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Blood cell counts and nonalcoholic fatty liver disease: Evidence from Mendelian randomization analysis

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World Journal of Hepatology 2024年第8期16卷 1145-1155页

作者： Bin hu Ai-Hong Wan Xi-Qiao xiang Yuan-Hao Wei Yi Chen Zhen Tang Chang-De Xu Zi-Wei Zheng shao-Ling Yang Kun Zhao Department of Laboratory Medicine Shanghai Jiao Tong University Affiliated Sixth People's Hospital South CampusShanghai 201499China Department of Cardiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital South CampusShanghai 201499China Department of Positron Emission Tomography-Computed Tomography Imaging Center Shanghai Jiao Tong University Affiliated Sixth People's Hospital South CampusShanghai 201499China Department of School of Public Health Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina Department of Cardiovascular Ultrasound Medicine Center Shanghai Eighth People's HospitalShanghai 200235China

BACKGROUND Previous research has highlighted correlations between blood cell counts and chronic liver ***,the causal relationships remain *** To evaluate the causal effect of blood cell traits on liver enzymes and nonalcoholic fatty liver disease(NAFLD)*** Independent genetic variants strongly associated with blood cell traits were extracted from a genome-wide association study(GWAS)conducted by the Blood Cell ***-level data for liver enzymes were obtained from the United Kingdom *** data were obtained from a GWAS meta-analysis(8434 cases and 770180 controls,discovery dataset)and the Fingen GWAS(2275 cases and 372727 controls,replication dataset).This analysis was conducted using the inverse-variance weighted method,followed by various sensitivity *** One SD increase in the genetically predicted haemoglobin concentration(HGB)was associated with aβof 0.0078(95%CI:0.0059-0.0096),0.0108(95%CI:0.0080-0.0136),0.0361(95%CI:0.0156-0.0567),and 0.0083(95%CI:00046-0.0121)for alkaline phosphatase(ALP),alanine aminotransferase(ALT),aspartate aminotransferase,and gammaglutamyl transferase,*** predicted haematocrit was associated with ALP(β=0.0078,95%CI:0.0052-0.0104)and ALT(β=0.0057,95%CI:0.0039-0.0075).Genetically determined HGB and the reticulocyte fraction of red blood cells increased the risk of NAFLD[odds ratio(OR)=1.199,95%CI:1.087-1.322]and(OR=1.157,95%CI:1.071-1.250).The results of the sensitivity analyses remained *** Novel causal blood cell traits related to liver enzymes and NAFLD development were revealed through Mendelian randomization analysis,which may facilitate the diagnosis and prevention of NAFLD.

关键词： Blood cell counts Liver enzymes Nonalcoholic fatty liver disease Genome-wide association Mendelian randomization study Causal relationship

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某SUV气动减阻优化及其流场机制

汽车工程 2024年第2期46卷 356-365页

作者：邵景峰左辉辉胡兴军上海汽车集团股份有限公司创新研究开发总院上海201804 吉林大学汽车底盘集成与仿生全国重点实验室长春130022

为了提高整车燃油经济性,本文以某款SUV车型为研究对象,将仿真与试验相结合改善汽车行驶过程中的气动阻力系数。首先通过风洞试验确定对整车气动阻力有重要影响的区域或部件,其次对气动阻力系数贡献值较大的部件或区域进行减阻优化。结... 详细信息

为了提高整车燃油经济性,本文以某款SUV车型为研究对象,将仿真与试验相结合改善汽车行驶过程中的气动阻力系数。首先通过风洞试验确定对整车气动阻力有重要影响的区域或部件,其次对气动阻力系数贡献值较大的部件或区域进行减阻优化。结果表明,前轮阻风板、尾灯和尾翼对整车气动阻力系数贡献值较大。对前轮阻风板的改型,有效降低正压区面积以及减弱车轮干扰阻力;对尾灯和尾翼的优化设计,改善了尾部负压区,缩短了分离流在后窗上部的再附着的距离。基于本征正交分解方法进行局部流场信息的提取和分析可知,1阶与2阶模态主要构成了该SUV尾流场的关键流态。经试验与仿真验证,相比于初始方案,气动优化组合设计减阻率可达7.5%。本文为新一代SUV改型与升级换代提供了理论基础与技术支持。

关键词：汽车空气动力学气动减阻风洞试验本征正交分解

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智能弹药用新型电控固体推进剂的研究进展

火炸药学报 2024年第4期47卷 287-304页

作者：夏旭付小龙胡少青赵昱西安近代化学研究所陕西西安710065

针对当前固体火箭发动机无法重复启停、难以实现推力可控等需求,结合固体火箭和液体火箭的优点,国内外研究机构探究了一种具有重复点火与熄火、燃烧速度可调、输出能量可控的电控固体推进剂。系统介绍了新型电控固体推进剂领域的国内外... 详细信息

针对当前固体火箭发动机无法重复启停、难以实现推力可控等需求,结合固体火箭和液体火箭的优点,国内外研究机构探究了一种具有重复点火与熄火、燃烧速度可调、输出能量可控的电控固体推进剂。系统介绍了新型电控固体推进剂领域的国内外研究现状,首先,总结了国内外各类电控固体推进剂(硝酸铵基、硝酸羟胺基、高氯酸锂基)的发展,以及在微推、炮弹点火器和固体发动机方面的应用情况;其次,概述了配方组分、电压、电流、外界环境温度和压强等因素对电控固体推进剂的燃速、点火延迟时间以及力学性能的影响;然后,分析了电控固体推进剂的启停机理,介绍了硝酸铵羟胺和高氯酸锂基电控固体推进剂的反应机理;最后,对电控固体推进剂的未来发展进行了展望,指出未来仍需重点研究的方向:加强电控固体推进剂制备工艺放大研究;设计新型电敏氧化剂,解决高压下无法可控燃烧的问题;开展大尺寸电控固体发动机试验研究;通过数值模拟进一步揭示电能与推进剂燃烧耦合效应。附参考文献62篇。

关键词：应用化学电控固体推进剂 ECSP 启停机理智能弹药

The importance of Righi-Leduc heat flux to the ablative Rayleigh-Taylor instability during a laser irradiating targets

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High Power Laser Science and Engineering 2024年第3期 14-24页

作者： Ye Cui Xiao-hu Yang Yan-Yun Ma Guo-Bo Zhang Bi-Hao Xu Ze-Hao Chen Ze Li Fu-Qiu shao Jie Zhang Department of Nuclear Science and Technology National University of Defense Technology Collaborative Innovation Centre of IFSA Shanghai Jiao Tong University College of Advanced Interdisciplinary Studies National University of Defense Technology Department of Physics National University of Defense Technology Key Laboratory for Laser Plasmas (Ministry of Education) School of Physics and Astronomy Shanghai Jiao Tong University

The Righi±Leduc heat flux generated by the self-generated magnetic field in the ablative Rayleigh±Taylor instability driven by a laser irradiating thin targets is studied through two-dimensional extended-magnetohydrodynamic simulations. The perturbation structure gets into a low magnetization state though the peak strength of the self-generated magnetic field could reach hundreds of teslas. The Righi±Leduc effect plays an essential impact both in the linear and nonlinear stages, and it deflects the total heat flux towards the spike base. Compared to the case without the self-generated magnetic field included, less heat flux is concentrated at the spike tip, finally mitigating the ablative stabilization and leading to an increase in the velocity of the spike tip. It is shown that the linear growth rate is increased by about 10%and the amplitude during the nonlinear stage is increased by even more than 10%due to the feedback of the magnetic field,respectively. Our results reveal the importance of Righi±Leduc heat flux to the growth of the instability and promote deep understanding of the instability evolution together with the self-generated magnetic field, especially during the acceleration stage in inertial confinement fusion.

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声表面波-自旋波耦合及磁声非互易性器件

物理学报 2024年第15期73卷 30-48页

作者：黄铭贤胡文彬白飞明电子科技大学电子科学与工程学院成都610054 电子科技大学电子薄膜与集成器件全国重点实验室成都611731

声表面波是激发和控制自旋波的一种新兴手段,不仅激励效率高,而且传输长度可以达到毫米量级,通过引入磁声耦合还可以打破时空反演对称性,实现声表面波的非互易传播.本文对不同类型的磁声耦合的物理机制进行了梳理,对比了磁弹性耦合、自... 详细信息

声表面波是激发和控制自旋波的一种新兴手段,不仅激励效率高,而且传输长度可以达到毫米量级,通过引入磁声耦合还可以打破时空反演对称性,实现声表面波的非互易传播.本文对不同类型的磁声耦合的物理机制进行了梳理,对比了磁弹性耦合、自旋-涡度耦合(包括非磁性层注入交变自旋流和磁性材料自身的Barnett效应),以及磁-旋转耦合在不同模式的声表面波激发下的等效驱动磁场,讨论了这些等效驱动场的角度依赖性,以及相应功率吸收的频率依赖性.这为在实际应用中区分和利用各种磁声耦合机制提供了理论支持.此外,本文还介绍了利用磁声耦合实现声表面波非互易性传输的两种主流手段,包括利用手性失配效应和引入具有非互易性自旋波色散关系的磁结构,对比并讨论了它们各自的物理机制和优劣势,希望为设计和发展基于磁声耦合的固态声学隔离器、环形器提供参考.

关键词：磁声耦合自旋波声表面波声子-磁振子耦合非互易性器件

Deep learning framework for comprehensive molecular and prognostic stratifications of triple-negative breast cancer

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Fundamental Research 2024年第3期4卷 678-689页

作者： Shen Zhao Chao-Yang Yan Hong Lv Jing-Cheng Yang Chao You Zi-Ang Li Ding Ma Yi Xiao Jia hu Wen-Tao Yang Yi-Zhou Jiang Jun Xu Zhi-Ming shao Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghai 200032China Institute for AI in Medicine School of Artificial IntelligenceNanjing University of Information Science and TechnologyNanjing 210044China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Greater Bay Area Institute of Precision Medicine Guangzhou 511466China Department of Radiology Fudan University Shanghai Cancer CenterShanghai 200032China

Triple-negative breast cancer(TNBC)is the most challenging breast cancer *** stratification and target therapy bring clinical benefit for TNBC patients,but it is difficult to implement comprehensive molecular testing in clinical ***,using our multi-omics TNBC cohort(N=425),a deep learning-based framework was devised and validated for comprehensive predictions of molecular features,subtypes and prognosis from pathological whole slide *** framework first incorporated a neural network to decompose the tissue on WSIs,followed by a second one which was trained based on certain tissue types for predicting different ***-omics molecular features were analyzed including somatic mutations,copy number alterations,germline mutations,biological pathway activities,metabolomics features and immunotherapy *** was shown that the molecular features with therapeutic implications can be predicted including the somatic PIK3CA mutation,germline BRCA2 mutation and PD-L1 protein expression(area under the curve[AUC]:0.78,0.79 and 0.74 respectively).The molecular subtypes of TNBC can be identified(AUC:0.84,0.85,0.93 and 0.73 for the basal-like immune-suppressed,immunomodulatory,luminal androgen receptor,and mesenchymal-like subtypes respectively)and their distinctive morphological patterns were revealed,which provided novel insights into the heterogeneity of TNBC.A neural network integrating image features and clinical covariates stratified patients into groups with different survival outcomes(log-rank P<0.001).Our prediction framework and neural network models were externally validated on the TNBC cases from TCGA(N=143)and appeared robust to the changes in patient *** potential clinical translation,we built a novel online platform,where we modularized and deployed our framework along with the validated *** can realize real-time one-stop prediction for new *** summary,using only pathological WSIs,our proposed framework

关键词： Triple-negative breast cancer Deep learning Digital pathology Patient stratification Online platform

Combined ATAC-seq,RNA-seq,and GWAS analysis reveals glycogen metabolism regulatory network in Jinjiang oyster(Crassostrea ariakensis)

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Zoological Research 2024年第1期45卷 201-214页

作者： Biao Wu Xi Chen Jie hu Zhen-Yuan Wang Yan Wang Da-You Xu Hao-Bing Guo Chang-Wei shao Li-Qing Zhou Xiu-Jun Sun Tao Yu Xiao-Mei Wang Yan-Xin Zheng Guang-Yi Fan Zhi-Hong Liu State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdaoShandong 266071China BGI-Qingdao BGI-ShenzhenQingdaoShandong 266426China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai 201306China Changdao Enhancement and Experiment Station Chinese Academy of Fishery SciencesYantaiShandong 265800China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhenGuangdong 518083China

Glycogen serves as the principal energy reserve for metabolic processes in aquatic shellfish and substantially contributes to the flavor and quality of *** Jinjiang oyster(Crassostrea ariakensis)is an economically and ecologically important species in *** the present study,RNA sequencing(RNA-seq)and assay for transposase-accessible chromatin using sequencing(ATAC-seq)were performed to investigate gene expression and chromatin accessibility variations in oysters with different glycogen *** identified 9483 differentially expressed genes(DEGs)and 7215 genes with significantly differential chromatin accessibility(DCAGs)were obtained,with an overlap of 2600 genes between ***,a significant proportion of these genes were enriched in pathways related to glycogen metabolism,including“Glycogen metabolic process”and“Starch and sucrose metabolism”.In addition,genome-wide association study(GWAS)identified 526 single nucleotide polymorphism(SNP)loci associated with glycogen *** loci corresponded to 241 genes,63 of which were categorized as both DEGs and *** study enriches basic research data and provides insights into the molecular mechanisms underlying the regulation of glycogen metabolism in ***.

关键词： Crassostrea ariakensis Glycogen Transcriptome ATAC GWAS

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快慢车模式下早高峰时空乘车路径选择研究

交通运输系统工程与信息 2024年第2期24卷 225-233页

作者：汪景邵雨晨胡华刘志钢上海工程技术大学城市轨道交通学院上海201620

研究早高峰通勤乘客的时空出行规律有助于更好地组织快慢车运营模式。本文从一种常见的快慢车运营模式出发,首先,根据乘客的起点车次和直达/换乘方案联合选择构建乘车路径;其次,以出行时间、早到/迟到延误和车内拥挤度作为早高峰通勤乘... 详细信息

研究早高峰通勤乘客的时空出行规律有助于更好地组织快慢车运营模式。本文从一种常见的快慢车运营模式出发,首先,根据乘客的起点车次和直达/换乘方案联合选择构建乘车路径;其次,以出行时间、早到/迟到延误和车内拥挤度作为早高峰通勤乘客出行选择的影响因素,对不同乘车路径下的出行成本进行构建;再次,以用户均衡理论建立乘车路径分配模型,并证明了该模型用户均衡路段解的存在性及唯一性;最后通过案例,对均衡模型进行验证。研究结果发现:短途乘客更愿意接受高拥挤但终点到达时刻接近工作开始时刻的车次,而长途乘客的车次选择分布较为均匀;除出行时间因素以外,延误惩罚和乘车拥挤同样影响早高峰通勤乘客的换乘行为,虽然换乘快车有可能降低出行时间,但高延误惩罚和拥挤成本会导致部分站点的乘客不选择换乘路径。

关键词：城市交通出行选择用户均衡轨道交通快慢车模式时间价值拥挤成本

Integrated network pharmacology and metabolomics to explore the mechanisms of Shenzao dripping pill against chronic myocardial ischemia

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Traditional Medicine Research 2024年第11期9卷 12-26页

作者： Jie-hui Kuang Tao hu Lu-Yong Zhang Yu-Feng Yao Ming-hua xian Shu-Mei Wang School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of Traditional Chinese Medicine Guangdong Pharmaceutical UniversityGuangzhou 510006China Engineering&Technology Research Center for Chinese Materia Medica Quality of the Universities of Guangdong Province Guangdong Pharmaceutical UniversityGuangzhou 510006China Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical UniversityGuangzhou 510006China Traditional Chinese Medicine Resource Germplasm Bank Management Center Yunfu 527500China.

Background:Shenzao dripping pill(SZDP)is empirically prescribed for treating cardiac ***,there is a lack of comprehensive knowledge regarding the underlying mechanisms contributing to its therapeutic *** objective of this study is to investigate the underlying mechanism of SZDP against chronic myocardial ischemia(CMI)in a rat ***:In this study,we utilized electrocardiographic and echocardiographic detection along with pathological tissue analysis to evaluate the efficacy of *** integration of network pharmacology and metabolomics was conducted to investigate the *** docking and molecular dynamics simulations were used to validate the binding energy between the compounds of SZDP and the associated ***:The results showed that SZDP was able to improve T wave voltage,reverse CMI abnormalities in ejection fraction and fractional shortening,and restore histopathological heart *** results indicated that disturbances of metabolic profile in CMI rats were partly corrected after SZDP administration,mainly affecting purine metabolism.13-Docosenamide may be the potential metabolic biomarker of the therapeutic application of SZDP for *** network pharmacology and metabolomics,thiopurine S-methyltransferase(TPMT),xanthine dehydrogenase/oxidase(XDH),bifunctional purine biosynthesis protein ATIC(ATIC),and cytochrome p4501A1(CYP1A1)were identified as possible targets of SZDP to exert therapeutic effects by enhancing the metabolic levels of L-Tryptophan,Deoxyribose 1-phosphate and Phosphoribosyl ***:SZDP has a therapeutic effect on CMI by regulating metabolite levels,acting on the targets of TMPT,XDH,ATIC,and CYP1A1,and reducing cardiomyocyte injury and myocardial fibrosis.

关键词： chronic myocardial ischemia metabolomics network pharmacology serum metabolites Shenzao dripping pill