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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao jing-Wen Li Hui Ye xue-Zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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维生素D和肥胖

国际内分泌代谢杂志 2010年第3期30卷 168-170页

作者：邵雪景缪珩南京医科大学第二附属医院内分泌科 210011

大量研究表明维生素D及维牛素D受体（VDR）与肥胖密切相关.血清25（OH）D及1,25（OH）,D的浓度都与体重指数（BMI）呈负相关.潜在的原因可能是由于肥胖者活动少及着装习惯导致的日光照射少以及大量的维生素D储存于脂肪组织中所致.研究发... 详细信息

大量研究表明维生素D及维牛素D受体（VDR）与肥胖密切相关.血清25（OH）D及1,25（OH）,D的浓度都与体重指数（BMI）呈负相关.潜在的原因可能是由于肥胖者活动少及着装习惯导致的日光照射少以及大量的维生素D储存于脂肪组织中所致.研究发现,补充维生素D有利于减轻体重.因此,肥胖者比非肥胖者更需要补充维生素D.只有增加安全、合适的日照时间,食用强化维生素D的食品或者补充高剂量的维牛素D才能保证体内充足的维生素D水平.

关键词：维生素D 维生素D受体肥胖

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

2型糖尿病患者颈动脉粥样硬化的危险因素分析

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中外医疗 2020年第36期39卷 29-31页

作者：薛一薛冰霜邵雪景江苏大学附属武进医院内分泌科江苏常州213000 徐州医科大学武进临床学院内分泌科江苏徐州221000

目的分析2型糖尿病患者发生颈动脉粥样硬化的危险因素。方法方便选择于2017年3月—2018年12月在该院内分泌科住院的124例2型糖尿病患者,根据颈动脉彩超有无颈动脉粥样硬化分为病变组(65例)及对照组(59例),比较两组基本资料和生化指标,应... 详细信息

目的分析2型糖尿病患者发生颈动脉粥样硬化的危险因素。方法方便选择于2017年3月—2018年12月在该院内分泌科住院的124例2型糖尿病患者,根据颈动脉彩超有无颈动脉粥样硬化分为病变组(65例)及对照组(59例),比较两组基本资料和生化指标,应用Logistic回归分析颈动脉粥样硬化相关影响因素。结果颈动脉粥样硬化病变组,年龄(64.39±8.26)岁、糖尿病病程(12.47±5.13)年、高血压史45例(69.23%)、餐后2 h血糖(16.35±3.51)mmol/L、糖化血红蛋白(9.43±1.24)%、低密度脂蛋白(3.38±0.46)mmol/L与对照组比较,差异有统计学意义(t=5.526、8.099,χ^(2)=6.995,t=3.878、5.024、2.805,P<0.05)。Logistic回归分析显示,年龄、糖尿病病程、高血压史是糖尿病患者发生颈动脉粥样硬化的危险因素。结论年龄、糖尿病病程、高血压史是2型糖尿病患者颈动脉粥样硬化的影响因素,注重早期干预控制,对糖尿病大血管病变的防治有重要意义。

关键词：颈动脉粥样硬化 2型糖尿病危险因素

CDK2 suppressionsynergizes with all-transretinoic acid toovercome myeloid differentiation blockade of AML cells

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中国药理学与毒理学杂志 2019年第10期 788-788页

作者： XU Ai-xiao XIANG Sen-feng CHEN Ying-qian SHI Xiao-xian shao xue-jing YANG Bo HE Qiao-jun YING Mei-dan College of Pharmaceutical Sciences Zhejiang University

OBJECTIVE To investigate the synergistic effect and mechanism of cyclin-dependent kinase 2(CDK2) inhibition and all-trans-retinoic acid(ATRA) in acute myeloid leukemia(AML) cell differentiation. METHODS sh RNAs targeting CDK2 and CDK2 inhibitors were introduced into AML cel s to explore the effect on cel proliferation, cell cycle and cell differentiation upon the ATRA treatment. The m RNA level of STAT1, PU.1 and CEBPβwere detected by quantitative-real-time PCR and protein expression were detected by Western blotting in AML cells when CDK2 were knockout. RNA-sequence analysis was performed to gain specific insight into the mechanism of synergistic effect induced by CDK2 decline with ATRA. NOD/SCID model was gene rated to test whether CDK2 inhibition and ATRA synergized in vivo. RESULTS Both the depletion and pharmacological inhibitor of CDK2 sensitized three subtypes of AML to ATRA-induced cell growth inhibition, G0/G1 phase arrest,CD11 b expression, NBT reduction, mature morphologic changes andmyeloid regulator expression. The m RNA levels of STAT1,PU.1 or CEBPβ were enhanced by sh CDK2. And the RNA-sequence results showed that significant translation activation of differentiation and maturation pathway played an important role on differentiation triggered by CDK2 depletion combined with ATRA. Furthermore, the down-regulation of CDK2 sensitized AML cells to ATRAinduced engraftment prevention of leukemia cells in NOD-SCID mice and promotes the primary AML blasts differentiation when combined with ATRA. CONCLUSION This study estimated the synergism between CDK2 decrease and ATRA in the differentiation induction of AML cells, thus suggesting that CDK2 may be a novel therapeutic target to sensitive non-APL cells to ATRA treatment.

关键词： CDK2 all-trans-retinoic acid acute myeloid leukemia differentiation synergism

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie jing Zhang xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

南京汉族人群维生素D结合蛋白受体基因多态性与2型糖尿病的相关性研究

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中国现代医学杂志 2012年第15期22卷 45-48页

作者：邵雪景缪珩蒋秀琴韦玉和江苏大学附属武进医院内分泌科江苏常州213002

目的探讨南京汉族人群中维生素D结合蛋白(DBP)受体基因Asp416Glu与Thr420Lys多态性与2型糖尿病及血清1,25-二羟基维生素D3[1,25(OH)2D3]的相关性。方法采用聚合酶链反应限制性片段长度多态性(PCR-R FLP)技术,检测105例2型糖尿病患者和10... 详细信息

目的探讨南京汉族人群中维生素D结合蛋白(DBP)受体基因Asp416Glu与Thr420Lys多态性与2型糖尿病及血清1,25-二羟基维生素D3[1,25(OH)2D3]的相关性。方法采用聚合酶链反应限制性片段长度多态性(PCR-R FLP)技术,检测105例2型糖尿病患者和105例正常者的DBP基因型,用酶联免疫吸附(Elisa)法测定血清1,25(OH)2D3水平,并检测相关临床及生化指标,比较DBP基因型和等位基因频率的分布差异及不同基因型血清1,25(OH)2D3等相关指标的差异。结果维生素D结合蛋白受体基因Asp416Glu与Thr420Lys多态性位点基因型和等位基因频率在两组中的分布无显著性差异(P>0.05)。血清1,25(OH)2D3在不同基因型间无有意义的差别(P>0.05)。结论 DBP受体基因Asp416Glu与Thr420Lys多态性与2型糖尿病及血清1,25(OH)2D3无关。

关键词： 2型糖尿病维生素D结合蛋白基因多态性 1,25二羟维生素D3

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu jing Zhang jing Yang jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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硒化蓖麻酸对肿瘤细胞DNA合成的影响

陕西师大学报(自然科学版) 1992年第3期 87-88页

作者：王仲会齐浩薛少安薛永泉井申荣陕西师大生物系陕西师大化学系陕西师大生物系西北大学生物系

大量的研究报道表明,克山病、大骨节病与缺硒有关,多种肿瘤的发生率也与周围环境硒含量呈负相关,说明微量元素硒具有多种生物学功能.补硒能预防并抑制肿瘤发生和发展;自60年代起,就有关于不饱和脂肪酸抗肿瘤的报道.笔者将硒与一种不饱... 详细信息

大量的研究报道表明,克山病、大骨节病与缺硒有关,多种肿瘤的发生率也与周围环境硒含量呈负相关,说明微量元素硒具有多种生物学功能.补硒能预防并抑制肿瘤发生和发展;自60年代起,就有关于不饱和脂肪酸抗肿瘤的报道.笔者将硒与一种不饱和脂肪酸——蓖麻酸共价结合,使之形成硒化蓖麻酸,并对其体内外抗肿瘤活性进行了研究,结果表明:硒化蓖麻酸具有较强的抗肿瘤活性.其作用机理及对肿瘤

关键词： ricinoleic acid containing selenium DNA cancer cell