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Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice

World Journal of Gastroenterology 2016年第23期22卷 5374-5383页

作者： Hai-Mei Zhao Rong Xu Xiao-Ying Huang shao-min cheng min-Fang Huang Hai-Yang Yue Xin Wang Yong Zou Ai-Ping Lu Duan-Yong Liu School of Basic Medical Sciences Jiangxi University of Traditional Chinese Medicine Department of postgraduate Jiangxi University of Traditional Chinese Medicine Key Laboratory of Modern preparation of Traditional Chinese Medicine Ministry of EducationJiangxi university of Traditional Chinese Medicine School of Chinese Medicine Hong Kong Baptist University Science and Technology College Jiangxi University of Traditional Chinese Medicine

AIM: To explore the probable pathway by which curcumin(Cur) regulates the function of Treg cells by observing the expression of costimulatory molecules of dendritic cells(DCs).METHODS: Experimental colitis was induced by administering 2, 4, 6-trinitrobenzene sulfonic acid(TNBS)/ethanol solution. Forty male C57BL/6 mice were randomly divided into four groups: normal, TNBS + Cur, TNBS + mesalazine(Mes) and TNBS groups. The mice in the TNBS + Cur and TNBS +Mes groups were treated with Cur and Mes, respectively, while those in the TNBS group were treated with physiological saline for 7 d. After treatment, the curative effect of Cur was evaluated by colonic weight, colonic length, weight index of the colon, and histological observation and score. The levels of CD4+CD25+Foxp3+ T cells(Treg cells) and costimulatory molecules of DCs were measured by flow cytometry. Also, related cytokines were analyzed by enzyme-linked immunosorbent assay. RESULTS: Cur alleviated inflammatory injury of the colonic mucosa, decreased colonic weigh and histological score, and restored colonic length. The number of Treg cells was increased, while the secretion of TNF-α, IL-2, IL-6, IL-12 p40, IL-17 and IL-21 and the expression of costimulatory molecules(CD205, CD54 [ICAM-1], TLR4, CD252[OX40 L], CD256 [RANK] and CD254 [RANK L]) of DCs were notably inhibited in colitis mice treated with ***: Cur potentially modulates activation of DCs to enhance the suppressive functions of Treg cells and promote the recovery of damaged colonic mucosa in inflammatory bowel disease.

关键词： Curcumin Regulatory T cells Dendritic cells Costimulatory molecules

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Therapeutic effect of curcumin on experimental colitis mediated by inhibiting CD8^+ CD11c^+ cells

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World Journal of Gastroenterology 2017年第10期23卷 1804-1815页

作者： Hai-Mei Zhao Fei Han Rong Xu Xiao-Ying Huang shao-min cheng min-Fang Huang Hai-Yang Yue Xin Wang Yong Zou Han-Lin Xu Duan-Yong Liu School of Basic Medical Sciences Jiangxi University of Traditional Chinese Medicine College of Pharmacy Jiangxi University of Traditional Chinese Medicine College of Pharmacy Hubei University of Traditional Chinese Medicine Department of Postgraduate Jiangxi University of Traditional Chinese Medicine Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Traditional Chinese Medicine Collaborative Innovation Center of TCM of New Products for Geriatrics Science and Technology College Jiangxi University of Traditional Chinese Medicine

AIM To verify whether curcumin (Cur) can treat inflammatory bowel disease by regulating CD8(+)CD11c(+) cells. METHODS We evaluated the suppressive effect of Cur on CD8(+)CD11c(+) cells in spleen and Peyer's patches (PPs) in colitis induced by trinitrobenzene sulfonic acid. Mice with colitis were treated by 200 mg/kg Cur for 7 d. On day 8, the therapeutic effect of Cur was evaluated by visual assessment and histological examination, while co-stimulatory molecules of CD8(+)CD11c(+) cells in the spleen and PPs were measured by flow cytometry. The levels of interleukin (IL)-10, interferon (IFN)-gamma and transforming growth factor (TGF)-beta 1 in spleen and colonic mucosa were determined by ELISA. RESULTS The disease activity index, colon weight, weight index of colon and histological score of experimental colitis were obviously decreased after Cur treatment, while the body weight and colon length recovered. After treatment with Cur, CD8(+)CD11c(+) cells were decreased in the spleen and PPs, and the expression of major histocompatibility complex., CD205, CD40, CD40L and intercellular adhesion molecule-1 was inhibited. IL-10, IFN-gamma and TGF-beta 1 levels were increased compared with those in mice with untreated colitis. CONCLUSION Cur can effectively treat experimental colitis, which is realized by inhibiting CD8(+)CD11c(+) cells.

关键词： CD8 CD11c Curcumin Experimental colitis Therapeutic effect

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SYNTHESIS OF NEW CYCLIC PHOSPHATES OF 3-HYDROXYISOXAZOLE AND THEIR DIASTEREOMERS

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Chinese Chemical Letters 1993年第9期4卷 767-768页

作者： Rui Lian shao min Hua YANG cheng Xin ZHI The National Laboratory of Elemento-organic Chemistry NanKai University,Tianjin 300071

Keeping in view the biological activities of 3-hydroxyisoxa- zole and cyclic phosphate derivatives,some compounds possessing these two moieties have been synthesized,the structural elucidation of these diastereomers was made depending on spectral *** mechanism could be illustrated by the theories of trigonal bipyramide intermediate and pseudorotation.

关键词： SYNTHESIS OF NEW CYCLIC PHOSPHATES OF 3-HYDROXYISOXAZOLE AND THEIR DIASTEREOMERS THF

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新疆巴音郭楞蒙古自治州湖泊动态变化及分析

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干旱区研究 2009年第3期26卷 318-325页

作者：邵民诚邵年沈强林平新疆巴音郭楞蒙古自治州水利局水管处新疆库尔勒841000 郑州大学水利与环境学院河南郑州450001

湖泊相关数据的完整与准确是对湖泊进行研究的重要基础。利用国内关于湖泊的最新研究成果及相关资料,采用归纳总结的方法,分析了近20年巴音郭楞蒙古自治州湖泊的变化,并按湖泊类型总结了湖泊变化的详细情况,得到了湖泊动态变化的一些新... 详细信息

湖泊相关数据的完整与准确是对湖泊进行研究的重要基础。利用国内关于湖泊的最新研究成果及相关资料,采用归纳总结的方法,分析了近20年巴音郭楞蒙古自治州湖泊的变化,并按湖泊类型总结了湖泊变化的详细情况,得到了湖泊动态变化的一些新结论。

关键词：湖泊动态变化巴音郭楞蒙古自治州新疆

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo shao Chao-min Xu Ke Wang Jia-Zhu Wen Li-Kang Luo Jia-cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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高压力制备柯萨奇病毒疫苗

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生物化学与生物物理学报 2001年第1期33卷 128-130页

作者：陈忠明田少敏阮康成中国科学院上海生命科学研究院生物化学与细胞生物学研究所!上海200031

以HeLa细胞和BALB/c小鼠为模型 ,研究了高压力对柯萨奇B组病毒 (CVB)感染活性和免疫原性的影响。发现在 2 30MPa压力下 ,结合其他相应的物理条件 ,CVB的感染活性可完全消失。该CVB仍具有抗原性 ,可诱导小鼠产生CVB特异性抗体 ,效价可达 ... 详细信息

以HeLa细胞和BALB/c小鼠为模型 ,研究了高压力对柯萨奇B组病毒 (CVB)感染活性和免疫原性的影响。发现在 2 30MPa压力下 ,结合其他相应的物理条件 ,CVB的感染活性可完全消失。该CVB仍具有抗原性 ,可诱导小鼠产生CVB特异性抗体 ,效价可达 1∶15 0 0。用高压力处理的CVB免疫小鼠 ,再用正常CVB攻击 ,其生存率为 6 7% ,具有疫苗的特性。这些结果表明 ,高压力处理的CVB具有免疫保护作用 ,可作为一种具有潜在应用前景的病毒疫苗

关键词：高压力柯萨奇B组病毒(CVB) 免疫原性疫苗

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紫苏梗酶解糖化条件优化

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南方农业学报 2017年第6期48卷 1054-1061页

作者：赵莉娟胥江河王星敏邵承斌曾雪重庆工商大学环境与资源学院重庆400067 催化与功能有机分子重庆市重点实验室重庆400067

【目的】研究复合酶制剂催化水解紫苏梗的适宜条件,为紫苏梗生物质资源化利用提供技术支持。【方法】选用质量比4∶25∶12的纤维素酶、木聚糖酶和漆酶为复合酶制剂,在单因素试验的基础上,采用响应曲面法,以还原糖含量(Y)为响应值,建立... 详细信息

【目的】研究复合酶制剂催化水解紫苏梗的适宜条件,为紫苏梗生物质资源化利用提供技术支持。【方法】选用质量比4∶25∶12的纤维素酶、木聚糖酶和漆酶为复合酶制剂,在单因素试验的基础上,采用响应曲面法,以还原糖含量(Y)为响应值,建立紫苏梗水解糖化的数学模型和优化其工艺参数,并探究复合酶制剂投加量(A)、酶解时间(B)、酶解温度(C)和pH(D)4个因素对复合酶制剂催化水解紫苏梗组织纤维的影响。【结果】建立的紫苏梗催化水解二次多项回归方程为Y=107.28+7.26A+6.88B+3.09C-1.68D-20.57A2-19.41B2-18.42C2-28.26D2-3.63AB-4.98AC-2.93AD+1.93BC-1.20BD-1.33CD,其中复合酶制剂投加量对紫苏梗还原糖含量影响极显著(P<0.01),酶解时间影响显著(P<0.05)。复合酶制剂催化水解紫苏梗的最佳工艺条件为:在复合酶制剂投加量1.0 g、酶解温度45℃、pH 5的条件下酶解5.4 h,可水解产还原糖108.8 mg/g,与预测值相差0.1 mg/g。【结论】采用响应曲面法优化获得的复合酶制剂催化水解紫苏梗产糖工艺,具有试验周期短、耗能低等优点,建立的数学模型对优化工艺具有可行性,可用于实际预测。

关键词：紫苏梗酶解还原糖工艺优化

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老年2型糖尿病患者尿路感染与血糖控制的相关性分析

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中华医院感染学杂志 2017年第20期27卷 4661-4663,4667页

作者：张耿占达良邓炳取胡少敏肖成东海南省海口市第三人民医院老年病科海南海口571100

目的分析老年2型糖尿病患者尿路感染临床特点和血糖控制情况。方法选取医院2015年11月-2017年1月收治的老年2型糖尿病合并尿路感染患者52例为观察组,同时选取同期在医院治疗的老年2型糖尿病未合并尿路感染患者51例为对照组,分析老年2型... 详细信息

目的分析老年2型糖尿病患者尿路感染临床特点和血糖控制情况。方法选取医院2015年11月-2017年1月收治的老年2型糖尿病合并尿路感染患者52例为观察组,同时选取同期在医院治疗的老年2型糖尿病未合并尿路感染患者51例为对照组,分析老年2型糖尿病患者尿路感染临床特点,并对比两组的治疗时间、病程、生化指标情况。结果 52例感染患者共分离培养病原菌52株,其中革兰阴性菌48株占92.31%,以大肠埃希菌为主;真菌4株占7.69%;观察组治疗时间、病程、尿素氮、甘油三酯、糖化血红蛋白、空腹血糖及餐后2h血糖分别为(16.62±2.90)d、(11.34±2.00)年、(6.73±1.23)mmol/L、(2.08±0.70)mmol/L、(14.03±1.80)%、(8.30±1.92)mmol/L、(14.41±2.22)mmol/L均显著高于对照组(12.48±2.50)d、(8.46±2.03)年、(4.67±1.20)mmol/L、(1.40±0.40)mmol/L、(9.64±1.56)%、(7.05±1.17)mmol/L、(11.12±1.90)mmol/L(P<0.05)。结论老年2型糖尿病患者尿路感染病原菌以大肠埃希菌为主,同时患者的各项生化指标、治疗时间、病程均明显升高,血糖控制效果不佳。

关键词：老年尿路感染 2型糖尿病临床特点血糖控制

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Landslide prediction based on improved principal component analysis and mixed kernel function least squares support vector regression model

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Journal of Mountain Science 2021年第8期18卷 2130-2142页

作者： LI Li-min cheng shao-kang WEN Zong-zhou School of Electronics and Information Xi’an Polytechnic UniversityXi’an710048China School of Automation Northwestern Polytechnical UniversityXi’an710072China

Landslide probability prediction plays an important role in understanding landslide information in advance and taking preventive *** factors can influence the occurrence of landslides,which is easy to have a curse of dimensionality and thus lead to reduce prediction *** the generalization ability of the model will also decline sharply when there are only small *** reduce the dimension of calculation and balance the model’s generalization and learning ability,this study proposed a landslide prediction method based on improved principal component analysis(PCA)and mixed kernel function least squares support vector regression(LSSVR)***,the traditional PCA was introduced with the idea of linear discrimination,and the dimensions of initial influencing factors were reduced from 8 to *** improved PCA can not only weight variables but also extract the original ***,combined with global and local kernel function,the mixed kernel function LSSVR model was framed to improve the generalization *** optimization algorithm(WOA)was used to optimize the ***,Root Mean Square Error(RMSE),the sum of squared errors(SSE),Mean Absolute Error(MAE),Mean Absolute Precentage Error(MAPE),and reliability were employed to verify the performance of the *** with radial basis function(RBF)LSSVR model,Elman neural network model,and fuzzy decision model,the proposed method has a smaller ***,the landslide warning level obtained from the landslide probability can also provide references for relevant decision-making departments in emergency response.

关键词： Landslide probability LSSVR Mixed kernel function Improved PCA Warning level

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Robust H_∞ control for networked control systems

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Journal of Systems Engineering and Electronics 2008年第5期19卷 1003-1009页

作者： Ma Weiguo shao cheng Inst. of Advanced Control Technology School of Electronic and Information Engineering Dalian Univ. of Technology Dalian 116024 P. R. China

The robust H∞ control for networked control systems with both stochastic network-induced delay and data packet dropout is studied. When data are transmitted over network, the stochastic data packet dropout process can be described by a two-state Markov chain. The networked control systems with stochastic network-induced delay and data packet dropout are modeled as a discrete time Markov jump linear system with two operation modes. The sufficient condition of robust H∞ control for networked control systems stabilized by state feedback controller is presented in terms of linear matrix inequality. The state feedback controller can be constructed via the solution of a set of linear matrix inequalities. An example is given to verify the effectiveness of the method proposed.

关键词： networked control systems H∞ control Markov jump linear systems linear matrix inequality.

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