浸渍法构建富锂锰基锂离子电池正极材料的表面异质层

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常熟理工学院学报 2021年第5期35卷 15-19页

作者：黄志雄金子涵卢俊杰汤贝贝陆君龙季红梅杨刚施少君常熟理工学院江苏省新型功能材料重点建设实验室江苏常熟215500 常熟理工学院材料工程学院江苏常熟215500

通过微波水热法以及低温熔融盐浸渍法合成了一种含Zn表面异质层改性的富锂正极材料Li_(1.2)Mn_(0.56)Ni_(0.16)Co_(0.08)O_(2)(Zn-LLO).XRD表明没有杂质相的掺入,且合成的材料结晶性十分优异;在扫描电镜和透射电镜下呈现出200 nm左右的... 详细信息

通过微波水热法以及低温熔融盐浸渍法合成了一种含Zn表面异质层改性的富锂正极材料Li_(1.2)Mn_(0.56)Ni_(0.16)Co_(0.08)O_(2)(Zn-LLO).XRD表明没有杂质相的掺入,且合成的材料结晶性十分优异;在扫描电镜和透射电镜下呈现出200 nm左右的二级颗粒组成的球状一级结构;在XPS中可以看出掺入的Zn是存在的,证明了Zn表面异质层的存在.得益于微波水热法,合成的材料结晶性较好,具有较好的性能,同时得益于低温熔融盐浸渍法不破坏材料的结构又形成了Zn表面异质层,Zn-LLO展现出极其优异的电化学性能.在100 mA·g^(-1)下经过100圈的循环,Zn-LLO有209.4 mAh·g^(-1)的超高容量,并且在20,100,200,400,1000和2000 mA·g^(-1)下分别有276.8,236.1,204.4,171.1,127.8和95.1 mAh·g^(-1)的优异的平均容量.经过分析,这主要是由于Zn表面异质层对材料的保护作用,LLO与电解液减少接触使得LLO在循环过程中不容易被电解液腐蚀分解,电化学性能从而更加优异且稳定.

关键词：低温熔融盐浸渍法富锂材料表面异质层锂离子电池

Efficacy of Cigu Xiaozhi pill(慈菇消脂丸) on non-alcoholic steatohepatitis-associated lipoapoptosis through stress-activated c-Jun N-terminal kinase signalling pathway

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Journal of Traditional Chinese Medicine 2021年第1期41卷 79-88页

作者： MA Yanhua YU Chengzu WU Yan HAN Tao YANG shaojun shi Xia College of Clinical Medicine Gansu University of Chinese MedicineLanzhou 730000China College of Pharmacy Gansu University of Chinese MedicineLanzhou 730000China Guangxi Beihai Hospital of Traditional Chinese Medicine Beihai 536000China Center of Teaching experiment Gansu University of Chinese MedicineLanzhou 730000China

OBJECTIVE: To investigate the efficacy of Cigu Xiaozhi pill(慈菇消脂丸, CGXZ) on non-alcoholic steatohepatitis(NASH)-associated lipoapoptosis through the stress-activated c-Jun N-terminal kinase(JNK)/stress-activated protein kinase signalling ***: Sixty male Sprague-Dawley rats were randomly divided into the following groups(10 rats each): blank control, model, low-dose CGXZ,medium-dose CGXZ, high-dose CGXZ, and positive control(treated with SP600125, a JNK inhibitor).The NASH model was established and the histomor-phological characteristics of haematoxylin and eosin-stained liver tissues were examined under a light microscope. Cell apoptosis in liver tissues was assessed via terminal deoxynucleotidyl transferase d UTP nick-end labelling assay. In addition, the m RNA and protein expression levels of p-JNK,p-c-Jun, caspase-8, Fas, and Fas-L were determined via fluorescence-based quantitative real-time PCR,immunohistochemical and Western blot ***: Histopathological examination of the liver showed that the model rats had moderate-to-severe steatosis with infiltration of inflammatory cells as well as significantly higher expression levels of the p-JNK, p-c-Jun, caspase-8, Fas, and Fas-L proteins, compared with those in the blank control group(P < 0.01). Hepatic lobules of the rats in the treatment groups showed significantly reduced vacuolar degeneration and steatosis as well as alleviated inflammatory cell infiltration. The high and medium-dose CGXZ groups exhibited significantly lower m RNA and protein expression levels of p-JNK, p-c-Jun, caspase-8, Fas, and Fas-L, compared with those in the model group(P < 0.05 or P <0.01).CONCLUSION: CGXZ pill inhibited the onset of hepatocyte apoptosis by regulating the expression of p-JNK, p-c-Jun, caspase-8, Fas, and Fas-L, thereby exerting therapeutic effects against NASH.

关键词： Non-alcoholic fatty liver disease JNK mitogen-activated protein kinases apoptosis stress-activated signaling pathway Cigu Xiaozhi pill