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The big bang of genome editing technology: development and application of the CRISPR/Cas9 system in disease animal models

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Zoological Research 2016年第4期37卷 191-204页

作者： Ming shao Tian-rui XU Ce-shi CHEN Faculty of Life Science and Technology Kunming University of Science and Technology Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences

Targeted genome editing technology has been widely used in biomedical studies. The CRISPR- associated RNA-guided endonuclease Cas9 has become a versatile genome editing tool. The CRISPR/Cas9 system is useful for studying gene function through efficient knock-out, knock-in or chromatin modification of the targeted gene loci in various cell types and organisms. It can be applied in a number of fields, such as genetic breeding, disease treatment and gene functional investigation In this review, we introduce the most recent developments and applications, the challenges, and future directions of Cas9 in generating disease animal model. Derived from the CRISPR adaptive immune system of bacteria, the development trend of Cas9 will inevitably fuel the vital applications from basic research to biotechnology and bio- medicine.

关键词： CRISPR/Cas9 Animal models Genetherapy

Center for Elliptic Quantum Group Eτ，η(sln)

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Communications in Theoretical Physics 2003年第1期39卷 67-72页

作者： Zhao shao-You shi Kang-Jie Yue rui-Hong Department of Physics Beijing Institute of Technology Beijing 100081 China Institute of Modern Physics Northwest University Xi'an 710069 China

We give the center of the elliptic quantum group in general cases. Based on the dynamical Yang-Baxter relation and the fusion method, we prove that the center commutes with all generators of the elliptic quantum group. Then for a kind of assumed form of these generators, we find that the coefficients of these generators form a new type of closed algebra. We also give the center for the algebra.

关键词：凝聚物理椭圆量子群 YangBaxter关系式

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina Qing-rui Zhang Xiao-Ge Li Qi-Bao Jiang shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Enhancing wireless sensing via a target-mounted intelligent reflecting surface

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National Science Review 2023年第8期10卷 13-14页

作者： Xiaodan shao rui Zhang School of Science and Engineering Shenzhen Research Institute of Big Data The Chinese University of Hong Kong Department of Electrical and Computer Engineering National University of Singapore

An intelligent reflecting surface(IRS),or its various equivalents such as an reconfigurable intelligent surface(RIS), is an emerging technology to control radio signal propagation in wireless systems. An IRS is a digitally controlled metasurface consisting of a large number of passive reflecting elements, which are connected to a smart controller to enable dynamic adjustments of the amplitude and/or phase of the incident signal on each element independently [1].

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罗氏e411电化学发光分析仪死腔试剂的性能评价

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成都医学院学报 2012年第1期7卷 113-115页

作者：李光富施绍瑞胡孝彬郭晓聪四川省宜宾市第二人民医院检验科四川宜宾644000

目的评价罗氏Cobas e411全自动电化学发光免疫分析仪死腔试剂的性能,探讨其再利用的可行性。方法对两盒死腔混合试剂进行精密度、准确度、线性检测、回收试验,观察其试剂稳定性。采用死腔试剂和原装试剂检测同一组标本的血浆氨基末端脑... 详细信息

目的评价罗氏Cobas e411全自动电化学发光免疫分析仪死腔试剂的性能,探讨其再利用的可行性。方法对两盒死腔混合试剂进行精密度、准确度、线性检测、回收试验,观察其试剂稳定性。采用死腔试剂和原装试剂检测同一组标本的血浆氨基末端脑利钠肽前体(NT-proBNP)含量,并进行比较。结果两盒死腔混合试剂检测NT-proBNP质控血清低、高浓度变异系数(CV)批内分别为2.74%、2.62%(未校准),2.39%、2.51%;批间分别为4.81%、4.95%(未校准),4.17%、4.56%。未校准死腔混合试剂与原装试剂检测结果比较,差异有统计学意义(P0.05)。NT-proBNP的线性回归分析方程为y=0.997x+4.38,r=0.995,平均回收率99.62%。结论校准后死腔混合试剂的线性、精密度、准确度符合要求,且性能稳定、质量可靠、检测结果准确,可再利用,能有效降低成本。

关键词：二维条码死腔试剂电化学发光

The structural order of protein hydration water

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Communications in Theoretical Physics 2022年第9期74卷 170-176页

作者： rui shi Zhejiang Province Key Laboratory of Quantum Technology and Device School of PhysicsZhejiang UniversityHangzhou 310027China

The ability of water to dissolve biomolecules is crucial for our *** has been shown that protein has a profound effect on the behavior of water in its hydration shell,which in turn affects the structure and function of the ***,there is still no consensus on whether protein promotes or destroys the structural order of water in its hydration shell until today,because of the lack of proper structural descriptor incorporating hydrogen-bond(H-bond)information for water at the protein/water *** we performed all-atom molecular dynamics simulations of lysozyme protein in water and analyzed the H-bond structure of protein hydration water by using a newly developed structural *** find that the protein promotes local structural ordering of the hydration water while having a negligible effect on the strength of individual *** findings are fundamental to the structure and function of biomolecules and provide new insights into the hydration of protein in water.

关键词： protein hydration water structure hydrogen bond molecular dynamics

Estimates for Vector-valued Commutators on Weighted Morrey Space and Applications

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Acta Mathematica Sinica,English Series 2013年第5期29卷 883-896页

作者： shao Guang shi School of Science Linyi University School of Mathematical Sciences Beijing Normal University

In this paper, we introduce weighted vector-valued Morrey spaces and obtain some estimates for vector-valued commutators on these spaces. Applications to CalderSn-Zygmund singular integral operators, oscillatory singu... 详细信息

关键词： Weighted Morrey space vector-valued commutator Ap weights

Lateral epitaxial grown of two-dimensional halide perovskite heterostructures

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Rare Metals 2020年第8期39卷 863-864页

作者： Cheng-rui shao Wei Hu School of Physics and Electronics Hunan UniversityChangsha 410083China

In last decade,the halide perovskite materials have been widely explored all over the world for their excellent optoelectronic *** perovskite solar cells in particular are reshaping the landscape of ***,the perovskite... 详细信息

关键词： properties. perovskite landscape

Anisotropic flow in high baryon density region

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Nuclear Science and Techniques 2022年第2期33卷 79-86页

作者： shao-Wei Lan Shu-Su shi Key Laboratory of Quark and Lepton Physics(MOE)and Institute of Particle Physics Central China Normal UniversityWuhan 430079China

Collective flow is a powerful tool used to analyze the properties of a medium created during high-energy nuclear ***,we report a systematic study of the first two Fourier coefficients v_(1)and v_(2)of the proton andπ^(+)from Au+Au collisions in the energy range√sNN=2.11-4.9 GeV within the framework of a hadronic transport model(UrQMD).Recent results from the STAR experiment were used to test the model calculations.A meanfield mode with strong repulsive interaction is needed to reproduce the 10-40%data at 3 *** implies that hadronic interactions play an important role in the collective flow development in the high baryon density *** mean values of the freeze-out time for protons andπ^(+)are shifted earlier owing to the additional repulsive *** predict the energy dependence of the mean values of the transverse momentum,v_(1),and v_(2)for both protons andπ^(+)from the Au+Au collisions.

关键词： Heavy-ion collisions QCD phase diagram UrQMD Collective flow Mean-field potential