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Expert consensus on the diagnosis and therapy of endo-periodontal lesions

International Journal of Oral Science 2024年第3期16卷 381-389页

作者： Bin Chen Yanan Zhu Minkui Lin Yangheng Zhang Yanfen Li Xiangying Ouyang Song ge Jiang Lin Yaping Pan Yan Xu Yi Ding shaohua ge Faming Chen Zhongchen Song Shaoyun Jiang Jiang Sun Lijun Luo Junqi Ling Zhi Chen Lin Yue Xuedong Zhou Fuhua Yan Department of Periodontology Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina Department of Endodontics Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province&Fujian Key Laboratory of Oral Diseases&Fujian Provincial Engineering Research Center of Oral Biomaterial School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Periodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina School and Hospital of Stomatology Zunyi Medical UniversityZunyiChina Department of Stomatology Beijing TongRen HospitalCapital Medical UniversityBeijingChina Department of Periodontics School and Hospital of StomatologyChina Medical UniversityShenyangChina Department of Periodontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityJiangsu Key Laboratory of Oral DiseasesNanjing Medical UniversityNanjingChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Periodontics West China Hospital of StomatologySichuan UniversityChengduChina Department of Periodontology School and Hospital of StomatologyShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral Diseases JinanJinanChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesDepartment of periodontologySchool of StomatologyThe Fou

Endo-periodontal lesions (EPLs) involve both the periodontium and pulp tissue and have complicated etiologies and pathogenic mechanisms,including unique anatomical and microbiological characteristics and multiple contributing *** etiological complexity leads to difficulties in determining patient prognosis,posing great challenges in clinical ***,EPL-affected teeth require multidisciplinary therapy,including periodontal therapy,endodontic therapy and others,but there is still much debate about the appropriate timing of periodontal therapy and root canal *** compiling the most recent findings on the etiology,pathogenesis,clinical characteristics,diagnosis,therapy,and prognosis of EPL-affected teeth,this consensus sought to support clinicians in making the best possible treatment decisions based on both biological and clinical evidence.

关键词： diagnosis periodontal lesions

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Enhanced multifunctional liquid metal-based hydrogels with vinyl silica nanoparticles for advanced strain sensing applications

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Science China Materials 2024年第10期67卷 3309-3320页

作者： Bingyan Wang Wenxia Liu Zhaoping Song Guodong Li Dehai Yu Xiaona Liu Huili Wang shaohua ge State Key Laboratory of Biobased Materials and Green Papermaking Qilu University of TechnologyShandong Academy of ScienceJinan 250353China Department of Periodontology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinan 250012China

Conductive hydrogels have garnered considerable interest for their applications in wearable electronic skins,owing to their superior ***,challenges persist,including low sensitivity,poor cyclic stability,and limited tolerance to extreme *** study develops a novel liquid metal-based conductive hydrogel with a dual cross-linked polyacrylic acid(PAA)matrix,employing both“soft”coordination and“hard”covalent cross-linking *** hybrid network is formulated using guar gum(GG)-stabilized gallium(Ga)droplets,which catalyze the copolymerization of vinyl-hybrid silica nanoparticles(VSNPs)and acrylic acid(AA).The resultant Ga3+ions interact with carboxyl groups in the PAA,forming soft coordination links that enhance the hydrogel’s rapid *** incorporation of VSNPs significantly enhances the hydrogel’s elasticity,toughness,and low-temperature resilience without ***,its intrinsic moldability,adhesion,and self-healing properties are *** as a strain sensor,this hydrogel demonstrates a high gauge factor(GF)of 17.4,responsive time of 250 ms for both activation and recovery,an ultra-low detection limit of 0.1%,and excellent durability over 800 cycles at 100%***-term immersion in a glycerol solution(20 min)further augments its stretchability to 2688%and GF to 28.1 across a strain range of 1325%–1450%,broadening its operational ranges to 0–1450%at−18°*** exposure(4 h)also improves water retention and high-temperature resistance,making this hydrogel a promising material for sustainable,high-performance wearable electronics.

关键词： vinyl silica nanoparticles liquid metals guar gum hydrogel strain sensor

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下调G蛋白偶联受体C家族5A表达抑制脂多糖诱导的人牙龈成纤维细胞炎症反应

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中华口腔医学杂志 2024年第4期59卷 344-353页

作者：胡芋含商玲玲葛少华山东大学齐鲁医学院口腔医学院·口腔医院牙周科、山东省口腔组织再生重点实验室口腔生物材料与组织再生山东省工程研究中心、山东省口腔疾病临床医学研究中心济南250012

目的探究下调G蛋白偶联受体C家族5A(GPRC5A)表达对脂多糖诱导的人牙龈成纤维细胞(GFs)炎症反应的影响并探索其机制,为深入探讨G蛋白偶联受体(GPCR)在牙周炎中的调控作用及其机制奠定基础。方法于2022年12月至2023年2月在山东大学口腔医... 详细信息

目的探究下调G蛋白偶联受体C家族5A(GPRC5A)表达对脂多糖诱导的人牙龈成纤维细胞(GFs)炎症反应的影响并探索其机制,为深入探讨G蛋白偶联受体(GPCR)在牙周炎中的调控作用及其机制奠定基础。方法于2022年12月至2023年2月在山东大学口腔医学院·口腔医院口腔颌面外科、牙周科收集3名牙周健康者(牙周健康组)和3例牙周炎患者(牙周炎组)的牙龈组织,采用免疫组化染色检测两组牙龈组织中GPRC5A的表达。收集健康牙龈组织提取GFs,健康牙龈组织来自2022年12月至2023年2月在山东大学齐鲁医学院口腔医学院·口腔医院口腔颌面外科招募的6例16~20岁需拔除埋伏阻生齿的患者。应用胶原酶消化法提取并培养GFs,设置30、50和80μmol/L浓度转染GPRC5A小干扰RNA(siGPRC5A)的实验组和阴性对照小干扰RNA(siNC),利用实时荧光定量PCR(RT-qPCR)检测siGPRC5A的沉默效率;设置阴性对照、脂多糖、siGPRC5A+脂多糖和siGPRC5A 4个组,通过RT-qPCR和蛋白质印迹法分别验证应用siGPRC5A对1 mg/L脂多糖诱导的GFs炎症状态下GPRC5A在基因和蛋白水平的表达;下调GPRC5A表达后,RT-qPCR检测脂多糖诱导的GFs白细胞介素(IL)-1β、IL-6、IL-8、肿瘤坏死因子-α(TNF-α)、前列腺素内过氧化物合酶2(PTGS2)基因的表达;通过蛋白质印迹法、免疫荧光染色检测核因子-κB(NF-κB)信号通路的激活情况。结果免疫组化结果显示,牙周炎组牙龈组织中GPRC5A表达(0.132±0.006)显著高于牙周健康组(0.036±0.019)(t=8.24,P=0.001)。RT-qPCR结果显示,在脂多糖作用2、6、12和24 h时,脂多糖组GPRC5A基因水平表达量(分别为0.026±0.002、0.042±0.005、0.004±0.000、0.016±0.000)均分别显著高于阴性对照组(分别为0.004±0.000、0.004±0.000、0.002±0.000、0.007±0.000)(均P<0.001),且6 h时达峰值。50μmol/L siGPRC5A(31.16±3.29)与siNC组(100.00±4.88)相比能有效沉默GFs中GPRC5A的表达(F=297.98,P<0.001)。RT-qPCR和蛋白质印迹法结果显示,脂多糖组GPRC5A在基因和蛋白水平的表达(分别为1.30±0.10、1.43±0.03)均显著高于阴性对照组(分别为1.00±0.01、1.00±0.00)(均P<0.001),siGPRC5A组(分别为0.27±0.03、0.71±0.00)均显著低于阴性对照组(分别为1.00±0.01、1.00±0.00)(均P<0.001),siGPRC5A+脂多糖组(分别为0.39±0.03、1.06±0.16)均显著低于脂多糖组(分别为1.30±0.10、1.43±0.03)(均P<0.001)。RT-qPCR结果显示,脂多糖组IL-8、IL-1β、IL-6、TNF-α、PTGS2基因表达水平均显著高于阴性对照组,siGPRC5A+脂多糖组均显著低于脂多糖组(均P<0.001)。蛋白质印迹法结果表明,脂多糖组p65和IκBα蛋白磷酸化水平均显著高于阴性对照组,而siGPRC5A+脂多糖组均显著低于脂多糖组(均P<0.01)。免疫荧光染色结果显示,对照组NF-κB p65集中表达于胞质,在脂多糖刺激下p65部分向核内转位,应用siGPRC5A后能一定程度上抑制脂多糖诱导的p65核内转位。结论GPRC5A在GFs炎症状态下表达增加,下调GPRC5A的表达能抑制脂多糖诱导的炎症反应,且GPRC5A可通过NF-κB信号通路发挥炎症调控的作用。

关键词：牙周炎 G蛋白偶联受体 G蛋白偶联受体C家族5A 核因子κB 炎症因子牙龈成纤维细胞

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一步一步做好舒适化牙周基础治疗

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中华口腔医学杂志 2024年第5期59卷 523-527页

作者：邵金龙吕春旭于洋葛少华山东大学口腔医学院·口腔医院牙周科、山东省口腔组织再生重点实验室、口腔生物材料与组织再生山东省工程研究中心、山东省口腔疾病临床医学研究中心济南250012

随着医学模式由传统的生物医学模式向社会-心理-生物医学模式转变,口腔操作的舒适化、无痛化、微创化和可视化成为现代医学发展的趋势和要求,人们对舒适化口腔治疗的需求也越来越高。牙周基础治疗操作中常伴随着疼痛,患者对疼痛的反应... 详细信息

随着医学模式由传统的生物医学模式向社会-心理-生物医学模式转变,口腔操作的舒适化、无痛化、微创化和可视化成为现代医学发展的趋势和要求,人们对舒适化口腔治疗的需求也越来越高。牙周基础治疗操作中常伴随着疼痛,患者对疼痛的反应从紧张到牙科恐惧症不等,可出现烦躁不安、过度换气甚至恶心呕吐、拒绝合作等表现,使治疗的实施变得困难甚至无法实施。本文从治疗前诊室布置、患者信任的获取和预防性镇静的实施,治疗过程中的舒适化操作及护理、心理干预措施、局部麻醉和镇静技术的使用,以及治疗后的健康教育和随访等方面,阐述如何一步一步做好舒适化牙周基础治疗。

关键词：镇痛麻醉牙科舒适化牙周基础治疗牙科恐惧症镇静

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Periodontitis may induce gut microbiota dysbiosis via salivary microbiota

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International Journal of Oral Science 2022年第3期14卷 349-359页

作者： Jun Bao Lili Li Yangheng Zhang Min Wang Faming Chen shaohua ge Bin Chen Fuhua Yan Department of Periodontology Nanjing Stomatological HospitalMedical School of Nanjing UniversityNo.30 Zhongyang RoadNanjingChina State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases Department of PeriodontologySchool of StomatologyFourth Military Medical UniversityXi’anChina Department of Periodontology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinanChina

The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary ***,faecal and salivary samples were collected from periodontally healthy participants(PH group,n=16)and patients with severe periodontitis(SP group,n=21)and analysed by 16S ribosomal RNA *** differences were observed in both the faecal and salivary microbiota between the PH and SP ***,more saliva-sourced microbes were observed in the faecal samples of the SP ***,the remaining salivary microbes were transplanted into C57BL6/J mice(the C-PH group and the C-SP group),and it was found that the composition of the gut microbiota of the C-SP group was significantly different from that of the C-PH group,with Porphyromonadaceae and Fusobacterium being significantly enriched in the C-SP *** the colon,the C-SP group showed significantly reduced crypt depth and zonula occludens-1 *** m RNA expression levels of pro-inflammatory cytokines,chemokines and tight junction proteins were significantly higher in the C-SP *** further investigate whether salivary bacteria could persist in the intestine,the salivary microbiota was stained with carboxyfluorescein diacetate succinimidyl ester and transplanted into *** found that salivary microbes from both the PH group and the SP group could persist in the gut for at least 24 ***,our data demonstrate that periodontitis may induce gut microbiota dysbiosis through the influx of salivary microbes.

关键词： Periodontitis may induce gut microbiota dysbiosis via salivary microbiota

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Dimethyloxallyl glycine/nanosilicates-loaded osteogenic/angiogenic difunctional fibrous structure for functional periodontal tissue regeneration

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Bioactive Materials 2021年第4期6卷 1175-1188页

作者： Lingling Shang Ziqi Liu Baojin Ma Jinlong Shao Bing Wang Chenxi Ma shaohua ge Department of Periodontology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue RegenerationJinanShandong250012China

The coupled process of osteogenesis-angiogenesis plays a crucial role in periodontal tissue *** various cytokines or chemokines have been widely applied in periodontal in situ tissue engineering,most of them are macromolecular proteins with the drawbacks of short effective half-life,poor stability and high cost,which constrain their clinical *** study aimed to develop a difunctional structure for periodontal tissue regeneration by incorporating an angiogenic small molecule,dimethyloxalylglycine(DMOG),and an osteoinductive inorganic nanomaterial,nanosilicate(nSi)into poly(lactic-co-glycolic acid)(PLGA)fibers by *** physiochemical properties of DMOG/nSi-PLGA fibrous membranes were ***,the effect of DMOG/nSi-PLGA membranes on periodontal tissue regeneration was evaluated by detecting osteogenic and angiogenic differentiation potential of periodontal ligament stem cells(PDLSCs)in ***,the fibrous membranes were transplanted into rat periodontal defects,and tissue regeneration was assessed with histological evaluation,micro-computed tomography(micro-CT),and immunohistochemical ***/nSi-PLGA membranes possessed preferable mechanical property and *** seeded on the DMOG/nSi-PLGA membranes showed up-regulated expression of osteogenic and angiogenic markers,higher alkaline phosphatase(ALP)activity,and more tube formation in comparison with single ***,in vivo study showed that the DMOG/nSi-PLGA membranes promoted recruitment of CD90+/CD34􀀀stromal cells,induced angiogenesis and osteogenesis,and regenerated cementum-ligament-bone complex in periodontal ***,the combination of DMOG and nSi exerted admirable effects on periodontal tissue ***/nSi-PLGA fibrous membranes could enhance and orchestrate osteogenesis-angiogenesis,and may have the potential to be translated as an effective scaffold in periodontal tissue engineering.

关键词： Periodontal tissue regeneration DMOG Nanosilicate Osteogenesis-angiogenesis coupling Electrospinning

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Single‑cell sequencing reveals the reproductive variations between primiparous and multiparous Hu ewes

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Journal of Animal Science and Biotechnology 2024年第2期15卷 614-631页

作者： Ting ge Yifan Wen Bo Li Xiaoyu Huang shaohua Jiang Enping Zhang Key Laboratory of Animal genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China

Background In the modern sheep production systems,the reproductive performance of ewes determines the economic profitability of *** the genetic mechanisms underlying differences in the litter size is important for the selection and breeding of highly prolific *** sheep,a high-quality Chinese sheep breed,is known for its high fecundity and is often used as a model to study prolificacy *** the current study,animals were divided into two groups according to their delivery rates in three consecutive lambing seasons(namely,the high and low reproductive groups with≥3 lambs and one lamb per season,n=3,respectively).The ewes were slaughtered within 12 h of estrus,and unilateral ovarian tissues were collected and analyzed by 10×genomics single-cell RNA *** A total of 5 types of somatic cells were identified and corresponding expression profiles were mapped in the ovaries of each ***,the differences in the ovary somatic cell expression profiles between the high and low reproductive groups were mainly clustered in the granulosa ***,four granulosa cell subtypes were *** analysis revealed that the abundance of JPH1 expression and the reduction of LOC101112291 expression could lead to different evolutionary directions of the granulosa ***,the expression levels of FTH1 and FTL in mural granulosa cells of the highly reproductive group were significantly *** genes inhibit necroptosis and ferroptosis of mural granulosa cells,which helps prevent follicular *** This study provides insights into the molecular mechanisms underlying the high fecundity of Hu *** differences in gene expression profiles,particularly in the granulosa cells,suggest that these cells play a critical role in female *** findings also highlight the importance of genes such as JPH1,LOC101112291,FTH1,and FTL in regulating granulosa cell function and follicular development.

关键词： Granulosa cells Hu sheep Lambing number Ovarian somatic cells Single-cell RNA sequencing

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Stem cell microencapsulation maintains stemness in inflammatory microenvironment

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International Journal of Oral Science 2022年第4期14卷 549-560页

作者： Yajun Zhao Yilin Shi Huiqi Yang Mengmeng Liu Lanbo Shen Shengben Zhang Yue Liu Jie Zhu Jing Lan Jianhua Li shaohua ge Department of Implantology&Periodontology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral DiseasesJinanChina Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi'an Jiaotong UniversityXi'anChina Airong Plastic Surgery Hospital JinanChina

Maintaining the stemness of the transplanted stem cell spheroids in an inflammatory microenvironment is challenging but important in regenerative medicine. Direct delivery of stem cells to repair periodontal defects may yield suboptimal effects due to the complexity of the periodontal inflammatory environment. Herein, stem cell spheroid is encapsulated by interfacial assembly of metal-phenolic network(MPN) nanofilm to form a stem cell microsphere capsule. Specifically, periodontal ligament stem cells(PDLSCs) spheroid was coated with FeⅢ/tannic acid coordination network to obtain spheroid@[FeⅢ-TA] microcapsules. The formed biodegradable MPN biointerface acted as a cytoprotective barrier and exhibited antioxidative, antibacterial and anti-inflammatory activities, effectively remodeling the inflammatory microenvironment and maintaining the stemness of PDLSCs. The stem cell microencapsulation proposed in this study can be applied to multiple stem cells with various functional metal ion/polyphenol coordination, providing a simple yet efficient delivery strategy for stem cell stemness maintenance in an inflammatory environment toward a better therapeutic outcome.

关键词： inflammatory protective maintain

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Biochar contributes to resistance against root rot disease by stimulating soil polyphenol oxidase

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Biochar 2023年第1期5卷 959-975页

作者： shaohua ge Jian Gao Dong Chang Tianyi He Heqing Cai Maoxian Wang Caibin Li Zhenbao Luo Yang E Jun Meng Mingxuan Gao National Biochar Institute of Shenyang Agricultural University Shenyang 110866China Key Laboratory of Biochar and Soil Improvement Ministry of Agriculture and Rural AffairsShenyang 110866People’s Republic of China Pingdingshan Tobacco Company of Henan Province Pingdingshan 467000HenanChina Bijie Tobacco Company of Guizhou Province Bijie 551700GuizhouChina

Biochar has been considered an effective approach as soil amendment for decreasing incidences of disease and regulating microbial populations in continuous-cropping *** researches have extensively focused on changes of soil microbes and unbalance of nutrition in continuous-cropping soil,the relationship between soil properties and pathogens by biochar application remains poorly *** this study,we applied ITS ribosomal RNA gene profiling to analyze tobacco root microbiota of biochar and non-biochar treatment in a 3-year continuous-cropping tobacco field,comparing firstly planting tobacco as *** found that biochar application decreased the relative abundance of the soil fungal pathogens(Ceratobasidium and Monosporascus),which are the prime pathogens of tobacco root rot in continuous-cropping *** RDA,co-occurrence and PLS-PM approaches,we provided evidence that there was a negative correlation between fungal genera(especially for Ceratobasidium and Monosporascus)and soil polyphenol oxidase(PPO)activity(R^(2)_(incidence rate)=−0.930,R^(2)_(disease index)=−0.905,both pgens,and further decrease incidence of root ***,biochar application forward continuous cropping was more effective for the continuous-cropping soil improvement than the other *** data should help in appropriate timing of biochar application for alleviating continuous-cropping obstacle.

关键词： Continuous-cropping soil Tobacco Root rot Biochar

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Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin4-yl)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as an orally active antitumor agent

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Acta Pharmaceutica Sinica B 2024年第2期14卷 893-896页

作者： Mingwei Fu Min ge Wanxiang Yang Chunchen Hu Xiaowei Li Yuanjiang Wang shaohua Gou Pharmaceutical Research Center and School of Chemistry and Chemical Engineering Southeast UniversityNanjing 211189China Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research Southeast UniversityNanjing 211189China Zenji Research Laboratories Nanjing 211189China

To the Editor:Kinase cell division cycle 7(CDC7),a cell division cycle protein,takes a vital role in mediating DNA ***7 complexes in the nucleus can phosphorylate the minichromosome maintenance complex(MCM)family members that bind to *** addition,CDC7 kinase,as a molecular switch regulating DNA replication,can mediate DNA damage signaling pathways to stimulate cell cycle termination as well as DNA *** have shown that CDC7 is overexpressed in many types of cancer cells,and its overexpression was related to poor patient survival,tumor grade,genetic instability,aneuploidy and so ***,CDC7 is a promising target for antitumor therapy.

关键词： Cell division cycle 7 DNA replication CDC7 inhibitor Anti-tumor

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