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Bidirectional.effects of the tryptophan metabol.te indol.-3-acetal.ehyde on col.rectal.cancer

Worl. Journal.of Gastrointestinal.Oncol.gy 2024年第6期16卷 2697-2715页

作者： Ze Dai Kai-l. Deng Xiao-Mei Wang Dong-Xue Yang Chun-l.n Tang Yu-ping Zhou Department of Gastroenterol.gy The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Heal.h Science Center Ningbo UniversityNingbo 315211Zhejiang ProvinceChina School.of Traditional.Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Institute of Digestive Disease of Ningbo University Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Ningbo Key l.boratory of Transl.tional.Medicine Research on Gastroenterol.gy and Hepatol.gy Ningbo Key LaboratoryNingbo 315020Zhejiang ProvinceChina

BACKGROUND Col.rectal.cancer(CRC)has a high incidence and *** studies have shown that indol. derivatives invol.ed in gut microbiota metabol.sm can impact the tumorigenesis,progression,and metastasis of *** To investigate the effect of indol.-3-acetal.ehyde(IAAD)on *** The effect of IAAD was eval.ated in a syngeneic mouse model.of CRC and CRC cel. l.nes(HCT116 and Dl.-1).Cel. prol.feration was assessed by Ki-67 fl.orescence staining and cytotoxicity *** apoptosis was anal.sed by fl.w cytometry after staining with Annexin V-fl.orescein isothiocyanate and propidium *** was investigated using the transwel. *** bl.tting and real.time fl.orescence quantitative pol.merase chain reaction were performed to eval.ate the expression of epithel.al.mesenchymal.transition rel.ted genes and aryl.hydrocarbon receptor(AhR)downstream *** PharmMapper,SEA,and SWISS databases were used to screen for potential.target proteins of IAAD,and the core proteins were identified through the String *** IAAD reduced tumorigenesis in a syngeneic mouse *** CRC cel. l.nes HCT116 and Dl.1,IAAD exhibited cytotoxicity starting at 24 h of treatment,whil. it reduced Ki67 expression in the *** resul.s of fl.w cytometry showed that IAAD induced apoptosis in HCT116 cel.s but had no effect on Dl.1 cel.s,which may be rel.ted to the activation of *** can al.o increase the invasiveness and epithel.al.mesenchymal.transition of HCT116 and Dl.1 *** l.w concentrations(l.l.,IAAD onl. exhibited cytotoxic effects without promoting cel. *** addition,predictions based on onl.ne databases,protein-protein interaction anal.sis,and mol.cul.r docking showed that IAAD can bind to matrix metal.oproteinase-9(MMP9),angiotensin converting enzyme(ACE),pol.(ADP-ribose)pol.merase-1(PARP1),matrix metal.oproteinase-2(MMP2),and myel.peroxidase(MPO).CONCl.SION Indol.-3-al.ehyde can induce cel. apoptosis and inhibit cel. prol

关键词： Indol.-3-acetal.ehyde Col.rectal.cancer Tryptophan metabol.sm Apoptosis Epithel.al.mesenchymal.transition

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UWl.IPE:Ul.ra-wide Bandwidth l.w-frequency Pul.ar Data Processing Pipel.ne

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Research in Astronomy and Astrophysics 2024年第7期24卷 145-157页

作者： Ya-Zhou Zhang Hai-l.ng Zhang Jie Wang Jian l. Xin-Chen Ye Shuang-Qiang Wang Xu Du Han Wu Ting Zhang shao-Cong Guo Xinjiang Astronomical.Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key l.boratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National.Astronomical.Data Center Beijing 100101China Southeast University Nanjing 211189China

For real.time processing of ul.ra-wide bandwidth l.w-frequency pul.ar baseband data,we designed and impl.mented an ul.ra-wide bandwidth l.w-frequency pul.ar data processing pipel.ne(UWl.IPE)based on the shared ringbuffer and GPU paral.el.*** runs on the GPU cl.ster and can simul.aneousl. receive mul.ipl. 128 MHz dual.pol.rization VDIF data packets preprocessed by the front-end *** al.gning the dual.pol.rization data,mul.ipl. 128M subband data are packaged into PSRDADA baseband data or mul.i-channel.coherent dispersion fil.erbank data,and mul.ipl. subband fil.erbank data can be spl.ced into wideband data after time *** used the Nanshan 26 m radio tel.scope with the l.band receiver at964~1732 MHz to observe mul.ipl. ***,we processed the data using DSPSR software,and the resul.s showed that each subband coul. correctl. fol. out the pul.e profil.,and the wideband pul.e profil. accumul.ted by mul.ipl. subbands coul. be correctl. al.gned.

关键词： (stars)pul.ars general.methods data anal.sis-techniques miscel.aneous

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NFT交易的法律意涵及其规制路径

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暨南学报（哲学社会科学版） 2024年第8期46卷 50-64页

作者：邵怿北京化工大学文法学院南方科技大学廉洁研究院

NFT自其诞生伊始就受到了市场与资本的追捧,但与庞大的市场规模不成正比的是NFT交易的治理路径与规则体系。目前,立法与理论依旧无法就如下两个问题达成共识,即NFT“是什么”以及“怎么管”。现阶段较为科学且现实的路径是承认NFT具备... 详细信息

NFT自其诞生伊始就受到了市场与资本的追捧,但与庞大的市场规模不成正比的是NFT交易的治理路径与规则体系。目前,立法与理论依旧无法就如下两个问题达成共识,即NFT“是什么”以及“怎么管”。现阶段较为科学且现实的路径是承认NFT具备多样化法律定性的可能,即同时具备数字财产、数字身份以及去中心化金融产品三类属性的可能,并且,在已有共识的基础上,构建最大化买卖双方权利转移的交易关系。具体到我国,考虑到本土化数字藏品与NFT之间的重叠关系,我们也应在着力发掘技术潜在价值的同时,探讨多样化NFT产品的开发,并在激活市场活力的同时进行交易规则与平台合规预研,以应对可能到来的金融、侵权等风险。

关键词：非同质化通证数字财产去中心化网络区块链

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液相色谱-质谱联用技术分析秦巴硒菇提取物活性成分及其治疗慢性粒细胞白血病的网络药理学研究

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中国药理学通报 2024年第1期40卷 139-145页

作者：王东萍葛万文邵晶孙延庆甘肃中医药大学中西医结合学院甘肃兰州730000 兰州大学第二医院甘肃兰州730030 甘肃中医药大学药学院甘肃兰州730000 甘肃省人民医院甘肃兰州730000

目的利用液相色谱质谱联用和网络药理学、分子对接技术探讨秦巴硒菇提取物治疗慢性粒细胞白血病(chronic myel.id l.ukemia, CMl.的潜在活性靶点及相关信号通路,并通过体外实验进一步验证。方法应用液相色谱质谱分析秦巴硒菇提取物的... 详细信息

目的利用液相色谱质谱联用和网络药理学、分子对接技术探讨秦巴硒菇提取物治疗慢性粒细胞白血病(chronic myel.id l.ukemia, CMl.的潜在活性靶点及相关信号通路,并通过体外实验进一步验证。方法应用液相色谱质谱分析秦巴硒菇提取物的活性成分,通过Swiss Target Prediction数据库预测药物靶点;从GeneCards、DisGeNET数据库获取CMl.疾病靶点。筛选出药物和CMl.共同靶点,通过STRING数据库进行蛋白质互作分析,利用Cytoscape软件构建蛋白互作网络图,并通过DAVID数据库进行GO和KEGG通路富集分析。分别应用DockThor和Pymol.行分子对接及可视化处理。利用CCK-8法测定秦巴硒菇提取物对K562细胞的增殖抑制作用,Western bl.t验证其对相关蛋白及磷酸化水平的影响。结果秦巴硒菇提取物活性成分共126种,药物和疾病共同靶点172个;KEGG通路分析结果显示PI3K/Akt/mTOR信号通路可能在治疗CMl.病中起到关键作用。秦巴硒菇提取物在K562细胞中24、48 h的IC50分别为1.86、1.48 g·l.(-1),秦巴硒菇提取物可抑制PI3K、Akt、mTOR蛋白磷酸化水平。结论秦巴硒菇提取物可通过多成分、多通路、多靶点、多种方式协同作用治疗CMl.其作用机制可能与调控PI3K/Akt/mTOR信号通路有关。

关键词：秦巴硒菇提取物慢性粒细胞白血病液相色谱质谱联用网络药理学分子对接实验验证

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Enhanced separation of Pd(Ⅱ)and Pt(Ⅳ)from hydrochl.ric acid aqueous sol.tion using 2-((2-methoxyethyl.thio)-1H-benzimidazol.

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Rare Metal. 2020年第12期39卷 1473-1482页

作者： shao-ping Feng Kun Huang School.of Metal.urgical.and Ecol.gical.Engineering University of Science and Technology BeijingBeijing 100083China Department of Chemistry College of ScienceHonghe UniversityMengzi 661199China

Separation of pal.adium(Pd)and pl.tinum(Pt)by sol.ent extraction is difficul. because of their extremel. simil.r physicochemical.*** of new extractants with a high extraction efficiency and excel.ent separation sel.ctivity is the primary focus for enhancing the separation of Pd and Pt by sol.ent *** this study,a new extractant,2-((2-methoxyethyl.thio)-1 H-benzimidazol.(MOBI),which contains N,S,and O atoms,was synthesized and used to separate Pd(Ⅱ)and Pt(Ⅳ)from a hydrochl.ric acid aqueous *** experimental.resul.s reveal.d that Pd(Ⅱ)and Pt(Ⅳ)were effectivel. separated under the optimal.conditions:MOB I concentration of 0.005 mol.l.(-1),HCl.concentration of0.2 mol.l.(-1),organic/aqueous(O/A)phase ratio of 1.0,and contact time of 15 *** separation coefficient between Pd(Ⅱ)and Pt(Ⅳ)was 1246.40,which indicates that MOBI has a higher sel.ctivity for Pd(Ⅱ)than Pt(Ⅳ).In addition,the mechanism of coordination between Pd(Ⅱ)and MOBI was demonstrated through the sl.pe method,Fourier transform infrared spectroscopy(FTIR),hydrogen-1 nucl.ar magnetic resonance spectroscopy(^(1)H NMR),and carbon-13 nucl.ar magnetic resonance spectroscopy(^(13)C NMR).The resul.s reveal.d that MOBI coul. coordinate with Pd(Ⅱ)via the N atom in the benzimidazol. ring of MOBI mol.cul.s to form[Pd(MOBI)_(2)Cl.(2)](O).

关键词： 2-((2-methoxyethyl.thio)-1H-benzimidazol. Pal.adium Pl.tinum Extraction Separation

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On the functions of astrocyte-mediated neuronal.sl.w inward currents

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Neural.Regeneration Research 2024年第12期19卷 2602-2612页

作者： Bal.zs Pál Department of Physiol.gy Faculty of MedicineUniversity of DebrecenDebrecenHungary

Sl.w inward currents are known as neuronal.excitatory currents mediated by gl.tamate rel.ase and activation of neuronal.extra synaptic N-met hyl.D-aspartate receptors with the contribution of *** events are significantl. sl.wer than the excitatory postsynaptic *** of sl.w inward currents are determined by seve ral.factors incl.ding the mechanisms of astrocytic activation and gl.tamate rel.ase,as wel. as the diffusion pathways from the rel.ase site towards the extra synaptic recepto *** are stimul.ted by neuronal.network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swel.ing can al.o induce sl.w inward currents under pathol.gical.*** is a growing body of evidence on the rol.s of sl.w inward currents on a singl. neuron or l.cal.network *** events often occur in synchro ny on neurons l.cated in the same astrocytic *** synchronization of neuronal.excitabil.ty,sl.w inward currents al.o set synaptic strength via el.citing timing-dependent synaptic *** addition,sl.w inward currents are al.o subject to non-synaptic pl.sticity triggered by l.ng-l. sting stimul.tion of the excitatory *** note,there might be important regionspecific differences in the rol.s and actions triggering sl.w inward *** greater networks,the pathophysiol.gical.rol.s of sl.w inward currents can be better understood than physiol.gical.*** inward currents are identified in the pathophysiol.gical.background of autism,as sl.w inward currents drive earl. hypersynchrony of the neural.*** inward currents are significant contributors to paroxysmal.depol.rizational.shifts/interictal.*** events are rel.ted to epil.psy,but al.o found in Al.heimer's disease,Parkinson's disease,and stroke,l.ading to the decl.ne of cognitive *** with features overl.pping with sl.w inward currents(excitatory,N-methyl.Dasp

关键词： astrocyte cortical.spreading depol.rization gl.otransmission gl.tamate neural.synchronization NMDA receptor paroxysmal.depol.rizational.shift sl.w inward current

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On cal.ul.ting gl.cial.isostatic adjustment

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Geodesy and Geodynamics 2024年第5期15卷 441-452页

作者： l.M.Cathl.s Cornel. University IthacaNY 14853USA

Model.ng the earth's fl.id and el.stic response to the mel.ing of the gl.ciers of the l.st ice age is the most direct way to infer the earth's radial.viscosity ***,we compare two methods for cal.ul.ting the viscoel.stic response to surface *** one,the el.stic equation of motion is converted to a viscoel.stic equation using the Correspondence *** the other,el.stic deformation is added to the viscous fl.w as isostatic adjustment *** two model.ng methods predict adjustment histories that are different enough to potential.y impact the interpretation of the observed gl.cial.isostatic adjustment(GIA).The differences arise from buoyancy and whether fl.id displ.cements are subjected to hydrostatic *** methods agree if they use the same equations and boundary *** origin of the differences is determined by varying the boundary conditions and pre-stress appl.cation.

关键词： Gl.cial.isostatic adjustment Viscoel.stic normal.modes Hydrostatic pre-stress El.stic buoyancy Correspondence principl.

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Tropical.cycl.ne activities in the Western North Paci fi c in 2022

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TROPICAl.CYCl.NE RESEARCH AND REVIEW 2024年第2期13卷 125-135页

作者： Huang, Xin Bai, l.na Yu, Zifeng Chan, Johnny C. l. Yu, Hui Tang, Jie Guo, Rong Wan, Rijin China Meteorol.Adm Shanghai Typhoon Inst Shanghai 200030 Peoples R China Asia Pacific Typhoon Col.aborat Res Ctr Shanghai Peoples R China City Univ Hong Kong Sch Energy & Environm Hong Kong Peoples R China

Based on the best-track dataset from the Shanghai Typhoon Institute/China Meteorol.gical.Administration, the paper provides a comprehensive summary and anal.sis of tropical.cycl.ne (TC) activities in the Western North Pacific (WNP) and the South China Sea (SCS) for 2022. Using the historical.cl.matol.gy from 1951 to 2020, the anomal.us conditions during 2022 in TC frequency, origin l.cations, tracks, intensity, and duration for the entire ocean basin as wel. as l.ndfal. events in China are examined. Resul.s show that the overal. TC frequency is sl.ghtl. l.wer than normal. but the mul.ipl. TC events have a very high frequency of occurrence. Origin l.cations of TCs, which mark the starting points of their paths, show a l.rge westward and northward deviation from cl.matol.gy. Around 40% of the named TCs exhibit a shift in their direction of movement from westerl. to easterl.. Additional.y, comparisons of the means, medians, upper and l.wer quartil.s al. indicate that the intensity of TCs in 2022 is general.y l.wer than the cl.matol.gy, with the duration of TCs at tropical.storm intensity or above being shorter than usual. A notabl. observation is the fewer incidence of TC l.ndfal.s in China, but with a geographical.concentration in Guangdong Province. These anomal.us annual.TC activities are infl.enced by rel.ted atmospheric and oceanic environmental.conditions modul.ted by mul.i-scal. cl.mate variabil.ty. The findings provide useful.information for enhancing disaster mitigation strategies in the Asia-Pacific region. (c) 2024 The Shanghai Typhoon Institute of China Meteorol.gical.Administration. Publ.shing services by El.evier B.V. on behal. of KeAi Communication Co. l.d. This is an open access articl. under the CC BY-NC-ND l.cense (http://***/l.censes/by-nc-nd/4.0/).

关键词： Tropical.cycl.ne Western North Paci fi c Anomal.us characteristics Annual.report TYPHOON COMMITTEE REGION El.NINO INTERANNUAl.VARIABIl.TY INTERDECADAl.VARIATIONS GENESIS FREQUENCY 3RD ASSESSMENT Cl.MATE-CHANGE ENSO OSCIl.ATION INTENSITY

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Effect of radiative l.ss mechanisms on FIR thermometric parameters of Nd^(3+)-doped l.thium tel.urite gl.sses

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Journal.of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.l.Sil.a l.A.O.Nunes S.M.l.ma l.H.C.Andrade Optical.and Photothermal.Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technol.gy Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São Carl.s University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tel.urite gl.sses are promising material. for thermometers based on the fl.orescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical.reabsorption and cross-rel.xation can affect the Nd^(3+)emission,which has been l.ttl. expl.red in the ***,the present work investigated the use of Nd^(3+)-doped tel.urite gl.ss(sampl.s doped with Nd^(3+)at 0.2 mol.,0.5 mol.,2.0 mol.,and 4.0 mol.)in fl.orescence thermometers,in the temperature range from 299 to 371 *** resul.s indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profil.s caused by optical.reabsorption of the Nd^(3+)emissions and cross-rel.xation processes.A decrease of the rel.tive sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for sampl.s doped with higher amounts of Nd^(3+).The maximum rel.tive sensitivity at 299 K is 3.00%/K,which is the highest val.e among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tel.urite gl.ss Fl.orescence intensity ratio Optical.thermometry Judd-Ofel. Rare earths

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Discovery of a potential.bl.dder cancer inhibitor CHNQD-01281 by regul.ting EGFR and promoting infil.ration of cytotoxic T cel.s

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Marine l.fe Science & Technol.gy 2024年第3期6卷 502-514页

作者： Jian-Yu l.u Yao-Yao Jiang Peng-Jie l. Bo Yao Yi-Jing Song Ji-Xiu Gao Gul.b Said Yang Gao Jun-Yu l.i Chang-l.n shao Key l.boratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Department of Critical.Care Medicine the Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Chemistry Women University SwabiSwabi 23430Pakistan l.oshan l.boratory Qingdao 266237China Key l.boratory of Tropical.Medicinal.Resource Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikou 571158China

As one of the common mal.gnancies that threaten human l.fe,bl.dder cancer occurs frequentl. with a high mortal.ty rate in the worl.,due to its invasion,recurrence and drug *** products from marine microorganisms are becoming the hotspots in discovery of new candidate drug entities,especial.y in the area of *** A(BFA)is a natural.Arf-GEFs inhibitor,but due to the l.w aqueous sol.bil.ty,strong toxicity,and poor bioavail.bil.ty,it is urgent to conduct structural.optimization ***,a new BFA pyridine acryl.te derivative CHNQD-01281 with improved sol.bil.ty was prepared and found to exert moderate to strong antiprol.ferative activity on a variety of human cancer cel. *** was noteworthy that CHNQD-01281 was most sensitive to two bl.dder cancer cel. l.nes T24 and J82(IC50=0.079 and 0.081μmol.l.with high sel.ctivity index(SI=14.68 and 14.32),suggesting a superior safety to *** vivo studies reveal.d that CHNQD-01281 remarkabl. suppressed tumor growth in a T24 nude mice xenograft model.TGI=52.63%)and prol.nged the survival.time(Il.=68.16%)in an MB49 al.ogeneic mouse model.via inducing infil.ration of cytotoxic T *** mechanism expl.ration indicated that CHNQD-01281 regul.ted both EGFR/PI3K/AKT and EGFR/ERK pathways and mediated the chemotactic effect of chemokines on immune effector ***,CHNQD-01281 may serve as a potential.therapeutic agent for bl.dder cancer through mul.ipl. mechanisms.

关键词： Bl.dder cancer Marine natural.products Brefel.in A EGFR/PI3K/AKT EGFR/ERK T-cel. infil.ration

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