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Apparent diffusion coefficient in normal and abnormal pattern of intervertebral lumbar discs: initial experience

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The Journal of Biomedical Research 2011年第3期25卷 197-203页

作者： Gang Niu Xuewen Yu Jian Yang Rong Wang shaojuan Zhang Youmin Guo Department of Diagnostic Radiology the First Hospital of Medical School Xi'an Jiaotong University Xi'an Shaanxi 710061 China

The aim of the present study was to compare the relationship of morphologically defined non-bulging/herni-ated, bulging and herniated intervertebral lumbar discs with quantitative apparent diffusion coefficient （ADC）. Thirty-two healthy volunteers and 2. patients with back pain or sciatica were examined by MRI. All intervertebral lumbar discs from L1 to S1 were classified according to morphological abnormality and degenerated grades. The ADC values of nucleus pulposus （NP） were measured and recorded. The significant differences about mean ADC values of NP were found between non-bulging/herniated discs and bulging discs as well as herniated discs （P 0.05）, whereas there were no significant differences in ADC values between bulging and herniated discs （P 0.05）. Moreover, statistically significant relationship was found in the mean ADC values of NP between ＂non-bulging/herniated and non-degenerated discs＂ and ＂non-bulging/herniated degenerated discs＂ as well as herniated discs （P 0.05）. Linear regression analysis between ADC value and disc level revealed an inverse correlation （r = -0.18）. The ADC map of the NP is a potentially useful tool for the quantitative assessment of componential and molecular alterations accompanied with lumbar disc abnormalities.

关键词： intervertebral lumbar disc apparent diffusion coefficient disc bulging disc herniation

针对性心理干预在CT引导下经皮肺穿刺活检中的应用效果及其对术后并发症的影响

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临床心身疾病杂志 2024年第2期30卷 99-103页

作者：吕绍娟牛瑾王新宇徐皓博周志刚滑县人民医院河南安阳456400 郑州大学第一附属医院河南郑州450052

目的探究针对性心理干预在CT引导下经皮肺穿刺活检的应用效果及其对术后并发症的影响。方法将98例行CT引导下经皮肺穿刺活检术患者按照随机数字表法分为对照组、研究组,各49例。两组患者均进行CT引导下经皮肺穿刺活检术,对照组患者给... 详细信息

目的探究针对性心理干预在CT引导下经皮肺穿刺活检的应用效果及其对术后并发症的影响。方法将98例行CT引导下经皮肺穿刺活检术患者按照随机数字表法分为对照组、研究组,各49例。两组患者均进行CT引导下经皮肺穿刺活检术,对照组患者给予常规干预,研究组患者在对照组的基础上给予针对性心理干预(两组患者均干预两周)。比较两组患者干预前后血压、心率及焦虑自评量表(SAS)、抑郁自评量表(SDS)、90项症状清单(SCL-90)、视觉模拟评分量表(VAS)评分,并比较两组患者干预后并发症发生率以及患者满意度。结果干预后,两组患者收缩压、舒张压、心率均有所上升,但与对照组相比,研究组收缩压、舒张压、心率较低(P<0.01);两组患者SAS、SDS、VAS评分及SCL-90总分、各因子分均较干预前降低,且研究组低于对照组(P<0.01)。干预后,研究组患者并发症总发生率低于对照组,总满意度高于对照组(P<0.05或0.01)。结论针对性心理干预应用于CT引导下经皮肺穿刺活检术患者,可有效改善患者负面情绪,降低患者并发症发生率。

关键词：针对性心理干预 CT引导穿刺活检术并发症

Highly responsive broadband black phosphorus photodetectors

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Chinese Optics Letters 2018年第2期16卷 3-7页

作者： Yan Liu Tian Sun Weiliang Ma Wenzhi Yu Shivananju B.Nanjunda shaojuan Li Qiaoliang Bao Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devicesand Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215123China Department of Materials Science and Engineering Monash UniversityClayton 3800Australia

Black phosphorus(BP)is a promising material for ultrafast and broadband photodetection because of its narrow bandgap from 0.35 eV(bulk)to 1.8 eV(monolayer)and high carrier *** photodetectors based on BP with different configurations have been reported,high photosensitivity was mostly observed in the visible range.A highly efficient BP-based infrared photodetector operated in the telecom spectral range,especially at 1550 nm,has not been ***,we report a Schottky-type photodetector based on thin BP flakes,operating in a broad spectral range from visible(635 nm)to infrared(1550 nm).A responsivity as high as 2.0 A·W^(-1)was achieved at 1550 nm with a source-drain bias of 1 *** rise time is 4.8 ms,and the fall time is 6.8 *** light illumination and external bias,the Schottky barrier between the BP and metal was reduced,leading to efficient photocurrent *** unprecedented performance of the BP photodetector indicates intriguing potential for sensing,imaging,and optical communication.

关键词： Atomic force microscopy Infrared imaging Light beams Photodetectors Raman spectroscopy Scanning electron microscopy

Genetic structure and domestication footprints of the tusk,coat color,and ear morphology in East Chinese pigs

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Journal of Genetics and Genomics 2022年第11期49卷 1053-1063页

作者： Sumei Zheng Pan Xu Zhongping Wu Hui Zhang Desen Li shaojuan Liu Bingbing Liu Jun Ren Hao Chen Min Huang College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhouGuangdong 510642China School of Animal Science and Technology Jiangsu Agri-animal Husbandry Vocational CollegeTaizhouJiangsu 225300China Zhongkai University of Agriculture and Engineering GuangzhouGuangdong 510225China College of Life Sciences Jiangxi Science and Technology Normal UniversityNanchangJiangxi 330013China

The domestication and artificial selection of wild boars have led to dramatic morphological and behavioral changes,especially in East Chinese(ECN)***,we provide insights into the population structure and current genetic diversity of representative ECN pig *** identify a 500-kb region containing six tooth development-relevant genes with almost completely different haplotypes between ECN pigs and Chinese wild boars or European domestic ***,the c.195A>G missense mutation in exon 2.of AMBN may cause alterations in its protein structure associated with tusk degradation in ECN *** addition,ESR1 may play an important role in the reproductive performance of ECN pigs.A major haplotype of the large lop ear-related MSRB3 gene and eight alleles in the deafness-related GRM7 gene may affect ear morphology and hearing in ECN ***,we find that the two-end black(TEB)coat color in Jinhua pigs is most likely caused by EDNRB with genetic mechanisms different from other Chinese TEB *** study identifies key loci that may be artificially selected in Chinese native pigs related to the tusk,coat color,and ear morphology,thus providing new insights into the genetic mechanisms of domesticated pigs.

关键词： East Chinese pigs Tusk degradation Fertility Large lop ear Two-end black coat color

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急性白血病脂质代谢的最新研究进展

华西医学 2024年第7期39卷 1162-1167页

作者：董少娟崔梦莹何丽鲍颖朱丹霞吴骏陈烨湖北医药学院附属襄阳市第一人民医院血液内科湖北襄阳441000 苏州大学附属第三医院/常州市第一人民医院肿瘤内科江苏常州213003

急性白血病患者治疗效果不佳,生存期短,主要原因之一是缺乏有效的早期诊断和治疗靶标。脂质代谢重编程满足了快速增殖和分裂肿瘤细胞的物质和能量需求,并且与急性白血病的侵袭性、复发、化学治疗耐药性有关。该文综述了白血病细胞脂质... 详细信息

急性白血病患者治疗效果不佳,生存期短,主要原因之一是缺乏有效的早期诊断和治疗靶标。脂质代谢重编程满足了快速增殖和分裂肿瘤细胞的物质和能量需求,并且与急性白血病的侵袭性、复发、化学治疗耐药性有关。该文综述了白血病细胞脂质代谢重编程的致癌和化学治疗耐药机制,并总结了靶向脂肪酸代谢途径的最新发现,旨在为细胞内脂肪酸代谢在急性白血病发生发展中的作用提供新的视角,期望能为其耐药机制的阐明以及相应靶向治疗的研发提供理论依据。

关键词：急性白血病脂质代谢重编程靶向代谢靶向治疗化学治疗耐药

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红树莓接骨木果复合饮料配方优化

食品工业 2024年第3期45卷 79-82页

作者：尹俊涛刘艳怀雷勇代绍娟袁莹莹石河子开发区神内食品有限公司石河子832000

以红树莓、接骨木果为主要原料,研制一款营养健康的复合饮料。为优化红树莓接骨木果复合饮料配方,以感官评分为指标,通过单因素试验和正交试验确定最优配方。结果表明,红树莓浆用量18.00%、接骨木果浆用量12.00%、赤藓糖醇用量5.00%、DL... 详细信息

以红树莓、接骨木果为主要原料,研制一款营养健康的复合饮料。为优化红树莓接骨木果复合饮料配方,以感官评分为指标,通过单因素试验和正交试验确定最优配方。结果表明,红树莓浆用量18.00%、接骨木果浆用量12.00%、赤藓糖醇用量5.00%、DL-苹果酸用量0.06%、果胶用量0.06%、瓜尔豆胶用量0.02.、汉生胶用量0.01%时,产品状态均匀,色泽呈紫红色,酸甜可口,果香浓郁。

关键词：红树莓接骨木果复合饮料配方优化

基于应变不变量失效理论的碳纤维增强树脂基复合材料层合板开孔结构压缩损伤模拟

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复合材料学报 2015年第6期32卷 1573-1580页

作者：卢少娟湖北航天化学技术研究所襄阳441003

应变不变量失效理论(SIFT)是一种新型的基于物理失效模式的复合材料强度理论,被广泛应用于复合材料结构失效分析。首先,为了提高理论分析的精度,SIFT被扩展用于分析碳纤维增强树脂基复合材料(CFRP)层合板开孔结构的静载压缩逐步失效机... 详细信息

应变不变量失效理论(SIFT)是一种新型的基于物理失效模式的复合材料强度理论,被广泛应用于复合材料结构失效分析。首先,为了提高理论分析的精度,SIFT被扩展用于分析碳纤维增强树脂基复合材料(CFRP)层合板开孔结构的静载压缩逐步失效机制和强度。开发的SIFT实施方法包括材料强度表征和结构强度预测两个部分。结构强度预测是基于ABAQUS平台并使用Fortran语言编写用户自定义材料子程序(UMAT)实现的。随后,将SIFT预测值与经典复合材料强度理论Tsai-Wu和Hashin理论的预测结果和试验结果进行了对比,结果显示SIFT预测的精度最高。同时,基于SIFT对静载压缩下的AS4/3501-6层合板开孔结构从初始失效到最终失效的失效机制演变进行了详细的分析。最后,将SIFT预测的AS4/3501-6层合板开孔结构静载压缩的失效机制与试验结果进行了对比。结果表明SIFT预测的逐步失效机制与试验结果相吻合,所得结论为CFRP结构强度的预测提供了新思路。

关键词：应变不变量失效理论失效准则 UMAT 逐步失效开孔结构

The stability analysis in stochastic logistic system via orthogonal polynomial approximation

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The stability analysis in stochastic logistic system via ort...

脂肪酸代谢相关基因ACSL1在急性髓系白血病中的作用及潜在价值

第九届全国动力学与控制学术会议

作者： shaojuan Ma School of Information & Computation Science North University for Nationalities

Orthogonal polynomial approximation is applied to study the stability in a stochastic Logistic system with random *** shows that orthogonal polynomial approximation is effective to reduce the stochastic Logistic system with a random parameter into its equivalent deterministic system,and then the linear stability theory and Jury criterion for nonlinear deterministic discrete systems are applied to the equivalent *** means of the mathematics analysis method we discovered that in stochastic Logistic system when the random intensity and statics parameters of

关键词： Stochastic dynamical system Orthogonal polynomial approximation Asymptotic stability

来源： cnki会议评论

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癌变．畸变．突变 2024年第4期36卷 298-304页

作者：崔建陈烨何丽鲍颖董少娟朱丹霞吴骏崔梦莹襄阳市襄州区人民医院心血管内科湖北襄阳441000 湖北医药学院附属襄阳市第一人民医院血液内科湖北襄阳441000 苏州大学附属第三医院肿瘤科江苏常州213003

目的:通过生物信息学数据分析脂肪酸代谢相关基因长链酯酰辅酶A合成酶1(ACSL1)在急性髓系白血病(AML)中的作用及潜在价值。方法:使用基因表达谱交互分析(GEPIA)数据库分析ACSL1基因在AML患者和健康对照人群中的表达水平。使用R包(以最... 详细信息

目的:通过生物信息学数据分析脂肪酸代谢相关基因长链酯酰辅酶A合成酶1(ACSL1)在急性髓系白血病(AML)中的作用及潜在价值。方法:使用基因表达谱交互分析(GEPIA)数据库分析ACSL1基因在AML患者和健康对照人群中的表达水平。使用R包(以最优截断值10.73为高、低表达的分界)survminer绘制ACSL1高、低表达组的Kaplan-Meier生存曲线,分析ACSL1基因表达与AML患者生存率之间的相关性。使用R语言中timeROC包绘制ACSL1的受试者工作特征(ROC)曲线,探究ACSL1基因对正常和AML患者的诊断效率。通过单基因富集分析(GSEA),明确ACSL1基因的作用通路。采用Kaplan-Meier生存分析确定ACSL1表达水平与患者总生存期(OS)之间的关系。通过单因素和多因素Cox回归分析建立预后模型,确定ACSL1是否为AML的独立预后因素以及验证模型的预测效果。结果:ACSL1在AML患者中的表达水平较健康对照组明显升高(P2.3年生存时间的曲线下面积(AUC)均大于0.6,说明ACSL1预测准确率较高。富集分析表明,ACSL1主要通过脂肪酸降解、脂肪酸代谢等途径在AML发生和发展中发挥重要作用。单因素Cox分析显示年龄和ACSL1表达水平是影响AML患者总生存率的高风险因素(HR>1,P<0.05),多因素Cox分析显示年龄、染色体异常分数、基因突变分数是AML影响患者预后的独立因素(P<0.05)。结论:脂肪酸代谢相关基因ACSL1在AML中高表达,在多个致癌通路和脂肪酸代谢通路中富集,与不良预后密切相关,可作为AML的潜在治疗靶点和预后生物标志物。

关键词：急性髓系白血病脂肪酸代谢长链酯酰辅酶A合成酶1 预后分析生物信息学

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