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Relationship between exercise induced elevation of left ventricular filling pressure and exercise intolerance in patients with atrial fibrillation

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Journal of Geriatric Cardiology 2016年第6期13卷 546-551页

作者： shao-min chen Rong HE Wei-Hong LI Zhao-Ping LI Bao-Xia chen Xin-Heng FENG Department of Cardiology Peking University Third Hospital Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides Ministry of Health Beijing China Department of Cardiology Beijing Tsinghua Changgung Hospital Medical Center Tsinghua University Beijing China

Background Elevated left ventricular filling pressure （LVFP） is an important cause of exercise intolerance in patients with atrial fib- dilation （AF）. Exercise stress echocardiography could assess LVFP during exercise. The objective of this study was to investigate the relationship between exercise induced elevation of LVFP and exercise capacity in patients with AF. Methods This study included 145 con- secutive patients （81 men and 64 women; mean age 65.5 ± 8.0 years） with persistent non-valvular AF and normal left ventricular systolic function （left ventdcular ejection fraction 〉 50%）. All patients underwent a symptom-limited cardiopulmonary exercise test （CPET）. Doppler echocardiography was performed both at rest and immediately after exercise. Five consecutive measurements of early diastolic mitral inflow velocity （E） and early diastolic mitral annular velocity （e＇） were taken and averaged. E/e＇ ratio was calculated. Elevated LVFP was defined as E/e＇〉 9, and patients with elevated LVFP at rest were excluded. Results Patients were classified into two groups according to LVFP estimated by E/e＇ ratio after exercise： 39 （26.9%） with elevated LVFP after exercise and 106 （73.1%） with normal LVFP. As compared with patients with normal LVFP, the ones with elevated LVFP after exercise had significantly lower peak oxygen uptake （VO2 peak）（21.7 ± 2.3 vs. 26.4 ± 3.8 mL/min per kilogram, P 〈 0.001）, lower anaerobic threshold （19.9 ± 2.5 vs. 26.0± 4.0 mL/min per kilogram, P 〈 0.001）, and shorter exercise time duration （6.2± 0.8 vs. 7.0 ±1.3 min, P 〈 0.001）. Multivariate analysis showed that age, gender and E/e＇ after exercise were significantly correlated with VO2peak. Conclusion Elevated LVFP estimated by E/e＇ ratio after exercise is independently associated with reduced exercise capacity in AF patients.

关键词： Atrial fibrillation Diastolic dysfunction Exercise capacity, Exercise stress echocardiography

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Neurofibromatosis type 1-associated multiple rectal neuroendocrine tumors: A case report and review of the literature

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World Journal of Gastroenterology 2018年第33期24卷 3806-3812页

作者： Rui Xie Kuang-I Fu shao-min chen Bi-Guang Tuo Hui-ChaoWu Department of Gastroenterology Affiliated Hospital to Zunyi Medical College Department of Endoscopy Kanma Memorial Hospital

Neurofibromatosis type 1(NF-1) is commonly associated with benign or malignant tumors in both the central and peripheral nervous systems. However, rare cases of NF-1-associated multiplerectal neuroendocrine tumors have been reported. This report describes a case of a 39 year old female with NF-1 and intermittent hematochezia as a primary symptom. Physical examination showed multiple subcutaneous nodules and café au lait spots with obvious scoliosis of the back. Imaging examinations and colonoscopy found malformation of the left external iliac vein and multiple gray-yellow nodules with varying sizes and shapes in the rectal submucosal layer. Histological and immunohistochemical results suggested multiple rectal neuroendocrine tumors, a rare disease with few appreciable symptoms and a particularly poor prognosis. The patient with NF-1 presented here had not only multiple rectal neuroendocrine neoplasms but also vascular malformations, scoliosis and other multiple system lesions. This case therefore contributes to improving clinical understanding, diagnosis and treatment of related complications for patients with NF-1 who present with associated medical conditions.

关键词： Neurofibromatosis type 1 Multiple rectal neuroendocrine tumors Vascular malformations Scoliosis

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Two case of preoperative bridging therapy for patients undergoing non- cardiac surgery after coronary stent implantation

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Journal of Geriatric Cardiology 2017年第7期14卷 488-490页

作者： Le-Qun ZHOU shao-min chen Yong-Zhen ZHANG Li-Yun HE Wei GAO Department of Cardiology Peking University Third HospitalKey Laboratory of Cardiovascular Molecular Biology and RegulatoryPeptidesMinistry of HealthBeijingChina

It has been reported that up to 12% of patients underwent non-cardiac surgery or invasive procedures within the first year after the coronary stent implantation. Premature dis- continuation of antiplatelet therapy is associated with a sig- nificant increase in mortality and major adverse cardiac events, in particular, stent thrombosis. Thus, postpone- ment of elective surgery is advocated during the first year after the coronary stent implantation.

关键词： Coronary stent implantation Non-cardiac surgery Preoperative bridging therapy Tirofiban

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Left atrial area index predicts adverse cardiovascular events in patients with unstable angina pectoris

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Journal of Geriatric Cardiology 2016年第8期13卷 652-657页

作者： Yi-Fan LI Wei-Hong LI Zhao-Ping LI Xin-Heng FENG Wei-Xian XU shao-min chen Wei GAO Department of Cardiology Peking University Third Hospital Beijing China Department of Pediatric Cardiology Guangdong Cardiovascular institute Guangdong General Hospital GuangzhouChina.

Background The left atrial size has been considered as a useful marker of adverse cardiovascular outcomes. However, it is not well known whether left atrial area index （LAAI） has predictive value for prognosis in patients with unstable angina pectoris （UAP）. This study was aimed to assess the association between LAAI and outcomes in UAP patients. Methods We enrolled a total of 391 in-hospital patients diag- nosed as UAP. Clinical and echocardiographic data at baseline were collected. The patients were followed for the development of ad- verse cardiovascular （CV） events, including hospital readmission for angina pectoris, acute myocardial infarction （AMI）, congestive heart failure （CHF）, stroke and all-cause mortality. Results During a mean follow-up time of 26.3±8.6 months, 98 adverse CV events occurred （84 hospital readmission for angina pectoris, four AMI, four CHF, one stroke and five all-cause mortality）. In a multivariate Cox model, LAAI [OR： 1.140, 95% CI： 1.01±1.279, P = 0.026], diastolic blood pressure （OR： 0.976, 95% CI： 0.956-0.996, P = 0.020） and pulse pressure （OR 1.020, 95% CI： 1.007-1.034, P = 0.004） were independent predictors for adverse CV events in UAP patients. Conclusions LAAI is a predictor of adverse CV events independent of clinical and other echocardiographic parameters in UAP patients.

关键词： Adverse cardiovascular events Left atrial area index Prognostic factor Unstable angina pectoris

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Higher serum angiopoietin 2 levels are independently associated with coronary microvascular dysfunction in patients with angina in the absence of obstructive coronary artery disease

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Chinese Medical Journal 2020年第14期133卷 1662-1668页

作者： shao-min chen Dan Li Xing Xing Zhao-Ping Li Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalKey Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesMinistry of HealthKey Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing Key Laboratory of Cardiovascular Receptors ResearchBeijing 100191China Department of Cardiovascular Medicine Beijing First Hospital of Integrated Chinese and Western MedicineBeijing 100039China.

Background:Angiopoietin-2(Ang-2)is a type of endothelial growth factor involved in angiogenesis and vascular *** Ang-2 levels are elevated in patients with obstructive coronary artery disease(CAD).This study aimed to evaluate the association between serum Ang-2 levels and coronary microvascular dysfunction in patients without obstructive ***:A total of 125 patients with angina in the absence of obstructive CAD were included in this cross-sectional *** flow reserve(CFR)was measured in the distal left anterior descending coronary artery by trans-thoracic Doppler *** patients were divided into the following two sub-groups according to CFR:the impaired CFR group with CFR valuesmined using enzyme-linked immunosorbent *** predictors for impaired CFR were identified by binary logistic regression *** receiveroperating characteristic curve was determined to evaluate the ability of serum Ang-2 in predicting impaired ***:We found that age,percentage of female sex,N-terminal pro-B-type natriuretic peptide levels,Ang-2 levels(763.3±264.9 vs.579.7±169.3 pg/mL,P<0.001),and the left atrial volume index were significantly higher in patients with impaired CFR than in patients with preserved *** Ang-2 levels were negatively correlated with CFR(r=0.386,P<0.001).Binary logistic regression analysis showed that Ang-2(odds ratio:1.004,95%confidence interval[CI]:1.001–1.006,P=0.003)and age(odds ratio:1.088,95%CI:1.023–1.156,P=0.007)were independently associated with impaired ***,Ang-2 was a significant predictor of impaired CFR on the receiver-operating characteristic curve(P<0.001).The area under the curve was 0.712(95%CI:0.612–0.813).Conclusions:High serum Ang-2 levels are independently associated with impaired CFR in patients with angina in the absence of obstructive CAD.

关键词： Coronary microvascular dysfunction Angiopoietin 2 Coronary flow reserve

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Extracorporeal membrane oxygenation successfully treated massive right ventricular myocardial infaction with aneurysm

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Journal of Geriatric Cardiology 2022年第8期19卷 618-621页

作者： cheng-Duo ZHANG Li-Jie SUN Bao-Xia chen Jiang-Li HAN shao-min chen Xin-Yu WANG Yuan-Yuan FAN Dan LI Xin-Ye XU Department of Cardiology Peking University Third HospitalNHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory PeptidesBeijingChina

Acute obstruction of the right coronary ar-tery(RCA)can lead to right ventricular myocardial infarction(MI),which rarely lead to cardiogenic shock(CS).Hemodynamic sta-bility could be restored through fluid resuscitation and vasoactive drugs in most ***,we present a highly representative case of refractory CS caused by massive right ventricular MI with api-cal aneurysm formation,who was successfully treated with extracorporeal membrane oxygenation(ECMO)post severe complication of acute right coronal dis-section.

关键词： ventricular aneurysm drugs

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Precise Asymptotics of Error Variance Estimator in Partially Linear Models

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Acta Mathematicae Applicatae Sinica 2008年第1期24卷 59-74页

作者： shao-jun Guo, min chen, Feng Liu Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100080, China Department of Statistics, Chongqing Institute of Technology, Chongqing 630000, China Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing China Department of Statistics Chongqing Institute of Technology Chongqing China

In this paper, we focus our attention on the precise asymptotics of error variance estimator in partially linear regression models, yi = xiτβ+ g(ti) +εi, 1≤i≤n, {εi,i = 1,…, n} are i.i.d random errors with mean 0 and positive finite varianceσ2. Following the ideas of Allan Gut and Aurel Spatarut and Zhang, on precise asymptotics in the Baum-Katz and Davis laws of large numbers and precise rate in laws of the iterated logarithm, respectively, and subject to some regular conditions, we obtain the corresponding results in partially linear regression models.

关键词： Precise asymptotics partially linear models error variance estimator

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Effect of dopamine and metaraminol on the renal function of patients with septic shock

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Chinese Medical Journal 2007年第8期120卷 680-683页

作者： HOU Li-chao LI Shu-zhi XIONG Li-ze chen shao-yang chen min ZHANG Xi-jing HUO Ting-ting WANG Qiang WANG Ya-li HU Wen-neng Department of Anaesthesiology Xijing Hospital Fourth Military Medical University Xi＇an 710032 China

Background Vasoactive drugs are often necessary for reversing hypotension in patients with severe infection. The standard for evaluating effects of vasoactive drugs should not only be based on the increase of arterial blood pressure, but also on the blood flow perfusion of internal organs. The effects of dopamine and metaraminol on the renal function of the patients with septic shock were investigated retrospectively in this study. Methods Ninety-eight patients with septic shock were divided into three groups according to the highest infusing rate of metaraminol, with the lightest infusing rate of （0.1-0.5, 0.6-1.0, 〉1.0） pg · kg^-1 · min^-1 in group A, B and C respectively. Urine output, mean arterial blood pressure （MAP）, heart rate （HR）, urine output, blood urea nitrogen （BUN）, creatinine （CRE）, urine albumin （U-ALB）, urine β2-microglubulin （Uβ2-MG） and Apache Ⅲ scores were recorded. Results Before antishock therapy, hypotension, tachycardia and oliguria occurred to all the 98 patients with septic shock and CRE, BUN, U-ALB, Uβ2-MG and Apache Ⅲ scoring were abnormal in most cases. With the antishock therapy, MAP, HR, urine output, BUN and CRE in all patients returned gradually to normal （P〈0.05 or 〈0.01 compared to those before antishock therapy）. U-ALB, Uβ2-MG output and Apache Ⅲ scoring also reverted but remained abnormal （P〈0.01 compared to those before antishock therapy）. No statistically significant differences in the changes of these indices with the time existed among the three groups （P〉0.05）.Conclusion Dopamine and metaraminol when applied to the patients with septic shock could effectively maintain the circulatory stability and promote restoration of renal function.

关键词： dopamine metaraminol septic shock renal function

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Muon flux measurement at China Jinping Underground Laboratory

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Chinese Physics C 2021年第2期45卷 509-517页

作者： Zi-yi Guo Lars Bathe-Peters shao-min chen Mourad Chouaki Wei Dou Lei Guo Ghulam Hussain Jin-jing Li Qian Liu Guang Luo Wen-tai Luo ming Qi Wen-hui shao Jian Tang Lin-yan Wan Zhe Wang Ben-da Xu Tong Xu Wei-ran Xu Yu-zi Yang minfang Yeh Lin Zhao Department of Engineering Physics Tsinghua UniversityBeijing 100084China Center for High Energy Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle&Radiation Imaging(Tsinghua University) Ministry of EducationChina Institut für Physik Technische Universität BerlinBerlin 10623Germany École Polytechnique Fédérale de Lausanne Lausanne 1015Switzerland School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China School of Physics Nanjing UniversityNanjing 210093China Brookhaven National Laboratory UptonNew York 11973USA

China Jinping Underground Laboratory(CJPL)is ideal for studying solar,geo-,and supernova neutrinos.A precise measurement of the cosmic-ray background is essential in proceeding with R&D research for these MeV-scale neutrino *** a 1-ton prototype detector for the Jinping Neutrino Experiment(JNE),we detected 264 high-energy muon events from a 645.2-day dataset from the first phase of CJPL(CJPL-I),reconstructed their directions,and measured the cosmic-ray muon flux to be (3.53±0.22_stat.±0.07_sys.)×-10^(-10)cm^(-2).The observed angular distributions indicate the leakage of cosmic-ray muon background and agree with simulation data accounting for Jinping mountain's terrain.A survey of muon fluxes at different laboratory locations,considering both those situated under mountains and those down mine shafts,indicates that the flux at the former is generally a factor of (4±2) larger than at the latter,with the same vertical *** study provides a convenient back-of-the-envelope estimation for the muon flux of an underground experiment.

关键词： CJPL cosmic-ray muon flux angular distribution neutrino detector liquid scintillator

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Immunogenicity and safety of a recombinant fusion protein vaccine(V-01)against coronavirus disease 2019 in healthy adults:a randomized,double-blind,placebo-controlled,phaseⅡtrial

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Chinese Medical Journal 2021年第16期134卷 1967-1976页

作者： Ya-Jun Shu Jian-Feng He Rong-Juan Pei Peng He Zhu-Hang Huang shao-min chen Zhi-Qiang Ou Jing-Long Deng Pei-Yu Zeng Jian Zhou Yuan-Qin min Fei Deng Hua Peng Zheng Zhang Bo Wang Zhong-Hui Xu Wu-Xiang Guan Zhong-Yu Hu Ji-Kai Zhang Guangdong Provincial Institute of Biological Products and Materia Medica GuangzhouGuangdong 510440China Guangdong Provincial Center for Disease Control and Prevention GuangzhouGuangdong 511430China Wuhan Institute of Virology Chinese Academy of SciencesWuhanHubei 430071China National Institutes for Food and Drug Control Beijing 100050China Gaozhou Center for Disease Control and Prevention MaomingGuangdong 525000China Livzon Bio Inc. ZhuhaiGuangdong 519045China Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalShenzhenGuangdong 518112China.

Background:Innovative coronavirus disease 2019(COVID-19)vaccines,with elevated global manufacturing capacity,enhanced safety and efficacy,simplified dosing regimens,and distribution that is less cold chain-dependent,are still global imperatives for tackling the ongoing pandemic.A previous phase I trial indicated that the recombinant COVID-19 vaccine(V-01),which contains a fusion protein(IFN-PADRE-RBD-Fc dimer)as its antigen,is safe and well tolerated,capable of inducing rapid and robust immune responses,and warranted further testing in additional clinical ***,we aimed to assess the immunogenicity and safety of V-01,providing rationales of appropriate dose regimen for further efficacy ***:A randomized,double-blind,placebo-controlled phaseⅡclinical trial was initiated at the Gaozhou Municipal Centre for Disease Control and Prevention(Guangdong,China)in March *** younger(n=440;18–59 years of age)and older(n=440;≥60 years of age)adult participants in this trial were sequentially recruited into two distinct groups:two-dose regimen group in which participants were randomized either to follow a 10 or 25 mg of V-01 or placebo given intramuscularly 21 days apart(allocation ratio,3:3:1,n=120,120,40 for each regimen,respectively),or one-dose regimen groups in which participants were randomized either to receive a single injection of 50 mg of V-01 or placebo(allocation ratio,3:1,n=120,40,respectively).The primary immunogenicity endpoints were the geometric mean titers of neutralizing antibodies against live severe acute respiratory syndrome coronavirus 2,and specific binding antibodies to the receptor binding domain(RBD).The primary safety endpoint evaluation was the frequencies and percentages of overall adverse events(AEs)within 30 days after full ***:V-01 provoked substantial immune responses in the two-dose group,achieving encouragingly high titers of neutralizing antibody and anti-RBDimmunoglobulin,which peaked at day 35(161.9[95%

关键词： COVID-19 PhaseⅡ Clinical trial Recombinant fusion protein vaccine Safety Immunogenicity

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