检索结果-南通市图书馆

Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-onchronic liver failure

引用

World Journal of Gastroenterology 2024年第8期30卷 881-900页

作者： Yu Zhang Xiao-Ling Tian Jie-Qun Li Dong-sheng Wu Qiang Li Bin chen Department of Hepatology Institute of HepatologyThe First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina Department of Liver Transplant Transplant Medical Research CenterThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Surgery The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina

BACKGROUND Immune dysregulation and metabolic derangement have been recognized as key factors that contribute to the progression of hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).However,the mechanisms underlying immune and metabolic derangement in patients with advanced HBV-ACLF are *** To identify the bioenergetic alterations in the liver of patients with HBV-ACLF causing hepatic immune dysregulation and metabolic *** Liver samples were collected from 16 healthy donors(HDs)and 17 advanced HBV-ACLF patients who were eligible for liver *** mitochondrial ultrastructure,metabolic characteristics,and immune microenvironment of the liver were *** focus was given to organic acid metabolism as well as the function and subpopulations of macrophages in patients with *** Compared with HDs,there was extensive hepatocyte necrosis,immune cell infiltration,and ductular reaction in patients with *** patients,the liver suffered severe hypoxia,as evidenced by increased expression of hypoxia-inducible factor-1α.Swollen mitochondria and cristae were observed in the liver of *** number,length,width,and area of mitochondria were adaptively increased in *** metabolomics analysis revealed that mitochondrial oxidative phosphorylation decreased,while anaerobic glycolysis was enhanced in patients with *** findings suggested that,to a greater extent,hepa-tocytes used the extra-mitochondrial glycolytic pathway as an energy *** with HBV-ACLF had elevated levels of chemokine C-C motif ligand 2 in the liver homogenate,which stimulates peripheral monocyte infiltration into the *** and functional analysis of macrophage subsets revealed that patients with ACLF had a high abundance of CD68^(+)HLA-DR^(+)macrophages and elevated levels of both interleukin-1βand transforming growth factor-β1 in their *** abundance of CD206^(+)CD163^(+)macrophag

关键词： Acute-on-chronic liver failure Hypoxia-inducible factor-1α Mitochondria Metabolic phenotype Immune cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zokor activity promotes soil water infiltration in the Mu Us sandy land of northern Shaanxi,China

引用

Pedosphere 2024年第1期34卷 136-145页

作者： Miao GAN Xuchao ZHU Xueqin YANG Xiaorong WEI Qingyin ZHANG Tongchuan LI Ming'an shao Meixia MI Xi YANG Mingyu chen State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling 712100China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China Henan Institute of Science and Technology Xinxiang 453003China College of Urban and Rural Construction Shanxi Agricultural UniversityJinzhong 030801China

Zokors are common subterranean rodents that inhabit agricultural fields, shrublands, and grasslands in the arid and semi-arid regions of China. Zokor burrowing activities can alter soil structure and affect soil hydrological processes;however, there are few studies regarding their effects on soil preferential flow in the Mu Us sandy land. An evaluation of the effects of zokor disturbance on their habitat and soil water is important for understanding the ecological role of zokors in the soil ecosystem of the Mu Us sandy land. A field dye-tracing experiment was conducted in the Gechougou watershed on the southeastern edge of the Mu Us sandy land to investigate the effect of zokor burrowing activity on soil preferential flow characteristics. Our results showed that the density of zokor tunnels was the highest(0.40–0.46 m m^(-2)) under 30%–50% vegetation coverage and that the tunnels were approximately 3 cm from the *** stained area ratio and stained path number were higher at sites with zokors than without zokors. Stained path widths were 10–80 and > 80 mm at zokor-harboring sites exhibiting homogeneous flow and heterogeneous finger flow, respectively. In the absence of zokors, homogeneous flow and highly interacted macropore flow were predominant. Soil water content below the zokor tunnels was higher than that above the tunnels. Moderate disturbance of soil structure by zokor activity facilitated soil water infiltration. These results enabled a better understanding of the effect of soil fauna on soil structure and hydrological processes and provided recommendations for ecological construction and renovation in arid and semi-arid regions.

关键词： eld dye-tracing experiment preferential flow soil fauna stained area ratio stained path number stained path width subterranean rodent surface tortoise crack

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MOF-derived 1D CGO Cathode for Efficient Solid Oxide Electrolysis Cells

引用

Chemical Research in Chinese Universities 2024年第4期40卷 737-746页

作者： TIAN Jiayu SUN Qi LIU Pei DAI Jiuyi CAI Yezheng XU Miao YE Tian-Nan chen Jie-sheng Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai200240P.R.China Zhangjiang Institute for Advanced Study Shanghai Jiao Tong UniversityShanghai200240P.R.China State Key Laboratory of Space Power-sources Shanghai Institute of Space Power-sourcesShanghai200245P.R.China

Solid oxide electrolysis cells(SOECs)provide a promising way for converting renewable energy into chemical ***,NiO/CGO(nickel-gadolinium doped ceria)cermet has shown its excellent properties in ionic and electronic conductivity under reducing ***,we developed a novel 1D NiO/CGO cathode through a cerium metal-organic framework(MOF)derived *** cathode’s 1D nanostructure integrated with a microchannel scaffold facilitates enhanced mass transport,providing vertically aligned pathways for CO_(2)and H_(2)O ***,the 1D framework increases the number of interfacial sites and reduces ion diffusion distances,thereby simplifying electron/ion ***,this advanced cathode achieved a significant breakthrough in SOEC performance,maintaining efficient CO_(2)and H_(2)O electrolysis at an extraordinary current density of 1.41 A/cm^(2)at 1.5 V and excellent stability over 24 h at 850℃.The enhanced performance of this newly developed cathode not only achieves a remarkable 100%improvement compared to those of NiO/CGO cathodes with varying geometrical configurations but also surpasses those of commercial NiO/CGO catalysts by an outstanding 40%when tested under identical *** development of the 1D NiO/CGO enhances the efficiency and durability of ceramic cathodes for CO_(2)and H_(2)O co-electrolysis in SOECs and improves the scalability and effectiveness of SOECs in renewable energy applications.

关键词： Cerium metal-organic framework One-dimensional structure Gadolinium doped ceria CO_(2)activation co-Electrolysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Suppression of Multi-Harmonic Currents in the High-Speed Magnetically Suspended Motor Based on Adaptive Cascaded Notch Filters with Variable Phase Angle

引用

Guidance, Navigation and Control 2024年第2期4卷 104-122页

作者： Xianzhang Wang Xiangbo Xu shao chen Lingbo Zheng Junfeng Li Bolun Li School of Technology Beijing Forestry University Beijing 100084 P.R.China

Rotor imbalance is identified as one of the predominant vibration sources in high-speed magnetically suspended *** to factors such as rotor machining accuracy errors and uneven material distribution,synchronous vibration interference is ***,sensor runout generates harmonic currents,which are attributed to material irregularities and inhomogeneity in the roundness of the sensor detection *** currents can generate harmonic vibrational forces that are transmitted to the motor housing,jeopardizing control accuracy and the device's operational *** order to achieve real-time reduction of harmonic currents at specified frequencies and improve the accuracy of harmonic suppression,this paper proposes an algorithm for variable phase anglefiltering of an adaptive cascaded mode *** paper performed dynamic modeling and analysis of the magnetically suspended rotor system with rotor imbalance and verified the correctness of the dynamic ***,the structure of an adaptive notchfilter with variable phase angle is introduced,highlighting the capability to maintain stability by adjusting the compensatory phase of the *** comparing the harmonic current suppression performance of cascaded and parallel mode notchfilters,the cascaded method can better enhance the overall frequency selectivity,emphasizing its ability to adjust the compensation phase based on the phase angle of the input signal at different frequencies to maintain system *** and experimental results show that harmonic currents can be successfully suppressed in the cascade mode,and the amplitude of the synchronous frequency current is reduced by 94.4%.

关键词： Multi-harmonic current suppression rotor imbalance sensor runout cascaded mode notchfilter variable phase angle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization

引用

Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 25-34页

作者： Hai-Li Bao Chuan-Zhi chen Chang-Zhen Ren Ke-Yan Sun Hao Liu shao-Hua Song Zhi-Ren Fu Department of Organ Transplantation Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China Department of Surgical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Cardiology Shanghai Changzheng HospitalNaval Military Medical UniversityShanghai 200003China Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various ***,little is known about its effect on hepatic ischemia-reperfusion(I/R)*** study aimed to elucidate whether polydatin protects liver against I/R-induced injury and to explore the underlying ***:After gavage feeding polydatin once daily for a week,mice underwent a partial hepatic I/R *** alanine aminotransferase(ALT)/aspartate aminotransferase(AST),hematoxylin-eosin(H&E)and TdT-mediated dUTP nick-end labeling(TUNEL)staining were used to evaluate liver *** severity related to the inflammatory response and reactive oxygen species(ROS)production was also ***,immunofluorescence and Western blotting were used to detect macrophage polarization and the NF-κB signaling pathway in ***:Compared with the I/R group,polydatin pretreatment significantly attenuated I/R-induced liver damage and *** oxidative stress marker(dihydroethidium fluorescence,malondialdehyde,superoxide dismutase and glutathione peroxidase)and I/R related inflammatory cytokines(interleukin1β,interleukin-10 and tumor necrosis factor-α)were significantly suppressed after polydatin *** addition,the result of immunofluorescence indicated that polydatin reduced the polarization of macrophages toward M1 macrophages both in vivo and in *** blotting showed that polydatin inhibited the pro-inflammatory function of RAW264.7 via down-regulating the NF-κB signaling ***:Polydatin protects the liver from I/R injury by remodeling macrophage polarization via NFκB signaling.

关键词： Hepatic ischemia-reperfusion injury Polydatin Macrophage Polarization Inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Time-resolved photoluminescence:a precision tool for shallow trap density determination in perovskite films

引用

Chinese Optics Letters 2024年第8期22卷 124-130页

作者： Wei chen Yifeng Shi Pengxiang Wang Guodong Zhang Hu Wang Yifan Zheng Yuchuan shao Key Laboratory of Materials for High-Power Laser Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China School of Material Science and Technology ShanghaiTech UniversityShanghai 201210China

Determining the trap density in the absorbing layer thin film of perovskite solar cells is a critically important task,as it directly influences the efficiency of the ***,we proposed time-resolved photoluminescence(TRPL)as a nondestructive method to assess trap density.A model was constructed to investigate carrier recombination and transition in perovskite *** model was utilized for numerical calculations and successfully fitted TRPL signals of perovskite ***,a genetic algorithm was employed to optimize the ***,statistical methods were applied to obtain the parameters associated with the trap states of the *** approach facilitates the successful determination of trap densities for different samples with clear differentiation.

关键词： perovskite solar cell time-resolved photoluminescence genetic algorithm trap density methylammonium lead triiodide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surface engineering of Li-and Mn-rich layered oxides for superior Li-ion battery

引用

Tungsten 2024年第1期6卷 259-268页

作者： Lu-Xiang Ma Tian-Dong chen Chun-Xi Hai sheng-De Dong Xin He Qi Xu Hang Feng AXin Ji-Tao chen Yuan Zhou College of Materials and Chemistry and Chemical Engineering Chengdu University of TechnologyChendu 610000China Qinghai Building and Materials Research Co. LtdXining 810000China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The Li-and Mn-rich layered oxides(R-LNCM)are considered as promising cathode materials for high-energy density lithium-ion batteries(LIBs).However,the interface side reaction aggravates the voltage and capacity fading between cathode material and electrolyte at high voltage,which severely hinders the practical application of LIB ***,lithium polyacrylate(LiPAA)as the binder and coating agent is applied to suppress the voltage and capacity fading of R-LNCM *** flexible LiPAA layers with high elasticity are capable of impeding cathode cracks on the particle surface via mechanical stress ***,superior voltage and capacity fading suppression on R-LNCM electrode is finally *** a result,LiPAA-R-LNCM cathode exhibits a remarkable specific capacity of 186 mA·h·g^(-1)with~73%retention at 1℃after ***,the corresponding average discharge potential is maintained to~3.1 V with only~0.4 V falling.

关键词： LiPAA interphase layer Interface side reaction Cathode cracks Capacity and voltage fading suppression Liand Mn-rich cathode

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TPpred-SC: multi-functional therapeutic peptide prediction based on multi-label supervised contrastive learning

引用

Science China(Information Sciences) 2024年第11期67卷 136-147页

作者： Ke YAN Hongwu LV Jiangyi shao Shutao chen Bin LIU School of Computer Science and Technology Beijing Institute of Technology

Therapeutic peptides contribute significantly to human health and have the potential for personalized medicine. The prediction for the therapeutic peptides is beneficial and emerging for the discovery of drugs. Although several computational approaches have emerged to discern the functions of therapeutic peptides, predicting multi-functional therapeutic peptide types is challenging. In this research, a novel approach termed TPpred-SC has been introduced. This method leverages a pretrained protein language model alongside multi-label supervised contrastive learning to predict multi-functional therapeutic *** framework incorporates sequential semantic information directly from large-scale protein sequences in TAPE. Then, TPpred-SC exploits multi-label supervised contrastive learning to enhance the representation of peptide sequences for imbalanced multi-label therapeutic peptide prediction. The experimental findings demonstrate that TPpred-SC achieves superior performance compared to existing related methods. To serve our work more efficiently, the web server of TPpred-SC can be accessed at http://***/TPpred-SC.

关键词： therapeutic peptide prediction multi-label classification pretrained protein language model multi-label supervised contrastive learning

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Decoding the fish genome opens a new era in important trait research and molecular breeding in China

引用

Science China(Life Sciences) 2024年第10期67卷 2064-2083页

作者： Qian Zhou Jialin Wang Jiongtang Li Zhangfan chen Na Wang Ming Li Lei Wang Yufeng Si sheng Lu Zhongkai Cui Xuhui Liu Songlin chen State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China Laboratory for Marine Fisheries Science and Food Production Processes Qingdao Marine Science and Technology CenterQingdaoShandong 266237China Key Laboratory of Aquatic Genomics Ministry of Agriculture and Rural AffairsBeijing Key Laboratory of Fishery BiotechnologyChinese Academy of Fishery SciencesBeijing 100041China

Aquaculture represents the fastest-growing global food production sector,as it has become an essential component of the global food *** has the world's largest aquaculture industry in terms of production ***,the sustainable development of fish culture is hindered by several concerns,including germplasm degradation and disease *** practice of genomic breeding,which relies heavily on genome information and genotypephenotype relationships,has significant potential for increasing the efficiency of aquaculture *** 2014,the completion of the genome sequencing and annotation of the Chinese tongue sole signified the beginning of the fish genomics era in *** then,domestic researchers have made dramatic progress in functional genomic *** date,the genomes of more than 60 species of fish in China have been assembled and *** on these reference genomes,evolutionary,comparative,and functional genomic studies have revolutionized our understanding of a wide range of biologically and economically important traits of fishes,including growth and development,sex determination,disease resistance,metamorphosis,and ***,genomic tools and breeding techniques such as SNP arrays,genomic selection,and genome editing have greatly accelerated genetic improvement through the incorporation of functional genomic information into breeding *** review aims to summarize the current status,advances,and perspectives of the genome resources,genomic study of important traits,and genomic breeding techniques of fish in *** review will provide aquaculture researchers,fish breeders,and farmers with updated information concerning fish genomic research and breeding *** summary will help to promote the genetic improvement of production traits and thus will support the sustainable development of fish aquaculture.

关键词： fish genomics economic traits genomic selection genome editing genomic breeding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High Magnetic Property and Toxicity of Particulate Matter Generated during Welding and Cutting Processes

引用

Environment & Health 2024年第6期2卷 381-389页

作者： Wei Cui Zizhen Ma Yuanzheng chen Shuya Li Di Wu Xiu chen Yuankai shao Yuzhe Liu Qing Li Jianmin chen Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China School of Environmental and Municipal Engineering Qingdao University of TechnologyQingdao 266520China Shanghai Institute of Eco-Chongming(SIEC) Shanghai 200062China National Engineering Laboratory for Mobile Source Emission Control Technology China Automotive Technology&Research Center Co.LtdTianjin 300300China

Magnetic particulate matter(PM)has raised increasing concern due to its abundant presence in ambient air and negative health ***,there is still a lack of comprehensive understanding of their emission sources and *** here report the observation of high magnetic property and toxicity of PM generated during typical welding and cutting ***,formed during high-temperature operation with less oxygen pressure,was revealed to be the major magnetic *** averaged saturation magnetization and magnetic susceptibility values of fine PM(PM_(2.5))from welding processes are 1.4−4.2 times greater than those of PM emitted from other unintended emission sources,including iron and steel plants and brake wear,while they are 2.0−5.7 times greater for the cutting ***,PM_(2.5)from welding and cutting processes are nearly 3.5−4.5 times more neurovirulent and 2.1−7.0 times more likely to induce oxidative stress than those from other magnetic sources in the nerve cells ***,all of these magnetic PM_(2.5)exhibit greater negative health effects than typical atmospheric PM_(2.5)collected in Shanghai urban *** new findings suggest that appropriate occupational protection measures should be implemented for the welding and cutting process to reduce adverse health impacts.

关键词： pollutant emission magnetic property particulate matters magnetite welding and cutting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：