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Continuous Symmetry Analysis of the Effects of City Infrastructures on Invariant Metrics for House Market Volatilities

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 619-638页

作者： Chien-Wen Lin Jen-Cheng Wang Bo-Yan Zhong Joe-Air Jiang Ya-Fen Wu shao-wei leu Tzer-En Nee Department of Electrical Engineering Taiwan Ocean UniversityKeelung20224Taiwan Department of Computer Science National Taipei University of EducationTaipei10671Taiwan Department of Electronic Engineering Chang Gung UniversityTao-Yuan City33302Taiwan Department of Biomechatronics Engineering National Taiwan UniversityTaipei10617Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung40447Taiwan Department of Electronic Engineering Ming Chi University of TechnologyNew Taipei City24301Taiwan Artificial Intelligence Research Center Chang Gung UniversityTao-Yuan City33302Taiwan

The invariant metrics of the effects of park size and distance to public transportation on housing value volatilities in Boston,Milwaukee,Taipei and Tokyo are *** reveal a Cobb-Douglas-like *** scaleinvariant exponents corresponding to the percentage of a green area(a)are 7.4,8.41,14.1 and 15.5 for Boston,Milwaukee,Taipei and Tokyo,respectively,while the corresponding direct distances to the nearest metro station(d)are−5,−5.88,−10 and−10,for Boston,Milwaukee,Taipei and Tokyo,*** multiphysics-based analysis provides a powerful approach for the symmetry characterization of market *** scaling exponent ratio between park area percentages and distances to metro stations is approximately 3/*** scaling exponent ratio expressed in the perceptual stimuli will remain invariant under group *** to Stevens’power law,the perception-dependent feature spaces for parks and public transportation can be described as two-and three-dimensional conceptual *** on the prolongation structure of the Schroinger equation,the SL(2,R)models are used to analyze the house-price *** with Shepard’s law,the rotational group leads to a Gaussian pattern,exhibiting an extension of the special linear group structure by embedding SO(3)■R(3)in SL(2,R).The influencing factors related to cognitive functioning exhibit substantially different scaleinvariant characteristics corresponding to the complexity of the socio-economic ***,the contour shapes of the price volatilities obtained from the group-theoretical analysis not only corroborate the impact of the housing pricing estimation in these cities but also reveal the invariant features of their housing markets are faced with the forthcoming sustainable development of big data technologies and computational urban science research.

关键词： Invariant metrics Schroinger equation group theory

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Time Parameter Based Low-Energy Data Encryption Method for Mobile Applications

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2779-2794页

作者： Li-Woei Chen Kun-Lin Tsai Fang-Yie leu Wen-Cheng Jiang Shih-Ting Tseng Department of Computer and Information Sciences Chinese Military AcademyKaohsiung830Taiwan Department of Electrical Engineering Tunghai UniversityTaichung407Taiwan Department of Computer Science Tunghai UniversityTaichung407Taiwan

Various mobile devices and applications are now used in daily *** devices require high-speed data processing,low energy consumption,low communication latency,and secure data transmission,especially in 5G and 6G mobile ***-security cryptography guarantees that essential data can be transmitted securely;however,it increases energy consumption and reduces data processing ***,this study proposes a low-energy data encryption(LEDE)algorithm based on the Advanced Encryption Standard(AES)for improving data transmission security and reducing the energy consumption of encryption in Internet-of-Things(IoT)*** the proposed LEDE algorithm,the system time parameter is employed to create a dynamic S-Box to replace the static S-Box of *** indicated that six-round LEDE encryption achieves the same security level as 10-round conventional AES *** reduction in encryption time results in the LEDE algorithm having a 67.4%lower energy consumption and 43.9%shorter encryption time than conventional AES;thus,the proposed LEDE algorithm can improve the performance and the energy consumption of IoT edge devices.

关键词： Mobile application security AES data encryption time parameter mobile device

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Aldo-keto reductase family member C3(AKR1C3)promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

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Oncology Research 2024年第1期32卷 163-174页

作者： KUO-SHYANG JENG PO-YU CHENG YUEH-HSIEN LIN PO-CHUN LIU PING-HUI TSENG YU-CHAO WANG CHIUNG-FANG CHANG CHUEN-MIIN leu Division of General Surgery Far Eastern Memorial HospitalNew Taipei City22060Taiwan Institute of Microbiology and Immunology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biomedical Informatics National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Department of Medical Research Far Eastern Memorial HospitalNew Taipei City22060Taiwan

Hepatocellular carcinoma(HCC)is a leading cause of death *** therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to ***,new therapeutic targets are *** analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly *** analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC *** vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell *** of AKR1C3 in Huh7 cells reduced tumor growth in *** explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target *** of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 *** of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC *** showed that indomethacin potentiated the sensitivity of Huh7 cells to *** summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC ***,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC.

关键词： Hepatocellular carcinoma Aldo-keto reductase family member C3 Prostaglandin F2 alpha Prostaglandin F receptor

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Aptamerized silica/gold nanocapsules for stimulated release of doxorubicin through remote two-photon excitation

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International Journal of Smart and Nano Materials 2022年第1期13卷 79-99,I0005页

作者： Lih Shin Tew Tsung-Hsi Lee leu-wei Lo Yit Lung Khung Nai-Tzu Chen Laboratory Service Bagan Specialist CentreButterworthMalaysia Department of Biological Science and Technology China Medical UniversityTaichung406040Taiwan Institute of Biomedical Engineering and Nanomedicine National Health Research InstitutesZhunanTaiwan Department of Cosmeceutics China Medical UniversityTaichung406040Taiwan

Precision-based drug delivery via remote triggering is fast becoming an attractive therapeutic design and is highly useful in complicated clinical situations that may require accurate site-delivery of drug while reducing the risk of collateral damage to surrounding healthy *** the many strategies available to achieve these desirable effects,silica/gold nano-assemblies offers a practical means to achieving these ***,as a proof-of-concept,a silica nanocapsule passivated with a gold outer nanoshell had been fabricated to deliver Doxorubicin,and this nano-assembly can be remotely triggered via two-photon excitation(TPE),even under in vivo setting.A polyethylene glycol(PEG)layer as well as AS1411 DNA aptamer had also been grafted to the surface to improve homing specificity toward MDA-MB-231 breast cancer *** assembly of silica/gold nanocapsules was characterized via TEM,FTIR,and UVVis to validate the the *** TPE irradiation,a higher expression level of Annexin V and Caspase-3 was observed in both in vitro and in vivo animal models.A significant reduction in tumor size on mice model was noticed after 21 days,and these results had suggested a viable nano-sized design serving as remotely triggered drug release platform based on current well-established silica nanoparticulate methodologies.

关键词： Gold nanoshell mesoporous silica nanoparticles twophoton excitation chemophotothermal therapy DNA aptamer

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Epigenetic changes in virus-associated human cancers

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Cell Research 2005年第4期15卷 262-271页

作者： Hsin Pai LI,Yu wei leu Graduate Institute of Basic Medical Sciences Chang Gung University Kwei-shan Taoyuan Department of Life Science and Institute of Molecular Biology ChungCheng University Ming-Hsiung Chia-Yi 5] Taiwan

Epigenetics of human cancer becomes an area of emerging research direction due to a growing understanding ofspecific epigenetic pathways and rapid development of detection technologies. Aberrant promoter hypermethylation is aprevalent phenonmena in human cancers. Tumor suppressor genes are often hypermethylated due to the increasedactivity or deregulation of DNMTs. Increasing evidence also reveals that viral genes are one of the key players inregulating DNA methylation. In this review, we will focus on hypermethylation and tumor suppressor gene silencing andthe signal pathways that are involved, particularly in cancers closely associated with the hepatitis B virus, simian virus40 (SV40), and Epstein-Barr virus. In addition, we will discuss current technologies for genome-wide detection ofepigenetically regulated targets, which allow for systematic DNA hypermethylation analysis. The study of epigeneticchanges should provide a global view of gene profile in cancer, and epigenetic markers could be used for early detection,prognosis, and therapy of cancer.

关键词： epigenetics DNA methylation cancer HBV SV40 EBV.

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Mechanically durable,super-repellent 3D printed microcell/nanoparticle surfaces

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Nano Research 2022年第6期15卷 5678-5686页

作者： Sajad Haghanifar Anthony J Galante Mehdi Zarei Jun Chen Susheng Tan Paul W leu Department of Industrial Engineering University of PittsburghPittsburghPA 15261USA Department of Mechanical Engineering and Materials Science University of PittsburghPittsburghPA 15261USA Department of Electrical and Computer Engineering and Peterson Institute of NanoScience and Engineering University of PittsburghPittsburghPA 15261USA Department of Chemical Engineering University of PittsburghPittsburghPA 15261USA

Three-dimensional(3D)printed re-entrant micropillars have demonstrated high static contact angles for an unprecedented variety of liquids,but have yet to achieve this with low contact angle hysteresis and excellent abrasion *** report on the demonstration of 3D printed microcell/nanoparticle structures that exhibit high static contact angle,low contact angle hysteresis,and high mechanical *** and microcells both exhibit high static contact angles with water and ethylene glycol(EG),but suffer from high contact angle hysteresis,indicative of rose petal *** modeling results indicate that micropillars are able to achieve higher static contact angle and breakthrough pressure simultaneously compared with ***,simulations also indicate that micropillars have higher maximum equivalent stress at their bases,so that they are more prone to mechanical *** address contact angle hysteresis and mechanical durability issues by the creation of 3D printed microcell/nanoparticle arrays that demonstrate super-repellency and retain their super-repellency after 100 cycles of mechanical abrasion with a Scotch-Brite abrasive pad under a pressure of 1.2 *** use of interconnected microcell structures as opposed to micropillars addresses mechanical durability *** contact angle hysteresis is realized by coating 3D printed structures with low surface energy nanoparticles,which lowers the solid–liquid contact area *** results demonstrate new 3D printed structures with mechanical durability and super-repellency through the use of microcell structures integrated with fluorinated nanoparticles.

关键词： superomniphobicity three-dimensional(3D)printing surface evolver mechanical durability microcell re-entrant micropillar

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樟叶木防己叶绿体基因组特征分析

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分子植物育种 2024年第8期22卷 2544-2554页

作者：苏永精谢澳温海成韦威广西中医药大学壮医药学院南宁530001

为探讨樟叶木防己(Cocculus laurifolius)叶绿体基因组特征及与同科属叶绿体基因组的系统发育关系。采用Illumina HiSeq 4000平台对樟叶木防己进行测序、组装和注释,并对其序列特征、密码子偏好性、重复序列、简单重复序列、系统发育进... 详细信息

为探讨樟叶木防己(Cocculus laurifolius)叶绿体基因组特征及与同科属叶绿体基因组的系统发育关系。采用Illumina HiSeq 4000平台对樟叶木防己进行测序、组装和注释,并对其序列特征、密码子偏好性、重复序列、简单重复序列、系统发育进行分析。结果表明,樟叶木防己叶绿体基因组呈典型的四分体结构,总长度为157 961 bp,包括大单拷贝区长度为89 173 bp,小单拷贝区长度为20198bp,反向互补重复区长度为24295 bp;共有基因129个,其中蛋白质编码基因85个,tRNA基因36个和rRNA基因8个;密码子偏好性分析表明,亮氨酸(leu)的密码子数量最多(4 920个),而半胱氨酸(Cys)的密码子数量最少(568个);从樟叶木防己叶绿体基因组中共检测出26个长重复序列及65个SSR位点;系统发育分析表明,樟叶木防己与粉防己(Stephania tetrandra)聚为一支,亲缘关系最密切。本研究为防己科和木防己属分子标记、物种鉴定、亲属关系解析、遗传多样性分析等研究提供科学依据。

关键词：樟叶木防己叶绿体基因组密码子偏好性重复序列系统发育

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Two-Stage High-Efficiency Encryption Key Update Scheme for LoRaWAN Based IoT Environment

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Computers, Materials & Continua 2022年第10期73卷 547-562页

作者： Kun-Lin Tsai Li-Woei Chen Fang-Yie leu Chuan-Tian Wu Department of Electrical Engineering Tunghai UniversityTaichung407Taiwan Research Center for Smart Sustainable Circular Economy Tunghai UniversityTaichung407Taiwan Department of Computer and Information Sciences Chinese Military AcademyKaohsiung830Taiwan Department of Computer Science Tunghai UniversityTaichung407Taiwan Emergency Response Management Center Industry-Academia Collaboration and University Extension DivisionMing-Chuan UniversityTaipei111Taiwan

Secure data communication is an essential requirement for an Internet of Things(IoT)*** in Industrial Internet of Things(IIoT)and Internet of Medical Things(IoMT)systems,when important data are hacked,it may induce property loss or life *** though many IoTrelated communication protocols are equipped with secure policies,they still have some security weaknesses in their IoT *** is one of the low power wide-area network protocols,and it adopts Advanced Encryption Standard(AES)to provide message integrity and ***,LoRaWAN’s encryption key update scheme can be further *** this paper,a Two-stage High-efficiency LoRaWAN encryption key Update Scheme(THUS for short)is proposed to update LoRaWAN’s root keys and session keys in a secure and efficient *** THUS consists of two stages,i.e.,the Root Key Update(RKU)stage and the Session Key Update(SKU)stage,and with different update frequencies,the RKU and SKU provide higher security level than the normal LoRaWAN specification does.A modified AES encryption/decryption process is also utilized in the THUS for enhancing the security of the *** security analyses demonstrate that the THUS not only protects important parameter during key update stages,but also satisfies confidentiality,integrity,and mutual ***,The THUS can further resist replay and eavesdropping attacks.

关键词： Key update AES LoRaWAN IoT security high efficiency

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A Wrapping Encryption Based on Double Randomness Mechanism

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Computers, Materials & Continua 2023年第10期77卷 1143-1164页

作者： Yi-Li Huang Fang-Yie leu Ruey-Kai Sheu Jung-Chun Liu Chi-Jan Huang Department of Computer Science Tunghai UniversityTaichung40764Taiwan Emergency Response Management Center Ming Chung UniversityTaipei11103Taiwan General Education Center Ming Chuan UniversityTaipei11103Taiwan

Currently,data security mainly relies on password(PW)or system channel key(SKCH)to encrypt data before they are sent,no matter whether in broadband networks,the 5th generation(5G)mobile communications,satellite communications,and so *** these environments,a fixed password or channel key(e.g.,PW/SKCH)is often adopted to encrypt different data,resulting in security risks since thisPW/SKCH may be solved after hackers collect a huge amount of encrypted ***,the most popularly used security mechanism Advanced Encryption Standard(AES)has its own problems,e.g.,several rounds have been *** the other hand,if data protected by the same PW/SKCH at different time points can derive different data encryption parameters,the system’s security level will be then greatly ***,in this study,a security scheme,named Wrapping Encryption Based on Double Randomness Mechanism(WEBDR),is proposed by integrating a password key(or a system channel key)and an Initialization Vector(IV)to generate an Initial Encryption Key(IEK).Also,an Accumulated Shifting Substitution(ASS)function and a three-dimensional encryption method are adopted to produce a set of *** randomness encryption mechanisms are *** first generates system sub-keys and calculates the length of the first pseudo-random numbers by employing IEK for providing subsequent encryption/*** second produces a random encryption key and a sequence of internal feedback codes and computes the length of the second pseudo-random numbers for encrypting delivered messages.A wrapped mechanism is further utilized to pack a ciphertext file so that a wrapped ciphertext file,rather than the ciphertext,will be produced and then transmitted to its *** findings are as *** theoretic analyses and simulations demonstrate that the security of the WEBDR in cloud communication has achieved its practical ***,AES requires 176 times exclusive OR(XOR)operations for both encryption an

关键词： Initial encryption key accumulated shifting substitution three-dimensional operation wrapped ciphertext file

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Nck, a missing adaptor between the B-cell receptor complex and the BCAP/PI3K/Akt pathway

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Cellular & Molecular Immunology 2014年第2期11卷 120-122页

作者： Chuen-Miin leu Natl Yang Ming Univ Inst Microbiol & Immunol Taipei 11221 Taiwan

The signaling pathways activated by the B-cell antigen receptor （BCR）play a crucial role in the development, activation, and differentiation of B cells. Among them, the activation ofphospha- tidylinositol 3-kinase （PI3K）/Akt is par- ticularly important.1-5 The recruitment of PI3K to the plasma membrane is necessary for the generation ofphospha- tidyl-inositol-3,4,5-triphosphate, which activates PDK1 （Akt/PKB kinase）; in turn, PDK1 activates Akt （Figure 1）.

关键词： Nck BCAP PI3K

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