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RON in hepatobiliary and pancreatic cancers:Pathogenesis and potential therapeutic targets

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World Journal of Gastroenterology 2021年第20期27卷 2507-2520页

作者： shao-long chen Guo-Ping Wang Dan-Rong Shi Shu-Hao Yao Ke-Da chen Hang-Ping Yao Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310000Zhejiang ProvinceChina Department of Surgical Oncology The Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Stomatology Wenzhou Medical University Renji CollegeWenzhou 325035Zhejiang ProvinceChina

The receptor protein tyrosine kinase RON belongs to the c-MET proto-oncogene *** has shown that RON has a role in cancer pathogenesis,which places RON on the frontline of the development of novel cancer therapeutic *** and pancreatic(HBP)cancers have a poor prognosis,being reported as having higher rates of cancer-related ***,to combat these malignant diseases,the mechanism underlying the aberrant expression and signaling of RON in HBP cancer pathogenesis,and the development of RON as a drug target for therapeutic intervention should be *** RON expression and signaling have been identified in HBP cancers,and also act as tumorigenic determinants for HBP cancer malignant *** addition,RON is emerging as an important mediator of the clinical prognosis of HBP ***,not only is RON significant in HBP cancers,but also RON-targeted therapeutics could be developed to treat these cancers,for example,therapeutic monoclonal antibodies and small-molecule *** them,antibody-drug conjugates have become increasingly popular in current research and their potential as novel anti-cancer biotherapeutics will be determined in future clinical trials.

关键词： RON Signal transduction Hepatobiliary Pancreatic neoplasms Molecular targeted therapy

Quantitative evaluation of space charge effects of laser-cooled three-dimensional ion system on a secular motion period scale

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Chinese Physics B 2018年第4期27卷 292-298页

作者： Li-Jun Du Hong-Fang Song shao-long chen Yao Huang Xin Tong Hua Guan Ke-Lin Gao China Academy of Space Technology (Xi'an) Xi'an 710100 China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China Key Laboratory of Atomic Frequency Standards Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China Center for Cold Atom Physics Chinese Academy of Sciences Wuhan 430071 China University of Chinese Academy of Sciences Beijing 100049 China

In this paper,we introduce a method of quantitatively evaluating and controlling the space charge effect of a lasercooled three-dimensional（3 D） ion system in a linear Paul *** relationship among cooling efficiency,ion quantity,and trapping strength is analyzed quantitatively,and the dynamic space distribution and temporal evolution of the 3 D ion system on a secular motion period time scale in the cooling process are *** ion number influences the eigen-micromotion feature of the ion *** trapping parameter q is ～ 0.3,relatively ideal cooling efficiency and equilibrium temperature can be *** decrease of axial electrostatic potential is helpful in reducing the micromotion heating effect and the degradation in the total *** a single secular motion period under different cooling conditions,ions transform from the cloud state（each ion disperses throughout the envelope of the ion system） to the liquid state（each ion is concentrated at a specific location in the ion system） and then to the crystal state（each ion is subjected to a fixed motion track）.These results are conducive to long-term storage and precise control,motion effect suppression,high-efficiency cooling,and increasing the precision of spectroscopy for a 3 D ion system.

关键词： space charge effects cooling dynamics ion trajectory ion energy

Aerial target threat assessment based on gated recurrent unit and self-attention mechanism

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Journal of Systems Engineering and Electronics 2024年第2期35卷 361-373页

作者： chen chen QUAN Wei shao Zhuang School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Intelligent Control and Decision of Complex Systems Beijing 100081China

Aerial threat assessment is a crucial link in modern air combat, whose result counts a great deal for commanders to make decisions. With the consideration that the existing threat assessment methods have difficulties in dealing with high dimensional time series target data, a threat assessment method based on self-attention mechanism and gated recurrent unit(SAGRU) is proposed. Firstly, a threat feature system including air combat situations and capability features is established. Moreover, a data augmentation process based on fractional Fourier transform(FRFT) is applied to extract more valuable information from time series situation features. Furthermore, aiming to capture key characteristics of battlefield evolution, a bidirectional GRU and SA mechanisms are designed for enhanced ***, after the concatenation of the processed air combat situation and capability features, the target threat level will be predicted by fully connected neural layers and the softmax classifier. Finally, in order to validate this model, an air combat dataset generated by a combat simulation system is introduced for model training and testing. The comparison experiments show the proposed model has structural rationality and can perform threat assessment faster and more accurately than the other existing models based on deep learning.

关键词： target threat assessment gated recurrent unit(GRU) self-attention(SA) fractional Fourier transform(FRFT)

Topologically Correct Intersection Curves of Two Trimmed Quadrics with Tolerance Control

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Journal of Systems Science & Complexity 2024年第5期37卷 2207-2239页

作者： shao Wenbing chen Falai Department of Mathematics University of Science and Technology of China

Surface/surface intersection is a fundamental problem in Compute Aided Design and Geometric Modeling since it is essential to solid modeling, numerically controlled machining, feature recognition, computer animation, etc. In practical applications, quadric surfaces, which are the most basic type of surfaces, are typically bounded surfaces trimmed by a sequence of planes. In this paper,a robust algorithm is proposed for computing the intersection curve segments of two trimmed quadrics based on the parametric representation of the intersection curves of two quadrics. The proposed algorithm guarantees correct topology and ensures that the approximation errors of the end points of the intersection curve segments are less than a given tolerance. The error control is based on an effective solution to a set of polynomial inequality system using the root isolation technique. Some examples are presented to validate the robustness and effectiveness of the proposed algorithm.

关键词： Polynomial inequality system root isolation surface/surface intersection tolerance control trimmed quadrics

Significantly Improving the Escape Time of a Single 40Ca+Ion in a Linear Paul Trap by Fast Switching of the Endcap Voltage

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Chinese Physics Letters 2020年第9期37卷 21-25页

作者： Peng-Peng Zhou shao-long chen Shi-Yong Liang Wei Sun Huan-Yao Sun Yao Huang Hua Guan Ke-Lin Gao State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Center for Cold Atom Physics Chinese Academy of SciencesWuhan 430071China

Sympathetic cooling is a method used to lower the kinetic energy of ions with complicated energy-level structures,via Coulomb interactions with laser-cooled ions in an ion *** ion to be sympathetically cooled is sometimes prepared outside of the trap,and it is critical to introduce this ion into the trap by temporarily lowering the potential of one endcap without allowing the coolant ion to *** study the time required for a laser-cooled ion to escape from a linear Paul trap when the voltage of one endcap is *** escape time is on the order of a few microseconds,and varies significantly when the low-level voltage changes.A re-cooling time of a maximum of 13 s was measured,which can be reduced to approximately one hundred of milliseconds by decreasing the duration of the low-level *** measurement of these critical values lays the foundation for the smooth injection and cooling of the ion to be sympathetically cooled.

关键词： outside Paul critical

Deceleration of Metastable Li^+ Beam by Combining Electrostatic Lens and Ion Trap Technique

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Chinese Physics Letters 2020年第7期37卷 15-18页

作者： shao-long chen Peng-Peng Zhou Shi-Yong Liang Wei Sun Huan-Yao Sun Yao Huang Hua Guan Ke-Lin Gao State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Center for Cold Atom Physics Chinese Academy of SciencesWuhan 430071China

Ion deceleration has played a critical role in ion-related research when the ions are produced in the form of a high-energy *** present a deceleration method combining electrostatic lens and ion trap technique,which can effectively decelerate ions to energy below the trapping potential of a typical ion *** experiments were performed on metastable 1s2s3S1Li+ions,and demonstrated that the kinetic energy could easily be reduced from^450 e V to a few e V,with the latter being confirmed using the Doppler-shifted fluorescence spectra.

关键词： spectra. beam. latter

Solidification behaviour and hot cracking susceptibility of a novel Ni-based superalloy

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Journal of Iron and Steel Research International 2024年第4期31卷 956-966页

作者： Yue chen shao-min Lv Xing-fei Xie Xiao-can Wen Jng-long Qu Jin-hui Du High-Temperature Materials Institute China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China Beijing GAONA Materials and Technology Co. Ltd.Beijing 100081China Sichuan CISRI-GAONA Forging Co. Ltd.Deyang 610000SichuanChina

A novel Ni-based superalloy GH4151,with a γ′ volume fraction of about 55%and a service temperature capability up to 8oo oC,was *** to the different cooling conditions of various regions during the solidification of ingots,significant cooling rate variations may lead to the occurrence of hot *** scanning laser microscope was utilised to investigate the solidification process and phase precipitation behaviour of the GH4151 under wide range cooling *** characteristics of L→γ transformation were analysed,and the growth rates of at each stage were *** segregation behaviour was predicted using the Scheil equation,and the predicted results match well with the experimental *** sensitivity coefficient for hot cracking was modified,and cracking sensitivity coefficient values for the alloy under different cooling rates were computed,revealing that the alloy is most susceptible to hot cracking at 10℃/min cooling ***,controlling the cooling rate can reduce the possibility of hot cracking in ingot.

关键词： Ni-based superalloy Solidification behaviour In-situ observation Clyne and Davies's criterion:Hot cracking susceptibility

A highly reduced Mo_(74) polyoxometalate featuring high proton conductivity accessed by building block strategy

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Science China Chemistry 2024年第3期67卷 862-868页

作者： Shi-Yi Liu Xue-Xin Li Wei-Chao chen Kui-Zhan shao Xin-long Wang Chao Qin Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Highly reduced polyoxometalates(POMs) are predicted to be used as rather high energy density materials;however,it still suffers from the limited cluster species and reduction *** we demonstrate that it is possible to employ the building block strategy to generate a highly reduced polyoxomolybdate(C_(2)H_(8)N)_(14)(NH_(4))_(4)H_(14)[Mo_(48)-ⅤMo_(26)ⅥO_(202)(OH)_(12)(SO_(4))_(6)]·46H_(2)O(Mo_(74)).The fundamental Mo-based{Mo_x}(x=4,5,and 6) building blocks,which are templated by tetra-coordinated anions{MoO_(4)}or{SO_(4)},not only lay foundation for the formation of Mo_(74) featuring an unprecedented reduction ratio of 65%,but also give rise to SBBs-mediated(secondary building blocks) supramolecular dense packing interactions among the isolated Mo_(74) clusters that are favorable for proton ***,high proton conductivity(2.04×10^(-2)S cm^(-1)) had been realized at 50℃ and 90% relative humidity,revealing one of the well-known POMs-based crystalline proton conducting *** result highlights that this building block approach possesses great potential in producing highly reduced POM systems that can achieve controllable reduced ratio and desirable properties.

关键词： polyoxometalate building block molybdenum highly reduced state proton conduction

Global,regional and national burdens of bipolar disorders in adolescents and young adults:a trend analysis from 1990 to 2019

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General Psychiatry 2024年第1期37卷 122-132页

作者： Yunxi Zhong Yifan chen Xiaoying Su Meiqi Wang Qixiu Li Ziming shao long Sun Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinanShandongChina National Health Commission of China(NHC)Key Laboratory of Health Economics and Policy Research Shandong UniversityJinanShandongChina nstitute of Health and Elderly Care Shandong UniversityJinanShandongChina

Background Bipolar disorder is identified as a cause of severe damage to the physical,psychological and social functioning of adolescents and young *** The aim of this study is to ascertain the trends in the burden of bipolar disorder among individuals aged 10-24 years at global,regional and national levels from 1990 to *** The data analysed in this study were from the Global Burden of Diseases *** numbers,rates per 100000 population,average annual percentage changes(AAPCs)of incidence,prevalence and years lived with disability(YLDs)of bipolar disorder are reported at the global,regional and national levels among individuals aged 10-24 *** trends by age,sex and Social Development Index(SDI)were further *** Globally,the incidence of bipolar disorder among adolescents and young adults increased from 79.21 per 100000 population(95%uncertainty interval(Ul):58.13 to 105.15)in 1990 to 84.97 per 100000 population(95%Ul:61.73 to 113.46)in 2019,AAPC 0.24(95%confidence interval(Cl):0.22 to 0.26).In the past three decades,there has been an increase in incidence,prevalence and YLDs in both males and *** largest increase in incidence between 1990 and 2019 was observed in those aged 20-24 years old from 51.76 per 100000 population(95%Ul:26.81 to 87.20)in 1990 to 58.37 per 100000 population(95%UI:30.39 to 98.55)in 2019;AAPC 0.42(95%Cl:0.38 to 0.47).By the SDI quintile,the largest increase in incidence was observed in the middle SDl;however,the high SDI countries had the highest ***,the largest increase in incidence was observed in southern Latin *** the national level,the most pronounced increase in the incidence was in *** The global increase in incidence among adolescents and young adults between 1990 and 2019 indicates that strategies to improve their mental health still need to be emphasised.

关键词： adolescent bipolar young