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MicroRNA-363-3p inhibits colorectal cancer progression by targeting interferon-induced transmembrane protein 1

World Journal of Gastrointestinal Oncology 2023年第9期15卷 1556-1566页

作者： Yun Wang shao-Kai bai tao Zhang Cheng-Gong Liao Department of Oncology Tangdu HospitalAir Force Medical UniversityXi’an 710038Shaanxi ProvinceChina

BACKGROUND The molecular mechanisms of colorectal cancer development and progression are far from being *** To investigate the role of microRNA-363-3p(miR-363-3p)in the progression of colorectal *** Real-time polymerase chain reaction was performed to detect miRNA expression in human colorectal cancer tissues and paired normal colorectal *** 6 was utilized to predict the targets of ***-luciferase reporter system was used to validate the target of *** colony formation assay and wound-healing assay were performed to evaluate cancer cells’clonogenic survival ability and migration ability,*** proliferation was examined by cell counting kit-8 *** staining was used to determine the expression level of interferon-induced transmembrane protein 1(IFITM1)in colorectal cancer tissues and adjacent *** TCGA and GTEx databases were used to compare the expression levels of IFITM1 mRNA in colorectal cancer tissues and normal colorectal tissues and analyze the correlation between the expression levels of IFITM1 mRNA and overall survival and disease-free survival of patients.A colorectal cancer cell line with a deficiency of IFITM1 was constructed,and the regulation effect of IFITM1 on the clonogenic growth of colorectal cancer cells was *** MiR-363-3p was decreased in colorectal cancer tissues compared to normal colorectal ***1 was characterized as a direct target of *** of miR-363-3p led to decreased clonogenic survival,proliferation,and migration of colorectal cancer cells,which could be reversed by forced IFITM1 *** MiR-363-3p can constrain clonogenic survival,proliferation,and migration of colorectal cancer cells via targeting IFITM1.

关键词： MicroRNA-363-3p Proliferation Clonogenic survival Colorectal cancer Interferon-induced transmembrane protein 1

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采用骨料架构-固化技术对开挖淤泥加固试验研究

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土木与环境工程学报（中英文） 2025年第1期47卷 100-109页

作者：邵吉成袁波白银银骆嘉成浙江华坤地质发展有限公司浙江温州325006 温州市地质资源与生态环境重点实验室浙江温州325006 浙江省第十一地质大队浙江温州325006 温州市渣土利用开发股份有限公司浙江温州325700

为了对淤泥和建筑垃圾进行处置,实现二者的共同资源化利用,在室内和现场分别对淤泥进行固化试验。将建筑垃圾作为骨料按淤泥质量比的15%添加到淤泥中,再向淤泥中加入淤泥固化剂,通过机械搅拌的方式将淤泥与建筑垃圾、固化剂混合均匀,然... 详细信息

为了对淤泥和建筑垃圾进行处置,实现二者的共同资源化利用,在室内和现场分别对淤泥进行固化试验。将建筑垃圾作为骨料按淤泥质量比的15%添加到淤泥中,再向淤泥中加入淤泥固化剂,通过机械搅拌的方式将淤泥与建筑垃圾、固化剂混合均匀,然后对固化土进行养护。室内试验结果表明,当固化剂掺量为8%时,固化淤泥土强度较高,养护28 d后,室内无侧限抗压强度可达320 kPa;在现场试验中,静力触探试验和平板荷载试验表明,固化剂对淤泥的固化效果明显。将低剂量固化剂添加到淤泥中,固化淤泥土强度较低,骨料的架构作用不明显;当固化剂掺量为8%时,固化土的强度较高,骨料的架构作用有利于提升固化淤泥土的承载力,土体的承载力特征值可达325kPa,架构作用对固化淤泥土强度的提升率为71.05%,可实现淤泥和建筑垃圾的同步资源化利用。

关键词：淤泥固化骨料资源化利用架构作用承载力

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Thermal-induced transformation of wetting behaviors on laser-textured SiC surfaces

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Science China(Technological Sciences) 2016年第6期59卷 862-866页

作者： bai shao Xian WANG Rong College of Mechanical Engineering Zhejiang University of Technology

Thermal-induced transformation of wetting behaviors on laser-textured silicon carbide （SIC） surfaces was discussed in this work. To investigate the transformation, a quenching experiment was conducted and an X-ray diffractometer was used to measure the residual stress. The experimental results demonstrate that the significantly enhanced hydrophilicity was induced by the increasing thermal residual stress of SiC materials after the aqueous quenching. It was found that the decrease in the contact angle increased with the increasing quenching temperature. Quenching at 350℃ led to the change of contact angle from 89.28° to 70.88° for the smooth surface, while from 72.25° to 33.75° for the laser-textured surface with depth 8 μm. Further, the surface hydrophobicity was enhanced by the release of thermal residual stress after quenching, thereby leading to an increase in the contact angle over time. The transformation of wetting behaviors on laser textured SiC surfaces can be achieved mutually by the aqueous quenching method.

关键词： wettability transformation silicon carbide laser processing aqueous aquenching

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Preparation and characterization of 3-mercaptopropyl trimethoxysilane self-assembled monolayers

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Journal of University of Science and Technology Beijing 2008年第2期15卷 192-196页

作者： tao bai Xianhua Cheng School of Mechanical Engineering Shanghai Jiaotong University Shanghai 200030 China National Engineering Research Center for Nanotechnology Shanghai 200237 China

Silane coupling regent （3-mercaptopropyl trimethoxysilane （MPTS）） was prepared on the single-crystal silicon substrate to form 2-dimensional self-assembled monolayers （SAMs）. The growth behavior of SAMs formed from 3-MPTS was investigated using atomic force microscopy （AFM）, contact angle measurements, ellipsometry, and X-ray photoelectron spectroscopy （XPS）. The formation behavior of MPTS SAMs was investigated by a series of AFM images and the roughness of MPTS SAMs on silicon substrates with the assembling time from 1 min to 24 h. The water contact angle measurements indicated the growth behavior of MPTS that correlated with the AFM measurements at different immersion times, too. The chemical states of the typical elements in the MPTS SAMs were analyzed using X-ray photoelectron spectroscopy. The results show that MPTS is self-assembled on the substrate.

关键词： mercaptopropyl trimethoxysilane (MPTS) thin films self-assembly characterization atomic force microscopy (AFM)

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Sequential Gaussian simulation for geosystems modeling:A machine learning approach

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Geoscience Frontiers 2022年第1期13卷 1-14页

作者： tao bai Pejman Tahmasebi College of Engineering and Applied Science University of WyomingLaramieWY 82071USA

Sequential Gaussian Simulation(SGSIM)as a stochastic method has been developed to avoid the smoothing effect produced in deterministic methods by generating various stochastic *** of the main issues of this technique is,however,an intensive computation related to the inverse operation in solving the Kriging system,which significantly limits its application when several realizations need to be produced for uncertainty *** this paper,a physics-informed machine learning(PIML)model is proposed to improve the computational efficiency of the *** this end,only a small amount of data produced by SGSIM are used as the training dataset based on which the model can discover the spatial correlations between available data and unsampled *** achieve this,the governing equations of the SGSIM algorithm are incorporated into our proposed *** quality of realizations produced by the PIML model is compared for both 2D and 3D cases,visually and ***,computational performance is evaluated on different grid *** results demonstrate that the proposed PIML model can reduce the computational time of SGSIM by several orders of magnitude while similar results can be produced in a matter of seconds.

关键词： Artificial intelligence Uncertainty Geosystems Statistical modeling

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Fast FOCUSS method based on bi-conjugate gradient and its application to space-time clutter spectrum estimation

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Science China(Information Sciences) 2017年第8期60卷 163-175页

作者： Gatai bai Ran tao Juan ZHAO Xia bai Yue WANG School of Mathematics and Statistics Beijing Institute of Technology Beijing Key Laboratory of Fractional Signals and Systems School of Information and Electronics Beijing Institute of Technology

The focal underdetermined system solver(FOCUSS) is a powerful tool for sparse representation in complex underdetermined systems. This paper presents the fast FOCUSS method based on the bi-conjugate gradient(BICG), termed BICG-FOCUSS, to speed up the convergence rate of the original FOCUSS. BICGFOCUSS was specifically designed to reduce the computational complexity of FOCUSS by solving a complex linear equation using the BICG method according to the rank of the weight matrix in FOCUSS. Experimental results show that BICG-FOCUSS is more efficient in terms of computational time than FOCUSS without losing accuracy. Since FOCUSS is an efficient tool for estimating the space-time clutter spectrum in sparse recoverybased space-time adaptive processing(SR-STAP), we propose BICG-FOCUSS to achieve a fast estimation of the space-time clutter spectrum in mono-static array radar and in the mountaintop system. The high performance of the proposed BICG-FOCUSS in the application is demonstrated with both simulated and real data.

关键词： focal underdetermined system solver(FOCUSS) sparse recovery(SR) bi-conjugate gradient(BICG) space-time adaptive processing(STAP) space-time clutter spectrum

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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan bai Hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

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SOLUTIONS FOR CYLINDRICAL CAVITY IN SATURATED THERMOPOROELASTIC MEDIUM

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Acta Mechanica Solida Sinica 2009年第1期22卷 85-94页

作者： Bing bai tao Li School of Civil Engineering Beijing Jiaotong University Beijing 100044 China

Based on the thermodynamics of irreversible processes, the mass conservation equation and heat energy balance equation are established. The governing equations of thermal consolidation for homogeneous isotropic materials are presented, accounting for the coupling effects of the temperature, stress and displacement fields. The case of a saturated medium with a long cylindrical cavity subjected to a variable thermal loading and a variable hydrostatic pressure （or a variable radial water flux） with time is considered. The analytical solutions are derived in the Laplace transform space. Then, the time domain solutions are obtained by a numerical inversion scheme. The results of a typical example indicate that thermodynamically coupled effects have considerable influences on thermal responses.

关键词： cylindrical cavity boundary conditions irreversible thermodynamics thermo-osmosis,Laplace transform

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数媒时代焦虑、抑郁与社会比较的关系

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心理科学进展 2025年第1期33卷 92-106,I0001-I0007页

作者：赵立白莎首都经济贸易大学工商管理学院北京100070

社会焦虑和抑郁现象日益严重。为理解与探索数媒时代焦虑、抑郁的引致因素及应对策略,研究采用系统性文献综述方法,基于情感事件理论和社会比较理论构建框架,梳理了社会比较的不同亚型与焦虑、抑郁的关系以及网络媒体环境的权变作用。... 详细信息

社会焦虑和抑郁现象日益严重。为理解与探索数媒时代焦虑、抑郁的引致因素及应对策略,研究采用系统性文献综述方法,基于情感事件理论和社会比较理论构建框架,梳理了社会比较的不同亚型与焦虑、抑郁的关系以及网络媒体环境的权变作用。研究发现,消极社会比较(传统上行比较和下行同化比较)可能会引发焦虑和抑郁,社交网络平台对此负面影响具有催化作用;而情绪比较和下行对比比较可以缓解焦虑和抑郁,网络健康社区促进了情绪比较的积极作用的发挥。研究推进了社会比较理论在情绪情感领域的应用,确定了焦虑、抑郁与网络健康社区可供性的关联,也为网络社区服务、运营和设计的原则提供参考和借鉴以帮助个体应对心理健康问题。研究还指出焦虑、抑郁和社会比较关系后续研究的可能路径和方向。

关键词：社会比较焦虑抑郁社交网络平台网络健康社区

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Improved RIP-based performance guarantees for multipath matching pursuit

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Science China(Information Sciences) 2018年第10期61卷 173-186页

作者： Juan ZHAO Xia bai Ran tao School of Information and Electronics Beijing Institute of Technology Beijing Key Laboratory of Fractional Signals and Systems Beijing Institute of Technology

The multipath matching pursuit(MMP) is a generalization of the orthogonal matching pursuit(OMP), which generates multiple child paths for every candidate in each iteration and selects the candidate having the minimal residual as the final support set when iteration ends. In this paper we analyze its performance in both noiseless and noisy cases. The restricted isometry property(RIP)-based condition of MMP that ensures accurate recovery of sparse signals in the noiseless case is derived by using a simple technique. The performance guarantees of the MMP for support recovery in noisy cases are also *** is shown that under certain conditions on the RIP and minimum magnitude of nonzero components of the sparse signal, the MMP will exactly recover the true support of the sparse signal in cases of bounded noises and recover the true support with a high probability in the case of Gaussian noise. Our bounds on the RIP improve the existing results.

关键词： compressed sensing(CS) sparse signal reconstruction multipath matching pursuit(MMP) support recovery restricted isometry property(RIP)

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