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Trends in medication use and treatment patterns in Chinese patients with inflammatory bowel disease

World Journal of Gastroenterology 2022年第30期28卷 4102-4119页

作者： Ling-Ya Yao Bu-Le shao Feng Tian Mei Ye Yu-qin Li Xiao-Lei Wang Lin Wang shao-qi yang Xiao-Ping Lv Yan Jia Xue-Hong Wang Xiao-qi Zhang Yan-Ling Wei qian Cao Department of Gastroenterology Sir Run Run Shaw HospitalCollege of Medicine Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430000Hubei ProvinceChina Department of Gastroenterology Bethune First Affiliated Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Gastroenterology Shanghai 10th People's HospitalTongji UniversityShanghai 200072China Department of Gastroenterology Zhongshan Hospital Affiliated to Xiamen UniversityXiamen 361000Fujian ProvinceChina Department of Gastroenterology General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology The 7th Medical Center of Chinese PLA General HospitalBeijing 100000China Department of Gastroenterology Second Xiangya HospitalChangsha 410011Hunan ProvinceChina Department of Gastroenterology Nanjing Drum Tower HospitalNanjing 210000Jiangsu ProvinceChina Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqing 400000China

BACKGROUND Medications for inflammatory bowel disease(IBD)have changed dramatically over ***,no study on long-term medication profiles has been conducted in the Chinese *** To evaluate temporal changes in medication use and treatment patterns for Chinese patients with *** A multicenter retrospective cohort study was conducted among Chinese patients newly diagnosed with Crohn’s disease(CD)and ulcerative colitis(UC)between January 1999 and December *** characteristics and drug prescriptions were *** in medication use and therapeutic patterns were *** In total,3610 patients were *** follow-up,5-aminosalicylates(5-ASA)and corticosteroids(CS)prescriptions gradually decreased,accompanied by a notable increase in immunosuppressants(IMS)and infliximab(IFX)prescriptions in patients with *** rates of 5-ASA and CS were stable,whereas IMS and IFX slightly increased since 2007 in patients with ***(n=957)analyses showed a switch from conventional medications to IFX in patients with CD,while 5-ASA and CS were still steadily prescribed in patients with *** regression analyses revealed that surgical history,disease behavior,and disease location were associated with initial therapeutic strategies in patients with ***,medications before diagnosis,disease location,and diagnostic year might affect initial strategies in patients with *** Long-term treatment strategies analyses has provided unique insight into the switch from conventional drugs to IFX in Chinese patients with CD.

关键词： Inflammatory bowel disease Crohn's disease Ulcerative colitis Medication trends Treatment pattern Infliximab

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Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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Science China Mathematics 2025年第1期 223-252页

作者： Weidong Liu Dennis Leung qi-Man shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and Data Science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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电炉电极调节控制系统

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机械管理开发 2010年第1期25卷 105-106页

作者：祁少阳太原钢铁(集团)有限公司第二炼钢厂山西太原030003

主要介绍了太钢150万t不锈钢系统160 t电炉电极调节控制系统的硬件组成和控制功能。先进的电极调节控制系统对三相电极位置在冶炼过程中实现全自动调节。有利于不锈钢冶炼操作,同时缩短冶炼周期,节约电能,降低电极消耗。

关键词：电极调节控制 ArcosNT系统 DynArcos系统 ASO

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Endoscopic Ruler for varix size measurement:A multicenter pilot study

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World Journal of Gastrointestinal Endoscopy 2023年第9期15卷 564-573页

作者： Yi-Fei Huang Sheng-Juan Hu yang Bu Yi-Ling Li Yan-Hong Deng Jian-Ping Hu shao-qi yang qian Shen Mark McAlindon Rui-Chun Shi Xiao-qin Li Tie-Ying Song Hai-Long qi Tai-Wei Jiao Meng-Yuan Liu Fang He Jun Zhu Bin Ma Xiao-Bin Yu Jian-yang Guo Yue-Hua Yu Hai-Jiang Yong Wen-Tun Yao Ting Ye Hua Wang Wen-Fu Dong Jian-Guo Liu qiang Wei Jing Tian Xiao-Guo Li Xavier Dray Xiao-Long qi Institute of Portal Hypertension The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology People's Hospital of Ningxia Hui Autonomous RegionNingxia Medical University Affiliated People's Hospital of Autonomous RegionYinchuan 750000Ningxia Hui Autonomous RegionChina Department of Gastroenterology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Gastroenterology Yinchuan First People's HospitalYinchuan 750000Ningxia Hui Autonomous RegionChina Department of Gastroenterology Ningxia Medical University General HospitalYinchuan 750000Ningxia Hui Autonomous RegionChina Department of Gastroenterology Yinchuan Second People's HospitalYinchuan 750000Ningxia Hui Autonomous RegionChina Academic Department of Gastroenterology and Hepatology Sheffield Teaching Hospitals NHS TrustAL 35660SheffieldUnited Kingdom Department of Gastroenterology Wuzhong People's HospitalWuzhong 751100Ningxia Hui Autonomous RegionChina Department of Gastroenterology The Fifth People's Hospital of Ningxia Hui Autonomous RegionShizuishan 753000Ningxia Hui Autonomous RegionChina Department of Second Gastroenterology The Sixth People’s Hospital of ShenyangShenyang 110000Liaoning ProvinceChina Department of Gastroenterology Shizuishan Second People's HospitalShizuishan 753000Ningxia Hui Autonomous RegionChina Department of Gastroenterology Zhongwei People's HospitalZhongwei 755000Ningxia Hui Autonomous RegionChina Department of Hepato-Gastroenterology ETISENSEACNRSSorbonne Université&APHPHôpital Saint AntoineUniversitéParis-SeineUniversitéde Cergy-PontoiseParis 75012SélectionnerFrance Center of Portal Hypertension Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210000Jiangsu ProvinceChina

BACKGROUND We invented Endoscopic Ruler,a new endoscopic device to measure the size of varices in patients with cirrhosis and portal *** To assess the feasibility and safety of Endoscopic Ruler,and evaluate the agreement on identifying large oesophageal varices(OV)between Endoscopic Ruler and the endoscopists,as well as the interobserver agreement on diagnosing large OV using Endoscopic *** We prospectively and consecutively enrolled patients with cirrhosis from 11 hospitals,all of whom got esophagogastroduodenoscopy(EGD)with Endoscopic *** primary study outcome was a successful measurement of the size of varices using Endoscopic *** secondary outcomes included adverse events,operation time,the agreement of identifying large OV between the objective measurement of Endoscopic Ruler and the empirical reading of endoscopists,together with the interobserver agreement on diagnosing large OV by Endoscopic *** From November 2020 to April 2022,a total of 120 eligible patients with cirrhosis were recruited and all of them underwent EGD examinations with Endoscopic Ruler successfully without any adverse *** median operation time of Endoscopic Ruler was 3.00 min[interquartile range(IQR):3.00 min].The kappa value between Endoscopic Ruler and the endoscopists while detecting large OV was 0.52,demonstrating a moderate *** kappa value for diagnosing large OV using Endoscopic Ruler among the six independent observers was 0.77,demonstrating a substantial *** The data demonstrates that Endoscopic Ruler is feasible and safe for measuring the size of varices in patients with cirrhosis and portal *** Ruler is potential to promote the clinical practice of the two-grade classification system of OV.

关键词： Oesophageal varices Cirrhosis Portal hypertension Esophagogastroduodenoscopy Endoscopic ruler

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin shao qinqin Wang Xin Dong Bin Duan Feiyang Xing Jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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基于肌肉骨骼负荷的上肢姿势不舒适度评价方法

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工业工程与管理 2017年第5期22卷 88-93,101页

作者：张丽珍邵祺杨加庆赵嘉敏宋政戴鹏上海海洋大学工程学院上海201306 上海汽车集团股份有限公司乘用车公司上海201804

针对通过主观评价建立的人体姿势不舒适度评价方法的应用效果不理想的问题,提出了基于肌肉骨骼负荷的上肢姿势不舒适度评价方法(Upper Limb Posture Discomfort Assessment Method Based on Musculoskeletal Loads,UAML)。根据人体关节... 详细信息

针对通过主观评价建立的人体姿势不舒适度评价方法的应用效果不理想的问题,提出了基于肌肉骨骼负荷的上肢姿势不舒适度评价方法(Upper Limb Posture Discomfort Assessment Method Based on Musculoskeletal Loads,UAML)。根据人体关节负荷大小、肌张力收缩程度与人体姿势不舒适度之间的因果关系,应用DELMIA人机工程软件进行了人体关节负荷仿真实验,测量了虚拟人在不同人体姿势下关节力矩的变化情况,利用MP150生理记录仪测量了一组受试者在不同人体姿势下的表面肌电特性。对关节力矩数据和根据相关肌肉横截面积加权计算得到的肌电数据进行了归一化处理,利用回归分析的方法建立了以关节动作角度为变量的关节动作不舒适度模型,运用模糊综合评价的方法对关节不舒适度和上肢姿势不舒适度进行评价,将提出的评价方法应用到实际,与快速上肢评价法的评价结果相比,验证了其可靠性。

关键词：肌肉骨骼负荷姿势不舒适度评价方法

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三峡水轮机的非定常湍流计算及整机压力脉动分析

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水力发电学报 2004年第5期23卷 97-101页

作者：刘树红邵奇杨建明吴玉林戴江清华大学热能工程系北京100084 湖北清江水电开发有限责任公司宜昌443002 中国长江三峡工程开发总公司宜昌443000

本文对三峡原型混流式水轮机进行了三维非定常湍流计算 ,得到了水轮机的非定常流场 ,预测了尾水管内、转轮前、活动导叶前、固定导叶前和蜗壳进口的压力脉动。通过与模型试验结果进行比较可以看出 ,本文提供的计算结果能够准确预测水轮... 详细信息

本文对三峡原型混流式水轮机进行了三维非定常湍流计算 ,得到了水轮机的非定常流场 ,预测了尾水管内、转轮前、活动导叶前、固定导叶前和蜗壳进口的压力脉动。通过与模型试验结果进行比较可以看出 ,本文提供的计算结果能够准确预测水轮机内的压力脉动。分析结果表明 ,尾水管内涡带及转轮与活动导叶间的动静干扰是产生压力脉动的两个主要脉动源 ,并在整个水轮机流道内传播。

关键词：混流式水轮机数值模拟压力脉动非定常流动动静干扰

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扩散对污染斑块上Smith种群生存的影响

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生物数学学报 2003年第4期18卷 427-432页

作者：杨卓琴陆启韶杨在中北京航空航天大学理学院北京100083 内蒙古大学数学系内蒙古呼和浩特010021

通过建立两斑块的单种群扩散系统,主要研究扩散对其中受污染的斑块上种群生存的影响.文中所考虑的是污染斑块上外界毒素的输入量存在极限值的情形,得到如下结论:无扩散时,若此极限值超过某一定值,则污染斑块上的种群趋于灭绝;扩散存在... 详细信息

通过建立两斑块的单种群扩散系统,主要研究扩散对其中受污染的斑块上种群生存的影响.文中所考虑的是污染斑块上外界毒素的输入量存在极限值的情形,得到如下结论:无扩散时,若此极限值超过某一定值,则污染斑块上的种群趋于灭绝;扩散存在且两斑块上种群的扩散系数满足一定的条件时,则可使该系统的种群永久生存或灭绝.

关键词：斑块环境污染扩散系统永久生存种群

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肝硬化患者外周血TLR、CD14表达及其与内毒素血症的关系

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宁夏医科大学学报 2010年第1期32卷 63-65,F0003页

作者：杨少奇王莉黄睿杨芝红杨力宁夏医科大学附属医院消化内科银川750004 宁夏医科大学附属医院中心实验室银川750004

目的探讨肝硬化患者外周血单个核细胞(PBMC)表面CD14、TOLL样受体(TLR2、TLR4)的表达情况及其与内毒素血症的关系。方法分别采用显色基质鲎试剂试管法和流式细胞术检测50例肝硬化患者和30例健康志愿者外周血内毒素浓度及PBMC表面CD14、T... 详细信息

目的探讨肝硬化患者外周血单个核细胞(PBMC)表面CD14、TOLL样受体(TLR2、TLR4)的表达情况及其与内毒素血症的关系。方法分别采用显色基质鲎试剂试管法和流式细胞术检测50例肝硬化患者和30例健康志愿者外周血内毒素浓度及PBMC表面CD14、TLR2、TLR4的表达。结果肝硬化患者外周血内毒素浓度及PBMC表面CD14、TLR2、TLR4的表达高于正常对照组(P<0.05);肝硬化合并腹水患者外周血内毒素浓度及PBMC表面CD14、TLR2、TLR4的表达高于肝硬化无腹水患者(P<0.05);肝硬化患者外周血内毒素浓度与PB-MC表面CD14、TLR2、TLR4的表达呈正相关(P<0.05)。结论肝硬化患者外周血内毒素浓度及PBMC表面CD14、TLR2、TLR4的表达均高于正常人,内毒素及内毒素受体CD14、TLR2、TLR4协同作用介导机体炎症反应,可能导致肝硬化患者病情进一步加重。

关键词：肝硬化内毒素血症 Toll样受体

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西马克X-Pact控制系统在不锈钢轧钢厂的应用

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河南冶金 2016年第5期24卷 36-38页

作者：邵书东亓海燕杨成栾义平山东泰山钢铁集团有限公司

不锈钢炉卷轧机升级改造工程全部采用德国西马克自动化控制系统,并用世界领先的数字模拟技术控制板型,降低了成本,提高了质量,增强了产品核心竞争力。本文详细介绍了德国西马克X-Pact控制系统在不锈钢轧钢厂的应用,并描述了不锈钢轧钢厂... 详细信息

不锈钢炉卷轧机升级改造工程全部采用德国西马克自动化控制系统,并用世界领先的数字模拟技术控制板型,降低了成本,提高了质量,增强了产品核心竞争力。本文详细介绍了德国西马克X-Pact控制系统在不锈钢轧钢厂的应用,并描述了不锈钢轧钢厂X-Pact控制系统的配置结构及控制系统的控制原理。

关键词： X-Pact控制系统炉卷轧机不锈钢

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