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The zone-particle model for building fire simulation

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Chinese Science Bulletin 2010年第26期55卷 3060-3065页

作者： guo shaodong YANG Rui ZHANG Hui Center for Public Safety Research Department of Engineering Physics Tsinghua University Beijing 100084 China Department of Engineering Mechanics School of Aerospace Tsinghua University Beijing 100084 China

An effective fire and smoke propagation model is important for evaluating building safety, indicating safe rescue paths in emergencies, and determining proper control strategies. In this paper, a new model to simulate smoke propagation and to characterize mixing behavior is developed. In this model, a function considering the mixing behavior between the hot smoke and cool air is introduced to better resolve the temperature and smoke profiles in the vertical direction. Smoothed particle hydrodynamics (SPH) approach is used to obtain the function distribution through reconstructing velocities of marker particles and determining locations of particles in each layer in the zone model. The fundamentals of the model are presented in detail in this paper. A test (a simple building with experimental data and CFD simulation) is used to verify the model, in which experimental data and CFD simulations are compared to predictions from the new model and those from a two-layer model implemented using CFAST (Consolidated Model of Fire and Smoke Transport, developed by NIST). Favorable agreement of the new model results is seen with experiment data or CFD simulations. The new model also provides more accurate prediction of temperature distribution in comparison to the two-layer model.

关键词：建筑物安全粒子模型火灾模拟 CFD模拟实验数据空气混合分布预测流体动力学

Novel gene expressed during early embryogenesis of zebrafish identified by mRNA differential display

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Chinese Science Bulletin 1998年第11期43卷 936-940页

作者： Li Shuhong guo shaodong Sun Fangzhen Inst Dev Biol Beijing 100080 Peoples R China

Following the revelation of the molecular mechanism of morphogenesis in fruitfly, research on the molecular mechanism of morphogenesis in vertebrate becomes the focus of developmental biology. The isolation of genes controlling the embryogenesis of zebrafish, a vertebrate model animal, is considered as an initial step toward investigating this issue. There are several approaches that can be used to isolate developmental genes, each of which is suited to a particular situation. In this note, mRNA differential display was utilized to demonstrate the mRNA differences among zebrafish embryos at 4, 5 and 6 h post fertilization (28.5℃, corresponding to oblong, dome and shield stages, respectively, called blastula, gastrula and neurula in this note). One cDNA tag that was specific to embryos at neurula stage was cloned and sequenced. After sequence comparison in Genbank, we found that this cDNA tag represents a novel gene. The expression of this gene in the developing zebrafish embryos was examined by whole mount in situ hybridization. The hybridization results confirmed that this gene was specifically expressed in zebrafish neurula embryos.

关键词： mRNA differential display zebrafish morphogenesis gene.

Expression pattern of a β_2 tubulin gene in zebrafish embryos identified by whole mount in situ hybridization

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Chinese Science Bulletin 1998年第22期43卷 1894-1898页

作者： LI Shuhong, guo shaodong and SUN Fangzhen Institute of Developmental Biology, Chinese Academy of Sciences, Beijing 100080, China Institute of Developmental Biology Chinese Academy of Sciences Beijing China

Zebrafish is a good vertebrate model for development studies. Research on gene expression and regulation during zebrafish embryonic development plays an important role in revealing the molecular mechanism of morphogenesis in vertebrate. Tubulin locates the cytoplasmic determinants in eggs, organizes the formation of basic cytoskeleton and controls various cell movements. There are several types of tubulin, each of which has specific expression regions and functions. In this study, the full_length cDNA of a Xenopus β 2 tubulin was used as template to generate Dig_labeled antisense RNA which was used as a probe to carry out in situ hybridization on whole mount zebrafish embryos. Under the experimental conditions, the tubulin transcript was first detected in a group of cells in embryos at the midblastula stage. With the development of the embryo, this transcript was gradually restricted to the nervous system. These results demonstrate that the expression of this β 2 tubulin gene in zebrafish embryos is neural specific.

关键词： tubulin gene whole mount in situ hybridization zebrafish.

Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin

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World Journal of Diabetes 2021年第10期12卷 1750-1764页

作者： Qiong Wei Jong Han Lee Chia-Shan Wu Qun S Zang shaodong guo Hui-Chen Lu Yuxiang Sun Department of Endocrinology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210009Jiangsu ProvinceChina Department of Pediatrics USDA/ARS Children’s Nutrition Research CenterBaylor College of MedicineHoustonTX 77030United States Department of Marine Bioindustry Hanseo UniversitySeosan 31962South Korea Department of Nutrition Texas A and M UniversityCollege StationTX 7743United States Department of Surgery Stritch School of MedicineLoyola University Chicago Health Science CampusMaywoodIL 60153United States Department of Psychological and Brain Sciences Linda and Jack Gill Center of for Biomolecular ScienceBloomingtonIN 47405United States

BACKGROUND Antagonists of cannabinoid type 1 receptor(CB1)have been shown to promote body weight loss and improve insulin *** decrease adiponectin,and CB1 blocker increase ***,the mediators of CB1 actions are not well *** To investigate whether the beneficial effects of CB1 inhibition are,at least in part,mediated by *** We compared metabolic and inflammatory phenotypes of wild-type(WT)mice,CB1-null(CB1^(-/-))and CB1/adiponectin double-knockout(DKO)*** assessed the insulin sensitivity using insulin tolerance test and glucose tolerance test,and inflammation using flow cytometry analysis of *** CB1^(-/-)mice exhibited significantly reduced body weight and fat mass when compared to WT *** no significance was found in total daily food intake and locomotor activity,CB1^(-/-)mice showed increased energy expenditure,enhanced thermogenesis in brown adipose tissue(BAT),and improved insulin sensitivity compared to WT *** showed no difference in body weight,adiposity,nor insulin sensitivity;only showed a modestly elevated thermogenesis in BAT compared to CB1^(-/-)*** metabolic phenotype of DKO is largely similar to CB1^(-/-)mice,suggesting that adiponectin is not a key mediator of the metabolic effects of ***,CB1^(-/-)mice showed reduced pro-inflammatory macrophage polarization in both peritoneal macrophages and adipose tissue macrophages compared to WT mice;in contrast,DKO mice exhibited increased pro-inflammatory macrophage polarization in these macrophages compared to CB1^(-/-)mice,suggesting that adiponectin is an important mediator of the inflammatory effect of *** Our findings reveal that CB1 functions through both adiponectin-dependent and adiponectin-independent mechanisms:CB1 regulates energy metabolism in an adiponectin-independent manner,and inflammation in an adiponectin-dependent *** differential effects of adiponectin on CB1-mediated m

关键词： Cannabinoid type 1 receptor Adiponectin Thermogenesis Macrophages Inflammation Insulin resistance

组织特异性胰岛素抵抗及其代谢综合征的机制探讨

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第三军医大学学报 2014年第15期36卷 1535-1542页

作者：郭绍东 Division of Molecular Cardiology Department of MedicineCollege of MedicineTexas A&M University Health Science Center

肥胖、高血糖、高血脂和高血压症候群等被定义为“胰岛素抵抗综合征”或“X综合征”，与心血管疾病的高发病率和高病死率密切相关。早在1988年，“代谢综合征”（metabolicsyndrome，MeS）即被美国内分泌专家Reaven提出，此后，许多国... 详细信息

肥胖、高血糖、高血脂和高血压症候群等被定义为“胰岛素抵抗综合征”或“X综合征”，与心血管疾病的高发病率和高病死率密切相关。早在1988年，“代谢综合征”（metabolicsyndrome，MeS）即被美国内分泌专家Reaven提出，此后，许多国家和学术组织先后制定了各自的MeS临床诊断标准并不断更新。2009年，全世界对MeS的临床诊断标准达成了共识，

关键词：胰岛素抵抗代谢综合征胰岛素受体底物1,2 核转录因子FOXO1

微藻生物强化对藻-菌颗粒污泥的形成影响及污染物去除研究

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环境科学研究 2022年第3期35卷 761-767页

作者：肖亚兵张雪纯季斌樊杰郭绍东武汉科技大学城市建设学院湖北武汉430065

为了探究微藻强化好氧颗粒污泥(aerobic granular sludge,AGS)方式培养藻-菌颗粒污泥(microalgal-bacterial granular sludge,MBGS)的可行性及其关键藻种的潜在作用机理,分别向序批式光生物反应器(光强4000 lx)中投加小球藻(R1反应器),... 详细信息

为了探究微藻强化好氧颗粒污泥(aerobic granular sludge,AGS)方式培养藻-菌颗粒污泥(microalgal-bacterial granular sludge,MBGS)的可行性及其关键藻种的潜在作用机理,分别向序批式光生物反应器(光强4000 lx)中投加小球藻(R1反应器),小球藻和斜生栅藻(R2反应器),小球藻、斜生栅藻和鲍氏细鞘丝藻(R3反应器),并对形成的MBGS理化特性、污染物去除及微生物群落结构进行系统研究.结果表明:①MBGS均能在30 d左右形成,其稳态下的污染物去除总体优于AGS,对COD、NH_(4)^(+)-N、TN和TP的平均去除率分别在98%、97%、77%和93%以上,且R2、R3反应器对NH_(4)^(+)-N、TP的去除率显著高于R1反应器(P<0.05).②胞外聚合物(EPS)分析表明,与R1反应器相比,R2、R3反应器具有更多的芳香蛋白、可溶性微生物副产物、腐殖酸、类富里酸等成分,有利于MBGS的形成.③R3反应器中鲍氏细鞘丝藻被淘汰,形成了与R2反应器主要藻种类似的MBGS.④R1、R2和R3反应器稳态下具有硝化螺旋菌门(Nitrospirae)和红环菌科(Rhodocyclaceae)等脱氮除磷功能微生物.研究显示,在微藻生物强化形成MBGS的过程中,斜生栅藻可能起到重要作用,提高了氮、磷的去除率,并有利于维持MBGS的稳定性.

关键词：藻-菌颗粒污泥生物强化污染物去除斜生栅藻微生物群落

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山西省沿黄地区生态综合指数评价及时空变化

应用生态学报 2023年第12期34卷 3385-3392页

作者：郭少东王晓军王宁董秀丽付勇勇山西大学环境与资源学院太原030006 山西山川河原环境科技有限公司太原030006 山西财经大学资源环境学院太原030006

生态综合指数可以定量化、可视化地分析一个地区生态环境质量的时空变化特征。本研究以山西省沿黄地区为研究区域,基于2001、2005、2010、2015和2020年5期MODIS卫星数据获取的植被覆盖度、叶面积指数、总初级生产力、陆地表面温度和湿度... 详细信息

生态综合指数可以定量化、可视化地分析一个地区生态环境质量的时空变化特征。本研究以山西省沿黄地区为研究区域,基于2001、2005、2010、2015和2020年5期MODIS卫星数据获取的植被覆盖度、叶面积指数、总初级生产力、陆地表面温度和湿度5项指标,耦合构建生态综合指数(K),并引入主成分分析与空间自相关方法分析2001—2020年山西省沿黄地区生态质量时空变化特征。结果表明:2001—2020年,研究区K均值由0.3354增长至0.4389,沿黄地区生态质量整体提高,但生态质量呈现明显的时空变化特征。在大尺度上呈现“南优北差”的格局,小尺度上丘陵与山地也存在差异;时间上呈现不断向好的趋势但变化速率不同,南部向好趋势强于北部地区。2001—2020年间,K值的全局Moran I值均大于0.93,表明山西省沿黄地区生态质量具有较强的空间相关性。空间集聚类型主要表现为高-高和低-低集聚,高-高集聚区域主要呈块状分布在南部,而低-低集聚区域主要集中连片分布在北部。研究期间,山西省沿黄地区的生态质量得到极大提高,但仍有明显的空间异质性,需要继续加强生态保护。

关键词：生态环境质量生态综合指数空间自相关山西省沿黄地区

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电解活化过一硫酸盐改善污泥过滤及破解效能

华中科技大学学报（自然科学版） 2020年第4期48卷 7-11页

作者：郭绍东王健季斌谢世伟武汉科技大学城市建设学院湖北武汉430065

以铁棒(零价铁)为阴阳电极,通过电解活化过一硫酸盐(PMS)用于改善污泥的过滤及破解效能.结果表明:在电解活化PMS处理污泥过程中,当电流为0.2 A,1 g干污泥(DS)投加130 mgPMS时,显著降低污泥的毛细吸吮时间,降幅达到43.8%,同时破坏胞外聚... 详细信息

以铁棒(零价铁)为阴阳电极,通过电解活化过一硫酸盐(PMS)用于改善污泥的过滤及破解效能.结果表明:在电解活化PMS处理污泥过程中,当电流为0.2 A,1 g干污泥(DS)投加130 mgPMS时,显著降低污泥的毛细吸吮时间,降幅达到43.8%,同时破坏胞外聚合物质(EPS)和污泥细胞;污泥中的紧密束缚型胞外聚合物质(TB-EPS)转化为溶解型胞外聚合物质(S-EPS),导致TB-EPS中1 g挥发性悬浮固体产生的总有机碳从14.09 mg降到8.08 mg,S-EPS中1 g挥发性悬浮固体产生的总有机碳从1.74 mg升高到6.50 mg;S-EPS和TB-EPS中蛋白质和多糖含量变化趋势与总有机碳类似;三维荧光激发-发射矩阵光谱图显示TB-EPS中蛋白质类物质变化明显.

关键词：污泥过滤性能污泥破解电解过一硫酸盐胞外聚合物质

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管理会计与财务会计的关系探讨

生产力研究 2009年第12期 178-180页

作者：郭少东周萍重庆电子工程职业学院重庆401331

管理会计与财务会计既有联系也有区别,对其进行一种梳理与研究具有重要的意义。文章通过对管理会计与财务会计的全面分析比较,对两者的联系和区别进行了定位与明确,以期加深对管理会计与财务会计的理解。

关键词：管理会计财务会计联系与区别