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Nano Research 2025年第1期18卷 508-519页

作者： ke Jiang Zhi Chen Ji Yu Chen Zheng Shan Huang Ming Wang Chongqing key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

Development and validation of a nomogram model for predicting overall survival in patients with gastric carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 132-143页

作者： Guan-Zhong Liang Xiao-Sheng Li Zu-Hai Hu Qian-Jie Xu Fang Wu Xiang-Lin Wu Hai-ke Lei Chongqing key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China Research Center for Medicine and Social Development School of Public HealthChongqing Medical UniversityChongqing 400016China The Research Center of Big Data Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND The prevalence and mortality rates of gastric carcinoma are disproportionately elevated in China,with the disease's intricate and varied characteristics further amplifying its health *** forecasting of overall survival(OS)is of paramount importance for the clinical management of individuals afflicted with this *** To develop and validate a nomogram model that provides precise gastric cancer prevention and treatment guidance and more accurate survival outcome prediction for patients with gastric *** Data analysis was conducted on samples collected from hospitalized gastric cancer patients between 2018 and *** absolute shrinkage and selection operator,univariate,and multivariate Cox regression analyses were employed to identify independent prognostic factors.A nomogram model was developed to predict gastric cancer patient *** model's predictability and discriminative ability were evaluated via receiver operating characteristic *** evaluate the clinical utility of the model,Kaplan-Meier and decision curve analyses were *** A total of ten independent prognostic factors were identified,including body mass index,tumor-node-metastasis(TNM)stage,radiation,chemotherapy,surgery,albumin,globulin,neutrophil count,lactate dehydrogenase,and platelet-to-lymphocyte *** area under the curve(AUC)values for the 1-,3-,and 5-year survival prediction in the training set were 0.843,0.850,and 0.821,*** AUC values were 0.864,0.820,and 0.786 for the 1-,3-,and 5-year survival prediction in the validation set,*** model exhibited strong discriminative ability,with both the time AUC and time C-index exceeding *** with TNM staging,the model demonstrated superior clinical ***,a nomogram was developed via a web-based *** This study established and validated a novel nomogram model for predicting the OS of gastric cancer patients,which demonstrat

关键词： Gastric carcinoma Prediction Overall survival Nomogram Prospective

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Active source seismic imaging on near-surface granite body:case study of siting a geological disposal repository for high-level radioactive nuclear waste

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Petroleum Science 2021年第3期18卷 742-757页

作者： Wen Li Yi-ke Liu Yong Chen Bao-Jin Liu shao-ying Feng School of Earth Sciences and Engineering Nanjing UniversityNanjing 210008China key Laboratory of Petroleum Resource Research Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Geophysical Exploration Center China Earthquake AdministrationZhengzhou 450002China

In order to research whether it is suitable to set a geological disposal repository for high-level radioactive nuclear waste into one target granite body,two active source seismic profles were arranged near a small town named Tamusu,Western *** study area is with complex surface conditions,thus the seismic exploration encountered a variettraveltimey of technical difculties such as crossing obstacles,de-noising harmful scattered waves,and building complex near-surface velocity *** order to address those problems,techniques including cross-obstacle seismic geometry design,angle-domain harmful scattered noise removal,and an acoustic wave equation-based inversion method jointly utilizing both the and waveform of frst arrival waves were *** fnal seismic images clearly exhibit the target rock’s unconformable contact boundary and its top interface beneath the sedimentary and weathered *** this basis,it could be confrmed that the target rock is not thin or has been transported by geological process from somewhere else,but a native and massive *** are a few small size fractures whose space distribution could be revealed by seismic images within the *** fractures should be kept *** on current research,it could be considered that active source seismic exploration is demanded during the sitting process of the geological disposal repository for nuclear *** seismic acquisition and processing techniques proposed in the present paper would ofer a good reference value for similar researches in the future.

关键词： Geological disposal repository Nuclear waste Granite body Active source seismic exploration Near-surface velocity inversion

Analgesic effect and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive inguinal hernia surgery

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 161-170页

作者： Qian-Xing Lou ke-Ping Xu Department of Anesthesiology Yiwu Central HospitalYiwu 322000Zhejiang ProvinceChina Department of Anesthesia Zhuji Traditional Chinese Medicine Hospital of Zhejiang ProvinceShaoxing 311800Zhejiang ProvinceChina

BACKGROUND Currently,very few studies have examined the analgesic effectiveness and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal *** To investigate the analgesic effect and safety of dexmedetomidine-assisted intravenous-inhalation combined general anesthesia in laparoscopic minimally invasive surgery for inguinal *** In this retrospective study,94 patients scheduled for laparoscopic minimally invasive surgery for inguinal hernia,admitted to Yiwu Central Hospital between May 2022 and May 2023,were divided into a control group(inhalation combined general anesthesia)and a treatment group(dexmedetomidine-assisted intrave-nous-inhalation combined general anesthesia).Perioperative indicators,analgesic effect,preoperative and postoperative 24-hours blood pressure(BP)and heart rate(HR),stress indicators,immune function levels,and adverse reactions were com-pared between the two *** Baseline data,including age,hernia location,place of residence,weight,monthly income,education level,and underlying diseases,were not significantly different between the two groups,indicating comparability(P>0.05).No significant difference was found in operation time and anesthesia time between the two groups(P>0.05).However,the treatment group exhibited a shorter postoperative urinary catheter removal time and hospital stay than the control group(P0.05).However,at 12,18,and 24 hours postoper-atively,the treatment group had significantly lower VAS scores than the control group(P0.05),both groups experienced some extent of changes in postoperative HR,diastolic BP(DBP),and systolic BP(SBP).Nevertheless,the treatment group showed smaller c

关键词： Dexmedetomidine Intravenous-inhalation combined general anesthesia Inguinal hernia Laparoscopic minimally invasive surgery Analgesia Safety

Investigation on Cu promotion effect on Ce-based solid solution-anchored Rh single atoms for three-way catalysis

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Chinese Chemical Letters 2025年第2期36卷 574-578页

作者： Jianing He Xiao Wang Zijian Wang Ruize Jiang ke Wang Rui Zhang Huilin Wang Baokang Geng Hongyi Gao Shuyan Song Hongjie Zhang State key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China China School of Materials Science and Engineering University of Science and Technology Beijing Department of Chemistry Tsinghua University

The three-way catalyst（TWC）, as a promising approach to control automobile exhaust emission, has been widely studied and applied. However, it still suffers from the high light-off temperature and poor ***, we synthesized a multicomponent catalyst Rh/Cu-CeSn by using Cu metal doping to modify the Ce-based solid solution, which exhibited good TWC catalytic performance: the light-off temperatures for CO, NO, and C3H6conversion are 172 ℃, 266 ℃, and 193 ℃, respectively. Moreover, the catalyst still maintained good activity after 12 h of the continuous reaction under high-temperature conditions. The experiments and mechanism studies reveal that due to the redox pair Cu+/Cu2+, the Cu incorporation can effectively inhibit the Rh transition to the oxidation state and greatly enhance the catalytic activity and stability. This work provides a viable strategy for precise characteristic modulation of composite oxide supports during the fabrication of noble metal-based catalysts, which significantly reduces environmental pollution from energy applications.

关键词： Co-precipitation Oxygen vacancies Rhodium (Rh) catalyst Solid solution Three-way catalysts (TWC)

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma ke Ye Xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Obesity paradox in patients with community-acquired pneumonia:Have you fully considered the confounding factors?

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World Journal of Clinical Cases 2025年第9期13卷 53-55页

作者： Jin-ke Sun Hui Tian Department of Pulmonary and Critical Care Medicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000Shandong ProvinceChina Department of Critical Care Medicine Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

There exists a notion that there is an obesity paradox in the prognosis of community-acquired *** other words,obese individuals with communityacquired pneumonia have a better *** study by Wang et al supports this claim,but we believe that the obesity paradox should not be proposed hastily as it is influenced by numerous subjective and objective confounding factors.

关键词： Community-acquired pneumonia Mortality Body mass index Overweight Obesity paradox

Early‑life milk replacer feeding mediates lipid metabolism disorders induced by colonic microbiota and bile acid profiles to reduce body weight in goat model

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Journal of Animal Science and Biotechnology 2025年第1期16卷 300-315页

作者： ke Zhang Ting Zhang Mengmeng Guo Awang Cuoji Yangbin Xu Yitong Zhao Yuxin Yang Daniel Brugger Xiaolong Wang Langda Suo Yujiang Wu Yulin Chen key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China College of Animal Engineering Yangling Vocational and Technical CollegeYanglingShaanxi 712100China Institute of Animal Sciences Tibet Academy of Agricultural and Animal Husbandry SciencesLhasa 850009China Institute of Animal Nutrition and Dietetics Vetsuisse‑FacultyUniversity of ZurichZurich 8057Switzerland key Laboratory of Animal Genetics and Breeding On Tibetan Plateau Ministry of Agriculture and Rural AffairsLhasa 850009China.

Background Dysregulation of lipid metabolism and its consequences on growth performance in young ruminants have attracted attention,especially in the context of alternative feeding *** study aims to elucidate the effects of milk replacer(MR)feeding on growth,lipid metabolism,colonic epithelial gene expression,colonic microbiota composition and systemic metabolism in goat kids compared to breast milk(BM)feeding,addressing a critical knowledge gap in early life *** Ten female goat kids were divided into 2 groups:those fed breast milk(BM group)and those fed a milk replacer(MR group).Over a period of 28 d,body weight was monitored and blood and tissue samples were collected for biochemical,transcriptomic and metabolomic *** of the colonial microbiota was performed using 16S rRNA gene *** microbiota transplantation(IMT)experiments in gnotobiotic mice were per-formed to validate *** MR-fed pups exhibited reduced daily body-weight gain due to impaired lipid metabolism as evidenced by lower serum and liver total cholesterol(TC)and non-esterified fatty acid(NEFA)*** analysis of the colonic epithelium revealed upregulated genes involved in negative regulation of lipid metabolism,concomitant with microbiota shifts characterized by a decrease in Firmicutes and an increase in ***,genera such as Bifidobacterium and Prevotella were enriched in the MR group,while Clostridium and Fae-calibacterium were *** analyses confirmed alterations in bile acid and fatty acid metabolic *** experiments in mice recapitulated the metabolic phenotype observed in MR-fed goats,confirming the role of the microbiota in modulating host lipid *** Milk replacer feeding in goat kids disrupts lipid metabolism and gut microbiota dynamics,result-ing in reduced growth rates and metabolic *** findings highlight the importance of e

关键词： Bile acid Colon microbiota Goat model Lipid metabolism Milk replacer

Neoadjuvant therapy:Dawn of reducing the high post-surgery recurrence rate of hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2025年第3期17卷 57-68页

作者： Xiao-Dong Zhang Lu-Yi Zhang Jia-Liang Luo ke-Heng Yu ke-Lei Zhu Department of Hepatopancreatobiliary Surgery The Affiliated People's Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Zhejiang Provincial key Laboratory of Pathophysiology Health Science CenterNingbo UniversityNingbo 315211Zhejiang ProvinceChina

The high postoperative recurrence rate remains a major challenge in the treatment of hepatocellular carcinoma(HCC)following *** research has been delved into investigating the role of neoadjuvant therapy on the prognosis of resectable *** trends in combination therapy with molecularly targeted agents and immune checkpoint inhibitors have significantly improved the efficacy of systemic antitumor treatments,yielding survival benefits exceeding 40%.Neoadjuvant therapy for HCC,whether based on systemic antitumor treatments,locoregional therapies,or their combination,has emerged as a promising research ***,there remains a matter of debate on neoadjuvant *** this review,we summarize and discuss the research progress and challenges of neoadjuvant therapy for HCC over the past five years from the perspective of Chinese guidelines to provide new insights and future directions in this field.

关键词： Hepatocellular carcinoma Neoadjuvant therapy Locoregional therapy Molecularly targeted drug Immune checkpoint inhibitor