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Effect of niobium content on irradiation microstructure and hardening in FeCrAl-based alloys

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Journal of Materials Science & Technology 2021年第36期95卷 181-192页

作者： Xiong Zhou Hui Wang Liping Guo Yiheng Chen Fang Li Yunxiang Long Cheng Chen Ziyang Xie Hongtai Luo shaobo mo Hubei Nuclear Solid Physics Key Laboratory Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education and School of Physics and TechnologyWuhan UniversityWuhan 430072China Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of ChinaChengdu 610041China School of Mechanical Engineering Chengdu UniversityChengdu 610106China Analysis and Testing Center of Wuhan University Wuhan UniversityWuhan 430072China

Iron-chromium-aluminum(FeCrAl)alloys with different content of niobium(Nb)—0,0.4 wt%,0.8 wt%,and 1.2 wt%—were designed and *** samples were then irradiated with 2.4 MeV Fe^(2+)ion to the dose of 1 and 15 displacements per atom(dpa)at 400℃.The formations of dislocation loops induced by self-ion irradiation in these alloys were investigated by transmission electron microscopy(TEM).Nano-indentation tests were used to assess the hardness and irradiation hardening of *** the samples before irradiation,the(Fe,Cr)_(2)(Nb,mo)Laves phases density and the nano-indentation hardness increased with increasing Nb content of the *** irradiation to 1 and 15 dpa,both of a/2and adislocation loops were produced but no voids orα’phase were found in all *** increasing Nb content of the samples,the size of dislocation loops increased first and then decreased,while the total volume number density decreased and then *** fraction of adislocation loops increased first and then decreased with increasing Nb content,and increased with increasing irradiation *** networks and the amorphization of the Laves phases were observed in the samples with irradiation dose of 15 *** hardening of Nb free samples was two to four times that of Nb containing samples,and the irradiation hardening increased with increasing Nb content of Nb containing *** experimental results indicate that the increase of Nb content in Fe Cr Al alloys can increase the density of Laves phases,leading to the decrease of mo content and increase of Cr content in the *** competition between the two types of solutes affects the nucleation and growth of the dislocation loops.

关键词： FeCrAl alloy Dislocation loops Radiation damage Accident tolerant fuel cladding Laves phase

Study　of　Experimental　Electronic　Structure　of　Bidimensional　Semiconductor　Red　Bronze　K_（0．33）moO_3

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Wuhan University Journal of Natural Sciences 1996年第1期1卷 53-56页

作者： Shi Jing Tian Decheng Xia Haibo Tang Wufong Xong Rui Yu Zhuxing Yang Yezhi mo shaobo Department of Physics Wuhan University Wuhan China Center of Analysis and Measure Wuhan University Wuhan China

X ray photoemission spectra measurements were carried out to elucidate the valence band picture and bonding characters of the two dimensional semiconductor red bronze K,0.33moO3. The valence band spectrum is similar to that of measurement of UPS, and in agreement with the molecular orbital model presented by *** and b,roadening line shape of O-ls means the presence of several inequivalent bonds of oxygen. mo-3d core-level spectrum reveals that there are two kinds of valence states of molybdenum (mo+5,mo+6 ), and that its average valence state is + 5. 42.

关键词： potassium molybdenum red bronze electronic structure photoemission spectroscopy

PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism

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Cancer Communications 2022年第9期42卷 848-867页

作者： Weixing Dai Wenqiang Xiang Lingyu Han Zixu Yuan Renjie Wang Yanlei Ma Yongzhi Yang Sanjun Cai Ye Xu shaobo mo Qingguo Li Guoxiang Cai Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Department of Surgery Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 528406P.R.China

Background:Abnormal expression of protein tyrosine phosphatases(PTPs)has been reported to be a crucial cause of *** a member of PTPs,protein tyrosine phosphatase receptor type O(PTPRO)has been revealed to play tumor suppressive roles in several cancers,while its roles in colorectal cancer(CRC)remains to be ***,we aimed to explore the roles and mechanisms of PTPRO in CRC initiation and ***:The influences of PTPRO on the growth and liver metastasis of CRC cells and the expression patterns of different lipid metabolism enzymes were evaluated in vitro and in *** and biological experiments were conducted to uncover the underpinning mechanisms of dysregulated de novo lipogenesis and fatty acidβ-***:PTPRO expression was notably downregulated in CRC liver metastasis compared to the primary cancer,and such a downregulation was associated with poor prognosis of patients with *** silencing significantly promoted cell growth and liver *** with PTPRO wild-type mice,PTPROknockout mice developed more tumors and harbored larger tumor loads under treatment with azoxymethane and dextran sulfate *** set enrichment analysis revealed that PTPRO downregulation was significantly associated with the fatty acid metabolism *** of fatty acid synthesis abrogated the effects of PTPRO silencing on cell growth and liver *** experiments indicated that PTPRO silencing induced the activation of the AKT serine/threonine kinase(AKT)/mammalian target of rapamycin(mTOR)signaling axis,thus promoting de novo lipogenesis by enhancing the expression of sterol regulatory element-binding protein 1(SREBP1)and its target lipogenic enzyme acetyl-CoA carboxylase alpha(ACC1)by activating the AKT/mTOR signaling ***,PTPRO attenuation decreased the fatty acid oxidation rate by repressing the expression of peroxisome proliferator-activated receptor alpha(PPARα)and its downstream enzyme

关键词： AKT colorectal cancer fatty acid oxidation fatty acid synthesis lipid metabolism liver metastasis mTOR PTPRO tumorigenesis

GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies

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Signal Transduction and Targeted Therapy 2020年第1期5卷 965-978页

作者： Weixing Dai Ye Xu shaobo mo Qingguo Li Jun Yu Renjie Wang Yanlei Ma Yan Ni Wenqiang Xiang Lingyu Han Long Zhang Sanjun Cai Jun Qin Wen-Lian Chen Wei Jia Guoxiang Cai Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiChina Department of Surgery Johns Hopkins University School of MedicineBaltimoreMD 21287USA The Children’s Hospital School of MedicineZhejiang UniversityZhejiangChina The Key Laboratory of Stem Cell Biology CAS Center for Excellence in Molecular Cell ScienceInstitute of Health SciencesShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina Cancer Institute Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China University of Hawaii Cancer Center HonoluluHI 96813USA School of Chinese Medicine Hong Kong Baptist UniversityKowloon TongHong KongChina

Cancer cells are usually characterized by hyperactive glucose metabolism,which can often lead to glucose scarcity;thus,alternative pathways to rewire cancer metabolism are ***,we demonstrated that GLUT3 was highly expressed in colorectal cancer(CRC)and negatively linked to CRC patient outcomes,whereas GLUT1 was not associated with CRC *** glucoselimiting conditions,GLUT3 expedited CRC cell growth by accelerating glucose input and fuelling nucleotide ***,GLUT3 had a greater impact on cell growth than GLUT1 under glucose-limiting ***,low-glucose stress dramatically upregulated GLUT3 via the AMPK/CREB1 ***,high GLUT3 expression remarkably increased the sensitivity of CRC cells to treatment with vitamin C and vitamin C-containing ***,the results of this study highlight the importance of the AMPK/CREB1/GLUT3 pathway for CRC cells to withstand glucose-limiting stress and underscore the therapeutic potential of vitamin C in CRC with high GLUT3 expression.

关键词： GLUT3 vitamin AMPK

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氮化碳薄膜的X射线光电子谱

光谱学与光谱分析 1999年第5期19卷 734-737页

作者：莫少波刘英杨业智程宇航武汉大学分析测试科学系武汉430072 华中理工大学塑性成型模拟及模具国家重点实验室武汉430074

用ＸＰＳ研究射频－直流等离子体增强化学气相沉积（ＰＥＣＶＤ）获得的氮化碳（ＣＮ）薄膜的化学结构。Ｃ１ｓ和Ｎ１ｓ芯能级电子谱分析表明：在ＣＮ膜中含有Ｎ－ｓｐ３和Ｎ－ｓｐ２两类化学结构，在高含Ｎ膜中还含有少量的Ｎ－ｓｐ... 详细信息

用ＸＰＳ研究射频－直流等离子体增强化学气相沉积（ＰＥＣＶＤ）获得的氮化碳（ＣＮ）薄膜的化学结构。Ｃ１ｓ和Ｎ１ｓ芯能级电子谱分析表明：在ＣＮ膜中含有Ｎ－ｓｐ３和Ｎ－ｓｐ２两类化学结构，在高含Ｎ膜中还含有少量的Ｎ－ｓｐ相，且代表Ｎ－ｓｐ３结构的原子比为１．２８，接近４∶３，证明此膜中存在类β－Ｃ３Ｎ４相。且增加膜中含Ｎ量有利于提高类β－Ｃ３Ｎ４相的含量。ＣＮ膜的化学结构在离子辐照下会发生轻微变化，结果表明，随离子剂量增加，Ｎ－ｓｐ３／Ｎ－ｓｐ２比增高。

关键词：化学结构 XPS 离子辐照氮化碳薄膜

交联壳聚糖在痕量金预富集、分离中的应用研究

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分析化学 2005年第2期33卷 198-200页

作者：王昊云钱沙华莫少波黄淦泉武汉430072 武汉大学化学与分子科学学院武汉大学资源与环境科学学院武汉大学资源与环境科学学院武汉430079

研究了交联壳聚糖(CCTS)对于金的吸附性能,提出了用CCTS作为富集剂,预富集、分离水样中痕量Au 的新方法。研究结果表明:在pH为4.0,吸附25min的条件下,CCTS对金的吸附率达99.0%;采用 2.5%(W/V)的硫脲溶液可将吸附在CCTS上的金定量... 详细信息

研究了交联壳聚糖(CCTS)对于金的吸附性能,提出了用CCTS作为富集剂,预富集、分离水样中痕量Au 的新方法。研究结果表明:在pH为4.0,吸附25min的条件下,CCTS对金的吸附率达99.0%;采用 2.5%(W/V)的硫脲溶液可将吸附在CCTS上的金定量洗脱。将CCTS用于水中痕量金的预富集,富集倍数达 20倍;用火焰原子吸收光谱法(FAAS)检测,检出限(3σ,n=6)为0.088mg/L;相对标准偏差(RSD)小于 5.9%;回收率在92%～102%之间。所提出的预富集方法具有简便、快速、选择性好等特点。

关键词：交联壳聚糖预富集金吸附火焰原子吸收光谱法

Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma

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Protein & Cell 2020年第4期11卷 292-298页

作者： Yaqi Li Jian Li Renjie Wang Long Zhang Guoxiang Fu Xueying Wang Yebin Wang Chuantao Fang Dandan Zhang Duo Du Xiaoji Ma Mengxue Pan Qiang Guo Xiaoya Xu Xiang Hu Yi Zhou shaobo mo Huijun Wang Jianjun Gao Shenglin Huang Yun Liu Sanjun Cai Guoqiang Hua Junjie Peng Fa-Xing Yu Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Institute of Pediatrics Children's Hospital of Fudan UniversityShanghai 200032China Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical SciencesFudan UniversityShanghai 200032China Cancer Institute Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032China Institute of Radiation Medicine Fudan UniversityShanghai 200032China moE Key Laboratory of Metabolism and molecular Medicine Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Shanghai Medical CollegeFudan UniversityShanghai 200032China Institute of Radiation Medicine and Fudan University Shanghai Cancer Center Shanghai Medical schoolFudan UniversityShanghai 200032China

Dear Editor,Signet-ring cell carcinoma(SRCC)is a rare subtype of colorectal cancer(CRC)characterized histologically by the accumulation of mucins in the cytoplasm and displacement of nuclei to the cellular periphery,accounting for about 1%CRC(Fig.S1A)(Borger et al.,2007).Compare to common subtypes of CRC,such as adenocarcinoma(AC)and mucinous adenocarcinoma(MAC),SRCC is associated with aggressive behaviors and younger age at presentation(Kang et al.,2005;Sung et al.,2008;Nitsche et al.,2013;Hugen et al.,2014;Inamura et al.,2015).A retrospective analysis of CRC patient's data at Fudan University Shanghai Cancer Center(FUSCC)also indicated a worse overall and disease-free survival of SRCC patients(Fig.S1B and S1C,Table S1).

关键词： al. colorectal adenocarcinoma

新型苯丙/有机蒙脱土复合乳液的制备及其在防火涂料中的应用

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武汉大学学报（理学版） 2016年第1期62卷 25-30页

作者：刘攀王攀高志农莫少波武汉大学化学与分子科学学院湖北武汉430072 武汉生物工程学院园林系湖北武汉430415

通过十六烷基三甲基溴化铵(CTAB)对蒙脱土(MMT)进行有机改性,并将其与环氧树脂-苯丙乳液复合,得到了一种有机蒙脱土改性的苯丙乳液.该复合物粒径约140nm左右,蒙脱土片层均匀分散在乳液中.环氧树脂的加入提高了复合乳液的力学性能,附着... 详细信息

通过十六烷基三甲基溴化铵(CTAB)对蒙脱土(MMT)进行有机改性,并将其与环氧树脂-苯丙乳液复合,得到了一种有机蒙脱土改性的苯丙乳液.该复合物粒径约140nm左右,蒙脱土片层均匀分散在乳液中.环氧树脂的加入提高了复合乳液的力学性能,附着力最高可至0级,而有机蒙脱土(OMMT)的加入使苯丙乳液的耐黄变性与耐水性有明显改善.利用季戊四醇、三聚氰胺等与该复合乳液配制了一种膨胀型防火涂料,其防火性较普通防火涂料有明显提高.

关键词：苯丙乳液蒙脱土环氧树脂膨胀型防火涂料

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非晶态Ni基合金电极电子结构的XPS研究

Chinese Journal of Chemical Physics 2000年第4期13卷 487-491页

作者：莫少波杨业智王龙彪吴俊黄清安武汉大学测试中心武汉430072 武汉大学化学武汉430072 武汉大学化学系武汉430072

用ＸＰＳ测定了含Ｐ、Ｃｅ、Ｌａ的Ｎｉ基合金的费米能级及各元素的芯级电子结合能，讨论了合金的电子结构以及它与析氢反应的电催化活性即析氢超电势之间的联系。结果表明：合金中各元素的原子间存在着电荷传输，它对析氢反应活性起重... 详细信息

用ＸＰＳ测定了含Ｐ、Ｃｅ、Ｌａ的Ｎｉ基合金的费米能级及各元素的芯级电子结合能，讨论了合金的电子结构以及它与析氢反应的电催化活性即析氢超电势之间的联系。结果表明：合金中各元素的原子间存在着电荷传输，它对析氢反应活性起重要作用。

关键词： XPS 析氢反应非晶态Ni基合金电极电子结构