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“中国西南储气能力”建设的技术基础与发展思考

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天然气工业 2024年第2期44卷 1-13页

作者：胡勇王梦雨罗瑜李隆新彭先赵梓寒中国石油西南油气田公司中国石油西南油气田公司勘探开发研究院

为保障国家天然气安全平稳供应,2019年国家能源局启动了川渝天然气千亿立方米级“气大庆”的建设项目,将四川盆地天然气储气调峰和战略应急保供能力建设提升至国家战略安全高度。此外,中国石油在“十四五”期间确立了打造“西南储气中... 详细信息

为保障国家天然气安全平稳供应,2019年国家能源局启动了川渝天然气千亿立方米级“气大庆”的建设项目,将四川盆地天然气储气调峰和战略应急保供能力建设提升至国家战略安全高度。此外,中国石油在“十四五”期间确立了打造“西南储气中心”的战略目标,积极攻关各项地下储气库(以下简称储气库)建库技术难题,已初步形成“西南储气中心”建设格局。为此,在分析四川盆地建设储气库面临的挑战基础上,系统梳理总结了中国石油近17年在四川盆地的发展规划、建设现状、技术进展等方面的成果,并对打造“中国西南储气能力”提出了具体的攻关方向。研究结果表明:(1)四川盆地天然气资源丰富且拥有与全国天然气管网互连互通的完善管网设施,能够为盆地储气库建设提供坚实基础;(2)提出了复杂盆地气藏的“十指标”选址体系,建立了完善的储气库库址优选技术;(3)形成了储气库建库运行七大特色技术,健全了碳酸盐岩气藏建库主体技术系列;(4)构建了国内首个储气库地质体、井、地面完整性管理评价技术体系,保障了储气库安全稳定运行。结论认为,为支撑国家天然气千亿立方米级“气大庆”建设,提出了“中国西南储气能力”建设的概念,其核心是以中国石油初步建成的企业级“西南储气中心”为基础,走出单一油公司储气库建设模式,建立政府主导协调、跨企业的储气库协同共建共享共营机制,全面推动四川盆地整体储气能力建设,保障国家天然气能源安全。

关键词：中国西南储气能力四川盆地地下储气库复杂气藏条件选址完整性管理

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环量控制飞翼翼型隐身与气动联合优化

南京航空航天大学学报 2024年第3期56卷 526-533页

作者：贾高伟邵帅胡德昭郭正侯中喜国防科技大学空天科学学院长沙410073

飞翼无人机可利用主动流动控制技术取代传统舵面,避免舵面偏转产生的雷达回波,能够获得更好的隐身性能。本文面向装载环量控制器的大展弦比飞翼无人机,提出了一种兼顾气动和隐身性能的飞翼翼型联合优化方法。针对包含环量控制(Circulati... 详细信息

飞翼无人机可利用主动流动控制技术取代传统舵面,避免舵面偏转产生的雷达回波,能够获得更好的隐身性能。本文面向装载环量控制器的大展弦比飞翼无人机,提出了一种兼顾气动和隐身性能的飞翼翼型联合优化方法。针对包含环量控制(Circulation control,CC)机构的二维翼型建立了基于代理模型的联合优化框架,并通过寻优求解,获得了Pareto前沿解集。选择Pareto前沿中的3个点对应的二维翼型进行了气动与隐身性能评估,数值计算结果证实了本文提出的联合优化方法的可行性。

关键词：环量控制飞翼无人机隐身设计气动分析

Thermal-induced transformation of wetting behaviors on laser-textured SiC surfaces

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Science China(Technological Sciences) 2016年第6期59卷 862-866页

作者： BAI shao xian WANG Rong College of Mechanical Engineering Zhejiang University of Technology

Thermal-induced transformation of wetting behaviors on laser-textured silicon carbide （SIC） surfaces was discussed in this work. To investigate the transformation, a quenching experiment was conducted and an X-ray diffractometer was used to measure the residual stress. The experimental results demonstrate that the significantly enhanced hydrophilicity was induced by the increasing thermal residual stress of SiC materials after the aqueous quenching. It was found that the decrease in the contact angle increased with the increasing quenching temperature. Quenching at 350℃ led to the change of contact angle from 89.28° to 70.88° for the smooth surface, while from 72.25° to 33.75° for the laser-textured surface with depth 8 μm. Further, the surface hydrophobicity was enhanced by the release of thermal residual stress after quenching, thereby leading to an increase in the contact angle over time. The transformation of wetting behaviors on laser textured SiC surfaces can be achieved mutually by the aqueous quenching method.

关键词： wettability transformation silicon carbide laser processing aqueous aquenching

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan Jinyi Zhao Sulin Zhang Lu Liu Yumin Zhang Wei Xu Maolin shao Jingjing Peng Shuai Xia Yan Zhu Keke Zhang xianglei Zhang Ruxue Zhang jian Li Wenhao Dai Zhen Ge Shulei hu Changyue Yu Jiang Wang Dakota Ma Mingyue Zheng Haitao Yang Gengfu Xiao Zihe Rao Lu Lu Leike Zhang Fang Bai Yao Zhao Shibo Jiang Hong Liu Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several SARS-CoV-2-specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including SARS-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTSL)and calpain-1(CAPN1)are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual target inhibitors against CTSL and *** X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of a-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern(VOCs)with ECso values ranging from 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b also showed effective antiviral activity against HCoV-OC43 infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 14a and 14b exhibited excellent antiinflammatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

Isolated neurological involvement of lymphomatoid granulomatosis

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Chinese Medical Journal 2010年第21期123卷 3163-3166页

作者： hu Yu-hua shao En-de WU Jian-liang MENG xian-bing Department of Neurosurgery the Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Neurosurgery the People's Hospital of Langfang Langfang Hebei 065000 China

Lymphomatoid granulomatosis （LG） is a rare EpsteinBarr virus （EBV）-associated systemic granulomatous disease that is characterized by an angiocentric and occasionally angiodestructive polymorphic cellular infiltrate. It most frequently affects the lungs, kidneys,and brain.1,2 Usually the lesions are multi-systemic and multifocal. Central nervous system （CNS） involvement occurs in approximately 30% of affected patients, and patients may present with nonspecific neurological symptoms.3 Although CNS lesions usually appear as a secondary metastasis of pulmonary lesions, in rare conditions,

关键词： lymphomatoid granulomatosis central.nervous system

基于Aspen Plus的二甲苯塔优化及应用

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聚酯工业 2024年第2期37卷 46-49页

作者：胡贤雄中国石化海南炼油化工有限公司海南詹州578001

二甲苯塔在芳烃联合装置中作为关键设备,是能源消耗较高的分离塔器。中国石化海南炼化公司二甲苯塔含有对二甲苯、间二甲苯、邻二甲苯等同分异构体,组分之间沸点值相近,产品纯度要求非常严格,意味着精馏分离需要高热量与高回流比操作。... 详细信息

二甲苯塔在芳烃联合装置中作为关键设备,是能源消耗较高的分离塔器。中国石化海南炼化公司二甲苯塔含有对二甲苯、间二甲苯、邻二甲苯等同分异构体,组分之间沸点值相近,产品纯度要求非常严格,意味着精馏分离需要高热量与高回流比操作。为降低能耗,本文利用芳烃生产数据建立了AspenPlus二甲苯塔模型,经对比计算值与实际值验证了可行性,其准确性能够应用于实际生产。通过利用模型中的约束与优化及灵敏度分析,在保证二甲苯塔顶底控制指标的前提下,研究了回流比与塔压操作参数的变化对塔底热负荷与分离效果的影响,然后选择最优参数,提供运行优化方向,结果表明,降低回流比操作来降低塔底热负荷,可以达到节能降耗的目的。

关键词：模型二甲苯塔节能降耗工业应用

Ni-Mn基磁性形状记忆合金弹热制冷效应的研究现状

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材料热处理学报 2024年第4期45卷 1-12页

作者：辛向阳高丽胡少辉徐阳睿上海海洋大学工程学院上海201306

弹热制冷不仅具有大而可逆的温度变化,而且其驱动方式更为简单,同时兼具环保、高效、节能的特点,平衡了成本、制冷量、效率以及可行性,有望成为替代传统蒸汽压缩冷却技术的候选之一。本文综述了Ni-Mn基磁性形状记忆合金弹性热效应的研... 详细信息

弹热制冷不仅具有大而可逆的温度变化,而且其驱动方式更为简单,同时兼具环保、高效、节能的特点,平衡了成本、制冷量、效率以及可行性,有望成为替代传统蒸汽压缩冷却技术的候选之一。本文综述了Ni-Mn基磁性形状记忆合金弹性热效应的研究进展,从掺杂合金元素、热处理方法以及制备工艺等多个方面,总结了近年来对Ni-Mn基合金弹性热效应进行改进优化的研究成果。然而,目前Ni-Mn基合金弹热制冷材料的研究仍处于探索阶段,实现其实际应用还需进一步深入研究。未来的研究重点应集中在降低驱动能耗、提升疲劳寿命和循环稳定性、提高绝热温变以及优化传热效率等方面。

关键词： Ni-Mn基合金磁性形状记忆合金弹热材料弹热效应弹热制冷

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出口梗阻型便秘的国内外治疗进展

中国肛肠病杂志 2024年第1期44卷 77-80页

作者：胡献方临沂市中医医院山东临沂276000

功能性便秘包括慢传输型便秘(slow transit constipation, STC)、出口梗阻型便秘(outlet obstructive constipation, OOC)、混合型便秘(mixed constipation, MC),其中OOC又分为盆底痉挛型、盆底松弛型和肠外梗阻型便秘。盆底痉挛型有盆... 详细信息

功能性便秘包括慢传输型便秘(slow transit constipation, STC)、出口梗阻型便秘(outlet obstructive constipation, OOC)、混合型便秘(mixed constipation, MC),其中OOC又分为盆底痉挛型、盆底松弛型和肠外梗阻型便秘。盆底痉挛型有盆底痉挛综合征、耻骨直肠肌综合征,内括约肌失弛缓征等,盆底松弛型包括直肠前突、会阴下降、直肠黏膜内脱垂、盆底疝等[1]。

关键词：出口梗阻型便秘治疗进展

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NES cell

Applied Mathematics and Mechanics(English Edition) 2022年第12期43卷 1793-1804页

作者： hu DING Yufei shao Shanghai Key Laboratory of Mechanics in Energy Engineering School of Mechanics and Engineering ScienceShanghai UniversityShanghai200072China

A broadband adaptive vibration control strategy with high reliability and flexible versatility is *** high vibration damping performance of nonlinear energy sink(NES)has attracted ***,targeted energy transfer may cause severe vibration of ***,it is difficult to realize pure nonlinear stiffness without the linear *** a result,the reliability of NES is not *** low reliability of NES has hindered its application in *** addition,the performance of NES depends on its mass ratio of the primary system,and NES lacks versatility for different vibration ***,this paper proposes the concept of NES *** advantages of the adaptive vibration control of NES are applied to cellular *** applying a large number of NES cells in parallel,the reliability of NES and its versatility to complex vibration structures are *** elastic beam is used as the primary vibration structure,and a limited NES is used as the *** relationship between the vibration suppression effect of NES cells and the number of NES cell is *** addition,the effect of the distribution of NES cells on the multi-mode resonance suppression of the beam is also *** summary,the mode of the primary structure can be efficiently controlled by a large number of lightweight NES ***,the lightweight NES cell is flexible for vibration control of complex *** addition,it improves the reliability of NES ***,the distributed application of NES cells proposed in this paper is a valuable vibration suppression strategy.

关键词： vibration nonlinear energy sink(NES) NES cell vibration control clamped beam harmonic balance method(HBM)