检索结果-南通市图书馆

Aberrant single-subject morphological brain networks in first-episode,treatment-naive adolescents with major depressive disorder

在线全文

学校读者我要写书评

暂无评论

Psychoradiology 2023年第1期3卷 220-231页

作者： Xiaofan Qiu Junle Li Fen Pan Yuping Yang Weihua Zhou Jinkai Chen Ning Wei shaojia lu Xuchu Weng Manli Huang Jinhui Wang Institute for Brain Research and Rehabilitation South China Normnal UniversityGuangzhou 510631China Departnent of Psychiatry First Affliated HospitalCollge of MedicineZhejiang UniversityHangzhou 310013China The Key Laboratory of Mental Disorder's Management of Zhejiang Province Hangzhou 310013China Key Laboratory of Brain Cognition and Education SciencesMinistry of EducationGuangzhou 510631China Center for Studies of Psychological Application South China Normal UniversityGuangzhou 510631China Guangdong Key Laboratory of Mental Health and Cognitive Science Guangzhou 510631China Zhejiang Engineering Center for Mathematical Mental Health Hangzhou 310003China

Background:Neuroimaging-based connectome studies have indicated that major depressive disorder(MDD)is associated with dis-rupted topological organization of large-scale brain ***,the disruptions and their clinical and cognitive relevance are not well established for morphological brain networks in adolescent ***:To investigate the topological alterations of single-subject morphological brain networks in adolescent ***:Twenty-five first-episode,treatment-naive adolescents with MDD and 19 healthy controls(HCs)underwent T1-weighted magnetic resonance imaging and a battery of neuropsychological ***-subject morphological brain networks were constructed separately based on cortical thickness,fractal dimension,gyrification index,and sulcus depth,and topologically characterized by graph-based ***-group differences were inferred by permutation *** significant alterations,partial correla-tions were used to examine their associations with clinical and neuropsychological variables in the ***,a support vector machine was used to classify the patients from ***:Compared with the HCs,the patients exhibited topological alterations only in cortical thickness-based networks character-ized by higher nodal centralities in parietal(left primary sensory cortex)but lower nodal centralities in temporal(left parabelt complex,right perirhinal ectorhinal cortex,right area PHT and right ventral visual complex)***,decreased nodal centralities of some temporal regions were correlated with cognitive dysfunction and clinical characteristics of the *** results were largely reproducible for binary and weighted network ***,topological properties of the cortical thickness-based net-works were able to distinguish the MDD adolescents from HCs with 87.6%***:Adolescent MDD is associated with disrupted topological organization of morphological brain networks,and the d

关键词： adolescent major depressive disorder structural MRI morphological brain network cortical thickness support vector machine

Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder:a voxelbased morphometry study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2015年第1期31卷 4-12页

作者： Yi Cai Jun Liu Li Zhang Mei Liao Yan Zhang Lifeng Wang Hongjun Peng Zhong He Zexuan Li Weihui Li shaojia lu Yuqiang Ding Lingjiang Li Mental Health Institute of the Second Xiangya Hospital National Technology Institute of Psychiatry Key Laboratory of Psychiatry and Mental Health of Hunan ProvinceCentral South University Department of Mental Health and Psychiatry Brain Hospital of Hunan Province Hunan University of Chinese Medicine Clinical Medical College Department of Radiology the Second Xiangya Hospital of Central South University Guangzhou Psychiatric Hospital Affiliated Hospital of Guangzhou Medical College Key Laboratory of Arrhythmias Ministry of EducationEast HospitalTongji University School of Medicine Shenzhen Kangning Hospital of Guangdong Province

Bipolar disorder and unipolar depressive disorder（UD） may be different in brain structure. In the present study,we performed voxel-based morphometry（VBM） to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder（BP1） and 23 patients with UD,and 23 age-,gender-,and educationmatched healthy controls（HCs） using magnetic resonance imaging. We found that compared with the HC and UD groups,the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus,while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition,correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together,the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD,and decreasedgrey matter volume in the right middle cingulate gyrus may be specifi c to BP1.

关键词： bipolar depressive disorder unipolar depressive disorder prefrontal cortex cingulate gyrus voxel-based morphometry

Increased ratio of mature BDNF to precursor-BDNF in patients with major depressive disorder with severe anhedonia

在线全文

学校读者我要写书评

暂无评论

Increased ratio of mature BDNF to precursor-BDNF in patients...

一种具有类牙釉质多级结构的高强高韧羟基磷灰石基纤维

2020年浙江省医学会精神病学学术大会浙江省医师协会精...

作者： Congchong Wu Jing lu shaojia lu Manli Huang Yi Xu

Background:Although studies have shown that severe anhedonia in patients with major depressive disorder(MDD) is associated with poor treatment outcomes,the biological mechanism of this feature is *** aimof this study ...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Science China Materials 2024年第8期67卷 2496-2504页

作者：丁宝森刘少佳卢俊峰郭一然郑天赵赫威郭林 School of Chemistry Beihang UniversityBeijing 100191China

牙釉质是人体最硬的组织,力学性能优异.牙釉质内部的纳米线-微米簇-有序阵列的多级结构是其具有优异力学性能的关键.通过模仿牙釉质的微结构有望实现人造材料力学性能的突破,但是多级次模仿天然牙釉质的微结构仍是巨大的挑战.本文中,我... 详细信息

牙釉质是人体最硬的组织,力学性能优异.牙釉质内部的纳米线-微米簇-有序阵列的多级结构是其具有优异力学性能的关键.通过模仿牙釉质的微结构有望实现人造材料力学性能的突破,但是多级次模仿天然牙釉质的微结构仍是巨大的挑战.本文中,我们制备了由长程有序晶体/非晶羟基磷灰石(HAP)纳米线组成的HAP微米簇,并通过剪切诱导组装将其纺成类牙釉质高性能宏观纤维.该纤维具有高度有序的纳米线-微米簇结构,并且HAP纳米线、HAP微米簇和聚合物基体之间的强界面连接使得该纤维在受力时具有一种多级的能量耗散途径.因此该类牙釉质纤维兼具高强度(196.3 MPa)和高韧性(46.3 MJ m^(-3)),其断裂韧性超过了先前报道的HAP基复合纤维的最大值.这种多级类牙釉质设计策略为高强度和高韧性纤维的开发提供了新的思路,在潜在的工程和生物修复领域具有广阔的应用前景.

关键词：牙釉质羟基磷灰石长程有序高强高韧聚合物基体界面连接多级结构能量耗散

Relationships between dorsolateral prefrontal cortex metabolic change and cognitive impairment in first-episode neuroleptic-naive schizophrenia patients

在线全文

学校读者我要写书评

暂无评论

Relationships between dorsolateral prefrontal cortex metabol...

浙江省神经科学学会第五届学术年会

作者：黄满丽 Thongteck Khoh shaojia lu Fen Pan Jinkai Chen Jianbo Hu Shaohua Hu Weijuan Xu Weihua Zhou NingWei Hongli Qi Desheng Shang Yi Xu 浙江大学医学院附属第一医院精神卫生中心浙江大学医学院附属第一医院精神卫生中心浙江省精神障碍诊疗和防治技术重点实验室浙江省医学会精神病学分会青年委员会

The present study aimed to explore the possible associations between the dorsolateral prefrontal cortex(DLPFC) metabolites and the cognitive function in first-episode schizophrenia(FES).This study included 58 patients with FES(29 males and 29 females;mean age,22.66 ± 7.64 years) recruited from the First Affiliated Hospital,College of Medicine,Zhejiang University,and 43 locally recruited healthy controls(16 males and 27 females;mean age,23.07 ± 7.49 years).The single-voxel proton magnetic resonance spectroscopy was used to measure the levels of N-acetylaspartate(NAA),complex of glutamate,glutamine,and y-aminobutyric acid(Glx),choline-containing compounds and myo-inositol in the *** ratios of metabolites to creatine(Cr) were *** cognitive function was assessed by Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS) Consensus Cognitive Battery(MCCB).Correlation analysis was used to assess the relationships between the DLPFC metabolites and the cognitive *** with the healthy controls,the patients with FES showed significantly reduced scores in each part of the MCCB,significantly reduced NAA/Cr,and significantly increased Glx/Cr in the left *** performance in verbal learning and visual learning was correlated to the reduced NAA/Cr ratio in the left *** findings suggest that a lower NAA/Cr ratio in the left DLPFC is associated with the cognitive deficits in patients with FES,and may be an early biochemical marker for the cognitive impairment in schizophrenia.

关键词： Cognition first-episode schizophrenia dorsolateral prefrontal cortex 1H-MRS MCCB

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

东南亚野火对南海北部空气质量的影响

Science Bulletin 2024年第8期69卷 1011-1015页

作者：秦玉洁王海潮王一鸣卢骁唐海荣张建青李磊范绍佳 School of Atmospheric Sciences Sun Yat-sen UniversitySouthern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519000China Guangdong Provincial Observation and Research Station for Climate Environment and Air Quality Change in the Pearl River Estuary Key Laboratory of Tropical Atmosphere-Ocean System(Sun Yat-sen University)Ministry of EducationZhuhai 519000China Sansha Meteorological Bureau of Hainan Province Sansha 573199China

Wildfire smoke plays a crucial role in climate change,air quality,human health,and the *** the warming and drying of the climate,the scope,frequency,and intensity of global wildfire events are increasing rapidly[1,2].Southeast Asia,South America,Africa,and Australia are the major regions in which wildfires occur[3,4];Southeast Asia is the hotspot of wildfires and neighbors the South China Sea(SCS)[5].Therefore,the air quality and climate in the SCS can be affected by the transport of wildfire smoke in Southeast *** studies have focused on the transport pathways from Southeast Asia to the SCS,especially studies based on BASE-ASIA(Biomass-burning Aerosols in South-East Asia)and 7-SEAS(7-South-East Asian Studies)experiments[5,6].

关键词： climate warming East

中国散裂中子源自研前端专用芯片CSNS_VASD性能测试

在线全文

学校读者我要写书评

暂无评论

核技术 2024年第7期47卷 48-56页

作者：杨浩路书祥李怀申陈少佳唐彬王修库曾莉欣于莉万志永刘慧银孙志嘉郑州大学郑州450001 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803

中子闪烁体探测器是中国散裂中子源工程主力探测器之一,高探测效率是目前正在研制的第二代中子闪烁体探测器的设计目标。CSNS_VASD芯片是中国散裂中子源工程专门为第二代中子闪烁体探测器研发的一款专用集成电路芯片。为了验证芯片性能... 详细信息

中子闪烁体探测器是中国散裂中子源工程主力探测器之一,高探测效率是目前正在研制的第二代中子闪烁体探测器的设计目标。CSNS_VASD芯片是中国散裂中子源工程专门为第二代中子闪烁体探测器研发的一款专用集成电路芯片。为了验证芯片性能,设计了专用测试系统,并在实验室和中子束线对芯片进行了测试。测试结果显示:自研芯片的非线性误差≤1%、等效噪声电压≤0.63 mV、通道间串扰≤0.89%;探测器探测效率为40.7%@0.1 nm。性能指标均达到了工程设计指标的要求。CSNS_VASD芯片的成功研制为中国散裂中子源工程的顺利建设提供了可靠的技术保障。

关键词：中国散裂中子源中子闪烁体探测器专用集成电路芯片硅光电倍增管 FPGA

伴童年期创伤抑郁症炎症系统及脑影像学研究进展

在线全文

学校读者我要写书评

暂无评论

中国现代医生 2018年第25期56卷 161-164页

作者：王丹丹陆邵佳浙江大学医学院附属第一医院精神卫生科浙江省精神障碍诊疗和防治技术重点实验室浙江杭州310009

现有研究证据表明童年创伤是抑郁症发生发展的显著危险因素,而伴童年创伤的抑郁症可能是抑郁症的一个重要功能亚型,拥有其独特的临床表现和生物学改变。本文旨在总结伴童年期创伤抑郁症患者其炎症系统功能活性和情绪相关脑区影像学特征... 详细信息

现有研究证据表明童年创伤是抑郁症发生发展的显著危险因素,而伴童年创伤的抑郁症可能是抑郁症的一个重要功能亚型,拥有其独特的临床表现和生物学改变。本文旨在总结伴童年期创伤抑郁症患者其炎症系统功能活性和情绪相关脑区影像学特征以及这类患者炎症系统活性和情绪相关脑区结构与功能改变的相关性。

关键词：童年创伤抑郁症炎症系统情绪相关脑区脑结构和功能

Gut microbiota links to TRANK1 overexpression in bipolar depression

在线全文

学校读者我要写书评

暂无评论

Gut microbiota links to TRANK1 overexpression in bipolar dep...