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Science China(Life Sciences) 2016年第10期59卷 1048-1050页

作者： Jun Xu shaojing liu Xuezhong Yu Peking Union Medical College Hospital Beijing 100730China

Although there have been progressive advancements in the life sciences since the beginning of the 21st Century,basic medical sciences generally fail to be efficiently translated into clinical research and ultimately i... 详细信息

关键词：医学科学转化翻译临床实践医院北京平台基础科学

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超长空间激光传输数值模拟研究进展

光电工程 2024年第2期51卷 23-32页

作者：华喆怿徐兆锐彭韶婧刘烨刘崇吴兰刘东浙江大学光电科学与工程学院现代光学仪器国家重点实验室浙江杭州310027

文章主要围绕空间引力波探测中超长空间链路传输部分进行介绍,概述了目前国内外星间传输仿真时采用的计算方法,以及指向抖动引起的相位噪声分析方法。相较于地基引力波探测,空间引力波探测可以有效降低噪声,增加干涉臂长度,从而实现更... 详细信息

文章主要围绕空间引力波探测中超长空间链路传输部分进行介绍,概述了目前国内外星间传输仿真时采用的计算方法,以及指向抖动引起的相位噪声分析方法。相较于地基引力波探测,空间引力波探测可以有效降低噪声,增加干涉臂长度,从而实现更高精度、更低频率的探测。在长达数百万公里的传输距离,以及皮米量级数值模拟的精度要求下,需要考虑指向角变化引起的相位噪声。研究表明,在2.5×10~9 m的传输距离下,离焦和像散是影响指向抖动噪声的主要像差。通常情况下,相位驻点位置与原点位置存在一定偏离,需要对望远镜角度进行调整,才能使相位噪声最小化。在相位驻点位置进行引力波探测,可以有效降低相位噪声,并降低望远镜出瞳波前的质量要求。而大的离焦像差与小的彗差可以使相位驻点接近光轴,提高接收到的激光功率。

关键词：空间引力波探测空间链路传输指向抖动噪声相位驻点

Integration of nanoindentation and finite element method for interpretable tensile properties:A crossscale calculation method of uneven joints

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Chinese Journal of Aeronautics 2023年第6期36卷 233-248页

作者： Kun GAO Zhiying liu Xiuli SHEN Lizhong LANG shaojing DONG School of Energy and Power Engineering Beihang UniversityBeijing100191China Department of Materials Science and Engineering University of TorontoTorontoON M5S 3E4Canada

Nanoindentation testing and its Reverse Analysis Method(RAM)show great potential in understanding the tensile properties of metallic alloys with various microstructures.Nevertheless,the tensile properties of heterogeneous materials such as nickel-based superalloy welded joints have not been well interpreted by combining the microstructures and nanoindentation results,due to their diverse and complex microscopic zones,which throws shade on the properties of separated zones in the material.Here we demonstrated a new method of implanting nanoindentation results into Finite Element Method(FEM)and applied the method to the welded joints with the zones of various microstructure features.The local properties are calculated by the nanoindentation data using RAM,and used as input of Finite Element(FE)simulation of an identical indentation process,to in turn verify the accuracy and reliability of the reverse model.The simulation results reveal that the global mechanical behaviors,such as Young's modulus,yield strength and strain hardening exponent,are related to the local properties to a great extent.Thus,the global properties can be verified by simulation straight after experiments,taking consideration of local properties and dimension parameters of different zones.It is shown that the maximum error between calculation of RAM and testing is within 5.1%in different zones,and the errors of maximum indentation depth and residual depth obtained by FE simulation are less than 2.4%,which indicates that the method provides a reliable prediction of mechanical properties of superalloy welded joints.

关键词： Finite element method Nanoindentation Reverse analysis method Tensile properties Welded joints

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川楝子肝毒性的影响因素及最佳炮制工艺探究

中华中医药杂志 2024年第6期39卷 3054-3058页

作者：杜晓鹂郭晶杨新跃陈思羽陈邵静刘涛常静董玉内蒙古医科大学药学院呼和浩特010110 天津中医药大学天津301617

目的:利用网络药理学和分子对接对川楝子中的活性成分及相关靶点进行预测,探讨川楝子中的活性成分对肝毒性(脂肪肝)的影响,同时考查川楝子醋制的最佳炮制工艺。方法:通过联合运用TCMSP等多个数据库,对川楝子的活性化合物及作用靶点进行... 详细信息

目的:利用网络药理学和分子对接对川楝子中的活性成分及相关靶点进行预测,探讨川楝子中的活性成分对肝毒性(脂肪肝)的影响,同时考查川楝子醋制的最佳炮制工艺。方法:通过联合运用TCMSP等多个数据库,对川楝子的活性化合物及作用靶点进行检索,利用IPA软件对潜在靶点进行核心分析及分子对接验证,探讨其活性成分对肝毒性特别是脂肪肝的影响;同时通过单因素考察探究川楝子的最佳炮制工艺。结果:从川楝子中筛选得到活性成分35个,相关作用靶点209个。IPA核心分析显示川楝子中的主要活性成分,如川楝素、槲皮素、大豆黄素、异槲皮素、硬脂酸、甘露醇、山柰酚、香草醛、芦丁可通过作用于EIF2AK2、STAT1、STAT2、IRF9、TP53、DCK等主要靶点对脂肪肝进行调控;分子对接结果进一步验证了川楝子中所筛选的9个核心成分与12个核心靶点的相互作用关系;单因素试验的结果表明,过3目筛的川楝子细粉在加醋量为12 mL,闷润时间为2 h,烘干温度为140℃的条件下川楝素含量最低,为0.39 mg/mL。结论:川楝子中的主要活性成分对脂肪肝具有调控作用且以川楝素含量作为其中一项指标,通过单因素试验可以为川楝子炮制工艺的优化提供科学依据。

关键词：川楝子网络药理学分子对接炮制工艺醋制脂肪肝肝毒性川楝素

An analysis method of injection and production dynamic transient flow in a gas field storage facility

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Petroleum Exploration and Development 2022年第1期49卷 179-190页

作者： WANG Jieming LI Chun SUN Junchang TANG Ligen ZHONG Rong liu Xianshan ZHENG shaojing PetroChina Research Institute of Petroleum Exploration&Development Langfang 065007China Key Laboratory of Oil and Gas Underground Storage Project of China National Petroleum Corporation Langfang 065007China

A dynamic transient flow analysis method considering complex factors such as the cyclic injection and production history in a gas field storage facility was established in view of the limitations of the existing methods for transient flow analysis and the characteristics of the injection-production operation of strongly heterogeneous gas reservoirs, and the corresponding theoretical charts were drawn. In addition, an injection-production dynamic transient flow analysis model named "three points and two stages" suitable for an underground gas storage(UGS) well with alternate working conditions was proposed. The "three points" refer to three time points during cyclic injection and production, namely, the starting point of gas injection for UGS construction, the beginning and ending points of the injection-production analysis stage;and the "two stages" refer to historical flow stage and injection-production analysis stage. The study shows that the dimensionless pseudo-pressure and dimensionless pseudo-pressure integral curves of UGS well flex downward in the early stage of the injection and production process, and the dimensionless pseudo-pressure integral derivative curve is convex during the gas production period and concave during the gas injection period, and the curves under different flow histories have atypical features. The new method present in this paper can analyze transient flow of UGS accurately. The application of this method to typical wells in Hutubi gas storage shows that the new method can fit the pressure history accurately, and obtain reliable parameters and results.

关键词： gas field storage facility injection and production performance alternate working conditions transient flow analysis theoretical chart

陇东地区极端高温天气气候特征及影响系统分析

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现代农业科技 2024年第14期 119-123页

作者：李祥科张洪芬刘翔翟少婧庆阳市气象局甘肃庆阳745000

本文利用1991—2022年庆阳市极端高温天气(35℃以上)的地面、高低空观测资料以及实况观测资料,运用统计学方法和小波分析法,分析了陇东地区极端高温天气时空分布特征及影响系统。结果表明:庆阳市极端高温天气的出现受地形影响较大,其中... 详细信息

本文利用1991—2022年庆阳市极端高温天气(35℃以上)的地面、高低空观测资料以及实况观测资料,运用统计学方法和小波分析法,分析了陇东地区极端高温天气时空分布特征及影响系统。结果表明:庆阳市极端高温天气的出现受地形影响较大,其中山川沟壑区出现较多,塬区出现较少;在时间分布上,一天中大部分极端高温出现在14:00—15:00和15:00—16:00,一年中6月、7月极端高温天气较多,年际变化以10年为周期;庆阳市极端高温天气的影响系统主要为高原暖区、青藏高压、副热带高压等,可分为青藏高压控制型、副高环流型以及其他型。

关键词：极端高温天气气候特征时空分布影响系统

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口服脂肪耐量试验的优化研究

中华内分泌代谢杂志 2024年第3期40卷 204-211页

作者：侯艺林马倩宋光耀侯晓宇卢亚敏田培培张婷雪刘丹丹曾少静冀金蕊任路平河北医科大学附属河北省人民医院内分泌科石家庄050051 河北医科大学附属河北省人民医院检验科石家庄050051 河北医科大学附属河北省人民医院核医学科石家庄050051

目的本研究旨在对比不同试验餐对餐后三酰甘油的影响,优化口服脂肪耐量试验标准餐配方和采血方案。方法本研究为前瞻性、开放标签、随机、交叉试验。2023年3月在河北省人民医院招募志愿者36名,经过健康查体和口服葡萄糖耐量试验,26名健... 详细信息

目的本研究旨在对比不同试验餐对餐后三酰甘油的影响,优化口服脂肪耐量试验标准餐配方和采血方案。方法本研究为前瞻性、开放标签、随机、交叉试验。2023年3月在河北省人民医院招募志愿者36名,经过健康查体和口服葡萄糖耐量试验,26名健康志愿者符合入选标准(男性11名,女性15名),平均年龄(39.08±4.56)岁。每位志愿者分别接受75 g蛋白餐、75 g脂肪餐、700 kcal固定热量高脂混合餐及根据10 kcal/kg体重调整热量的高脂混合餐试验,每次试验前普通饮食洗脱1周。在每次试验的空腹和餐后1、2、3、4、5、6 h采血,取血清检测三酰甘油、总胆固醇、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、血糖、胰岛素。分析不同试验餐餐后代谢指标随时间变化情况,比较两种混合餐的餐后代谢反应差异。结果蛋白餐、脂肪餐、固定热量高脂混合餐、调整热量高脂混合餐分别使餐后三酰甘油升高22.45%、115.40%、77.14%、63.63%,胰岛素升高560.43%、85.69%、554.18%、598.97%,总胆固醇、LDL-C、HDL-C降低5.64%~21.81%,血糖变化较小。代谢指标的主要变化发生在4 h以内。比较2种高脂混合餐后三酰甘油的特征,差异无统计学意义(P>0.05)。结论以700 kcal固定热量高脂混合餐为标准餐,在空腹和餐后1、2、3、4 h分别采血检测血脂水平,可作为口服脂肪耐量试验的优化方案。

关键词：三酰甘油口服脂肪耐量试验餐后血脂健康人群心血管疾病

恶性实体瘤手术患儿围手术期的营养状态及相关危险因素

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肿瘤代谢与营养电子杂志 2024年第1期11卷 65-69页

作者：陆洁婷张京吴少晶刘琪陈春容黄艾慧海南省妇女儿童医学中心普外肿瘤外科海南海口570311 海南省妇女儿童医学中心临床营养科海南海口570311 海南省妇女儿童医学中心血液肿瘤内科海南海口570311

目的调查恶性实体瘤手术患儿围手术期营养状态及其危险因素。方法选取海南省妇女儿童医学中心2020年3月至2023年3月收治的60例恶性实体瘤手术患儿,按术后3个月营养状况分为营养不良组和无营养不良组,分析恶性实体瘤手术患儿围手术期营... 详细信息

目的调查恶性实体瘤手术患儿围手术期营养状态及其危险因素。方法选取海南省妇女儿童医学中心2020年3月至2023年3月收治的60例恶性实体瘤手术患儿,按术后3个月营养状况分为营养不良组和无营养不良组,分析恶性实体瘤手术患儿围手术期营养状态及其营养不良的危险因素。结果术后3个月,60例恶性实体瘤手术患儿中无营养不良32例(53.33%)、营养不良28例(46.67%)。营养不良组患儿体质量指数(BMI)、去脂体质指数(FFMI)、身体细胞质量指数(BCMI)低于无营养不良组,脂肪质量指数(FMI)明显高于无营养不良组(P=0.005、P=0.004、P<0.001、P=0.007)。相比无营养不良组,营养不良组术后放化疗、入院时营养状况为中高风险占比明显更高,住院期间膳食摄入符合标准、特殊营养治疗占比明显更低,差异有统计学意义(P<0.001、P=0.001、P<0.001、P=0.006)。术后放化疗、入院时营养状况是恶性实体瘤手术患儿营养不良的危险因素(P=0.017、P=0.029)。结论恶性实体瘤手术患儿围手术期营养状况差,术后营养不良风险较高,需加强对入院时营养状况不佳及术后放化疗患儿的营养治疗。

关键词：恶性实体瘤患儿围手术期营养状态危险因素

Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine

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Protein & Cell 2023年第5期14卷 376-381页

作者： Jiani Cao Meng Li Kun liu Xingxing Shi Ning Sui Yuchen Yao Xiaojing Wang Shiyu Li Yuchang Tian shaojing Tan Qian Zhao Liang Wang Xiahua Chai Lin Zhang Chong liu Xing Li Zhijie Chang Dong Li Tongbiao Zhao State Key Laboratory of Stem Cell and Reproductive Biology Institute for Stem Cell and RegenerationInstitute of ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Membrane Biology School of MedicineCenter for Synthetic and Systems BiologyTsinghua UniversityBeijing 100084China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Qufu Normal University Qufu 273165China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,Embryonic stem cells(ESCs)have been assumed to possess immature mitochondria and to favor anaerobic glycolysis over oxidative phosphorylation(OXPHOS)for energy production.This proposition is largely based on the findings that ESCs possess globular mitochondria with blurred cristae,and the facts that ESCs have higher glycolysis activity and lower mitochondrial respiration capacity than somatic cells(Kondoh et al.,2007;Folmes et al.,2011,2012;Zhang et al.,2012;Xu et al.,2013;Ito and Suda,2014;Gu et al.,2016).However,recent studies have shown that mitochondrial autophagy and mitochondrial dynamics are pivotal for ESC self-renewal and pluripotency(Todd et al.,2010;liu et al.,2016,2020;Wang et al.,2019;Zhong et al.,2019).These studies have raised a fundamental question:what is the contribution and functional mechanism of mitochondrial respiration in pluripotency regulation?

关键词： Kondo phosphorylation raised

All-in-one phototheranostics based on BTP-4F-DMO nanoparticles for NIR-II fluorescence/photoacoustic dual-mode imaging and combinational therapy

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Chinese Chemical Letters 2023年第6期34卷 395-400页

作者： Ke Yang Bowen Yu Wei liu Zequn Zhang Li Huang shaojing Zhao Benhua Wang Jianing Yi Jun Yuan Yingping Zou Changwei Lin Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Department of Gastrointestinal Surgery The Third Xiangya Hospital of Central South UniversityChangsha 410013China Surgical Department of Breast and Thyroid Gland Hunan Provincial People’s HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410083China

Various phototheranostics have recently been developed for phototherapy.Through proper molecular design,the photochemical and photophysical properties of these phototheranostics can be promoted.Herein,an acceptor-donor-acceptor(A-D-A)-structured dye,BTP-4F-DMO,was synthesized and prepared into water-soluble nanoparticles(NPs).The obtained BTP-4F-DMO NPs had strong absorption from650 nm to 850 nm and a fluorescence emission peak at~900 nm that tailed to~1100 nm.The NPs showed a superhigh photothermal conversion efficiency of 90.5%±5%and could simultaneously generate·OH and^(1)O_(2)with a^(1)O_(2)generation quantum yield of 4.6%under 808 nm laser irradiation.Due to these advanced properties,BTP-4F-DMO NPs can switch the role of autophagy from pro-survival to prodeath,thereby further promoting cancer cell death.These features make BTP-4F-DMO NPs a promising multifunctional phototheranostic agent for NIR-II fluorescence/photoacoustic dual-mode imaging-guided synergetic photodynamic/photothermal therapy.In general,this work provides a strategy for expanding the biomedical applications of organic A-D-A-structured phototheranostics.

关键词： Photodynamic therapy NIR-Ⅱfluorescence imaging Photothermal therapy Photoacoustic imaging Autophagy-induced death