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Horticulture Research 2020年第1期7卷 1572-1583页

作者： Luming Zou Wenwen liu Zhan Zhang Everard J.Edwards Elias Kirabi Gathunga Peige Fan Wei Duan shaohua li Zhenchang liang Beijing Key Laboratory of Grape Science and Enology and CAS Key Laboratory of Plant Resources Institute of BotanyChinese Academy of SciencesBeijing 100093PR China University of the Chinese Academy of Sciences Beijing 100049PR China College of life Science Shanxi Normal UniversityShanxi 041004PR China CSIRO Agriculture&Food Locked Bag 2Glen OsmondSA 5064Australia Sino-Africa Joint Research Center Chinese Academy of SciencesWuhan 430074PR China

A colchicine-induced autotetraploid grapevine exhibiting potentially valuable agronomic traits for grape production and breeding,including self-pruning,was *** study investigated DNA methylation variation and its role in gene expression during self-pruning in the autotetraploid *** used RNA-Seq to estimate differentially expressed genes between diploid and autotetraploid grapevine shoot *** genes showing increases in the autotetraploid were mainly related to stress response pathways,whereas those showing decreases in the autotetraploid were related to biological metabolism and ***-genome bisulfite sequencing was performed to produce single-base methylomes for the diploid and autotetraploid *** between the methylomes revealed that they were conserved in CG and CHG *** the autotetraploid grapevine,hypodifferentially methylated regions(DMRs)and hyper-DMRs in the gene body increased or decreased gene expression,*** results indicated that a hypo-DMR in the ACO1 gene body increased its expression and might promote *** study reports that hypo-DMRs in the gene body increase gene expression in plants and reveals the mechanism underlying the changes in the modifications affecting gene expression during genome ***,our results provide valuable information for understanding the relationships between DNA methylation,gene expression,and autotetraploid breeding in grape.

关键词： metabolism breeding showing

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沉积模拟实验信息系统的设计与实现

长江大学学报（自然科学版） 2024年第2期21卷 13-22页

作者：刘远刚张明望李少华于金彪龙颖波喻思羽长江大学地球科学学院湖北武汉430100 中国石化胜利油田分公司勘探开发研究院山东东营257015 油气资源与勘探技术教育部重点实验室(长江大学) 湖北武汉430100

多年来,国内外地质学家在沉积模拟实验研究中积累了海量的实验数据和资料,但目前缺少对此类信息进行规范化管理和共享应用的软件系统。对此,提出浏览器/服务器(B/S)模式的沉积模拟实验信息系统,实现了沉积模拟实验的实验设计方案、实验... 详细信息

多年来,国内外地质学家在沉积模拟实验研究中积累了海量的实验数据和资料,但目前缺少对此类信息进行规范化管理和共享应用的软件系统。对此,提出浏览器/服务器(B/S)模式的沉积模拟实验信息系统,实现了沉积模拟实验的实验设计方案、实验观测数据、实验结果等信息的集成管理、高效检索和可视化分析等功能,从而为沉积模拟实验的网上信息化管理与分析应用提供可行方案。最后,以某油田辫状河储层沉积模拟实验为例,介绍了系统中实验项目检索、实验详情浏览、砂体测量数据的统计分析等功能的应用效果,说明了本系统的实用性。本系统的研发与应用可极大地方便沉积模拟实验数据的管理、分享及分析工作。

关键词：沉积模拟实验信息系统 *** MVC Web *** Entity Framework ECharts

利用宏转录组学技术分析酸马奶发酵过程中活性微生物功能基因表达的变化特征

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畜牧与饲料科学 2024年第4期45卷 1-9页

作者：布仁其其格董超包玉龙红梅张三润李少华芒来马春丽内蒙古医科大学内蒙古呼和浩特010110 内蒙古农业大学内蒙古呼和浩特010018

[目的]探究酸马奶不同发酵时期活性微生物功能基因表达的变化特征。[方法]收集发酵初期(12 h)、中期(48 h)、后期(96 h)酸马奶样品,构建宏转录组文库,进行RNA-Seq高通量测序;对测序数据进行组装和功能注释后,分析差异表达基因,确定GO和K... 详细信息

[目的]探究酸马奶不同发酵时期活性微生物功能基因表达的变化特征。[方法]收集发酵初期(12 h)、中期(48 h)、后期(96 h)酸马奶样品,构建宏转录组文库,进行RNA-Seq高通量测序;对测序数据进行组装和功能注释后,分析差异表达基因,确定GO和KEGG信号通路中显著差异表达基因的静态富集。[结果]3个发酵时期酸马奶样品的宏转录组高通量测序共产生12.17 GB的高质量短序列。序列组装后进行数据分析,发现酸马奶发酵过程中代谢过程相关基因表达占主导地位。差异表达基因的筛选与分析显示,发酵前期、中期、后期酸马奶样品间两两相比,下调表达基因数量多于上调表达基因数量。GO功能富集分析显示,发酵初期与中期酸马奶样品间差异表达基因高度富集的GO条目是细胞过程、代谢过程、有机环状化合物结合、杂环化合物结合;发酵中期与后期样品间差异表达基因高度富集的GO条目是细胞过程、细胞大分子代谢过程;发酵初期与后期样品间差异表达基因高度富集的GO条目主要涉及细胞过程、有机物质代谢过程、核苷结合、核糖核苷结合、嘌呤核苷酸结合。KEGG通路富集分析显示,发酵前期与中期酸马奶样品间仅有1条差异表达基因显著富集的信号通路,即核糖体通路;发酵中期与后期酸马奶样品间差异表达基因显著富集的信号通路包括醚酯代谢、氨基苯甲酸降解、mRNA监测途径、类固醇生物合成;发酵前期与后期酸马奶样品间差异表达基因显著富集的信号通路包括类固醇生物合成、氨基苯甲酸降解、mRNA监测途径、核糖体、乙苯降解。[结论]酸马奶发酵过程中涉及活性微生物多种功能基因的差异表达,不同发酵时期活性微生物功能基因的差异表达呈现动态变化。研究结果为深入了解酸马奶发酵机制、优化酸马奶发酵工艺提供了参考。

关键词：酸马奶发酵宏转录组功能基因

大麻素受体CB1三维结构的同源模建及其对接研究

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化学学报 2011年第8期69卷 1007-1010页

作者：涂国刚李少华南昌大学药学系药物化学教研室南昌330006

大麻素CB1受体属于G蛋白偶联受体.以牛视紫红质的晶体结构为模板,利用同源模建法对CB1受体的三维结构进行了模拟,并采用分子动力学方法对模型进行了修正和优化.在此基础上,分析了活性位点的组成和结构,研究了拮抗剂利莫那班与CB1受体的... 详细信息

大麻素CB1受体属于G蛋白偶联受体.以牛视紫红质的晶体结构为模板,利用同源模建法对CB1受体的三维结构进行了模拟,并采用分子动力学方法对模型进行了修正和优化.在此基础上,分析了活性位点的组成和结构,研究了拮抗剂利莫那班与CB1受体的对接,明确了CB1受体与利莫那班结合时起重要作用的氨基酸残基.发现利莫那班与CB1受体残基Lys192形成氢键相互作用是CB1受体拮抗剂的重要分子作用基础.

关键词： CB1受体利莫那班同源模建分子对接

基于碎屑岩储层孔喉特征的油水渗流微观解释——以桑塔木油田三叠系储层为例

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非常规油气 2024年第5期11卷 106-113页

作者：吕端川汪如军王超朱正俊王开宇代梦莹李绍华宋金鹏中国石油超深层复杂油气藏勘探开发技术研发中心新疆库尔勒841000 新疆维吾尔自治区超深层复杂油气藏勘探开发工程研究中心新疆库尔勒841000 长江大学地球科学学院武汉430100

为了对碎屑岩储层孔喉系统内油水两相渗流特征进行微观解释,通过对多口取芯井上真实岩心样品的薄片观察、压汞测试和相渗测试,以及对测试结果的统计学分析,发现研究区三叠系储层主要发育原生粒间孔,其孔隙结构类型有大孔粗喉型、大孔细... 详细信息

为了对碎屑岩储层孔喉系统内油水两相渗流特征进行微观解释,通过对多口取芯井上真实岩心样品的薄片观察、压汞测试和相渗测试,以及对测试结果的统计学分析,发现研究区三叠系储层主要发育原生粒间孔,其孔隙结构类型有大孔粗喉型、大孔细喉型、中孔细喉型、小孔细喉型和微孔微喉型5种。特低渗、低渗、中渗、高渗和特高渗样品的顶点半径平均值依次为1.78μm,2.98μm,7.76μm,24.05μm和45.66μm,则正韵律储层在水驱油过程中,特低渗与低渗以及高渗与特高渗单元组合内的水相渗流阻力差别均为2倍左右,而低渗、中渗和高渗单元组合中的水相渗流阻力相差3倍左右。因此,可以通过储层中不同渗流能力的流动单元组合类型判断水相绕流程度的差异,进而确定绕流式剩余油的分布部位。

关键词：桑塔木油田三叠系碎屑岩储层孔喉系统微观解释两相流

Emerging hierarchical mesoporous materials of covalent organic frameworks

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Science China Chemistry 2024年第9期67卷 2796-2802页

作者： lingyan Huang Wenda li Hongyi Zhang Shanzhe Ke Hao Chen Jianwei Fu Chengbin Jing Jiangong Cheng shaohua liu State Key Laboratory of Precision Spectroscopy/Engineering Research Center of Nanophotonics&Advanced Instrument(Ministry of Education) School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450052China State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China

Benefiting from abundant exposed active sites,minimized diffusion resistance of guest molecules,facilitated mass transfer process and enhanced storage capacity,covalent organic frameworks(COFs)have gained widespread scientific attention[1–4].Further construction of mesopores regarding pore engineering(pore size,pore geometry,pore volume,and framework compositions)in COFs can improve mass transport,accessibility as well as size-selectivity of the special guest moieties,thus exhibiting potential in catalysis,energy storage and separation and so on[5,6].

关键词： gained catalysis separation

Progress,challenges,and prospects of spent lithium-ion batteries recycling:A review

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Journal of Energy Chemistry 2024年第2期89卷 144-171,I0005页

作者： Pengwei li shaohua Luo lin Zhang Qiuyue liu Yikai Wang Yicheng lin Can Xu Jia Guo Peam Cheali Xiaoning Xia School of Materials Science and Engineering Northeastern UniversityShenyang 110819LiaoningChina School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004HebeiChina Department of Chemistry and Bioscience Aalborg UniversityAalborg 9220Denmark Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Qinhuangdao 066004HebeiChina Department of Materials and Production Aalborg UniversityAalborg 9220Denmark School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina

The recycling and reutilization of spent lithium-ion batteries(liBs)have become an important measure to alleviate problems like resource scarcity and environmental *** some progress has been made,battery recycling technology still faces challenges in terms of efficiency,effectiveness and environmental *** review aims to systematically review and analyze the current status of spent liB recycling,and conduct a detailed comparison and evaluation of different recycling *** addition,this review introduces emerging recycling techniques,including deep eutectic solvents,molten salt roasting,and direct regeneration,with the intent of enhancing recycling efficiency and diminishing environmental ***,to increase the added value of recycled materials,this review proposes the concept of upgrading recycled materials into high value-added functional materials,such as catalysts,adsorbents,and *** life cycle assessment,the paper also explores the economic and environmental impacts of current battery recycling and highlights the importance that future recycling technologies should achieve a balance between recycling efficiency,economics and environmental ***,this review outlines the opportunities and challenges of recycling key materials for next-generation batteries,and proposes relevant policy recommendations to promote the green and sustainable development of batteries,circular economy,and ecological civilization.

关键词： Spent li-ion batteries Recycle Direct regeneration High-value conversion Functional materials

Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin4-yl)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as an orally active antitumor agent

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Acta Pharmaceutica Sinica B 2024年第2期14卷 893-896页

作者： Mingwei Fu Min Ge Wanxiang Yang Chunchen Hu Xiaowei li Yuanjiang Wang shaohua Gou Pharmaceutical Research Center and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research Southeast UniversityNanjing 211189China Zenji Research Laboratories Nanjing 211189China

To the Editor:Kinase cell division cycle 7(CDC7),a cell division cycle protein,takes a vital role in mediating DNA ***7 complexes in the nucleus can phosphorylate the minichromosome maintenance complex(MCM)family members that bind to *** addition,CDC7 kinase,as a molecular switch regulating DNA replication,can mediate DNA damage signaling pathways to stimulate cell cycle termination as well as DNA *** have shown that CDC7 is overexpressed in many types of cancer cells,and its overexpression was related to poor patient survival,tumor grade,genetic instability,aneuploidy and so ***,CDC7 is a promising target for antitumor therapy.

关键词： Cell division cycle 7 DNA replication CDC7 inhibitor Anti-tumor

采用改进Bingham模型的非线性汽车悬架的主共振

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振动与冲击 2006年第4期25卷 109-111,128页

作者：李韶华杨绍普石家庄铁道学院石家庄050043

采用一种改进的B ingham模型描述汽车悬架中的非线性阻尼力,模型中的各参数具有明确的物理意义,都与阻尼器的特性有关。利用平均法研究了单自由度多频激励非线性汽车悬架系统的主共振,得到了一次近似解。然后,对理论解进行了数值验证,... 详细信息

采用一种改进的B ingham模型描述汽车悬架中的非线性阻尼力,模型中的各参数具有明确的物理意义,都与阻尼器的特性有关。利用平均法研究了单自由度多频激励非线性汽车悬架系统的主共振,得到了一次近似解。然后,对理论解进行了数值验证,并研究了系统参数对主共振的影响,从而可以更加有效地控制汽车振动。

关键词：主共振改进Bingham模型平均法多频激励非线性汽车悬架