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Pulsed radiofrequency alleviated neuropathic pain by down-regulating the expression of substance P in chronic constriction injury rat model

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Chinese Medical Journal 2020年第2期133卷 190-197页

作者： Jing-Ai Wang shao-ning niu Fang Luo Department of Anesthesiology Plastic Surgery HospitalChinese Academy of Medical ScienceBeijing 100144China Department of Anesthesiology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Pain Management Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China

Background:Pulsed radiofrequency(PRF),as a non-invasive treatment of neuropathic pain(NP),has been widely administered *** studies have shown that PRF has the potential to improve hyperalgesia in animal models of ***,there have been few reports to clarify whether the mechanism of PRF treatment of NP involves intervention in the expression of substance P(SP).Therefore,this study administered PRF treatment to chronic constriction injury(CCI)model rats and observed the sciatic nerve mechanical pain threshold and SP expression in the spinal cord to explore the mechanism of PRF ***:A total of 96 Sprague-Dawley rats were randomly divided into the sham-surgery-sham-treatment group(S-S group),the sham-surgery-PRF group(S-P group),the CCI-sham-treatment group(C-S group),and the CCI-PRF group(C-P group).The C-S group and the C-P group underwent sciatic nerve CCI,while the other groups received a sham *** 14 days after the operation,the C-P group and the S-P group were treated with PRF for 300 *** recorded the hindpaw withdrawal threshold(HWT)and the thermal withdrawal latency(TWL)of rats in the various groups at baseline,before treatment(0 days),and at 1,7,14,and 28 days after treatment.L4 to L6 spinal cord tissues were taken before treatment(0 days)and 1,7,14,and 28 days after *** transcription and translation of SP were measured by quantitative polymerase chain reaction and Western blotting,***:The HWT and the TWL in the C-P group 28 days after PRF treatment were significantly higher than those in the C-S group(95%confidence interval[CI]:5.84–19.50,P<0.01;95%CI:2.58–8.69,P=0.01).The expression of SP in the C-P group 28 days after PRF treatment was significantly lower than that in the C-S group(95%CI:1.17–2.48,P<0.01).Conclusions:PRF may alleviate CCI-induced NP by down-regulating the expression of SP in the spinal cord of CCI model rats.

关键词： Pulsed radiofrequency Chronic constriction injury Sciatic nerve Substance P

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Machine Learning-Based Research on Tensile Strength of SiC-Reinforced Magnesium Matrix Composites via Stir Casting

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 453-466页

作者： Zhihong Zhu Wenhang ning Xuanyang niu Yuhong Zhao Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Collaborative Innovation Center of Ministry of Education and Shanxi Province for High-Performance Al/Mg Alloy MaterialsNorth University of ChinaTaiyuan 030051China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

SiC is the most common reinforcement in magnesium matrix composites,and the tensile strength of SiC-reinforced magnesium matrix composites is closely related to the distribution of *** a uniform distribution of SiC requires fine control over the parameters of SiC and the processing and preparation ***,due to the numerous adjustable parameters,using traditional experimental methods requires a considerable amount of experimentation to obtain a uniformly distributed composite ***,this study adopts a machine learning approach to explore the tensile strength of SiC-reinforced magnesium matrix composites in the mechanical stirring casting *** analyzing the influence of SiC parameters and processing parameters on composite material performance,we have established an effective predictive ***,six different machine learning regression models have been developed to predict the tensile strength of SiC-reinforced magnesium matrix *** validation and comparison,our models demonstrate good accuracy and reliability in predicting the tensile strength of the composite *** research findings indicate that hot extrusion treatment,SiC content,and stirring time have a significant impact on the tensile strength.

关键词： Machine learning Stirring casting Magnesium matrix composite Tensile strength

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Unveiling evapotranspiration patterns and energy balance in a subalpine forest of the Qinghai-Tibet Plateau:observations and analysis from an eddy covariance system

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Journal of Forestry Research 2024年第3期35卷 175-188页

作者： niu Zhu Jinniu Wang Dongliang Luo Xufeng Wang Cheng Shen ning Wu ning Zhang Binghui Tian Aihong Gai Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041People's Republic of China College of Resources and Environmental Sciences Gansu Agricultural UniversityLanzhou 730070People's Republic of China Mangkang Ecological Monitoring Station Tibet Ecological Security Barrier Ecological Monitoring NetworkQamdo 854500People's Republic of China Northwest Institute of Eco Environmental Resources Chinese Academy of SciencesLanzhou 730000People's Republic of China

Evapotranspiration is an important parameter used to characterize the water cycle of *** under-stand the properties of the evapotranspiration and energy balance of a subalpine forest in the southeastern Qinghai-Tibet Plateau,an open-path eddy covariance system was set up to monitor the forest from November 2020 to October 2021 in a core area of the Three Parallel Rivers in the Qing-hai-Tibet *** results show that the evapotranspira-tion peaked daily,the maximum occurring between 11:00 and 15:*** factors had significant effects on evapotranspiration,among them,net radiation the greatest(R^(2)=0.487),and relative humidity the least(R^(2)=0.001).The energy flux varied considerably in different seasons and sensible heat flux accounted for the main part of turbulent *** energy balance ratio in the dormant season was less than that in the growing season,and there is an energy imbalance at the site on an annual time scale.

关键词： Evapotranspiration Energy balance Subalpine forest Three Parallel Rivers region Southeast Qinghai-Tibet Plateau

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A Review of Intelligent Configuration and Its Security for Complex Networks

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Chinese Journal of Electronics 2024年第4期33卷 920-947页

作者： Yue ZHAO Bin YANG Fei TENG Xianhua niu ning HU Bo TIAN Science and Technology on Communication Security Laboratory School of Computer and Information Engineering Chuzhou University School of Computing and Artificial Intelligence Southwest Jiaotong University School of Computer and Software Engineering Xihua University Cyberspace Institute of Advanced Technology Guangzhou University

Complex networks are becoming more complex because of the use of many components with diverse technologies. In fact, manual configuration that makes each component interoperable has breed latent danger to system security. There is still no comprehensive review of these studies and prospects for further research. According to the complexity of component configuration and difficulty of security assurance in typical complex networks, this paper systematically reviews the abstract models and formal analysis methods required for intelligent configuration of complex networks, specifically analyzes, and compares the current key technologies such as configuration semantic awareness, automatic generation of security configuration, dynamic deployment, and verification evaluation. These technologies can effectively improve the security of complex networks intelligent configuration and reduce the complexity of operation and maintenance. This paper also summarizes the mainstream construction methods of complex networks configuration and its security test environment and detection index system, which lays a theoretical foundation for the formation of the comprehensive effectiveness verification capability of configuration security. The whole lifecycle management system of configuration security process proposed in this paper provides an important technical reference for reducing the complexity of network operation and maintenance and improving network security.

关键词： Complex networks Intelligent configuration Configuration security Software defined network Lifecycle management SOFTWARE ALGORITHM AGENT

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Advances in advanced solution-synthesis-based structural materials for tactile sensors and their intelligent applications

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InfoMat 2024年第1期6卷 31-64页

作者： Hongsen niu ning Li Eun-Seoung Kim Young Kee Shin Nam-Young Kim Guozhen Shen Yang Li School of Information Science and Engineering University of JinanJinanthe People's Republic of China RFIC Centre Department of Electronics EngineeringKwangwoon UniversitySeoulRepublic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Seoul National UniversitySeoulRepublic of Korea School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijingthe People's Republic of China School of Microelectronics Shandong UniversityJinanthe People's Republic of China

Intelligent applications,with tactile sensors at their core,represent significant advancement in the field of artificial ***,achieving perception abilities in tactile sensors that match or exceed human skin remains a formidable ***,the design and implementation of hierarchical structural materials are considered the optimal solution to this *** contrast to conventional methods,such as complicated lithography and three-dimensional printing,the cost-effective and scalable nature of advanced solution-synthesis methods makes them ideal for preparing diverse tactile sensors with hierarchical structural ***,the process and applicability of advanced solution synthesis methods have yet to form a seamless ***,the development and intellectualization of tactile sensors based on advanced solution synthesis methods are still in their early stages,and require a comprehensive and systematic review to usher in *** study delves into the advantages and disadvantages of various advanced solution synthesis methods,providing detailed ***,the positive effects of hierarchical structural materials constructed using these methods in tactile sensors and their intelligent applications are also discussed in ***,the challenges and future opportunities faced by this emerging field are summarized.

关键词： aqueous phase reduction artificial intelligence hydrothermal growth in situ polymerization tactile sensor

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Mycoplasma hominis Pneumonia Presented as a Cavitary Mass with a Halo Sign in an Immunocompetent Adult Male:A Case Report

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Infectious Diseases & Immunity 2024年第3期4卷 142-145页

作者： Pan-Pan Xie Yao Yao ning Yang Wen-Kai niu Xin Yuan Department of Respiratory and Critical Care Diseases Senior Department of Infectious Diseasesthe Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China Anhui Medical University PLA 307 Clinical College Beijing 100039China.

Mycoplasma hominis is an opportunistic microorganism that colonizes the genitourinary tract and causes genitourinary ***,pulmonary infections caused by *** have rarely been reported in immunocompetent ***,we report a rare case of an immunocompetent adult male with *** pneumonia who presented with multiple pulmonary nodules that progressed to a cavitary mass with a halo *** presence of *** infection was confirmed using multiplex polymerase chain reaction(mPCR)of the bronchoalveolar lavage *** patient demonstrated no response to the initial levofloxacin therapy;however,the symptoms subsequently improved after the administration of *** may be an underestimated causative agent of community-acquired pneumonia of unknown etiology in immunocompetent adults,and the involvement of the organism should be especially suspected in sexually active *** diagnostic methods,such as mPCR,can be used to identify the etiology of atypical *** antibiotics are crucial for effective treatment.

关键词： M.hominis Halo sign Cavitary pneumonia Extragenital infections Case report

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Brightening heavily doped upconversion nanoparticles by tuning characteristics of core-shell structures

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Journal of Rare Earths 2024年第5期42卷 947-954,I0005页

作者： Yangyang niu Zhihao Bao Yuqin Gao Mengchao Guo Jingyao Liu Jinjun shao Min Lu Ze Yuan Xiaoji Xie School of Flexible Electronics(Future Technologies)&Institute of Advanced Materials(IAM) Nanjing Tech UniversityNanjing211816China

Heavily doped upconversion nanoparticles(UCNPs)potentially have exceptional photon upconversion abilities that are promising for diverse applications,such as lasing and super-resolution ***,heavily doped UCNPs typically can only offer mediocre upconversion luminescence intensity,and there still lacks general guidelines for the design and synthesis of heavily doped ***,in order to boost the upconversion luminescence of heavily doped UCNPs,we studied the influence of characteristics of the core-shell structure on heavily doped UCNPs'upconversion *** find that some empirical guidelines derived from conventional UCNPs are not suitable for heavily doped *** NaYbF_(4):Tm@NaYF_(4) core-shell UCNPs with a high concentration of Yb_(3+)as a representative,our studies reveal that a rather thick inert NaYF4 shell is needed to protect the UCNPs from surface quenching,and the upconversion luminescence may undergo the cooperative sensitization process,which should be due to the highly concentrated Yb~(3+)*** addition,the upconversion luminescence of heavily doped NaYbF4:Tm UCNPs exhibits no obvious dependence on the type of inert ***,our results show that confining both Yb~(3+)and Tm~(3+)dopants in a thin layer(known as theδ-doping strategy)does not work well in the heavily doped ***,we propose a NaYbF_(4):Tm@NaYbF_(4)@NaYF_(4) core-shell-shell structure to enhance the luminescence of heavily doped UCNPs,by weakening the dissipation of excitation energy and strengthening the *** findings should be helpful to establish general design principles for developing the brightest possible UCNPs that can meet the requirements of various applications.

关键词： Luminescence Upconversion Nanomaterials Rare earths Lanthanide doping

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Multifunctional high-performance pressure/proximity/temperature sensors enabled by hybrid resistive-supercapacitive response

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Nano Research 2024年第6期17卷 5604-5613页

作者： Huijun Kong Zhongqian Song Meichun Ding Changxiang shao Jiahui Yu Baolei Wang Weiyan Li Chenwei Li Li niu School of Chemistry and Pharmaceutical Engineering Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China College of Artificial Intelligence and Big Data for Medical Sciences Shandong First Medical University and Shandong Academy of Medical SciencesJinan 250117China School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

The issue of sensitivity attenuation in high-pressure region has been a persistent concern for pressure-sensitive electronic *** order to tackle such trade-off between sensitivity and linear range,herein,a hybrid piezoresistive-supercapacitive(HRSC)strategy is proposed via introducing a piezoresistive porous aerogel layer between the charge collecting electrodes and iontronic films of the pressure ***,the HRSC-induced impedance regulation and supercapacitive behavior contribute to significant mitigation in sensitivity attenuation,achieving high sensitivity across wide linear range(44.58 kPa^(−1)from 0 to 3 kPa and 23.6 kPa^(−1)from 3 to 12 kPa).The HRSC pressure sensor exhibits a low detection limit of 1 Pa,fast responsiveness(~130 ms),and excellent cycling stability,allowing to detect tiny pressure of air flow,finger bending,and human ***,the HRSC sensor exhibits exceptional perception capabilities for proximity and temperature,broadening its application scenarios in prosthetic perception and electronic *** proposed HRSC strategy may boost the ongoing research on structural design of high-performance and multimodal electronic sensors.

关键词： multimodal sensor pressure sensor high sensitivity MXene/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)aerogel structural design

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Transplantation of human placental chorionic plate-derived mesenchymal stem cells for repair of neurological damage in neonatal hypoxic-ischemic encephalopathy

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Neural Regeneration Research 2024年第9期19卷 2027-2035页

作者： Lulu Xue Ruolan Du ning Bi Qiuxia Xiao Yifei Sun Ruize niu Yaxin Tan Li Chen Jia Liu Tinghua Wang Liulin Xiong Transformation Research Laboratory The Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina State Key Laboratory of Biotherapy Sichuan UniversityChengduSichuan ProvinceChina Institute of Neurological Disease Translational Neuroscience CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Animal Zoology Institute of NeuroscienceKunming Medical UniversityKunmingYunnan ProvinceChina Department of Anesthesiology The Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina Department of Pediatrics the People’s Liberation Army Rocket Force Characteristic Medical CenterBeijingChina

Neonatal hypoxic-ischemic encephalopathy is often associated with permanent cerebral palsy,neurosensory impairments,and cognitive deficits,and there is no effective treatment for complications related to hypoxic-ischemic *** therapeutic potential of human placental chorionic plate-derived mesenchymal stem cells for various diseases has been ***,the potential use of human placental chorionic plate-derived mesenchymal stem cells for the treatment of neonatal hypoxic-ischemic encephalopathy has not yet been *** this study,we injected human placental chorionic plate-derived mesenchymal stem cells into the lateral ventricle of a neonatal hypoxic-ischemic encephalopathy rat model and observed significant improvements in both cognitive and motor *** chip analysis showed that interleukin-3 expression was significantly elevated in neonatal hypoxic-ischemic encephalopathy model *** transplantation of human placental chorionic plate-derived mesenchymal stem cells,interleukin-3 expression was *** further investigate the role of interleukin-3 in neonatal hypoxic-ischemic encephalopathy,we established an in vitro SH-SY5Y cell model of hypoxic-ischemic injury through oxygen-glucose deprivation and silenced interleukin-3 expression using small interfering *** found that the activity and proliferation of SH-SY5Y cells subjected to oxygen-glucose deprivation were further suppressed by interleukin-3 ***,interleukin-3 knockout exacerbated neuronal damage and cognitive and motor function impairment in rat models of hypoxic-ischemic *** findings suggest that transplantation of hpcMSCs ameliorated behavioral impairments in a rat model of hypoxic-ischemic encephalopathy,and this effect was mediated by interleukin-3-dependent neurological function.

关键词： behavioral evaluations gene knockout human neuroblastoma cells(SH-SY5Y) human placental chorionic derived mesenchymal stem cells interleukin-3 neonatal hypoxic-ischemic encephalopathy nerve injury oxygen-glucose deprivation protein chip small interfering RNA

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Single-cell RNA sequencing reveals abnormal transcriptome signature of erythroid progenitors in pure red cell aplasia

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Genes & Diseases 2024年第1期11卷 49-52页

作者： Yumei Liu Haiyue niu Jie Ren Zhiqin Wang Li Yan Limin Xing Zonghong shao Rong Fu Zhigang Cai Huaquan Wang Department of Hematology Tianjin Medical University General HospitalTianjin 300052China School of Basic Medical Sciences Tianjin Medical UniversityTianjin 300070China

Pure red cell aplasia(PRCA)is a bone marrow failure syndrome characterized by severe anemia,reticulocytopenia,selective reduction,and even the absence of bone marrow erythroid precursors,while leukocyte and platelet counts are normal.1 Acquired PRCA can be divided into primary and *** are mediated by immune *** in the quantity and dysfunction of committed erythroid progenitors(EPs),including burst forming uniterythroid(BFU-E)and colony forming unit-erythroid(CFU-E),may be the source of reduced erythropoiesis and needs to be elucidated.

关键词： progenitor anemia leukocyte

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