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Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 93-99页

作者： shao-shuai wang Fu-yuan QIAO Ling FENG Juan-juan LV Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective: To explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR), the central enzymes in folate metabolism that affects DNA methylation and synthesis, and the risk of Down syndrome in China. Methods: Genomic DNA was isolated from the peripheral lymphocytes of 64 mothers of children with Down syndrome and 70 age matched control subjects. Polymerase chain reaction and restriction fragment length polymorphism were used to examine the polymorphisms of MTHFR 677C→T, MTRR 66A→G and the relationship between these genotypes and the risk of Down syndrome was analyzed. Results: The results show that the MTHFR 677C→T polymorphism is more prevalent among mothers of children with Down syndrome than among control mothers, with an odds ratio of 3.78 (95% confidence interval (CI), 1.78～8.47). In addition, the homozygous MTRR 66A→G polymorphism was independently associated with a 5.2-fold increase in estimated risk (95% CI, 1.90～14.22). The combined presence of both polymorphisms was associated with a greater risk of Down syndrome than the presence of either alone, with an odds ratio of 6.0 (95% CI, 2.058～17.496). The two polymorphisms appear to act without a multiplicative interaction. Conclusion: MTHFR and MTRR gene mutation alleles are related to Down syndrome, and CT, TT and GG gene mutation types increase the risk of Down syndrome.

关键词： Tetrahydrofllate dehydrogenase Ligases Down syndrome Folate

Effect of Third Interstitial Fluid on Adverse Outcomes in Patients with Severe Pre-eclampsia and Twin Pregnancy:A 5-year Single-center Retrospective Study

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Current Medical Science 2023年第6期43卷 1213-1220页

作者： Liang-nan ZHANG Zi-zhuo wang Jian-li WU Wen-cheng DING Xing-guang LIN Teng JI shao-shuai wang Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective This study aims to identify the effect of third interstitial fluid on adverse outcomes in twin pregnancies with severe pre-eclampsia,and explore the differences in bad ending between twins and *** The present retrospective cohort study was conducted on patients with severe pre-eclampsia,who delivered in Tongji Hospital,Wuhan,China,between 2017 and *** adverse outcomes in singleton and twin pregnancies with severe pre-eclampsia were initially ***,the diverse maternal and fetal consequences between singleton and twin pregnancies in patients with severe pre-eclampsia were compared after merging with the third interstitial *** A total of 709 patients were included for the present *** these patients,68 patients had twin pregnancies,and 641 patients had singleton *** rate of postpartum hemorrhage(2.81%vs.13.24%,P<0.001),and admission rate to the Neonatal Intensive Care Unit(NICU)after birth(30.73%vs.63.24%,P=0.011)were significantly higher in twin *** neonatal weight of twins was statistically lower than singletons(1964.73±510.61 g vs.2142.92±731.25 g,P=0.008).For the groups with the third interstitial fluid,the delivery week(P=0.001)and rate of admission to the NICU after birth were significantly advanced in twin pregnancy group,when compared to singleton pregnancy group(P=0.032),and the length of hospital stay was shorter(P=0.044).Furthermore,there was no statistically significant difference between the twin pregnancy group and the singletony pregnancy group without the third interstitial *** The maternal and fetal adverse outcomes of patients with severe pre-eclampsia increased in twin pregnancies,when compared to singleton ***,when patients develop the third interstitial fluid,twin pregnancies would more likely lead to adverse fetal outcomes,when compared to singleton pregnancies,and there would be no significant difference in maternal adverse ***

关键词： third interstitial fluid twin pregnancies severe pre-eclampsia adverse outcome risk factors

Government Intervention Measures Effectively Control COVID-19 Epidemic in Wuhan,China

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Current Medical Science 2021年第1期41卷 77-83页

作者： Xing XIN Shu-fang LI Ling CHENG Chang-yu LIU Yin-juan XIN Hai-long HUANG Raijluxmee Beejadhursing shao-shuai wang Ling FENG Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhomg University of Sicience and TechnologyWhan 430030China Department of Geriatrics Tongji HospitalTongji Medical CollegeHuazhong University of Sicience and TechmologyWuhan 430030China Department of Thoracic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWwhan 430030China Center Primary School in Xichuan Town Qin'an CountyTianshui 741600China Department of Rehabilitation Medicine Zhongnan Hospital of Wuhan UniversityWuhan 43007Chind

The coronavirus disease 2019(COVID-19)outbreak has been brought under control through a nationwide effort,and now it has become a global pandemic and the situation seems *** summarized the measures taken in Wuhan and analyzed the effects to comprehensively describe the factors involved in controlling the COVID-19 in *** China,several measures such as the lockdown of Wuhan,restriction of traffic and communities,increasing hospital beds,nationwide support from medical staff,epidemic prevention equipment and supplies,and establishment of makeshift shelter hospitals have been *** lockdown of Wuhan reduced the propagation of cases to other cities in Hubei province and throughout China,traffic and community restrictions reduced the flow of population and the spread of disease,increasing wards and beds and medical personnel reduced the incidence of severe cases and mortality,the establishment of the Fangcang shelter hospitals provided a good isolation and monitoring environment,and further reduced the spread and fatality of the *** fact that China was able to control the spread of COVID-19 within three months without a specific drug or vaccine suggests that these measures are more adequate and effective.

关键词： COVID-19 China's Mainland government intervention measures healthcare

LncRNA HCG27 Promotes Glucose Uptake Ability of HUVECs by MiR-378a-3p/MAPK1 Pathway

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Current Medical Science 2023年第4期43卷 784-793页

作者： Jing-yi ZHANG Yi JIANG Li-jie WEI Xuan ZHOU Sheng-lan ZHU Hui-ting ZHANG Yu-ting CHEN Peng GAO Jun YU shao-shuai wang Ling FENG Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Gestational diabetes mellitus(GDM)is the most common metabolic disorder during *** HLA complex group 27(HCG27)plays a crucial role in various metabolic ***,the relationship between lncRNA HCG27 and GDM is not *** study aimed to verify a competing endogenous RNA(ceRNA)interaction regulation axis of miR-378a-3p/mitogen-activated protein kinase 1(MAPK1)regulated by HCG27 in ***:LncRNA HCG27 and miR-378a-3p were detected by *** expression of MAPK1 in umbilical vein endothelial cells(HUVECs)was detected by RT-qPCR and that in the placenta by Western *** explore the relationship among lncRNA HCG27,miR-378a-3p,MAPK1 and the glucose uptake ability of HUVECs,vector HCG27,si-HCG27,miR-378a-3p mimic and inhibitor were transfected to achieve overexpression and inhibition of HCG27 or *** interaction between miR-378a-3p and lncRNA HCG27 or MAPK1 was confirmed by the dual-luciferase reporter ***,glucose consumption by HUVECs was detected by the glucose assay ***:HCG27 expression was significantly decreased in both the placenta and primary umbilical vein endothelial cells,while the expression of miR-378a-3p was significantly increased in GDM tissues,and the expression of MAPK1 was decreased in GDM *** ceRNA interaction regulation axiswas proved to affect the glucose uptake function of *** transfection of si-HCG27 could significantly reduce the expression of the MAPK1 *** the MAPK1 overexpression plasmid was transfected simultaneously with si-HCG27 transfection,the reduced glucose uptake in HUVECs resulting from the decrease in lncRNA HCG27 was ***-378a-3p mimic can significantly reduce the mRNA expression of MAPK1 in HUVECs,whereas miR-378a-3p inhibitor can significantly increase the mRNA expression of *** inhibition of miR-378a-3p could restore the decreased glucose uptake of HUVECs treated with ***,overexpression of lncRNA HCG27 could

关键词： lncRNA ceRNA gestational diabetes mellitus human umbilical vein endothelial cells

No-go guide for the Hubble tension:Late-time or local-scale new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 73-85页

作者： Lu Huang shao-Jiang wang wang-Wei Yu CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of Sciences(CAS)Beijing100190China Asia Pacific Center for Theoretical Physics(APCTP) Pohang37673Korea Max-Planck-Institut für Gravitationsphysik(Albert-Einstein-Institut) HannoverD-30167Germany Leibniz Universität Hannover Hannover30167Germany

The standard model of modern cosmology might be cracked by the recent persistent hot debate on the Hubble-constant(H_(0))tension,which manifests itself as the sound-horizon(r_(s))tension or absolute-magnitude(M_(B))tension if deeming the origin of the Hubble tension from modifying the early or late Universe,*** this study,we achieve a fully model-independent constraint(fitting a model-independent global parameterization to a model-independent inverse distant ladder with a modelindependent high-redshift calibration)on late-time models with strong evidence against homogeneous new physics over theΛ-cold-dark-matter(ΛCDM)*** using this model-independent constraint to calibrate sufficiently local supernovae with corresponding late-time models extrapolated below the homogeneity scale,we find surprisingly that,although both H_(0)tension and MB tension are absent in our local Universe,a combination of H_(0)and M_(B)as the intercept a B of the magnitude-redshift relation exhibits 3~7σtension even for theΛCDM *** aBtension seems to call for local-scale inhomogeneous new physics disguised as local observational systematics.

关键词： Hubble constant inverse distance ladder local Universe

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 67-74页

作者： Song He Li Li Sai wang shao-Jiang wang Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China School of Physical Science and Technology Ningbo UniversityNingbo 315211China CAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences(UCAS)Hangzhou 310024China Theoretical Physics Division Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physical Sciences University of Chinese Academy of Sciences(UCAS)Beijing 100049China Max Planck Institute for Gravitational Physics(Albert Einstein Institute) Am Muhlenberg 1Golm 14476Germany

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition,yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT)left *** specific baryon chemical poten-tial,the first-order QCD phase transition agrees with the observational constraint of baryon ***,therefore,provides a scenario for phase transition gravitational waves(GWs)within the standard model of particle *** these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA)observations,the duration of this FoPT can be well constrained,and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

Photolithographic Microfabrication of Microbatteries for On-Chip Energy Storage

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Nano-Micro Letters 2025年第5期17卷 117-144页

作者： Yuan Ma Sen wang Zhong-shuai Wu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023People’s Republic of China School of Transportation Engineering Dalian Jiaotong UniversityDalian 116028People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023People’s Republic of China

Microbatteries(MBs)are crucial to power miniaturized devices for the Internet of *** the evolutionary journey of MBs,fabrication technology emerges as the cornerstone,guiding the intricacies of their configuration designs,ensuring precision,and facilitating scalability for mass *** stands out as an ideal technology,leveraging its unparalleled resolution,exceptional design flexibility,and entrenched position within the mature semiconductor ***,comprehensive reviews on its application in MB development remain *** review aims to bridge that gap by thoroughly assessing the recent status and promising prospects of photolithographic microfabrication for ***,we delve into the fundamental principles and step-by-step procedures of photolithography,offering a nuanced understanding of its operational mechanisms and the criteria for photoresist ***,we highlighted the specific roles of photolithography in the fabrication of MBs,including its utilization as a template for creating miniaturized micropatterns,a protective layer during the etching process,a mold for soft lithography,a constituent of MB active component,and a sacrificial layer in the construction of micro-Swiss-roll ***,the review concludes with a summary of the key challenges and future perspectives of MBs fabricated by photolithography,providing comprehensive insights and sparking research inspiration in this field.

关键词： Microbatteries Photolithography Internet of Things Micropatterns On-chip energy storage

Silencing of DsbA-L gene impairs the PPARγagonist function of improving insulin resistance in a high-glucose cell model

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第12期21卷 990-998页

作者： Xuan ZHOU Jia-qi LI Li-jie WEI Meng-zhou HE Jing JIA Jing-yi ZHANG shao-shuai wang Ling FENG Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Disulfide-bond A oxidoreductase-like protein(DsbA-L)is a molecular chaperone involved in the multimeri-zation of *** studies have found that DsbA-L is related to metabolic diseases including gestational diabetes mellitus(GDM),and can be regulated by peroxisome proliferator-activated receptorγ(PPARγ)agonists;the specific mechanism,however,is ***,the relationship between DsbA-L and the novel adipokine chemerin is also *** article aims to investigate the role of DsbA-L in the improvement of insulin resistance by PPARγagonists in trophoblast cells cultured by the high-glucose simulation of GDM *** and western blot were used to detect differences between GDM patients and normal pregnant women in DsbA-L expression in the adipose *** western blot technique was performed to verify the relationship between PPARγagonists and DsbA-L,and to explore changes in key molecules of the insulin signaling pathway,as well as the effect of chemerin on *** showed that DsbA-L was significantly downregulated in the adipose tissue of GDM *** PPARγagonists and chemerin could upregulate the level of *** DsbA-L affected the function of rosiglitazone to promote the phosphatidylinositol 3-kinase(PI3K)-protein kinase B(PKB)/AKT ***,it is plausible to speculate that DsbA-L is essential in the environment of PPARγagonists for raising insulin ***,we further clarified the mechanism by which PPARγagonists improve insulin resistance.

关键词： Disulfide-bond A oxidoreductase-like protein(DsbA-L) Peroxisome proliferator-activated receptorγ(PPARγ) Chemerin Insulin signaling pathway Gestational diabetes mellitus

An ionic liquid assisted hydrogel functionalized silica stationary phase for mixed-mode liquid chromatography

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Chinese Chemical Letters 2025年第1期36卷 491-495页

作者： Tong Zhang Xiaojing Liang Licheng wang shuai wang Xiaoxiao Liu Yong Guo Lanzhou Institute of Chemical Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Lanzhou Institute for Food and Drug Control Key Laboratory of Pesticide and Veterinary Drug Monitoring for State Market RegulationLanzhou 730050China

An ionic liquid assisted hydrogel modified silica was synthesized using a one-pot polymerization and physical coating technique and subsequently applied to mixed-mode liquid *** techniques,including Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),and elemental analysis,etc.,confirmed the successful prepared of this innovative stationary *** unique combination of amide,long alkyl chain,and imidazole ring in the hydrogel coating enables the stationary phase to function effectively in hydrophilic/reversed-phase/ion exchange liquid ***,the stationary phase exhibited superior separation performance owing to the synergistic effect of the ionic liquid and *** was particularly evident when analyzing various analytes such as organic acids,nucleosides/bases,polycyclic aromatic hydrocarbons(PAHs)and ***,under our operating conditions,an excellent column efficiency of 53,642.9 plates/m was achieved for *** summary,we have proposed a straightforward strategy to enhance the separation performance of hydrogel coatings in liquid chromatography,thereby broadening the potential applications of hydrogels in the field of separation.

关键词： Ionic liquid Hydrogel Functionalized silica Synergistic effect Stationary phase