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Evolution of plasticized MnO–Al2O3–SiO2-based nonmetallic inclusion in 18wt%Cr-8wt% Ni stainless steel and its properties during soaking process

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International Journal of Minerals,Metallurgy and Materials 2020年第3期27卷 328-339页

作者： Jing guo Xing-run Chen shao-wei Han Yan Yan Han-jie guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Jiuquan Iron and Steel Group Corporation Jiayuguan 735100China Beijing Shougang Co.Ltd. Qian'an 064400China

The properties of MnO–Al2O3–SiO2-based plasticized inclusion are likely to change during soaking process due to its low melting point. In this study, the evolution of the MnO–Al2O3–SiO2-based inclusion of 18 wt%Cr-8 wt%Ni stainless steel under isothermal soaking process at 1250°C for different times was investigated by laboratory-scale experiments and thermodynamic analysis. The results showed that the inclusion population density increased at the first stage and then decreased while their average size first decreased and then increased. In addition, almost no Cr2O3-concentrated regions existed within the inclusion before soaking, but more and more Cr2O3 precipitates were formed during soaking. Furthermore, the plasticity of the inclusion deteriorated due to a decrease in the amount of liquid phase and an increase in the high-melting-pointphase MnO–Cr2O3 spinel after the soaking process. In-situ observations by high-temperature confocal laser scanning microscopy(CLSM) confirmed that liquid phases were produced in the inclusions and the inclusions grew rather quickly during the soaking process. Both the experimental results and thermodynamic analysis conclude that there are three routes for inclusion evolution during the soaking process. In particular, Ostwald ripening plays an important role in the inclusion evolution, i.e., MnO–Al2O3–SiO2-based inclusions grow by absorbing the newly precipitated smaller-size MnO–Cr2O3 inclusions.

关键词： nonmetallic inclusion soaking process Ostwald ripening stainless steel

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Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： Fan YANG Zhaoyang MA Xingming guo Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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降钙素原、C反应蛋白和PaCO2对慢性阻塞性肺疾病急性加重期无创通气失败的预测价值

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国际呼吸杂志 2018年第5期38卷 346-351页

作者：王金荣商会棉郭淑芬邵立业郭伟崔朝勃河北医科大学附属衡水哈励逊国际和平医院重症医学科 053000

目的探索慢性阻塞性肺疾病急性加重期（AECOPD）无创通气（NIV）治疗失败的危险因素。方法将2014年5月至2017年3月确诊的AECOPD行NIV治疗的住院患者纳入研究。所有患者NIV前1h均行血常规、血沉、动脉血气分析、C反应蛋白（CRP）和降钙... 详细信息

目的探索慢性阻塞性肺疾病急性加重期（AECOPD）无创通气（NIV）治疗失败的危险因素。方法将2014年5月至2017年3月确诊的AECOPD行NIV治疗的住院患者纳入研究。所有患者NIV前1h均行血常规、血沉、动脉血气分析、C反应蛋白（CRP）和降钙素原（PCT）检测，观察上述指标对NIV失败的预测价值。结果共筛查402例患者，最后纳入376例，其中286例NIV成功，90例NIV失败行有创机械通气治疗。成功与失败组NIV治疗前1h PCT、CRP、pH、动脉血二氧化碳分压（PaCOt）水平差异有统计学意义。PCT仅与CRP呈弱相关（r=0．18，P〈0．05），而与血气指标及其他炎性指标无任何相关性。二分类Logistic回归分析发现高PCT、CRP和PaCO。是NIV失败的独立危险因素，比值比分别为2．26[（95％可信区间（CI）：1．21～3．241、1．14（95％CI：1．15～1．28）和1．17（95％CI：1．04～1．26）。通过绘制受试者工作曲线评估3个指标对NIV失败的预测价值，约登指数最高时PCT界限值为0．31pg／L（敏感度为83．37％，特异度为83．71％）；CRP界限值为15g／L（敏感度为75．64％，特异度为93．04％）；PaCO2界限值为73．50mmHg（1mmHg=0．133kPa）（敏感度为71．16％，特异度为100％）。曲线下面积（AUC）分别是PCT0．85（95％CI：0．79～0．91）、CRP0．85（95％CI：0．79～0．91）、PaCO2 0．83（95％CI：0．76～0．90），上述3个指标同时满足时，联合预测AUC为0．98（95％CI：0．96～0．99）。结论AECOPD患者NIV失败组较成功组PCT、PaCO2和CRP水平更高，pH更低，PCT、PaCO2和CRP与NIV治疗失败独立相关，预测界限值分别为0．31μg／L、73．5mmHg和15．0g／L，三者联合预测价值更高。

关键词：无创通气慢性阻塞性肺疾病急性加重期降钙素原 C反应蛋白动脉血气分析

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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli guo Chikako Harada Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

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Exact Solitary-wave Solutions and Periodic Wave Solutions for Generalized Modified Boussinesq Equation and the Effect of Wave Velocity on Wave Shape

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Acta Mathematicae Applicatae Sinica 2008年第4期24卷 691-705页

作者： wei-guo Zhang shao-wei Li wei-zhong Tian Lu Zhang College of Science University of Shanghai for Science and Technology Shanghai 200093 China School of mathematics and information engineering Taizhou university Zhejiang 317300 China

By means of the undetermined assumption method, we obtain some new exact solitary-wave solutions with hyperbolic secant function fractional form and periodic wave solutions with cosine function form for the generalized modified Boussinesq equation. We also discuss the boundedness of these solutions. More over, we study the correlative characteristic of the solitary-wave solutions and the periodic wave solutions along with the travelling wave velocity＇s variation.

关键词： Generalized modified Boussinesq equation exact solitary-wave solution periodic wave solution

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Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli guo Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

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基于3 DCT、4 DCT和CBCT增强扫描测量正常食管壁厚度的研究

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中华放射肿瘤学杂志 2016年第11期25卷 1187-1191页

作者：胡超月李建彬王金之邵倩王玮郭延娈徐敏李文武黄勇济南大学山东省医学科学院医学与生命科学学院 250117 山东大学附属山东省肿瘤医院放疗科济南250117 山东大学附属山东省肿瘤医院影像科济南250117

目的：比较3DCT、4DCT和CBCT增强扫描图像测量的正常食管壁厚度，为食管癌靶区的勾画提供参考。方法对2009—2016年间50例肺癌或转移性肺癌患者行胸部增强3DCT、4DCT模拟定位扫描，并于首次3DCRT时进行增强CBCT扫描。分别在3DCT、4DCT... 详细信息

目的：比较3DCT、4DCT和CBCT增强扫描图像测量的正常食管壁厚度，为食管癌靶区的勾画提供参考。方法对2009—2016年间50例肺癌或转移性肺癌患者行胸部增强3DCT、4DCT模拟定位扫描，并于首次3DCRT时进行增强CBCT扫描。分别在3DCT、4DCT呼气末时相（4DCT50）、4DCT最大密度投影图像（4DCTMIP）及CBCT图像上勾画正常食管，逐层测量各段食管壁厚度取平均值。对同段食管在不同CT图像上管壁厚度的比较行成组t检验，对不同段食管在同种CT图像上管壁厚度的比较行单因素方差分析。结果3DCT与4DCT50图像间胸段及腹段食管壁厚度差异无统计学意义（ P＝0．056～0.550）；3DCT与4DCTMIP、CBCT图像间胸段和腹段食管壁的厚度差异有统计学意义（ P＝0．000～0.004）；4DCTMIP与CBCT图像间胸上、中段食管壁厚度差异有统计学意义（ P＝0.008、0.001）。在3DCT、4DCTMIP、4DCT50图像上，胸下段食管壁均较胸上、中段厚（ P＝0．008～0.041），腹段食管壁较胸段厚（ P均＝0.000）；在 CBCT图像上，胸上、中、下段之间的差异均无统计学意义（ P＝0．088～0.945）。结论在3DCT、4DCT50图像上勾画胸段食管原发肿瘤GTV时正常食管壁厚度的判断可以使用同一标准，但在4DCTMIP、CBCT图像上采用5 mm作为勾画GTV时正常食管壁厚度的判定标准尚需谨慎。

关键词：体层摄影术,X线计算机,三维体层摄影术,X线计算机,四维体层摄影术,X线计算机,锥形束正常食管厚度

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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HSAEP:a new platform to evaluate hybrid simulation algorithms

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Frontiers of Computer Science 2021年第5期15卷 211-213页

作者： wei guo Xiaoxu DUAN Chen ZENG Ping shao School of Civil Engineering Central South UniversityChangsha 410075China

1 Introduction Hybrid simulation method in civil engineering is a test method that combines numerical simulation and physical testing[1].The basic procedure of hybrid simulation is shown in *** hybrid simulation,the performance of the algorithm has a great influence on the test results[2].However,there is no standard test platform or standard model to test the performance of the hybrid simulation *** situations limit the development of hybrid simulation algorithms and may lead to unreliable hybrid simulation results.

关键词： algorithm. simulation combine

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Mechanism and kinetics for scavenging superoxide anion by progesterone

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Chinese Science Bulletin 2001年第2期46卷 117-121页

作者： SONG Junfeng shao Yong guo wei Institute of Electroanalytical Chemistry Northwest UniversityXi’an 710069China Department of Merterial and Chemical Engineering Sichuan Institude of Light Industry and Chemical TechnologyZigong 643033China

The chemical reaction of progesterone with su-peroxide anion O2- in 0.1 mol/L NaHCO3 medium is studied by polarography. Differing from the indirect inhibition of O2- generation by synthesized glucocorticoids in mecha-nism, the function that progesterone scavenges O2- is as-cribed to that O2- directly oxidizes the C =C double bond conjugated with the carbonyl moiety of progesterone mole-cule to a free radical, and then is reduced to H2O2. The result obtained in this work gives new evidence for biomedical research. The equation of rate constant of the oxidization reaction is deduced, and the apparent rate constant obtained is308 L·mol-1·s-1.

关键词： superoxide progesterone scavenging kinetics anti-oxidation.

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