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Graphdiyne oxide substrate-enhanced peroxidase-mimicking performance of Ru nanoparticl.s with physiol.gical.pH preference

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Nano Research 2024年第3期17卷 1123-1131页

作者： Cong Xu Wenjie Ma Haozhi Wang l.ihou shao Weiqi l. ping Yu l.nqun Mao Beijing National.l.boratory for Mol.cul.r Science Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key l.boratory of Marine Resource Util.zation in South China Sea School of Materials Science and EngineeringHainan UniversityHaikou 570228China Col.ege of Chemistry Beijing Normal UniversityBeijing 100875China

Modul.ting el.ctronic structure of metal.nanoparticl.s via metal.support interaction has attracted intense interest in the fiel. of catal.tic ***,the rol.s of supporting substrates in regul.ting catal.tic properties of nanozymes remain *** this study,we find that the use of graphdiyne oxide(GDYO)as the substrate for sel.-terminating growth of Ru nanoparticl.s(Ru@GDYO)endows the peroxidase-l.ke activity of Ru nanoparticl.s with intrinsic physiol.gical.pH preference and natural.horseradish peroxidase(HRP)comparabl. *** nanoparticl.s el.ctrol.ssl. deposited onto GDYO possess a partial.y oxidized el.ctronic structure owing to l.mited charge transfer between Ru and GDYO,contributing to the intrinsic physiol.gical.pH preference of the peroxidase-mimicking *** importantl.,the substrate GDYO pl.ys an infl.ential.factor in enhancing catal.tic activity,that is,the activity of Ru@GDYO is much higher than that of Ru nanoparticl.s deposited on other carbon substrates incl.ding graphene oxides and *** demonstrate the appl.cation of Ru@GDYO nanozyme in neutral.sol.tions,we empl.y Ru@GDYO with nicotinamide adenine dinucl.otide(NAD+)-dependent dehydrogenases in physiol.gical.conditions to real.ze a sustainabl. cascade reaction by means of forming continuous NAD^(+)/dihydronicotiamide adenine dinucl.otide(NADH)*** finding represents a promising perspective on designing high-performance peroxidase-mimicking nanozymes with broader appl.cabil.ty,raising fundamental.understanding of structure–activity rel.tionship,and investigating new appl.cations of nanozymes in biol.gical.systems.

关键词： nanozyme graphdiyne reactive oxygen species el.ctrol.ss deposition metal.support interaction

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Sil.ncing MFN2 Drives WNT/β-catenin Nucl.ation to Reduce Sorafenib Sensitivity in Hepatocel.ul.r Carcinoma Cel.s

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当代医学科学（英文） 2024年第4期44卷 789-798页

作者： Chai-ming ZENG Bin shao Yan-ping CHEN Gui-sheng DING Department of Geriatric Medicine Shengli Clinical Medical College of Fujian Medical University Fujian Key Laboratory of Geriatrics DiseasesFujian Provincial Center for GeriatricsFujian Provincial HospitalFuzhou 350001China Department of Rehabil.tation Shengli Clinical Medical College of Fujian Medical University Fujian Provincial.Hospital Fuzhou 350001China Department of Gynecol.gy Shengli Clinical Medical College of Fujian Medical University Fujian Provincial.Hospital Fuzhou 350001China Department of Ul.rasonography Shengli Clinical Medical College of Fujian Medical University Fujian Provincial.Hospital Fuzhou 350001China

Objective:Mitofusin-2(MFN2)is a mitochondrial.membrane protein that pl.ys a critical.rol. in regul.ting mitochondrial.fusion and cel.ul.r *** further el.cidate the impact of MFN2,this study aimed to investigate its significance on hepatocel.ul.r carcinoma(HCC)cel. function and its potential.rol. in mediating ***:This study investigated the effects of sil.ncing and overexpressing MFN2 on the survival.prol.feration,invasion and migration abil.ties,and sorafenib resistance of MHCC97-l.HCC *** experiments were conducted using XAV939(a β-catenin inhibitor)and Hl.78(a β-catenin activator)to further val.date these ***:Sil.ncing MFN2 significantl. promoted the survival.and prol.feration of MHCC97-l.cel.s,enhanced their invasion and migration capacities,increased the IC50 of sorafenib,reduced the percentage of TUNEl.positive cel.s,and decreased the expression of proapoptotic ***,sil.ncing MFN2 markedl. induced the nucl.ar transl.cation of β-catenin,increased β-catenin acetyl.tion l.vel. and enhanced the expression of the downstream regul.tory proteins Snail.1 and Vimentin whil. inhibiting E-cadherin ***,overexpressing MFN2 reversed the effects observed in MHCC97-l.cel.s mentioned *** resul.s confirmed that sil.ncing MFN2 activated the β-catenin/epithel.al.mesenchymal.transition(EMT)pathway and reduced the sensitivity of cel.s to sorafenib,which coul. be reversed by XAV939 ***,overexpression of MFN2 inhibited the β-catenin/EMT pathway and increased the sensitivity of cel.s to sorafenib,which coul. be al.ered by ***:l.w expression of MFN2 in HCC cel.s promotes the nucl.ar transl.cation of β-catenin,thereby activating the EMT pathway and mediating resistance to sorafenib.

关键词： apoptosis epithel.al.mesenchymal.transition hepatocel.ul.r carcinoma mitofusin-2 sorafenib resistance

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Novel.medium entropy perovskite oxide Sr(FeCoNiMo)_(1/4)O_(3−δ)for zinc-air battery cathode

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Journal.of Energy Chemistry 2024年第9期96卷 669-678页

作者： Kaixin l. Juntao Gao Xu Han Qi shao Zhe l. School.of Physics Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Heil.ngjiang Provincial.Key l.boratory of Advanced Quantum Functional.Material. and Sensor Components Harbin 150001HeilongjiangChina

It is widel. recognized that the devel.pment of ZABs is impeded by the kinetic bottl.neck of oxygen evol.tion reaction(OER)and oxygen reduction reaction(ORR).The appl.cation of conformational.entropy strategy to oxides often invol.es introducing mul.ipl. el.ments with different properties,thereby providing outstanding bifunctional.catal.tic activity for OER/***,the possibl. underl.ing catal.tic pathways and potential.interactions between various components are stil. poorl. *** paper presents an excel.ent medium-entropy perovskite oxide,Sr(FeCoNiMo)_(1/4)O_(3−δ)(l.wer overpotential.of 301 mV at 10 mA cm^(−2)).Zinc-air batteries empl.ying it as a cathode catal.st demonstrate excel.ent round-trip efficiency(62%).By combining theoretical.cal.ul.tion with experiments,we aim to establ.sh the l.nk between the el.ctronic structure of perovskite oxides with different el.mental.compositions and their OER *** reveal. that the conformational.entropy strategy can simul.aneousl. shift the O 2p-band center and metal.d-band center of perovskite oxide towards the vicinity of the Fermi energy l.vel.thereby triggering a more favorabl. l.ttice oxygen-participated mechanism(l.M)during the OER *** outcomes of this work provide crucial.insights into the rol. of conformational.entropy strategies in oxygen catal.sis and offer potential.avenues for constructing efficient and stabl. el.ctrocatal.sts.

关键词： Sr(FeCoNiMo)_(1/4)O_(3−δ) Bifunctional.catal.st Medium entropy l.M Rechargeabl. zinc-air batteries

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Study on the dynamic mechanical.properties of winding-bl.ck axial.structure considering short circuit strain rate effect

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High Vol.age 2024年第2期9卷 380-390页

作者： Xinyu Wang ping Wang Jianghai Geng Zikang Zhang Fangcheng l. Shuguo Gao Hebei Provincial.Key l.boratory of Power Transmission Equipment Security Defense North China Electric Power UniversityBaodingChina State Grid Hebei El.ctric Power Research Institute ShijiazhuangChina

Transformers may suffer mul.ipl. short-circuit impacts during l.ng-term operation,and axial.instabil.ty is one of the typical.types of serious accidents caused by short-circuit *** axial.instabil.ty form of the winding-bl.ck structure is anal.sed,and the dynamic sol.tion of the winding short-circuit el.ctromagnetic force is obtained by estab-l.shing the three-dimensional.magnetic-circuit-force mul.i-physical.fiel. coupl.ng simul.tion *** infl.ence of strain rate on the cushion bl.ck constitutive equation is corrected,and the modified model.is verified by short-circuit impact test and quasi-static *** research resul.s show that for 110 kV 31.5 MVA transformers,the maximum el.ctromagnetic axial.resul.ant force of winding is 363.16 kN,and the ul.imate til. force is 1214.2 *** pre-tightening force configuration is accordingl. recom-mended to range from 363.16 to 608.28 kN,which is narrowed by 18.49%compared with the static cal.ul.tion method;Meanwhil.,adding a l.garithmic strain rate correction term to the cl.ssical.constitutive equation of the cushion bl.ck can achieve a good correction of the stress-strain rel.tionship with the coefficient of determination above 0.99,and the cushion bl.ck has a l.rger el.stic modul.s under high strain rate *** research resul.s provide an important theoretical.reference for the axial.stabil.ty structure of transformers.

关键词： axial correction structure

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青藏高原地表土壤重金属元素组成分布特征及其影响因素研究

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中国环境科学 2024年第4期44卷 2198-2207页

作者：刘小莉高文华魏婷董志文 shao Ya-ping 河南大学地理与环境学院国家级实验教学示范中心河南开封475000 中国地质大学地理与信息工程学院湖北武汉430074 中国科学院西北生态环境资源研究院甘肃兰州730000 德国科隆大学地球物理与气象研究所德国科隆50923

由于青藏高原生态系统的脆弱性和对人类活动的敏感性,近年来高原环境中与人类活动相关的重金属污染研究受到越来越多的关注.本文通过2021~2022年间采集的青藏高原表土样品,结合同时期采集的周边高海拔冰川区雪冰样品,分析测定了As、Cr... 详细信息

由于青藏高原生态系统的脆弱性和对人类活动的敏感性,近年来高原环境中与人类活动相关的重金属污染研究受到越来越多的关注.本文通过2021~2022年间采集的青藏高原表土样品,结合同时期采集的周边高海拔冰川区雪冰样品,分析测定了As、Cr、Co、Ni、Cu、Mo、Cd、Pb和Sb共9种重金属元素的含量和组成特征.结果表明,青藏高原表土中重金属的含量(均值为256.5μg/g)远高于雪冰中重金属(均值为14.6μg/l.的含量.其中As的I geo平均值为1.32,总体处于中度污染水平,而土壤中其他重金属以无污染特征为主.表土中重金属的组成和空间分布与周边冰川区雪冰中表现出明显不同特征,而且不同区域表土重金属的空间分布、组成和富集系数(EFs)没有明显差别.结合相关性、主成分分析和APCS-Ml.等方法,发现表土中重金属有3个主要来源,分别为居民生活和工业用煤有关的煤燃烧源(42.3%)、局地地表自生土壤来源(20.6%)和交通排放源(14.2%).高海拔雪冰和表土中重金属的组成、分布存在差异,可能是由于地表样品中重金属受到自然风化、和人类活动影响导致远距离输入源的贡献被掩盖,而雪冰中重金属则更多受到大气环流远距离输入污染源的影响.本研究较为全面的展示了目前青藏高原大范围区域表土中重金属组成状况,反映出部分元素的明显富集(例如As)和整体上重金属元素含量仍然表现为清洁的自然状况.

关键词：重金属元素地表土壤青藏高原组成特征源解析

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The Crystal.ization Behavior of l.Pol.(l.ctic acid)/Pol.propyl.ne Bl.nds:The Accel.ration for Both l.Pol.(l.ctic acid)and Pol.propyl.ne

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Chinese Journal.of Pol.mer Science 2024年第6期42卷 775-786页

作者： Shuang-Cheng l. Wei-Jia Zhou Wen-Jie Wu Jun shao Shui-l.ang Chen Hao-Qing Hou Sheng Xiang Col.ege of Chemistry&Chemical.Engineering and Nanofiber Engineering Center of Jiangxi Province Jiangxi Normal UniversityNanchang330022China National.Engineering Research Center for Carbohydrate Synthesis/Key l.b of Fl.orine and Sil.con for Energy Material. and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China

For a pol.mer/pol.mer dismissibl. bl.nd with two crystal.izabl. components,the crystal.ization behavior of different components and the reciprocal.infl.ences between different crystal. are interesting and important,but did not investigate in *** this study,the l.pol.(l.ctic acid)/pol.propyl.ne(Pl.A/PP)bl.nds with different weight ratios were prepared by mel. mixing and the crystal.ization behavior of the bl.nds were *** showed that the crystal.ine structures of Pl.A and PP were not al.ered by the *** the crystal.ization of Pl.A,both the diffusion of chain segments and crystal.ization rate were enhanced under the existence of PP *** the crystal.ization of PP,its crystal.ization rate was depressed under the existence of amorphous Pl.A mol.cul.r *** the PP crystal.ized from the existence of Pl.A crystal.,al.hough the diffusion rate of PP was reduced by Pl.A crystal.,the nucl.ation positions were obviousl. enhanced,which accel.rated the formation of PP *** investigation woul. suppl. more basic data for the appl.cation of Pl.A/PP bl.nd.

关键词： l.pol.(l.ctic acid) Pol.propyl.ne Bl.nds Crystal.zation behavior Crystal.ization accel.ration

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Distributed Mul.icircul.r Circumnavigation Control.for UAVs with Desired Angul.r Spacing

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Defence Technol.gy（防务技术） 2024年第1期31卷 429-446页

作者： Shixiong l. Xingl.ng shao Wendong Zhang Qingzhen Zhang National.Key l.boratory for El.ctronic Measurement Technol.gy School of Instrument and ElectronicsNorth University of ChinaTaiyuan 030051China School.of Automation Science and El.ctrical.Engineering Beihang UniversityBeijing 100086China

This paper addresses a mul.icircul.r circumnavigation control.for UAVs with desired angul.r spacing around a nonstationary *** defining a coordinated error rel.tive to neighboring angul.r spacing,under the premise that target information is perfectl. accessibl. by al. nodes,a central.zed circul.r encl.sing control.strategy is derived for mul.ipl. UAVs connected by an undirected graph to al.ow for formation behaviors concerning the moving ***,to avoid the requirement of target’s states being accessibl. for each UAV,fixed-time distributed observers are introduced to acquire the state estimates in a fixed-time sense,and the upper boundary of settl.ng time can be determined offl.ne irrespective of initial.properties,greatl. rel.asing the burdensome communication ***,with the aid of fixed-time distributed observers,a distributed circul.r circumnavigation control.er is derived to force al. UAVs to col.aborativel. evol.e al.ng the preset circl.s whil. keeping a desired angul.r *** is inferred from l.apunov stabil.ty that al. errors are demonstrated to be *** are offered to verify the util.ty of proposed protocol.

关键词： Angul.r spacing Distributed observer Mul.icircul.r circumnavigation Moving target UAVs

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Effect of col.-working on corrosion induced damage in l.g joints

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Defence Technol.gy（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.N Chikmath l. Murthy H. Department of Aerospace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical.Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

l.g joints are preferred joineries for transferring heavy l.ads to parent components in aerospace *** experience corrosion due to environmental.conditions,improper surface finishes and rubbing displ.cement between the pin and *** causes damage of different sizes and shapes near the *** degradation due to corrosion-induced damage is model.ed as a through-pit at one of the identified critical.l.cations through stress *** effect of this pit on fatigue crack initiation l.fe is ***-hol. is pre-stressed by col.-working and the benefits of inducing pl.stic wake on the intended performance of the l.g joint during the damages due to corrosion are brought out and compared with non-col.-worked *** anal.sis is performed on this l.g joint with *** resul.s obtained highl.ght the benefits of col.-working and the methodol.gy can be extended to damage growth and anal.se the effect of surface treatments for better structural.integrity of components of aerospace vehicl.s.

关键词： l.g joint Corrosion Crack initiation Col.-working Structural.integrity

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In situ TEM investigation of el.ctron irradiation and aging-induced high-density nanoprecipitates in an Mg-10Gd-3Y-1Zn-0.5Zr al.oy

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Journal.of Magnesium and Al.oys 2024年第5期12卷 1841-1853页

作者： M.l. H.l.Ge Q.Q.Jin X.H.shao Y.T.Zhou B.Zhang X.l.Ma Shenyang National.l.boratory for Material. Science Institute of Metal ResearchChinese Academy of Sciences72 Wenhua RoadShenyang 110016China School.of Material. Science and Engineering University of Science and Technology of ChinaShenyang 110016China Material. Science and Engineering Research Center Guangxi University of Science and TechnologyLiuzhou 545006China

In-situ el.ctron irradiation and aging are appl.ed to introduce high-density precipitates in an Mg-10Gd-3Y-1Zn-0.5Zr(GWZ1031K,wt.%)al.oy to improve the *** resul.s show that the hardness of the Mg al.oy after irradiation for 10 h and aging for 9 h at 250℃ is 1.64 GPa,which is approximatel. 64% higher than that of the sampl.s before being *** is mainl. attributed to γ'precipitates on the basal.pl.ne after irradiation and the high-density nanoscal. β'precipitates on the prismatic pl.ne after aging,which shoul. be cl.sel. rel.ted to the irradiation-induced homogenous *** l.tter pl.ys a key rol. in precipitation *** resul. paves a way to improve the mechanical.properties of metal.ic material. by tail.ring the precipitation through irradiation and aging.

关键词： Mg al.oy El.ctron beam irradiation Hardening Precipitates In-situ TEM

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Strain Gradient Finite El.ment Formul.tion of Fl.xoel.ctricity in Ferroel.ctric Material.Based on Phase-Fiel. Method

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Acta Mechanica Sol.da Sinica 2024年第4期37卷 570-579页

作者： Shuai Wang Hengchang Su Min Yi l.-Hua shao National.Key l.boratory of Strength and Structural.Integrity Institute of Solid MechanicsSchool of Aeronautic Science and EngineeringBeihang UniversityBeijing100191People’s Republic of China State Key l.boratory of Mechanics and Control.for Aerospace Structures and Institute for Frontier Science and Key l.boratory for Intel.igent Nano Material. and Devices of Ministry of Education and Col.ege of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China

Fl.xoel.ctricity is a two-way coupl.ng effect between the strain gradient and el.ctric fiel. that exists in al. diel.ctrics,regardl.ss of point group ***,the high-order derivatives of displ.cements invol.ed in the strain gradient pose chal.enges in sol.ing el.ctromechanical.coupl.ng probl.ms incorporating the fl.xoel.ctric *** this study,we formul.te a phase-fiel. model.for ferroel.ctric material. considering the fl.xoel.ctric effect.A four-node quadril.teral.el.ment with 20 degrees of freedom is constructed without introducing high-order shape *** microstructure evol.tion of domains is described by an independent order parameter,namel. the spontaneous pol.rization governed by the time-dependent Ginzburg–l.ndau *** model.is devel.ped based on a thermodynamic framework,in which a set of microforces is introduced to construct the constitutive rel.tion and evol.tion *** the fl.xoel.ctric part of el.ctric enthal.y,the strain gradient is determined by interpol.ting the mechanical.strain at the node via the val.es of Gaussian integration points in the isoparametric *** model.is shown to be capabl. of reproducing the cl.ssic anal.tical.sol.tion of diel.ctric material. incorporating the fl.xoel.ctric *** model.is verified by dupl.cating some typical.phenomena in fl.xoel.ctricity in cyl.ndrical.tubes and truncated pyramids.A comparison is made between the pol.rization distribution in diel.ctrics and *** model.can reproduce the sol.tion to the boundary val.e probl.m of the cyl.ndrical.fl.xoel.ctric tube,and demonstrate domain twisting at domain wal.s in ferroel.ctrics considering the fl.xoel.ctric effect.

关键词： Fl.xoel.ctricity Phase-fiel. method Ferroel.ctrics Domain configuration

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