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Transrectal versus transperineal prostate biopsy for cancer detection in patients with gray-zone prostatespecific antigen:a multicenter,real-world study

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Asian Journal of Andrology 2024年第4期26卷 377-381页

作者： Jun-xiao Liu Ze-Yuan Wang shao-xi niu xiao-Yong Sai Xu Zhang Xue-Pei Zhang xin Ma The Graduate School Chinese PLA General HospitalBeijing 100853China Department of Urology The Third Medical CenterChinese PLA General HospitalBeijing 100853China Department of Urology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Urology The First Medical CenterChinese PLA General HospitalBeijing 100853China Faculty of Epidemiology and Statistics The Graduate SchoolChinese PLA General HospitalBeijing 100853China.

Knowledge about the effect of different prostate biopsy approaches on the prostate cancer detection rate(CDR)in patients with gray-zone prostate-specific antigen(PSA)is *** performed this study to compare the CDR among patients who underwent different biopsy approaches and had rising PSA levels in the gray *** hundred and twenty-two patients who underwent transrectal prostate biopsy(TRB)and 216 patients who underwent transperineal prostate biopsy(TPB)between June 2016 and September 2022 were reviewed in this *** addition,110 patients who received additional targeted biopsies following the systematic TPB were *** parameters,including age,PSA derivative,prostate volume(PV),and needle core count,were *** data were fitted via propensity score matching(PSM),adjusting for potential *** outperformed TRB in terms of the CDR(49.6%vs 28.3%,P=0.001).The clinically significant prostate cancer(csPCa)detection rate was not significantly different between TPB and TRB(78.6%vs 68.8%,P=0.306).In stratified analysis,TPB outperformed TRB in CDR when the age of patients was 65–75 years(59.0%vs 22.0%,P<0.001),when PV was 25.00–50.00 ml(63.2%vs 28.3%,P<0.001),and when needle core count was no more than 12(58.5%vs 31.5%,P=0.005).The CDR(P=0.712)and detection rate of csPCa(P=0.993)did not significantly differ among the systematic,targeted,and combined *** outperformed TRB in CDR for patients with gray-zone ***,performing target biopsy after systematic TPB provided no additional benefits in CDR.

关键词： biopsy detection of cancer prostate-specific antigen transperineal transrectal

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Prediction of a Low-Dense BC_(2)N Phase

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Chinese Physics Letters 2011年第5期28卷 202-205页

作者： shao xi School of Physics Nankai UniversityTianjin 300071 National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093

We predict a low-dense phase of ternary boron-carbon-nitrogen compound with a cubic symmetry,named as ldBC_(2)*** and electronic structures are studied by the ab initio pseudopotential density functional *** constant,electronic band structure and density of state as well as the phonon spectrum of ld-BC_(2)N are *** results show that ld-BC_(2)N is an indirect gap semiconductor with a band gap of 3.6eV,a theoretical Vickers hardness of 67.5 GPa and the bulk modulus of 280 GPa suggest that ld-BC_(2)N is a superhard materialwhich has low elastic moduli and high hardness compared with cubic BN.

关键词： cubic electronic boron

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Models to predict sunlight-induced photodegradation rates of contaminants in wastewater stabilisation ponds and clarifiers

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Water Science and Engineering 2019年第4期12卷 293-297页

作者： xi-Zhi niu Department of Chemical and Environmental Engineering and Arizona Laboratory for Emerging Contaminants University of Arizona

Two kinetic models were established for conservative estimates of photodegradation rates of contaminants under sunlight irradiation,in particular for wastewater stabilisation ponds and clarifiers in conventional wastewater treatment *** two models were designated for(1)contaminants with high photolytic rates or high photolytic quantum yields,whose photodegradation is unlikely to be enhanced by aquatic photosensitisers;and(2)contaminants withstanding direct photolysis in sunlit waters but subjected to indirect *** effortlessly intelligible prediction procedure involves sampling and analysis of real water samples,simulated solar experiments in the laboratory,and transfer of the laboratory results to realise water treatment using the prediction *** similar models have been widely used for laboratory studies,this paper provides a preliminary example of translating laboratory results to the photochemical fate of contaminants in real waters.

关键词： Sunlight irradiation Photodegradation Contaminants Stabilisation ponds Solar water treatment

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Products of methotrexate during chlorination

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Journal of Environmental Sciences 2017年第5期29卷 100-108页

作者： Jie Yin Yumin niu Bing shao Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Research Center for Preventive Medicine Beijing 100013 China.

Methotrexate （MTX） is a cytotoxic drug widely used in the treatment of tumors, autoimmune diseases and severe asthma, jen00883This drug has been frequently detected in the aquatic environment with concentrations up to μg/L levels. The MTX present in environmental water might be transformed and removed during chlorination disinfection treatment. In this work, the fate of MTX during aqueous chlorination was investigated in laboratory batch experiments, and the transformation products of MTX were identified. Aqueous solutions of MTX （1 mg/L） were chlorinated by sodium hypochlorite solution at room temperature under neutral pH conditions. Chlorinated products were pre-concentrated with solid-phase extraction （SPE） cartridges and determined by liquid chromatography electrospray ionization tandem mass spectrometry （LC-ESI-MS/MS）. The reaction of MTX chlorination exhibited pseudo-first-order kinetics and the half-life time of MTX degradation was calculated to be 1.65 min, when the initial chlorine concentration was 2 mg/L. Two chlorinated MTX congeners, 4-amino-3-chlorinated-N10-methylpteroylglutamic （monochloro-MTX） and 4-amino-3,5-dichloro-N10-methylpteroylglutamic （dichloro-MTX） were found in the chlori- nated solution. Monochloro-MTX was successfully fractionated by high performance liquid chromatography （HPLC） and its structure was further identified using 1H nuclear magnetic resonance （NMR） analysis. The presence of the two products in real hospital wastewater was then examined and both compounds were detected. Finally, the effects of MTX and monochloro-MTX on the cell cycle progression in vitro were evaluated using zebrafish liver cell line. It was found that both compounds could inhibit the proliferation of zebrafish liver cells through S phase arrest and their effects on the cell cycle profile had no significant difference.

关键词： Methotrexate Chlorination Chlorinated methotrexate Cell cycle arrest

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Indication of Low-Energy BC5 Structures

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Chinese Physics Letters 2010年第1期27卷 182-185页

作者： shao xi National Laboratory of Solid State Microstructures and Department of Physics Nanjing University Nanjing 210093

The Bond counting rule is proved to be an important and effective criterion for searching low-energy metastable structures for ternary boron carbon nitrogen （B-C-N） compounds. The Bond counting rule, however, has its limitations for the binary diamond-like or ternary B-C-N polymorphs with the same bond ratio. First-principles calculations validate that the Mulliken charge difference may serve as an indication of low-energy crystal structures, and clarify the energy difference among those polymorphs to some extent. For example, we predict two ground state phases ofsuperhard BC5 （named as I-BC5 and II-BC5）, which are 0.28 and 0.27eV/formula lower in energy than the P3m1 structure reported recently in the literature [Calandra et al. Phys. Rev. Lett. 101（2008）016401], respectively. The charge transfer analysis reveals that the smaller Mulliken charge difference for the same kind of element will result in more stable structures.

关键词： Rules Energy Polymorphism

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Geochronology and Geochemistry of Wangjiadashan Quartz Syenite Porphyry in Suizao Area of Hubei Province in the Tongbai-Dabie Orogenic Belt

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Journal of Earth Science 2023年第3期34卷 790-805页

作者： Pan-Pan niu shao-Yong Jiang State Key Laboratory of Geological Processes and Mineral Resources School of Earth ResourcesChina University of GeosciencesWuhan 430074China Key Laboratory of Geological Survey and Evaluation of Ministry of Education China University of GeosciencesWuhan 430074China Collaborative Innovation Center for Exploration of Strategic Mineral Resources China University of GeosciencesWuhan 430074China

The Wangjiadashan area in Suizhou-Zaoyang region of Hubei Province in the Tongbai-Dabie orogenic belt hosts important copper-gold deposits and contains a large number of quartz syenite porphyry dykes,occurring mostly along the NEE-trend *** this study,we used LA-ICP-MS zircon U-Pb dating method and obtained an age of 143.6±1.4 Ma,which represents the emplacement of these quartz syenite porphyry dykes was at the Yanshanian,but it was slightly earlier than the previously reported ages(139-135 Ma)for granites widespreading in Suizao *** geochemical data of the Wangjiadashan quartz syenite porphyry show high K_(2)O,CaO,Na_(2)O and Al_(2)O_(3)contents but extremely low MgO contents(0.01 wt.%-0.46 wt.%).The geochemical characteristics indicate that these quartz syenite porphyry dykes belong to the typical C-type adakite and were possibly formed in the post-collisional ***-isotopic(Sr-Nd-Pb-Hf)analyses indicate that these quartz syenite porphyry dykes were originated from crust without distinct mantle materials *** is suggested that the Wangjiadashan quartz syenite porphyry was generated from partial melting of the thickened lower continental crust,and garnet but no plagioclase was left as residual *** with the widespread granites of the Tongbai area,the Wangjiadashan quartz syenite porphyry formed earlier and derived from more juvenile and K-rich lower crust,while they all belong to intensive magmatism concentrated during the Early Cretaceous epoch in the Tongbai area.

关键词： quartz syenite porphyry zircon U-Pb dating geochemistry Sr-Nd-Pb-Hf isotopes petrogenesis Wangjiadashan Tongbai Orogen

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LARGE EDDY SIMLIATION WAVE BREAKING OVER MUDDY SEABED

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Journal of Hydrodynamics 2012年第2期24卷 298-304页

作者： HU Yi niu xiao-jing YU xi-ping State Key Laboratory of Hydro-Science and Engineering Department of Hydraulic EngineeringTsinghua UniversityBeijing 100084China

The Large Eddy Simulation （LES） of the wave breaking over a muddy seabed is carried out with a Coupled Level Set and Volume Of Fluid （CLSVOF） method to capture the *** effects of the mud on the wave breaking are *** existence of a mud layer beneath an otherwise rigid bottom is found to have a similar effect as an increase of the water *** compared with the case of a simple rigid bottom,the inception of the wave breaking is evidently delayed and the breaking intensity is much *** dissipation of the wave energy is shown to have very different rates before,during and after the *** and after the breaking,the mud plays an important *** the breaking,however,the turbulence as well as the entrainment of the air also dissipate a large amount of energy.

关键词： wave breaking muddy seabed Large Eddy Simulation (LES) a Coupled Level Set and Volume Of Fluid (CLSVOF) method

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Factors controlling deep-profile soil organic carbon and water storage following Robinia pseudoacacia afforestation of the Loess Plateau in China

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Forest Ecosystems 2022年第6期9卷 838-851页

作者： xi Yang Tongchuan Li Ming'an shao State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling712100China College of Natural Resources and Environment Northwest A&F UniversityYangling712100China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing100190China

Background:Afforestation is a common and effective approach used for the restoration of degraded ecosystems *** China,Robinia pseudoacacia(RP)is among the main non-native tree species and has been widely planted in revegetation of the Loess ***,owing to uncertainties regarding soil water consumption and carbon sequestration,it is necessary to assess the suitability and sustainability of *** in *** this study,we aimed to analyse the dynamic effects of *** forest on soil carbon storage(SCS)and soil water storage(SWS).Specifically,we investigated the association between soil water content(SWC)and soil organic carbon(SOC)and underlying factors in the 0-500-cm profile of a 10-to 50-year-old ***:The results obtained indicated that the dynamics of SWS and SCS on this time scale could be divided into an initial reduction phase(the initial 20 years after afforestation)and subsequent recovery(20-50 years after afforestation).Compared with in the abandoned land(AL),the net accumulation of SCS in *** forest was 2.51 Mg·ha^(-1)at 50 years after afforestation,whereas there was a 398.76-mm deficit in ***,the natural succession of *** forest has contributed to the continuous change in stand structure(*** cover(VC),understory vegetation coverage(UVC),and litter biomass(LB)).Conclusions:These findings indicate that vegetation restoration increases carbon sequestration while causing soil water ***,stand density(SD)was established to make a predominant contribution to the dynamics of SWS and SCS via its effects in altering vegetation,soil,and litter ***,high-density plantation forests in the Loess Plateau area should be appropriately thinned to reduce the density of forest stands on the basis of soil erosion control and wind and sand fixation,so as to increase carbon sink with lower water consumption,thus realizing the synergistic

关键词： Afforestation Robinia pseudoacacia Soil organic carbon Soil water Coupling interaction

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Successful couplings for difusion processes with state-dependent switching

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Science China Mathematics 2013年第10期56卷 2135-2144页

作者： xi FuBao shao JingHai School of Mathematics Beijing Institute of Technology School of Mathematical Sciences Beijing Normal University

This work is concerned with successful couplings for a class of multidimensional diffusion processes with state-dependent switching. We construct a type of couplings for this class of processes, and give some sufficient conditions to guarantee this type of couplings to be successful. Besides, two illustrative examples are provided.

关键词： diffusion process state-dependent switching successful coupling

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Distributed Subgradient Algorithm for Multi-Agent Optimization With Dynamic Stepsize

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IEEE/CAA Journal of Automatica Sinica 2021年第8期8卷 1451-1464页

作者： xiaoxing Ren Dewei Li Yugeng xi Haibin shao Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China

In this paper,we consider distributed convex optimization problems on multi-agent *** develop and analyze the distributed gradient method which allows each agent to compute its dynamic stepsize by utilizing the time-varying estimate of the local function value at the global optimal *** approach can be applied to both synchronous and asynchronous communication ***,we propose the distributed subgradient with uncoordinated dynamic stepsizes(DS-UD)algorithm for synchronous protocol and the AsynDGD algorithm for asynchronous *** analysis shows that the proposed algorithms guarantee that all agents reach a consensus on the solution to the multi-agent optimization ***,the proposed approach with dynamic stepsizes eliminates the requirement of diminishing stepsize in existing *** examples of distributed estimation in sensor networks are provided to illustrate the effectiveness of the proposed approach.

关键词： Distributed optimization dynamic stepsize gradient method multi-agent networks

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