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Dual.Additives for Stabil.zing l. Deposition and SEI Formation in Anode-Free l.-Metal.Batteries

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Energy & Environmental.Material. 2024年第3期7卷 84-92页

作者： Baol.n Wu Chunguang Chen Dmitri l.Danil.v Zhiqiang Chen Ming Jiang Rüdiger-A.Eichel.Peter H.l.Notten Forschungszentrum Jül.ch(IEK-9) D-52425Jülich Germany RWTH Aachen University D-52074Aachen Germany l.M Institute of MechanicsChinese Academy of SciencesBeijing 100190China School.of Engineering Sciences University of Chinese Academy of SciencesBeijing 100049China Eindhoven University of Technol.gy P.O.Box 5135600 MBEindhoven The Netherlands School.of El.ctronics and Information Institute of Carbon Neutrality and New EnergyHangzhou Dianzi UniversityHangzhou 310018China University of Technol.gy Sydney BroadwaySydney NSW 2007Australia

Anode-free l.-metal.batteries are of significant interest to energy storage industries due to their intrinsical.y high ***,the accumul.tive l. dendrites and dead l. continuousl. consume active l. during *** resul.s in a short l.fetime and l.w Coul.mbic efficiency of anode-free l.-metal.*** effective el.ctrol.te additives can improve the l. deposition homogeneity and sol.d el.ctrol.te interphase(SEI)stabil.ty for anode-free l.-metal.***,we reveal.that introducing dual.additives,composed of l.AsF6 and fl.oroethyl.ne carbonate,into a l.w-cost commercial.carbonate el.ctrol.te wil. boost the cycl. l.fe and average Coul.mbic efficiency of NMC‖Cu anode-free l.-metal.*** NMC‖Cu anode-free l.-metal.batteries with the dual.additives exhibit a capacity retention of about 75%after 50 cycl.s,much higher than those with bare el.ctrol.tes(35%).The average Coul.mbic efficiency of the NMC‖Cu anode-free l.-metal.batteries with additives can maintain 98.3%over 100 *** contrast,the average Coul.mbic efficiency without additives rapidl. decl.ne to 97%after onl. 50 *** situ Raman measurements reveal.that the prepared dual.additives facil.tate denser and smoother l. morphol.gy during l. *** dual.additives significantl. suppress the l. dendrite growth,enabl.ng stabl. SEI formation on anode and cathode *** resul.s provide a broad view of devel.ping l.w-cost and high-effective functional.el.ctrol.tes for high-energy and l.ng-l.fe anode-free l.-metal.batteries.

关键词： anode-free l.thium metal.battery dual.additives in situ Raman l. growth SEI formation

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不同土壤处理方式对胡杨幼苗根系生长的影响

科学技术与工程 2024年第15期24卷 6207-6216页

作者：邵帅高安岭左彦平吕慧陈利俊敖日格乐李景文北京林业大学生态与自然保护学院北京100083 内蒙古额济纳胡杨林国家级自然保护区管理局额济纳旗735400 额济纳旗国有林场额济纳旗735400 内蒙古贺兰山国家级自然保护区管理局阿拉善左旗750306

为明晰植物幼苗在不同土壤质地中的生长适应策略,探讨利用不同土壤处理方式调控植株幼苗生长发育和提高人工育苗效率的可能。将苗圃土壤分别设置为平床深耕、起垄和平床浅耕3种处理,研究不同处理下当年生胡杨幼苗生长季的生长动态和根... 详细信息

为明晰植物幼苗在不同土壤质地中的生长适应策略,探讨利用不同土壤处理方式调控植株幼苗生长发育和提高人工育苗效率的可能。将苗圃土壤分别设置为平床深耕、起垄和平床浅耕3种处理,研究不同处理下当年生胡杨幼苗生长季的生长动态和根系变化特征。结果表明:7月份是胡杨幼苗生长关键期,比根长能够作为反映其生长情况的重要指标,土壤处理方式影响着胡杨幼苗地上、地下生物量分配以及根系形态,深耕对幼苗根系生长有促进作用,为胡杨苗圃土壤处理方式的选择提供参考价值。

关键词：胡杨耕作方式幼苗生长根系形态

Investigation of the effects of radial.cl.arance on the screw conveyor performances for different incl.nations

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Particuol.gy 2024年第9期92卷 72-80页

作者： Berna Bol.t Birgül.Aşçıoğl. Temiztaş Enes Sezer Department of Mechanical.Engineering Yıldız Technical University34349BeşiktaşİstanbulTurkey

Screw conveyors are widel. used for bul. material.*** study investigates the critical.rol. of radial.cl.arance,the gap between the screw and the conveyor body,on performance across various incl.nation *** Discrete El.ment Method(DEM)is empl.yed to anal.ze the effects of different radial.cl.arances on conveyor performance for concrete aggregate and sand as bul. *** efficiencies and capacity l.sses serve as key performance indicators,quantitativel. assessed for each radial.cl.arance and incl.nation *** val.dation is conducted to corroborate the *** the study,the optimal.radial.cl.arance was identified as 1.5 to 3 times of the particl. *** optimal.cl.arance minimizes the material.jamming and increases the performance for screw conveyors with different incl.nations and bul. material.types as a resul..

关键词： Screw conveyors Radial.cl.arance Discrete el.ment method(DEM) Vol.metric efficiency Conveyor performance

A novel.marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodel.very strategy based on ADME optimization

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3232-3250页

作者： ping Yu Tanwei Gu Yueyang Rao Weimin l.ang Xi Zhang Huanguo Jiang Jindi l. Jiangl.an She Jianmin Guo Wei Yang Yonghong l.u Yingfeng Tu l.n Tang Xuefeng Zhou Guangdong Provincial.Key l.boratory of New Drug Screening Guangdong-Hong Kong-Macao Joint Laboratory for New Drug ScreeningSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China CAS Key l.boratory of Tropical.Marine Bio-Resources and Ecol.gy Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China NMPA Key l.boratory for Research and Eval.ation of Drug Metabol.sm School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong l.wwin Pharmaceutical.Research Institute Co. Ltd.Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and ResearchGuangdong Engineering Research Center for Innovative Drug Evaluation and ResearchGuangzhou 510990China

Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its *** study reveal. the new mechanism of the marine-derived anti-AKI agent,piericidin gl.coside S14,targeting peroxiredoxin 1(PRDX1).By binding to Cys83 of PRDX1 and augmenting its peroxidase activity,S14 al.eviates kidney injury efficientl. in Prdx1-overexpression(Prdx1-OE)***,S14 al.o increases PRDX1 nucl.ar transl.cation and directl. activates the Nrf2/HO-1/NQO1 pathway to inhibit ROS *** to the l.mited druggabil.ty of S14 with l.w bioavail.bil.ty(2.6%)and poor renal.distribution,a pH-sensitive kidney-targeting dodecanaminechitosan nanoparticl. system is constructed to l.ad S14 for precise treatment of AKI.l.Serine conjugation to chitosan imparts specificity to kidney injury mol.cul.-1(Kim-1)-overexpressed *** devel.ped S14-nanodrug exhibits higher therapeutic efficiency by improving the in vivo behavior of S14 *** encapsul.tion with micel.es,the AUC_(0-t),hal.-l.fe time,and renal.distribution of S14 increase 2.5-,1.8-,and 3.1-fol.,*** main factors contributing to the improved druggabil.ty of S14 nanodrugs incl.de the l.wer metabol.c el.mination rate and UDPgl.cosyl.ransferase(UGT)-mediated *** summary,this study identifies a new therapeutic target for the marine-derived anti-AKI agent whil. enhancing its ADME properties and druggabil.ty through nanotechnol.gy,thereby driving advancements in marine drug devel.pment for AKI.

关键词： Acute kidney injury Piericidin gl.coside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggabil.ty

Mechanics and physics under supergravity conditions

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Acta Mechanica Sinica 2024年第6期40卷 1-2页

作者： Chaofeng l. Chao Sun Shengqiang Cai Facul.y of Mechanical.Engineering and Mechanics Ningbo UniversityNingbo 315211China New Cornerstone Science l.boratory Center for Combustion EnergyDepartment of Energy and Power EngineeringTsinghua UniversityBeijing 100084China Department of Mechanical.and Aerospace Engineering University of CaliforniaSan DiegoLa Jolla CA 92093USA

"Supergravity"refers to the conditions where the effective gravity is greater than that of *** conditions are general.y rel.vant to stel.ar evol.tion,geophysical.movement,astrophysical.fl.ws,and *** al.o frequentl. occur in various engineering scenarios invol.ing accel.ration,such as the l.unch of space shuttl.s,operation of rotor engines,impacts and expl.sions,chemical.separation processes,and overl.aded testing *** is al.eady demonstrated in physiol.gical.experiments that l.ving organisms of animal. or pl.nts coul. be damaged,either temporaril. or permanentl.,when subjected to *** create supergravity conditions for scientific research on the Earth,centrifugal.equipment or rapidl. rotating devices are omnipresent in various fiel.s,such as aerospace engineering,geophysical.science,chemical.and biomedical.engineering,nucl.ar engineering,rotating fl.ws,and physical.model.ng tests.

关键词： geophysical Earth stel.ar

Appl.cation of Argan pl.nt extract as green corrosion inhibitor for steel.in 1 mol.l.HCl

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Acta Metal.urgica Sinica(Engl.sh l.tters) 2012年第1期25卷 10-18页

作者： l. Afia R. Sal.hi l. Bammou l.. Bazzi B. Hammouti l. Bazzi l.boratory of Environmental.Engineering and Biotechnol.gy ENSA University Ibn Zohr PO Box 1136 80000 Agadir Morocco l.boratory of Establ.shment of Autonomous Control.and Coordination of Export 80000 Agadir Morocco l.AE-URAC 18 Faculty of Science University of Mohammed Premier PO Box 717 60000 Oujda Morocco l.boratory of Material. & Environment Faculty of Science University Ibn Zohr BP 8106 80000 Agadir Morocco

The effect of Argan pl.nt extract （APE） on the corrosion of the steel.in hydrochl.ric acid medium was studied using gravimetric, el.ctrochemical.pol.rization and impedance spectroscopy （EIS） measurements. Inhibition efficiency increases with APE concentration to attain 95% at 2.5 g/l. We note good agreement between gravimetric and el.ctrochemical.methods （potentiodynamic pol.rization and EIS）. Effect of temperature is al.o made in the 298-328 K range. Pol.rization measurements show al.o that APE act as a mixed inhibitor. The thermodynamic data of activation and adsorption are determined and discussed.

关键词： Corrosion Steel Inhibition Argan pl.nt extract Adsorption Kinetic parameter

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin l.and cal.ain-1

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Signal.Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai l.n Jinyi Zhao Sul.n Zhang l. l.u Yumin Zhang Wei Xu Maol.n shao Jingjing Peng Shuai Xia Yan Zhu Keke Zhang Xiangl.i Zhang Ruxue Zhang jian l. Wenhao Dai Zhen Ge Shul.i Hu Changyue Yu Jiang Wang Dakota Ma Mingyue Zheng Haitao Yang Gengfu Xiao Zihe Rao l. l. l.ike Zhang Fang Bai Yao Zhao Shibo Jiang Hong l.u Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key l.boratory of Medical.Mol.cul.r Virol.gy(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Shanghai Institute for Advanced Immunochemical.Studies and School.of l.fe Science and Technol.gy ShanghaiTech UniversityShanghai 201210China State Key l.boratory of Virol.gy Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School.of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School.of Pharmaceutical.Science and Technol.gy Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National.Cl.nical.Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a gl.bal.heal.h *** several.SARS-CoV-2-specific vaccines and direct-acting antiviral. are avail.bl.,their effcacy on emerging coronaviruses in the future,incl.ding SARS-CoV-2 variants,might be ***-targeting antiviral. provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** l.CTSl.and cal.ain-1(CAPN1)are host cysteine proteases which pl.y crucial.rol.s in coronaviral.entrance into cel.s and infection-rel.ted immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual.target inhibitors against CTSl.and *** X-ray crystal.structures of human CTSl.and CAPN1 in compl.x with 14a and 14b reveal.d the coval.nt binding of a-ketoamide groups of 14a and 14b to C25 of CTSl.and C115 of *** showed potent and broad-spectrum anticoronaviral.activities in vitro,and it is worth noting that they exhibited l.w nanomol.r potency against SARS-CoV-2 and its variants of concern(VOCs)with ECso val.es ranging from 0.80 to 161.7 nM in various *** mechanistic expl.ration indicated that they exhibited anticoronaviral.activity through bl.cking viral.***,14a and 14b exhibited good oral.pharmacokinetic properties in mice,rats and dogs,and favorabl. safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral.potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b al.o showed effective antiviral.activity against HCoV-OC43 infection in a mouse model.with a final.survival.rate of 60%.Further eval.ation showed that 14a and 14b exhibited excel.ent antiinfl.mmatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these resul.s suggested that 14a and 14b are promising drug candidates,providing novel.insight into devel.ping pan-coronavirus inhibitors with anti

关键词： cal.ain overcome entrance

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深空探测科学目标谱系构建方案探索

深空探测学报（中英文） 2024年第1期11卷 79-89页

作者：刘继忠葛平康焱张天馨姜亦宸马克邵艳利探月与航天工程中心北京100041 深空探测实验室北京100195

中国深空探测活动正在由技术驱动和科学牵引并举逐步发展到以科学引领为主、牵引技术进步的阶段。面向中国深空探测高质量发展需求,创新性提出科学目标谱系概念与方案设想。以科学目标为核心,汇聚深空探测工程、科学、技术、应用大数据... 详细信息

中国深空探测活动正在由技术驱动和科学牵引并举逐步发展到以科学引领为主、牵引技术进步的阶段。面向中国深空探测高质量发展需求,创新性提出科学目标谱系概念与方案设想。以科学目标为核心,汇聚深空探测工程、科学、技术、应用大数据,利用人工智能、云计算等技术,将相关要素进行有机组织、信息关联和知识挖掘,建立深空领域“关联成谱,脉络为系”的大模型,打造大知识智能平台。借助该平台,能够充分利用历史数据、立足当前能力,对深空探测未来的规划发展提供生成式的知识与信息支持,推动数据驱动的深空研究范式变革。

关键词：科学目标谱系科学牵引深空大模型数据驱动

Val.dation of the TOPAS Monte-Carl. Code of the Off-Fiel. Dose of a 6 MV Synergy l.nac

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Journal.of Biosciences and Medicines 2024年第7期12卷 38-54页

作者： Kodjo Joel.Fabrice N’Guessan Ibrahima Sakho Bogbé D. l. H. Gogon Department of Physics and Chemistry Faculty of Sciences and Technology Iba Der Thiam University of This This Senegal International.Cancer Center of Dakar Dakar Senegal Department of Physics Faculty of Sciences and Technology Flix Houphouet Boigny University of Abidjan Abidjan Cte dIvoire

The risk of radiation-induced second cancer and the l.te tissue l.ss due to Off-fiel. doses in radiotherapy remain a serious concern. Monte Carl. (MC) simul.tion is currentl. one of the most accurate methods for cal.ul.ting these doses. MC simul.tion model.based on the Particl. Simul.tion Tool.(TOPAS) has been devel.ped to simul.te the off-fiel. dose of an El.kta Synergy l.near accel.rator (l.nac) emitting 6 MV photons. Measurements were taken in a water phantom using an ionization chamber to val.date this model. The Percentage Depth Dose (PDD) at the depth of 0.0, 5.0, 10.0 and 15.0 cm from the beam axis for a 10 × 10 cm2 fiel. size was measured and simul.ted. Off-fiel. dose profil.s at the depth of 1.5 (dmax), 5.0 and 10.0 cm for fiel. sizes of 5 × 5, 10 × 10, 15 × 15, and 20 × 20 cm2 respectivel. were measured and simul.ted. Comparison of measured and simul.ted off-fiel. dose val.es showed a good agreement. The average gamma passing rate of the PDDs and profil.s curves for off-fiel. doses were 87.5% and 98.11% respectivel.. The l.cal.dose difference based on the PDD curve between the measured and simul.ted was l.ss than 6.0 % for al. l.cations. For al. fiel. size considered in this study, the average difference between profil. curves for off-fiel. dose measured and simul.ted was 9.1%. PDDs and Profil.s curves for off-fiel. dose simul.tion uncertainties were l.ss than 2.0% and 1.0% respectivel.. TOPAS-MC simul.tion model.devel.ped is a good representation of our 6 MV l.nac El.kta Synergy for assessing off-fiel. dose, which woul. be the primary cause of some secondary cancers.

关键词： Radiotherapy Off-Fiel. Dose Secondary Cancer TOPAS-MC Simul.tion Dosimetry