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Matrix Boundary Value Problem on Hyperbola

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Journal of Applied Mathematics and Physics 2023年第4期11卷 884-890页

作者： shaohua fan School of Science Tianjin University of Technology and Education Tianjin China

We study a special class of lower trigonometric matrix value boundary value problems on hyperbolas. Firstly, the pseudo-orthogonal polynomial on hyperbola is given in bilinear form and it is shown that it is the only one. Secondly, a special boundary value problem of lower triangular matrix is presented and transformed into four related boundary value problems. Finally, Liouville theorem and Painlevé theorem and pseudo-orthogonal polynomials are used to give solutions.

关键词： Hyperbola Matrix Boundary Value Problem Orthogonal Polynomial

Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1

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Protein & Cell 2019年第10期10卷 726-744页

作者： Hongmei Mao Zaiming Tang Hua Li Bo Sun Mingjia Tan shaohua fan Yuan Zhu Yi Sun The Cancer Institute of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Division of Radiation and Cancer Biology Department of Radiati on OncologyUniversity of MichiganAnn ArborMl 48109USA Gilbert Family Neurofibromatosis In stitute Center for Cancer and Immuno logy ResearchChildren's Research In stituteChildren's National Medical CenterWashingtonDC 20010USA

The primary cilium is a microtubule-based sensory organelle.The molecular mechanism that regulates ciliary dynamics remains elusive.Here,we report an unexpected finding that MLN4924,a small molecule inhibitor of NEDD8-activating enzyme(NAE),blocks primary ciliary formation by inhibiting synthesis/assembly and promoting disassembly.This is mainly mediated by MLN4924-induced phosphorylation of AKT1 at Ser473 under serum-starved,ciliary-promoting conditions.Indeed,pharmaceutical inhibition(by MK2206)or genetic depletion(via siRNA)of AKT1 rescues MLN4924 effect,indicating its causai role.Interestingly,pAKT 1-Ser473 activity regulates both ciliary synthesis/assembly and disassembly in a MLN4924 dependent manner,whereas pAKT-Thr308 determines the ciliary length in MLN4924-independent but VHL-dependent manner.Finally,MLN4924 inhibits mouse hair regrowth,a process requires ciliogenesis?Collectively,our study dem on strates an unexpected role of a neddylation inhibitor in regulation of ciliogenesis via AKT1,and pro?vides a proof-of-concept for potential utility of MLN4924 in the treatment of human diseases associated with abnormal ciliogenesis.

关键词： AKT Cilia MLN4924 neddylation siRNA VHL

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基于超导的小型化磁粒子成像系统仿真构建

沈阳工业大学学报 2024年第2期46卷 138-143页

作者：田育珅马少华王程松范霖沈阳工业大学电气工程学院辽宁沈阳110870 南京邮电大学集成电路科学与工程学院江苏南京210023 南京大学医学院江苏南京210093 东南大学生物电子学国家重点实验室江苏南京210096

针对磁粒子成像技术尚停留在实验室鼠用设备阶段,传统线材线圈过大,无法在可接受的设备体量内达到临床人体检测所需磁场强度的问题,提出了一种基于超导技术构建高场强、小型化磁粒子成像设备的方法。采用高温超导MgB_(2)线圈替代传统铜... 详细信息

针对磁粒子成像技术尚停留在实验室鼠用设备阶段,传统线材线圈过大,无法在可接受的设备体量内达到临床人体检测所需磁场强度的问题,提出了一种基于超导技术构建高场强、小型化磁粒子成像设备的方法。采用高温超导MgB_(2)线圈替代传统铜线圈,构建磁粒子成像选择场与驱动场。结果表明,在达到相同磁通量的情况下,超导磁粒子成像系统可将两组功能区总质量降低为0.01 kg,设备体积缩小至7 L。在此基础上,采用超导线圈构建梯度磁场还能够获得更高的变化斜率,使零磁扫描区边缘更为清晰规则,移动过程中形态更为稳定,平均直径缩小近二分之一。

关键词：磁粒子成像小型化设备梯度磁场零磁区高温超导 MgB_(2)线圈选择场驱动场

“迁都争议”与“迁都话题”——试论东汉“迁都”赋的文本模拟与性质变化

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中国人民大学学报 2024年第2期38卷 130-139页

作者：孙少华中国社会科学院文学研究所

东汉自杜笃《论都赋》以下,又有王景《金人论》、傅毅《反都赋》《洛都赋》、崔骃《反都赋》、班固《两都赋》、张衡《二京赋》等京都赋作。杜笃《论都赋》与是否定都洛阳有关,有“迁都”长安主题,可称作“迁都争议”赋;王景《金人论》... 详细信息

东汉自杜笃《论都赋》以下,又有王景《金人论》、傅毅《反都赋》《洛都赋》、崔骃《反都赋》、班固《两都赋》、张衡《二京赋》等京都赋作。杜笃《论都赋》与是否定都洛阳有关,有“迁都”长安主题,可称作“迁都争议”赋;王景《金人论》以下至张衡《二京赋》,其实并非为“迁都”争议而作,可称作“迁都话题”赋。在已经作为一个“话题”出现的京都赋中,其结构、内容、形式、语言上都有一定的模拟沿袭现象,呈现出明显的“文本模拟”痕迹。班固《两都赋》,被范晔《后汉书》与萧统《文选》分别收录,性质上已经发生了从“史”到“文”的变化。《两都赋》“文学”经典化的真正开始,即肇始于萧统编纂《文选》并以《两都赋》为首篇。

关键词：迁都争议迁都话题《论都赋》《两都赋》《二京赋》

Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 466-476页

作者： Yongdong Niu shaohua fan Qin Luo Liming Chen Danmei Huang Wenjun Chang Wenxin Qin Ganggang Shi Department of Pharmacology Shantou University Medical CollegeShantouGuangdongChina Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province School of Life ScienceJiangsu Normal UniversityXuzhouJiangsuChina State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Oncology First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdongChina Department of Environmental Hygiene Second Military Medical UniversityShanghaiChina

Background and Aims:Hepatitis B virus(HBV)infection has been found to increase hepatocellular sensitivity to carcinogenic xenobiotics,by unknown mechanisms,in the generation of hepatocellular carcinoma.The pregnane X receptor(PXR)is a key regulator of the body’s defense against xenobiotics,including xenobiotic carcinogens and clinical drugs.In this study,we aimed to investigate the molecular mechanisms of HBV X protein(HBx)-PXR signaling in the synergistic effects of chemical carcinogens in HBV-associated hepatocarcinogenesis.Methods:The expression profile of PXR-cytochrome p4503A4(CYP3A4)signaling was determined by PCR,western blotting,and tissue microarray.Cell viability and aflatoxin B1(AFB1)cytotoxicity were measured using the cell counting kit-8 assay.Target gene expression was evaluated using transient transfection and real time-PCR.The genotoxicity of AFB1 was assessed in newborn mice with a single dose of AFB1.Results:HBx enhanced the hepatotoxicity of AFB1 by activating CYP3A4 and reducing glutathione Stransferase Mu 1(GSTM1)in cell lines.Activation of PXR by pregnenolone 16α-carbonitrile increased AFB1-induced liver tumor incidence by up-regulating oncogenic KRAS to enhance interleukin(IL)-11:IL-11 receptor subunit alpha-1(IL11RA-1)-mediated inflammation in an HBx transgenic model.Conclusions:Our finding regarding AFB1 toxicity enhancement by an HBx-PXR-CYP3A4/GSTM1-KRASIL11:IL11RA signaling axis provides a rational explanation for the synergistic effects of chemical carcinogens in HBV infection-associated hepatocarcinogenesis.

关键词： Liver cancer Hepatitis B virus X protein Pregnane X receptor Aflatoxin B1 Hepatotoxicity

Development of a Self-Recording Per-Minute Precipitation Dataset for China

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Journal of Meteorological Research 2019年第6期33卷 1157-1167页

作者： Xiaohui JU Shaoping HUANG Changjun LI Jun LI Yunjian ZHAN shaohua fan National Meteorological Information Center China Meteorological AdministrationBeijing 100081 Jiangxi Meteorological Information Center Nanchang 330096 Shandong Meteorological Information Center Jinan 250031 Department of Forecasting and Networking China Meteorological AdministrationBeijing 100081

The establishment of self-recording precipitation observation systems in China began in 1951,and strips of self-recording precipitation graph paper have been archived since then.More than 9 million sheets of self-recording graph paper from 2253 stations in 31 provinces have been digitized by using image scanning and curve extraction technology.Format specification and quality control have been applied to the digitized data,and the China Surface Self-Recording Per-Minute Precipitation Dataset(V1.0)has been developed.The integrity and accuracy of this dataset are evaluated.This is the first attempt in China to establish a per-minute precipitation dataset that covers the period from1951 to present.Preliminary evaluation reveals that the station density is high and the data continuity is good in most areas of China.However,the integrity of stations in some areas of western China is relatively poor.The availability rate and accuracy rate in summer are higher than 99%at most stations,with the overall availability and accuracy rates reaching as much as 99.42%and 99.22%,respectively.

关键词： precipitation recording paper siphon rain gauge tipping bucket rain gauge digitalization curve extraction per-minute precipitation data datasets

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护理领域系统评价的报告要素与问题分析

中华护理杂志 2024年第3期59卷 281-286页

作者：范蕾宋继红陈少华杨辛茹赵亚曼吴杰灵福建医科大学护理学院福州市350122

系统评价通过全面而系统地收集现有证据,采用临床流行病学方法,严格评价证据质量,定性或定量地合并研究结果,最终为解决某一聚焦的临床问题提供可靠依据。护理类系统评价论文发表数量不断增长,但是报告质量参差不齐。该文总结护理类系... 详细信息

系统评价通过全面而系统地收集现有证据,采用临床流行病学方法,严格评价证据质量,定性或定量地合并研究结果,最终为解决某一聚焦的临床问题提供可靠依据。护理类系统评价论文发表数量不断增长,但是报告质量参差不齐。该文总结护理类系统评价的报告要素,围绕其关键步骤,参考报告规范,分析系统评价报告中的常见问题,以期为护理研究者提供参考。

关键词：系统评价 PRISMA清单报告规范护理

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甲状旁腺癌与甲状旁腺腺瘤的超声鉴别诊断

郑州大学学报（医学版） 2024年第1期59卷 130-133页

作者：张晓鸽樊玉霞滑少华郑州大学第一附属医院超声医学科郑州450052 郑州大学第一附属医院甲状腺外科郑州450052

目的:分析超声鉴别甲状旁腺癌和甲状旁腺腺瘤的价值。方法:回顾性分析2016年1月至2021年12月于郑州大学第一附属医院经手术切除明确诊断的甲状旁腺肿瘤患者的临床资料,其中甲状旁腺癌21例,腺瘤27例。比较两组的超声征象。结果:甲状旁腺... 详细信息

目的:分析超声鉴别甲状旁腺癌和甲状旁腺腺瘤的价值。方法:回顾性分析2016年1月至2021年12月于郑州大学第一附属医院经手术切除明确诊断的甲状旁腺肿瘤患者的临床资料,其中甲状旁腺癌21例,腺瘤27例。比较两组的超声征象。结果:甲状旁腺癌组男性患者比例高于腺瘤组,右下病变占比低于腺瘤组,超声回声为囊实性、血流为3级、有钙化的患者比例高于腺瘤组(P<0.05)。超声对甲状旁腺癌和腺瘤鉴别诊断的敏感度为85.71%,特异度为74.07%,约登指数为0.60。结论:超声检查对甲状旁腺癌及腺瘤具有一定的鉴别诊断价值。

关键词：甲状旁腺癌甲状旁腺腺瘤超声检查鉴别诊断

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蜂蜜抗炎作用的研究进展

食品工业科技 2024年第14期45卷 426-434页

作者：朱文振范营营谢绍华朱艳萍玄红专聊城大学生命科学学院山东聊城252059 聊城市人民医院儿科山东聊城252000

蜂蜜是由蜜蜂生产的天然产物,长期以来作为食品在世界范围内被人们普遍食用。蜂蜜具有抗炎作用,这与蜂蜜的抗菌和抗氧化功能是密切相关的。对蜂蜜抗炎功能的探究涉及两个方面:一方面基础研究探索蜂蜜生物学功能的分子机制并明确有效成分... 详细信息

蜂蜜是由蜜蜂生产的天然产物,长期以来作为食品在世界范围内被人们普遍食用。蜂蜜具有抗炎作用,这与蜂蜜的抗菌和抗氧化功能是密切相关的。对蜂蜜抗炎功能的探究涉及两个方面:一方面基础研究探索蜂蜜生物学功能的分子机制并明确有效成分;另一方面则通过临床研究评估蜂蜜对炎症性疾病的改善效果。基础研究揭示了蜂蜜发挥抗炎作用的关键有效成分,并进一步阐明了相关的分子机制。蜂蜜的抗炎功能与其含有的黄酮类化合物、酚酸、葡萄糖氧化酶、过氧化氢和甲基乙二醛密切相关,这些有效成分主要通过调控免疫细胞功能、调节炎症细胞因子水平、抑制致病菌生长和抗氧化而发挥作用。蜂蜜能减轻消化道炎症、改善肠道菌群、缓解慢性鼻窦炎症状以及预防和治疗放射性口腔炎。本文以近5年蜂蜜相关的研究为主,综述了蜂蜜抗炎作用的机制和关键有效成分的功能,以及目前蜂蜜在炎症性疾病领域的应用。

关键词：蜂蜜抗炎活性机制成分炎症性疾病