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考虑建成环境的电动自行车事故严重程度致因分析

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交通运输系统工程与信息 2024年第1期24卷 179-187页

作者：王菁董春娇李鹏辉姜文龙邵春福北京交通大学综合交通运输大数据应用技术交通运输行业重点实验室北京100044 中国人民公安大学治安与交通管理学院北京100038 新疆大学交通运输工程学院乌鲁木齐830017

为探究考虑建成环境影响下,电动自行车交通事故严重程度的影响因素,本文从事故属性、骑行者属性、对象车辆及驾驶员属性、道路属性及建成环境属性这5个方面,选取18个影响电动自行车交通事故严重性的潜在变量。在此基础上,构建考虑均值... 详细信息

为探究考虑建成环境影响下,电动自行车交通事故严重程度的影响因素,本文从事故属性、骑行者属性、对象车辆及驾驶员属性、道路属性及建成环境属性这5个方面,选取18个影响电动自行车交通事故严重性的潜在变量。在此基础上,构建考虑均值及方差异质性的随机参数Logit模型,利用边际效应量化显著变量对事故严重程度的影响差异。基于北京市近5年电动自行车事故抽样数据进行实证研究,结果表明:事故时段19:00-次日7:00、骑行者年龄大于40岁、重(大)型货车、到最近医院的距离增大及恶劣天气等因素会增加电动自行车事故严重程度。建成环境属性中,到最近医院的距离在死亡事故中的参数为服从正态分布的随机参数,路段及恶劣天气会增大其均值异质性,驾驶员年龄为(40,60]岁会增大其方差异质性;其他属性中,一般城市道路在受伤事故中的参数为服从正态分布的随机参数,路段会增大其均值异质性。研究结果可以为降低电动自行车事故严重程度提供理论支撑。

关键词：交通工程事故严重程度随机参数Logit模型电动自行车建成环境

政策工具视角下省(市)级生物医药产业高质量发展政策文本分析

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中国新药杂志 2024年第12期33卷 1194-1200页

作者：盛天翊蒋蓉邵蓉中国药科大学药品监管科学研究院南京211198 国家药品监督管理局药品监管创新与评价重点实验室南京211198

目的:从政策工具视角,结合产业创新价值链维度,总结我国生物医药产业高质量发展政策制定现状,分析政策工具使用偏好,为政策优化调整提供参考。方法:以政策工具为X维度,产业创新价值链为Y维度,采用Rothwell和Zegveld政策工具分类法对我... 详细信息

目的:从政策工具视角,结合产业创新价值链维度,总结我国生物医药产业高质量发展政策制定现状,分析政策工具使用偏好,为政策优化调整提供参考。方法:以政策工具为X维度,产业创新价值链为Y维度,采用Rothwell和Zegveld政策工具分类法对我国生物医药产业高质量发展政策文件进行编码和分类,并采用SPSS,Ucinet等工具结合产业创新价值链进行统计分析。结果:在X维度中,环境型政策工具的使用频率最高(50.2%),需求型政策工具的使用频率最低(11.1%)。在Y维度中,产业推广阶段的政策工具使用频率最高(44.2%),成果转化阶段的政策工具使用频率最低(27.2%)。在双维度视角下,成果转化和产业推广阶段环境型政策工具使用频次最多,在研究开发阶段则是供给型政策工具最多。结论:各省(市)生物医药产业高质量发展政策文件中环境型政策工具使用较多,供给型和需求型政策工具使用相对较少。建议相关部门加强各类型政策工具平衡应用,重点增加需求型政策工具的使用频次,加大信息化投入,并发挥研究主体的创新作用。

关键词：政策工具生物医药产业高质量发展社会网络文本编码

Continuous wave and active Q-switched operation of Watt-level LED-pumped two-rod Nd,Ce:YAG laser

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Chinese Physics B 2024年第7期33卷 361-366页

作者：沈建平芦鹏徐少聪江容容陈阳陈亮邢凤阳 College of Electronic and Optical Engineering&College of Flexible Electronics Nanjing University of Posts and TelecommunicationsNanjing 210023China

A high-performance LED-side-pumped two-rod Nd,Ce:YAG laser with continuous-wave(CW) and acousto–optical(A-O) Q-switched operation is demonstrated in this work. A symmetrically shaped flat–flat cavity with two identical LEDside-pumped laser modules is employed for power scalability. In the CW regime, the maximum output average power of laser at 1064 nm is 4.41 W, corresponding to a maximum optical conversion efficiency of 5.3% and a slope efficiency is 12.4%. In the active Q-switched regime, the pulse energy of laser reaches as high as 0.89 m J at a repetition rate of 800 Hz with a pulse width of 457.2 ns, the corresponding highest peak output power is 1.94 k W and the M~2 factor is measured to be about 8.8. To the best of the authors' knowledge, this is the first demonstration and the highest performance of a CW LED-side-pumped two-rod laser Nd,Ce:YAG with Watt-level output reported so far.

关键词： Watt-level LED-pumped CW Nd Ce:YAG actively Q-switched operation

Protective mechanism of Paeoniae Radix Alba against chemical liver injury based on network pharmacology,molecular docking,and in vitro experiments

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 55-66页

作者： Shuangqiao Liu Xin Liu Sijia jiang Min Fu Jinxi Hu Jiaqi Liu Xiaoxu Fan Yingtong Feng Shujing Zhang Jingxia wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese Medicine Xinjiang Medical UniversityUrumqi 830017China The Centre for Translational Biology Research Institute of McGill University Health CentreMontr eal H4A 3J1Canada

Objective:To explore and validate the potential targets of Paeoniae Radix Alba(***,Bai shao)in protecting against chemical liver injury through network pharmacology,molecular docking technology,and in vitro cell ***:Network pharmacology was used to identify the common potential targets of *** and chemical liver *** docking was used to fit the components,which were subsequently verified in vitro.A cell model of hepatic fibrosis was established by activating hepatic stellate cell(HSC)-LX2 cells with 10 ng/mL transforming growth factor-β*** cells were exposed to different concentrations of total glucosides of paeony(TGP),the active substance of ***,and then evaluated using the cell counting kit-8 assay,enzyme-linked immunosorbent assay,and western ***:Analysis through network pharmacology revealed 13 key compounds of ***,and the potential targets for preventing chemical liver injury were IL-6,AKT serine/threonine kinase 1,jun protooncogene,heat shock protein 90 alpha family class A member 1(HSP90AA1),peroxisome proliferator activated receptor gamma(PPARG),PTGS2,and *** Ontology(GO)enrichment analysis indicated the involvement of response to drugs,membrane rafts,and peptide *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis revealed that the main pathways involved lipid and atherosclerosis and chemical carcinogenesis-receptor *** and albiflorin exhibited strong affinity for HSP90AA1,PTGS2,PPARG,and *** concentrations of TGP can inhibit the expression of COL-I,COL-III,IL-6,TNF-a,IL-1β,HSP-90a,and PTGS2 while increasing the expression of PPAR-γand CASP3 in activated HSC-LX2 ***:*** primarily can regulate targets such as HSP90AA1,PTGS2,PPARG,***,the main active compound of ***,protects against chemical liver injury by reducing the inflammatory response,activating apoptotic proteins,and promoting the apoptosis of activated HSCs.

关键词： Paeoniae Radix Alba Total glycosides of paeony Chemical liver injury Liver fibrosis Network pharmacology Hepatic stellate cells

Investigation and analysis of the status of cancer health popularization in China,2023

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World Journal of Clinical Oncology 2024年第10期15卷 1269-1279页

作者： Hai-Tao Hu Yu-Juan jiang Xin-Xin shao Yi-Ming Lu Yan-Tao Tian Quan Xu Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Cancer presents a significant public health challenge in China,necessitating broad collaboration across *** Chinese government has articulated a goal to increase the overall five-year survival rate for cancer by 15%by *** this objective requires not only advances in medical technology,but also an im-provement in the dissemination of knowledge pertaining to cancer prevention and *** To provide a comprehensive understanding of the status of cancer prevention and level of popularization in China in *** From January 2023 to May 2023,online questionnaires were distributed to 3000 participants,including medical personnel,patients with cancer,their families,and the general *** were 2711 valid responses,covering the entire *** A total of 1020 medical personnel and 1691 patients with cancer,their family members,and the general public participated in the *** medical personnel,93.2%had popularized cancer *** addressed topics included cancer prevention(85.9%)and cancer screening(77.8%).Primary challenges included time constraints(73.9%),insufficient personnel and material support(66.7%),and uncertainty as to where to begin(49.3%).Among patients with cancer,their family members,and the general public,93.4%reported reading or watching cancer science popularization materials and 56.9%expressed a desire for deeper *** most sought-after topics in cancer science popularization included cancer screening(80.2%)and cancer prevention(75.8%).The greatest challenge encountered in accessing cancer health popularization was an abundance of misinformation(67.5%).CONCLUSION Most clinical doctors,patients,family,and the general public wish to participate in cancer ***,improvement in the quality of content in cancer prevention and treatment education is required.

关键词： Cancer health popularization Patient education Science popularization Cancer prevention

Pyramiding the disease resistant genes to southern rust and stalk rot in maize (Zea mays L.) with marker-assisted selection

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Pyramiding the disease resistant genes to southern rust and ...

中国作物学会2007年全国作物遗传育种学术研讨会

作者： LI Wei-hua~1 WU Suo-wei~1 ZHAO Feng~1 YE Chun-jiang~1 ZHOU Chun-jiang~1 YANG Dian-er~1 JIN De-min~1 CHEN shao-jiang~2 wang Shou-cai~2 wang Bin~(1*) 1.Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101 2.China Agricultural University,Beijing 100094

Southern corn rust(SCR)caused by Puccinia polysora Underw and maize stalk rot caused by Pythium inflatum Matthews(MSR-2)are two destructive diseases of maize(Zea mays L.)in *** previous studies indicated that maize inbred line Qi319 is highly resistant to SCR but susceptible to MSR-2,while inbred line 1145 is highly resistant to MSR-2 but susceptible to SCR. The SCR resistant gene(RppQ)in Qi319 and MSR-2 resistant gene(Rpi1)in 1145 have been mapped on chromosome 10 and 4 *** this research,through marker-assisted selection (MAS)with the molecular markers,bnlg1937 tightly linked to Rpil and phi041 tightly linked to RppQ,pyramid breeding of the two kinds of disease resistant genes were carried out from the year of 2003 to *** homozygotic inbred lines of F5 generation,DR94-1-1-1 and DR36-1-1- 1 were *** result suggested DR94-1-1-1 and DR36-1-1-1 contained the two resistance genes RppQ and *** inoculation tests confirmed their high resistance to the two *** addition,field investigation indicated that the two selected inbred lines,particularly DR94-1-1-1,had excellent agronomic traits such as plant height,ear height and yield-relating traits including ear length,ear diameter,ear weight,kernels per ear,kernels per row and kernel weight per *** two selected inbred lines DR94-1-1-1 and DR36-1-1-1 can either be directly developed into commercial variety or used as immediate donors of SCR and MSR resistance breeding programs in maize.

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北极海域海浪变化及归因分析

海洋通报 2024年第4期43卷 510-520页

作者：韩飞邵伟增江涛海南南海海岸工程与生态环境研究所海南海口570100 上海海洋大学上海201306

北极海浪是北极地区重要的海洋环境要素,为了进一步了解北极海域海浪变化及归因,本文通过利用海浪数值模式WAVEWATCH-Ⅲ(WW3)对1993-2021年期间北极海域海浪进行模拟,将WW3模拟的海浪结果与OSTM/Jason-2高度计数据时空匹配,对比结果显示... 详细信息

北极海浪是北极地区重要的海洋环境要素,为了进一步了解北极海域海浪变化及归因,本文通过利用海浪数值模式WAVEWATCH-Ⅲ(WW3)对1993-2021年期间北极海域海浪进行模拟,将WW3模拟的海浪结果与OSTM/Jason-2高度计数据时空匹配,对比结果显示:两者数据的相关性(COR)为0.93,均方根误差为0.63 m,模拟结果适用于北极海域海浪变化研究。结果表明:(1)由于冬季平均海表面风速值较夏季更大,无海冰区能产生更高的海浪,导致北极海域冬季海浪强度明显高于夏季。而夏季由于海冰分布减少和厚度小于1 m的冰层增多,无冰区海浪传播冲击薄冰区域引发海冰破碎,同时引发厚度较薄的海域海浪活动,以此使得海浪活动范围比冬季广。(2)北极海域海浪存在周期性变化,但在年平均尺度上海浪强度总体呈上升趋势。海冰的厚度及密集度分布与海浪变化相反,呈下降趋势。说明海冰的厚度和密集度数值越大在一定程度上会限制海浪活动,同时,北极海域海浪活动的主要动力源是海面风场。

关键词：北极波候 WAVEWATCH-Ⅲ ECMWF风场数据海冰数据

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高性能箱型复合结构增韧模型与优化计算

工程力学 2024年第S1期41卷 38-49页

作者：喻江胡少伟范向前陆俊水科学与水工程国际联合研究中心江苏南京210029 南京水利科学研究院江苏南京210024 郑州大学水利与土木工程学院河南郑州450001

为了深入揭示高性能箱型复合结构受力机理并有效提升结构整体性能,通过定义四种混凝土翼板模式开展高性能箱型复合结构增韧模型理论研究。通过建立剪力滞翘曲位移模型和界面滑移模式,推导出考虑剪力滞行为与界面滑移相互影响的控制微分... 详细信息

为了深入揭示高性能箱型复合结构受力机理并有效提升结构整体性能,通过定义四种混凝土翼板模式开展高性能箱型复合结构增韧模型理论研究。通过建立剪力滞翘曲位移模型和界面滑移模式,推导出考虑剪力滞行为与界面滑移相互影响的控制微分方程,求得在均布荷载作用下的增韧模型理论解析解,进一步以界面滑移量、剪力滞系数、混凝土材料为韧性指标,对提出的增韧模型进行优化计算分析表明:II型增韧模型受剪力滞影响程度仅为0.04%~0.05%,混凝土材料用量节约35.00%,为四种模型中基于剪力滞与滑移耦合行为的最优高性能箱型复合结构增韧模型,便于为水利、土木工程韧性指标设计提供技术支撑。

关键词：高性能复合结构增韧模型韧性指标优化计算

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超宽带信号的非视距识别与测距误差抑制

控制与决策 2024年第8期39卷 2605-2612页

作者：李文锋周敬龙王其蒋绍勇贺利军武汉理工大学交通与物流工程学院武汉430063

针对超宽带信号在非视距环境下测距误差大等问题,基于首径和最强径的位置差、接收信号与首径的功率差及距离残差,提出一种计算简单、识别准确度高的非视距识别方法,并基于偏置卡尔曼滤波和极大似然估计算法,提出一种超宽带信号接收强度... 详细信息

针对超宽带信号在非视距环境下测距误差大等问题,基于首径和最强径的位置差、接收信号与首径的功率差及距离残差,提出一种计算简单、识别准确度高的非视距识别方法,并基于偏置卡尔曼滤波和极大似然估计算法,提出一种超宽带信号接收强度与信号达到时间相融合的非视距误差抑制方法,最后开展动、静态场景实验以验证算法的可靠性.实验结果表明,所提出的方法对于非视距场景的平均识别准确度达到95.42%,定位的平均距离误差在0.14m以内.

关键词：超宽带测距与定位非视距识别非视距误差抑制偏置卡尔曼滤波极大似然估计