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Chinese Chemical Letters 2024年第3期35卷 352-357页

作者： Xuejian Xing E Pang shaojing zhao Tangna Pan Qiuxia Tan Benhua Wang Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China

Combining phototherapy and chemotherapy has been considered a promising modality for cancer therapy due to their synergistic ***,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B-B,B-C,and B-C-Pt).Due to their enlargedπ-conjugated structure and high intramolecular charge transfer effect,the synthesized BODIPYs had photothermal conversion capability,and their absorption and fluorescence spectra were *** cisplatin-appended BODIPY(B-C-Pt)exhibited good singlet oxygen(^1O_(2))generation ability and near infrared(NIR)absorption and fluorescence(λ_(Abs)=748 nm,λ_(Em)=947 nm).After being encapsulated by distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),which could inhibit the H-aggregation of B-C-Pt,the absorption and fluorescence of the obtained B-C-Pt nanoparticles(NPs)were red-shifted to 762 and 985 nm,***^1O_(2)quantum yield and photothermal conversion efficiency of the B-C-Pt NPs were 4.0%and 40.6%,***,B-C-Pt NPs had chemotherapeutic efficacy due to the presence of *** vitro and in vivo studies further demonstrated that B-C-Pt NPs had synergistic therapeutic ***,B-C-Pt NPs could be employed in NIRⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy for cancer treatment.

关键词： Phototherapy Chemotherapy Cisplatin Bodipy NIRⅡfluorescent imaging

Recent advances in nanomaterials for sonodynamic therapy

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Nano Research 2020年第11期13卷 2898-2908页

作者： Ting Xu shaojing zhao Changwei Lin Xiuli Zheng Minhuan Lan Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha410083China Department of Gastrointestinal surgery The Third Xiang Ya Hospital of Central South UniversityChangsha410013China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and Chemistry(TIPC)Chinese Academy of SciencesBeijing100190China

Sonodynamic therapy(SDT),as a novel non-invasive strategy for eliminating tumor,has the advantages of deeper tissue penetration,fewer side effects,and better patient compliance,compared with photodynamic therapy(PDT).In SDT,ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species(ROS),induce the collapse of vacuoles in solution,and bring about irreversible damage to cancer *** recent years,much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ***,the traditional organic sonosensitizers,such as porphyrins,hypericin,and curcumins,suffer from complex synthesis,poor water solubility,and low tumor targeting efficacy which limit the benefits of *** contrast,inorganic sonosensitizers show good in vivo stability,controllable physicochemical properties,ease of achieving multifunctionality,and high tumor targeting,which greatly expanded their application in *** this review,we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers,and directly produce ROS under ***,the prospects of inorganic nanomaterials for SDT application are also discussed.

关键词： sonodynamic therapy sonosensitizers reactive oxygen species carriers nanomaterial

Green synthesis of multifunctional carbon dots for anti-cancer and anti-fungal applications

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Chinese Journal of Chemical Engineering 2021年第9期34卷 97-104页

作者： shaojing zhao Li Huang Yong Xie Bin Wang Feng Wang Minhuan Lan Hunan Provincial Key Laboratory of Micro&Nano Materials Interface Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China State Key Laboratory of the Discovery and Development of Novel Pesticide Shenyang Sinochem Agrochemicals R&D Co.Ltd.Shenyang 110021China Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education Hubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Carbon dots(CDs)have become popular nanomaterials in biomedical and agricultural *** we synthesized multifunctional CDs which showed anti-cancer and anti-fungal *** low cytotoxicity,stable fluorescence and high photothermal conversion efficiency enable the CDs with imagingguided photothermal *** CDs also exhibited intrinsic anti-fungal activity even at a low concentration,i.e.,40 mg·L^(-1) of CDs induced 20%mortality in cucumber downy ***,the largeπ-conjugated nanostructure and the richness of amino and hydroxyl groups make them a powerful delivery platform for flumorph(a fungicide)with a high loading efficiency of 47.18%.Meanwhile,the heat converted from the light can accelerate the release of flumorph from CDs,and thus efficiently kill fungus.

关键词： Carbon dots Photothermal therapy Anti-fungus Delivery Pesticide

Optically tunable fluorescent carbon nanoparticles and their application in fluorometric sensing of copper ions

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Nano Research 2019年第10期12卷 2576-2583页

作者： Minhuan Lan shaojing zhao Shuilin Wu Xiaofang Wei Yanzhao Fu Juanjuan Wu Pengfei Wang Wenjun Zhang Center of Super-Diamond and Advanced Films(COSDAF)and Department of Materials Science and Engineering City University of Hong KongHongKong SARChina Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical EngineeringTianjin University oj TechnologyTianjin 300384China

A series of carb on nano particles(CNPs)with emissi on wavele ngth ranging from 483 to 525 nm were prepared by hydrothermal treatme nt of poly-3-thiopheneacetic acid(PTA)and *** emission wavelength and surface oxidation degree of CNPs were shown to be controllable by simply adjusti ng NaOH *** CNPs prese nted obvious fluoresce nee spectral response toward copper ions(Cu^2+)through static quenching caused synergistically by electron transfer and inner filter *** O-and S-containing groups on the surface of CNPs were dem on strated to be resp on sible for their outsta nding sensing performa *** on that,a CN Ps-based ratiometric fluoresce nt probe for Cu^2+with a high fluoresce nee quenching rate constant of 1.4×10^5 L/mol and a short resp onse time(10 s)was *** practical applications in detecting Cu^2+in pond water and living cells were also dem on strated.

关键词： carbon nano particles tun able fluorometric copper ions

Carbon dot-based fluorescent and colorimetric sensor for sensitive and selective visual detection of benzoyl peroxide

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Chinese Chemical Letters 2022年第3期33卷 1632-1636页

作者： Xiangcao Li Xuejian Xing shaojing zhao Shaohua Zhu Benhua Wang Minhuan Lan Xiangzhi Song Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Shenzhen Research Institute of Central South University Shenzhen 518057China Hunan Norui Environmental Technology Co. Ltd.Changsha 410021China

Benzoyl peroxide(BPO) has been added in wheat flour because of its bleaching effect. However, the abnormal used BPO has caused increasing concern due to its strong oxidization capability which may have adverse effects on living organisms. Herein, we present a carbon dot(CD)-based fluorescent and colorimetric probe for visually, sensitively and selectively sensing BPO. The addition of BPO could quench the red fluorescence of CDs peaked at 622 and 677 nm, and decrease the absorbance at 613 nm, while increase the absorbance at 450 nm, resulting in a fluorescence turn-off and colorimetric spectral ***, the CDs had short response time of 10 min and high sensitivity towards BPO with a low limit of detection of 28 nmol/L. The applicability of the CDs in detecting BPO in wheat, noodle and starch samples was further demonstrated, and good recovery results were obtained.

关键词： Carbon dots Benzoyl peroxide Colorimetric Fluorescent probe Food safety

A"donor–acceptor"structured semiconductor polymer for near infrared fluorescence imaging guided photodynamic therapy

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Journal of Innovative Optical Health Sciences 2022年第4期15卷 75-85页

作者： Baoling Li Ting Xu Xiaosha Wang shaojing zhao Benhua Wang Lihui Jiang Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical Engineering Central South University Changsha 410083 P.R.China State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 P.R.China

Near infrared(NIR)fluorescence imaging guided photodynamic therapy(PDT)is a technique which has been developed in many clinical trials due to its advantage of real-time optical monitoring,specific spatiotemporal selectivity,and minimal *** this,photosensitizers with NIR fluorescence emission and high^(1)O_(2)generation quantum yield are highly ***,we designed and synthesized a"donor-acceptor"(D-A)structured semiconductor polymer(SP),which was then wrapped with an amphiphilic compound(Pluronic■F127)to prepare water-soluble nanoparticles(F-SP NPs).The obtained F-SP NPs exhibit good water solubility,excellent particle size stability,strong absorbance at deep red region,and strong NIR fluorescent emission *** maximal mass extinction coe±cient and fluorescence quantum yield of these F-SPs were calculated to be 21.7 L/(g·cm)and 6.5%,***,the^(1)O_(2)quantum yield of 89%for F-SP NPs has been achieved under 635 nm laser irradiation,which is higher than Methylene Blue,Ce6,and *** outstanding properties of these F-SP NPs originate from their unique D-A molecular *** work should help guide the design of novel semiconductor polymer for NIR fluorescent imaging guided PDT applications.

关键词： Donor-acceptor structure semiconducting polymer nanoparticles photodynamic therapy near infrared fluorescence imaging

Two-photon-excited near-infrared emissive carbon dotsas multifunctional agents for fluorescence imaging andphotothermal therapy

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Nano Research 2017年第9期10卷 3113-3123页

作者： Minhuan Lan shaojing zhao Zhenyu Zhang Li Yan Liang Guo Guangle Niu Jinfeng Zhang Junfang zhao Hongyan Zhang Pengfei Wang Guangyu Zhu Chun-Sing Lee Wenjun Zhang Center of Super-Diamond and Advanced Films (COSDAF) Department of Physics and Materials Science City University ofHong Kong Hong Kong China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences 8eijing 100190 China School of Future Technology University of Chinese Academy of Sciences Beijing 100049 China Department of Biology and Chemistry City University of Hong Kong Hong Kong China

C dots (CDs) have shown great potential in bioimaging and phototherapy. However, it is challenging to manipulate their fluorescent properties and therapeutic efficacy to satisfy the requirements for clinic applications. In this study, we prepared S, Se-codoped CDs via a hydrothermal method and demonstrated that the doping resulted in excitation wavelength-independent near-infrared (NIR) emissions of the CDs, with peaks at 731 and 820 nm. Significantly, the CDs exhibited a photothermal conversion efficiency of ~58.2%, which is the highest reported value for C nanostructures and is comparable to that of Au nanostructures. Moreover, the CDs had a large two-photon absorption cross section (~30,045 GM), which allowed NIR emissions and the photothermal conversion of the CDs through the two-photon excitation (TPE) mechanism. In vitro and in vivo tests suggested that CDs can function as new multifunctional phototheranostic agents for the TPE fluorescence imaging and photothermal therapy of cancer cells.

关键词： carbon dots phototheranostic agent two-photon excitation NIR emission photothermal conversion

All-in-one phototheranostics based on BTP-4F-DMO nanoparticles for NIR-II fluorescence/photoacoustic dual-mode imaging and combinational therapy

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Chinese Chemical Letters 2023年第6期34卷 395-400页

作者： Ke Yang Bowen Yu Wei Liu Zequn Zhang Li Huang shaojing zhao Benhua Wang Jianing Yi Jun Yuan Yingping Zou Changwei Lin Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Department of Gastrointestinal Surgery The Third Xiangya Hospital of Central South UniversityChangsha 410013China Surgical Department of Breast and Thyroid Gland Hunan Provincial People’s HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410083China

Various phototheranostics have recently been developed for *** proper molecular design,the photochemical and photophysical properties of these phototheranostics can be ***,an acceptor-donor-acceptor(A-D-A)-structured dye,BTP-4F-DMO,was synthesized and prepared into water-soluble nanoparticles(NPs).The obtained BTP-4F-DMO NPs had strong absorption from650 nm to 850 nm and a fluorescence emission peak at~900 nm that tailed to~1100 *** NPs showed a superhigh photothermal conversion efficiency of 90.5%±5%and could simultaneously generate·OH and^(1)O_(2)with a^(1)O_(2)generation quantum yield of 4.6%under 808 nm laser *** to these advanced properties,BTP-4F-DMO NPs can switch the role of autophagy from pro-survival to prodeath,thereby further promoting cancer cell *** features make BTP-4F-DMO NPs a promising multifunctional phototheranostic agent for NIR-II fluorescence/photoacoustic dual-mode imaging-guided synergetic photodynamic/photothermal *** general,this work provides a strategy for expanding the biomedical applications of organic A-D-A-structured phototheranostics.

关键词： Photodynamic therapy NIR-Ⅱfluorescence imaging Photothermal therapy Photoacoustic imaging Autophagy-induced death

β?Cyclodextrin-Promoted Colorimetric and Fluorescence Turn-on Probe for Discriminating Highly Toxic Thiophenol from Biothiols

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β?Cyclodextrin-Promoted Colorimetric and Fluorescence Turn-...

A Tetraphenylethylene-Based Aggregation-Induced Emission Probe for Fluorescence Turn-on Detection of Lipopolysaccharide in Injectable Water with Sensitivity Down to Picomolar

中国化学会第二届全国光功能材料青年学者研讨会

作者： Ting Xu shaojing zhao Xiaoli Wu Lintao Zeng Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical Engineering Central South University Shenzhen Research Institute of Central South University

设计了由β-环糊精（β-CD）和黄酮衍生物（化合物5）组成的复合物,作为比色和荧光开启探针,用于区分环境水样品中的生物酚中的硫酚（PhSH）。该探针通过光致电子转移（PET）和激发态分子内质子转移（ESIPT）机制的结合来工作。在该络... 详细信息

设计了由β-环糊精（β-CD）和黄酮衍生物（化合物5）组成的复合物,作为比色和荧光开启探针,用于区分环境水样品中的生物酚中的硫酚（PhSH）。该探针通过光致电子转移（PET）和激发态分子内质子转移（ESIPT）机制的结合来工作。在该络合物（β-CD-5）中,2,4-二硝基苯磺酰基通过PET机理有效地猝灭了化合物5的荧光,并且磺酸盐被PhSH裂解以产生具有强荧光的化合物。同时,观察到源自黄酮的ESIPT荧光。明显地,β-CD相对于PhSH改善了化合物5的响应时间和敏感性。在最佳条件下,反应时间为5分钟,β-CD-5对PhSH的检出限为?2.8 nM。证明β-CD-5出色的传感性能源自化合物5和β-CD的几何匹配以及β-CD腔中PhSH的富集。

关键词：组装硫酚荧光传感器 PET ESIPT

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A Tetraphenylethylene-Based Aggregation-Induced Emission Pro...