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On Some Aspects of Perturbation Analysis for Matrix Cone Optimization Induced by Spectral Norm

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Journal of the Operations Research Society of China 2015年第3期3卷 275-296页

作者： shao-yan guo Li-Wei Zhang Shou-Lin Hao School of Mathematical Sciences Institute of Operations Research and Control TheoryDalian University of TechnologyDalian 116024China School of Control Science and Engineering Institute of Advanced Control TechnologyDalian University of TechnologyDalian 116024China

In this paper,we consider a cone problem of matrix optimization induced by spectral norm(MOSN).By Schur complement,MOSN can be reformulated as a nonlinear semidefinite programming(NLSDP)*** we discuss the constraint nondegeneracy conditions and strong second-order sufficient conditions of MOSN and its SDP reformulation,and obtain that the constraint nondegeneracy condition of MOSN is not always equivalent to that of ***,the strong second-order sufficient conditions of these two problems are equivalent without any ***,a sufficient condition is given to ensure the nonsingularity of the Clarke’s generalized Jacobian of the KKT system for MOSN.

关键词： Spectral norm Negative semidefinite cone Strong second-order sufficient condition Constraint nondegeneracy condition

Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma

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Cancer Communications 2019年第1期39卷 634-644页

作者： You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi yang Le Xia shao-yan guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui Sun Pei-Yu Huang Wei Fan Xiang guo Ming-Huang Hong Ming-Yuan Chen Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer Center651 Dongfeng East RoadGuangzhou 510060GuangdongP.R.China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Medical Imaging and Interventional Radiology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Nuclear Medicine Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Clinical Trials Center Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China

Background:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the *** nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical *** this study,we examined whether ENPG could be an effective treatment for localized stage I ***:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer ***,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference *** survival outcomes,quality of life(QOL),and medical costs between two groups were ***:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with *** 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,P<0.001)and improved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,P<0.001)and sticky saliva(3.3±10.5 vs.32.6±23.3,P<0.001).Conclusions:ENPG alone was associated with promising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused ***,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results.

关键词： Nasopharyngeal carcinoma Localized Early stage Endoscopic nasopharyngectomy Intensity-modulated radiotherapy Survival Medical cost Quality of life

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度洛西汀与氟西汀治疗抑郁症的对照研究

中国民康医学 2013年第17期25卷 42-44页

作者：邵国艳邢秀娟河南省许昌市建安医院河南许昌461000

目的:比较度洛西汀与氟西汀治疗抑郁症的疗效及安全性。方法:将60例抑郁症患者随机分为两组,分别用度洛西汀和氟西汀治疗,疗程6周。采用汉密尔顿抑郁量表(HAMD)评定临床疗效,副反应量表(TESS)评定不良反应。结果:度洛西汀组显效率为66.... 详细信息

目的:比较度洛西汀与氟西汀治疗抑郁症的疗效及安全性。方法:将60例抑郁症患者随机分为两组,分别用度洛西汀和氟西汀治疗,疗程6周。采用汉密尔顿抑郁量表(HAMD)评定临床疗效,副反应量表(TESS)评定不良反应。结果:度洛西汀组显效率为66.7%,有效率为86.7%;氟西汀组分别为63.3%和83.3%。两组差异无统计学意义(P>0.05)。治疗第1周末时,度洛西汀组HAMD评分显著低于氟西汀组(P<0.05)。两组不良反应轻微。结论:度洛西汀和氟西汀抗抑郁疗效肯定,不良反应轻。

关键词：度洛西汀氟西汀抑郁症

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谈高等职业学校学生创造性思维能力的培养

新疆职业大学学报 2007年第1期15卷 74-76页

作者：严绍国江苏省司法警官高等职业学校基础部江苏镇江212003

高等职业学校作为培养具有创新精神和实践能力的高级专门人才的摇篮和发展科学技术文化、促进社会和谐发展的重要阵地,必须在强化素质教育,提高专业技能的同时,不断进行教育教学改革,力求通过课内外教育教学的实践,发展学生的创造性思维... 详细信息

高等职业学校作为培养具有创新精神和实践能力的高级专门人才的摇篮和发展科学技术文化、促进社会和谐发展的重要阵地,必须在强化素质教育,提高专业技能的同时,不断进行教育教学改革,力求通过课内外教育教学的实践,发展学生的创造性思维,培养具有自主创新意识和实践能力的高级专门人才。

关键词：创造意识科学精神创新教学模式拓展创新空间

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan guo Qianqian shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu yan-Ping guo yan-Mei Lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(P<0.05).Tumor marker levels(NMP22,BTA,and UBC)were lower in the joint intervention group compared to the conventional group(P<0.05).The joint intervention group also showed a greater reduction in HAMD-17 scores(9.38±3.12 vs 15.45±4.86,P<0.05),higher QLQ-C30 scores,and lower CFS scores(both P<0.05).Additionally,the joint intervention group had a lower incidence of adverse reactions and higher nursing satisfaction(P<0.05).CONCLUSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

氨磺必利通过TLR/NLR通路对慢性应激抑郁大鼠的改善作用研究

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现代药物与临床 2021年第1期36卷 9-15页

作者：邵国艳黄业晟祝梦娅张樟进许昌市建安医院河南许昌461000 香港大学深圳医院广东深圳518020

目的观察氨磺必利对抑郁症大鼠行为的影响,并探究其对大鼠海马组织Toll样受体(TLR)/NOD样受体(NLR)通路相关蛋白表达的影响。方法将SD大鼠随机分为对照组、模型组及低、中、高剂量(0.3、1.2、4.8 g/kg)氨磺必利组,每组10只,除对照组外,... 详细信息

目的观察氨磺必利对抑郁症大鼠行为的影响,并探究其对大鼠海马组织Toll样受体(TLR)/NOD样受体(NLR)通路相关蛋白表达的影响。方法将SD大鼠随机分为对照组、模型组及低、中、高剂量(0.3、1.2、4.8 g/kg)氨磺必利组,每组10只,除对照组外,其他各组大鼠给予8周慢性温和不可预知应激(CUMS)刺激制备抑郁症大鼠模型,于造模第7~8周,低、中、高剂量氨磺必利组分别ig给予0.3、1.2、4.8 g/kg氨磺必利溶液,对照组、模型组ig等量生理盐水,给药体积10 mL/kg,分别于造模后(CUMS 6周)、给药后(CUMS 8周)采用糖水偏好、强迫游泳、悬尾及旷场实验评估大鼠行为;实验结束后,取各组大鼠海马组织,Werstern blotting法检测TLR2、NLRP1、NLRP3、ASC、TLR4及Caspase-1蛋白表达情况,ELISA法检测白细胞介素(IL)-6、IL-1β、IL-18水平。结果造模后,相较于对照组,模型组及低、中、高剂量氨磺必利组大鼠体质量、糖水偏好指数、旷场中活动距离及站立次数降低,强迫游泳及悬尾静止时间延长(P<0.05)。相较于造模后,给药后模型组大鼠体质量、糖分偏好指数、旷场中活动距离及站立次数降低,强迫游泳及悬尾静止时间延长(P<0.05);低、中、高剂量氨磺必利组大鼠体质量、糖分偏好指数、旷场中活动距离及站立次数增加,强迫游泳及悬尾静止时间缩短(P<0.05)。给药后,相较于对照组,模型组及低、中、高剂量氨磺必利组大鼠体质量、糖分偏好指数、旷场中活动距离及站立次数降低(P<0.05),强迫游泳及悬尾静止时间延长(P<0.05),海马中TLR2、TLR4、NLRP1、NLRP3、ASC、Caspase-1蛋白表达及IL-6、IL-1β、IL-18水平均增高(P<0.05);相较于模型组,低、中、高剂量氨磺必利组大鼠体质量、糖分偏好指数、旷场中活动距离及站立次数增加,且低、中剂量组依次增加,均高于高剂量氨磺必利组(P<0.05),强迫游泳及悬尾静止时间缩短,且低、中剂量组依次缩短,均短于高剂量氨磺必利组(P<0.05),海马中TLR2、TLR4、NLRP1、NLRP3、ASC、Caspase-1蛋白表达及IL-6、IL-1β、IL-18水平均降低,且低、中剂量组依次降低,均低于高剂量氨磺必利组(P<0.05)。结论低剂量氨磺必利可降低抑郁模型大鼠海马中TLR/NLR通路相关蛋白表达量,抑制下游炎性因子释放,从而改善CUMS诱导的大鼠抑郁样行为。

关键词：氨磺必利慢性温和不可预知应激抑郁样行为 Toll样受体 NOD样受体白细胞介素

Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng Wang Qinyi guo Bin Hu Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability

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窄刻槽亚波长金属波导光栅透射滤波研究

光通信研究 2017年第1期1期(24)卷 37-40页

作者：蒋文文桑田王睿邵泓焰陈国庆江南大学理学院光电信息科学与工程系江苏无锡214122 江南大学江苏省轻工光电工程技术研究中心江苏无锡214122

提出了一种窄刻槽亚波长金属波导光栅透射滤波器的设计,其工作原理是利用窄光栅刻槽取得低透射背景,再利用导模共振与表面等离子激元共振的混合产生峰值透射,进而实现良好的窄带透射滤波效应。研究发现,利用多模共振与表面等离子激元共... 详细信息

提出了一种窄刻槽亚波长金属波导光栅透射滤波器的设计,其工作原理是利用窄光栅刻槽取得低透射背景,再利用导模共振与表面等离子激元共振的混合产生峰值透射,进而实现良好的窄带透射滤波效应。研究发现,利用多模共振与表面等离子激元共振的混合模式,通过增加波导厚度即可实现性能良好的双通道透射滤波,在波长1 412和1 653nm处,峰值透射率分别为72.1%和63.6%。进一步分析表明,由于长波处磁场能量较多地局域在金属光栅层,峰值位置和峰值透射率受光栅深度变化影响显著;而短波处磁场能量较多地局域在波导层中,因此短波处峰值漂移对波导层厚度变化更为敏感。

关键词：窄刻槽金属波导光栅亚波长结构透射滤波器