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Yes-associated protein-mediated melatonin regulates the function of periodontal ligament stem cells under oxidative stress conditions

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World Journal of Stem Cells 2024年第11期16卷 926-943页

作者： Ke Gu Xiao-Mei Feng shao-qing sun Xing-Yao Hao Yong Wen Department of Implantology School and Hospital of StomatologyCheeloo College of MedicineShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissueegeneration&Shandong Provincial Clinical Research Center for Oral DiseasesNo.44-1 Wenhua Road WestJinan 250012Shandong ProvinceChina Stomatological Hospital School of MedicineNankai UniversityTianjin Key Laboratory of Oral and Maxillofacial Function ReconstructionTianjin 300041China

BACKGROUND Human periodontal ligament stem cells(PDLSCs)regenerate oral *** vitro expansion causes replicative senescence in stem *** causes intracellular reactive oxygen species(ROS)accumulation,which can impair stem cell *** engineering efficiency is reduced by exogenous ROS stimulation,which causes premature senescence under oxidative ***(MT),a powerful free radical scavenger,can delay PDLSCs senescence but may not maintain stemness under oxidative *** experiment examined the effects of hydrogen peroxide-induced oxidative stress on PDLSCs’apoptosis,senescence,and *** To determine if MT can reverse the above effects along with the underlying molecular mechanisms *** PDLSCs were isolated from human premolars and cultured in different *** cytometry was used to characterize the cell surface markers of BACKGROUND Human periodontal ligament stem cells(PDLSCs)regenerate oral *** vitro expansion causes replicative senescence in stem *** causes intracellular reactive oxygen species(ROS)accumulation,which can impair stem cell *** engineering efficiency is reduced by exogenous ROS stimulation,which causes premature senescence under oxidative ***(MT),a powerful free radical scavenger,can delay PDLSCs senescence but may not maintain stemness under oxidative *** experiment examined the effects of hydrogen peroxide-induced oxidative stress on PDLSCs’apoptosis,senescence,and *** To determine if MT can reverse the above effects along with the underlying molecular mechanisms *** PDLSCs were isolated from human premolars and cultured in different *** cytometry was used to characterize the cell surface markers of differentiation,ROS,and senescence-associatedβ-galactosidase activity were assessed by various *** transcription-polymerase chain reaction and western blot were used to measure the expression of genes and

关键词： Human periodontal ligament stem cells Melatonin Reactive oxygen species Senescence Yes-associated protein

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2D CaWO4 nanosheets derived from scheelite minerals for enhanced electrocatalysis in oxygen evolution reaction

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Science China Chemistry 2025年

作者： qing sun Yongxiang sun Yan Dong Hong Zhong Hongbo Zeng National&Local United Engineering Laboratory for New Petrochemical Materials&Fine Utilization of Resources College of Chemistry and Chemical EngineeringHunan Normal University Department of Chemical and Materials Engineering University of Alberta College of Chemistry and Materials Engineering Hunan University of Arts and Science College of Chemistry and Chemical Engineering Central South University

Scheelite （CaWO4） mineral holds promise as a cost-effective and efficient catalyst for the oxygen evolution reaction （OER）crucial in renewable energy ***,challenges such as limited active site exposure and low electrocatalytic performance need *** this work,we have fabricated two-dimensional （2D） CaWO4nanosheets from scheelite minerals via a straightforward ultrasonic exfoliation method and evaluated their efficacy as OER *** to scheelite powders,these 2D nanosheets exhibited superior crystallinity and a 1.26-fold increase in electrochemical surface area,promoting active site *** 2D CaWO4nanosheet electrode demonstrated outstanding OER catalytic performance,achieving a current density of 20 mA/cm2at an overpotential of 290 m V in alkaline conditions,which was lower than that of bulk CaWO4electrodes （～340 mV）.Density functional theory calculations attributed this enhanced catalytic performance to moderate adsorption of oxygenated intermediates （*OH,*O,and*OOH） on the W sites of 2D *** situ electrochemical atomic force microscopy tests also confirmed the catalytic enhancement by 2D CaWO4nanosheets during *** findings demonstrate the potential of affordable and abundant mineral resources in advancing electrochemical catalysts for oxygen evolution,highlighting their broader application in sustainable energy technologies.

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-qing Qiao Guo Hui Bojing sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying sun Haoyan Li Dongqing sun Shaliu Fu Lei Gu Xin shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang Jia-Qian Ju Jing-Cai Liu shao-Chen sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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美国小学科学教育标准修订的内容、特点及启示

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教学与管理 2025年第2期 73-76页

作者：张绍清付超然赣南师范大学教育科学学院江西赣州341000 赣南师范大学物理与电子信息学院江西赣州341000

美国的《新一代科学教育标准》代表了科学教育的创新进步,整合了前沿科研,并修正了旧标准的问题。通过分析《新一代科学教育标准》在教学素养、课程内容、教学方法和评估方面的创新,以及凸显科学学科的基础作用、学科工具的运用、学科... 详细信息

美国的《新一代科学教育标准》代表了科学教育的创新进步,整合了前沿科研,并修正了旧标准的问题。通过分析《新一代科学教育标准》在教学素养、课程内容、教学方法和评估方面的创新,以及凸显科学学科的基础作用、学科工具的运用、学科理念的革新和教育目标的重新定位等新特征,从科学教育理念、内容与方法方面为我国科学教育的发展提出建议。

关键词：美国小学科学教育科学课程教育标准

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Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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Preparation of W-TiC alloys from core-shell structure powders synthesized by an improved wet chemical method

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Rare Metals 2023年第4期42卷 1378-1386页

作者： shao-Ting Lang qing-Zhi Yan Ning-Bo sun Xiao-Xin Zhang Institute of Nuclear Materials University of Science and Technology BeijingBeijing100083China

In order to improve the homogeneous distribution of the TiC particles and facilitate the TiC particles to distribute in the tungsten grain interiors,two kinds of TiCdoped tungsten precursors with a core-shell structure were prepared by an improved wet chemical method at different reaction temperature ***,fine platelike precursor(200-400 nm)and flower-like precursor(approximately 1.25μm)are *** reduction and sintering,the microstructures of the samples were characterized by scanning electron microscopy and transmission electron *** the sample sintered from the platelike precursor,TiC particles with sizes in the range of40-300 nm and an average size of approximately 80 nm were uniformly distributed in the tungsten matrix with a high share in the grain ***,in the sample sintered from the flower-like precursor,the TiC particles with sizes in the range of 50-700 nm are significantly aggregated and non-uniformly distributed in the tungsten *** a result,the sample sintered from the plate-like precursor achieves higher mechanical properties and a much narrower range of bending strength values than that sintered from the flower-like *** average bending strength of the sample sintered from the plate-like precursor is 655 MPa,which is higher than that of the sample sintered from the flower-like precursor(524 MPa).Different reaction mechanisms and dispersing stabilities of the TiC particles at different temperature conditions should be accounted for the differences between the two samples.

关键词： Wet chemical method W-TiC alloy Core-shell structures Spark plasma sintering Microstructure characterization

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Biomarkers in retinoblastoma

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International Journal of Ophthalmology(English edition) 2020年第2期13卷 325-341页

作者： Jie sun Hui-Yu Xi qing shao qing-Huai Liu Department of Ophthalmology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Ophthalmology Xuzhou First People’s Hospital of Xuzhou Medical UniversityXuzhou Eye Research InstituteXuzhou 221002Jiangsu ProvinceChina

●Retinoblastoma(RB)is the most common intraocular malignancy of childhood caused by inactivation of the Rb *** prognosis of RB is better with an earlier *** diagnostic approaches and appropriate clinical treatments have been developed to improve clinical ***,limitations exist when utilizing current ***,many studies have identified identify new RB biomarkers which can be used in diagnosis,as prognostic indicators and may contribute to understanding the pathogenesis of RB and help determine specific treatment *** review focuses on recent advances in the discovery of RB biomarkers and discusses their clinical utility and challenges from areas such as epigenetics,proteomics and radiogenomics.

关键词： retinoblastoma biomarkers epigenetics proteomics radiogenomics

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Cross-polymerization between the model furans and phenolics in bio-oil with acid or alkaline catalysts

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Green Energy & Environment 2021年第1期6卷 138-149页

作者： qing Xu Xun Hu Lijun Zhang Kai sun Yuewen shao Zhiran Gao qing Liu Chun-Zhu Li School of Material Science and Engineering University of JinanJinan250022China Key Laboratory of Low Carbon Energy and Chemical Engineering College of Chemical and Environmental EngineeringShandong University of Science and TechnologyQingdao266590China Fuels and Energy Technology Institute Curtin UniversityGPO Box U1987PerthW16845Australia

Polymerization is a major challenge for the upgrading of bio-oil to biofuels,but is preferable for the production of carbon material from *** the mechanism for polymerization is of importance for tailoring property of carbon *** study investigated the characteristics for the polymerisation of furfural,vanillin,their cross-polymerization and the impacts of catalysts on their *** results indicated that the organic acids like acetic acid and formic acid could catalyze the polymerisation of furfural,while H_(2)SO_(4)or NaOH as catalyst could drastically enhance the degree of polymerization of *** showed a higher tendency towards polymerization than furfural and H_(2)SO_(4)or NaOH significantly facilitated the polymerization of vanillin via shifting the pasty product to solid *** crosspolymerization between furfural and vanillin occurred even in the absence of catalyst,while the presence of H_(2)SO_(4)or NaOH catalyst resulted in the formation of more solid polymer via *** polymerisation reactions were accompanied with the consumption of–C¼O via aldol addition/condensation *** addition,the morphology and thermal stability of the polymers formed were affected by both the type of the catalysts employed,which can in turn enhance the cross-polymerization between furfural and vanillin.

关键词： Furfural Vanillin Cross-polymerization Catalysts Polymers

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