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Decrease of Peripheral Blood CD8+/CD28- Suppressor T Cell Followed by Dentritic Cells Immunomodulation among Metastatic Breast Cancer Patients

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Chinese Journal of Cancer Research 2010年第4期22卷 310-315页

作者： Guo-hong Song jun Ren Lijun Di Jing Yu Jie Zhang Bin shao jun Jia wei Sun Key Laboratory of Carcinogenesis and Translational Research（Ministry of Education） Department of Medical Oncology Peking University Cancer Hospital ＆ Institute Beijing 100142 China

Objective： To explore the effects of dentritic cells on the peripheral blood lymphocyte subpopulations of metastatic breast cancer patients treated with chemotherapy. Methods： The current study involved 44 metastatic breast cancer patients treated with docetaxel-based chemotherapy. Among them, 25 cases were treated with dendritic cells derived from CD34＋ hematopoietic stem cells enriched autologous peripheral mononuclear cells after chemotherapy, and 19 cases received chemotherapy alone. Peripheral blood samples were collected from each patient before and after treatment, and lymphocyte subpopulations including CD3＋, CD3＋/CD4＋, CD3＋/CD8＋, CD3-/CD16＋56＋, CD3＋/CD16＋56＋, CD4＋/CD25＋, CD8＋/CD28-, CD8＋/CD28＋, CD4/CD8, DC1, DC2 and DC1/DC2 were analysed by a 3-color flow cytometric analysis. Results： The two treatment groups were well matched with regard to demographic and baseline disease characteristics. Comparing the changes of lymphocyte subpopulations between the two groups, it showed that the difference of the change of CD8＋/CD28-lymphocyte had statistic significance. The percentage of CD8＋/CD28-lymphocyte was lower in the chemotherapy＋DC group, but higher in the chemotherapy-alone group. Conclusion： As CD8＋/CD28-lymphocyte represent a kind of suppressive T lymphocyte, we conclude that dentritic cell therapy can relieve immunosuppression to some extent.

关键词： Metastatic breast cancer Dentritic cell Lymphocyte subpopulations Regulatory T cell

Distribution System Restoration with Cyber Failures Based on Co-dispatching of Multiple Recovery Resources

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1096-1112页

作者： Zhengze wei Kaigui Xie Bo Hu Yu Wang Changzheng shao Pierluigi Siano jun Zhong National Key Laboratory of Power Transmission Equipment Technology Chongqing UniversityChongqing 400044China Department of Management and Innovation Systems University of SalernoFisciano 84084Italyand he is also with the Department of Electrical and Electronic Engineering ScienceUniversity of JohannesburgJohannesburg 2006South Africa Shenzhen Power Supply Co. Ltd.China Southern Power GridShenzhen 518000China

Improving the restoration efficiency of a distribu-tion system is essential to enhance the ability of power systems to deal with extreme *** distribution system restoration(DSR)depends on the interaction among the electric network(EN),cyber network(CN),and traffic network(TN).However,the coordination of these three networks and co-dispatching of multiple recovery resources have been mostly *** paper proposes a novel DSR framework,which is formulated as a mixed-integer linear programming(MILP)*** fail-ures in cyber lines result in cyber blind areas,which restrict the normal operation of remote-controlled *** acceler-ate the recovery process,multiple recovery resources are uti-lized including electric maintenance crews(EMCs),cyber main-tenance crews(CMCs),and emergency communication vehicles(ECVs).Specifically,CMCs and ECVs restore the cyber func-tion of switches in cooperation,and EMCs repair damaged elec-tric *** travel time of these three dispatchable resources is determined by *** effectiveness and superiority of the proposed framework are verified on the modified IEEE 33-node and 123-node test systems.

关键词： Distribution system restoration(DSR) network coupling maintenance crew co-dispatching emergency communicationvehicle

Macroscopic model and statistical model to characterize electromagnetic information of a digital coding metasurface

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National Science Review 2024年第3期11卷 159-171页

作者： Rui Wen shao jun wei Wu Zheng Xing Wang Hui Xu Han Qing Yang Qiang Cheng Tie jun Cui Institute of Electromagnetic Space Southeast University State Key Laboratory of Millimeter Waves Southeast University Peng Cheng Laboratory Pazhou Laboratory(Huangpu)

A digital coding metasurface is a platform connecting the digital space and electromagnetic wave space, and has therefore gained much attention due to its intriguing value in reshaping wireless channels and realizing new communication architectures. Correspondingly, there is an urgent need for electromagnetic information theory that reveals the upper limit of communication capacity and supports the accurate design of metasurface-based communication systems. To this end, we propose a macroscopic model and a statistical model of the digital coding metasurface. The macroscopic model uniformly accommodates both digital and electromagnetic aspects of the meta-atoms and predicts all possible scattered fields of the digital coding metasurface based on a small number of simulations or measurements. Full-wave simulations and experimental results show that the macroscopic model is feasible and accurate. A statistical model is further proposed to correlate the mutual coupling between meta-atoms with covariance and to calculate the entropy of the equivalent currents of digital coding metasurface. These two models can help reconfigurable intelligent surfaces achieve more accurate beamforming and channel estimation, and thus improve signal power and coverage. Moreover, the models will encourage the creation of a precoding codebook in metasurface-based direct digital modulation systems, with the aim of approaching the upper limit of channel capacity. With these two models, the concepts of current space and current entropy, as well as the analysis of information loss from the coding space to wave space, is established for the first time, helping to bridge the gap between the digital world and the physical world, and advancing developments of electromagnetic information theory and new-architecture wireless systems.

关键词： electromagnetic information theory current entropy current space digital coding metasurface macroscopic model statistical model

WirelessLLM:Empowering Large Language Models Towards Wireless Intelligence

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Journal of Communications and Information Networks 2024年第2期9卷 99-112页

作者： Jiawei shao Jingwen Tong Qiong Wu wei Guo Zijian Li Zehong Lin jun Zhang Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China

The rapid evolution of wireless technologies and the growing complexity of network infrastructures necessitate a paradigm shift in how communication networks are designed,configured,and managed. Recent advancements in large language models (LLMs) have sparked interest in their potential to revolutionize wireless communication systems. However, existing studies on LLMs for wireless systems are limited to a direct application for telecom language understanding. To empower LLMs with knowledge and expertise in the wireless domain, this paper proposes WirelessLLM, a comprehensive framework for adapting and enhancing LLMs to address the unique challenges and requirements of wireless communication networks. We first identify three foundational principles that underpin WirelessLLM:knowledge alignment, knowledge fusion, and knowledge evolution. Then,we investigate the enabling technologies to build WirelessLLM, including prompt engineering, retrieval augmented generation, tool usage, multi-modal pre-training, and domain-specific fine-tuning. Moreover, we present three case studies to demonstrate the practical applicability and benefits of WirelessLLM for solving typical problems in wireless networks. Finally, we conclude this paper by highlighting key challenges and outlining potential avenues for future research.

关键词： large language models multi-modal models wireless communications power allocation spectrum sensing protocol understanding

Aerial target threat assessment based on gated recurrent unit and self-attention mechanism

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Journal of Systems Engineering and Electronics 2024年第2期35卷 361-373页

作者： CHEN Chen QUAN wei shao Zhuang School of Automation Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Intelligent Control and Decision of Complex Systems Beijing 100081China

Aerial threat assessment is a crucial link in modern air combat, whose result counts a great deal for commanders to make decisions. With the consideration that the existing threat assessment methods have difficulties in dealing with high dimensional time series target data, a threat assessment method based on self-attention mechanism and gated recurrent unit(SAGRU) is proposed. Firstly, a threat feature system including air combat situations and capability features is established. Moreover, a data augmentation process based on fractional Fourier transform(FRFT) is applied to extract more valuable information from time series situation features. Furthermore, aiming to capture key characteristics of battlefield evolution, a bidirectional GRU and SA mechanisms are designed for enhanced ***, after the concatenation of the processed air combat situation and capability features, the target threat level will be predicted by fully connected neural layers and the softmax classifier. Finally, in order to validate this model, an air combat dataset generated by a combat simulation system is introduced for model training and testing. The comparison experiments show the proposed model has structural rationality and can perform threat assessment faster and more accurately than the other existing models based on deep learning.

关键词： target threat assessment gated recurrent unit(GRU) self-attention(SA) fractional Fourier transform(FRFT)

Thermodynamic nature of black holes in coexistence region

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 27-32页

作者： shao-Wen wei Yu-Xiao Liu Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Provinceand Key Laboratory of Quantum Theory and Applications of Mo ELanzhou UniversityLanzhou 730000China Institute of Theoretical Physics&Research Center of Gravitation Lanzhou UniversityLanzhou 730000China

Studying the system state of coexistence regions will peek into to reveal microscopic interactions between different phases of a thermodynamic ***,there is no effective method to study thermodynamic nature of the coexistence black hole regions for the failure of the equation of *** at these coexistence states,in this work,we develop a general approach by introducing two new ratio *** first one is the ratio of the horizon radii of the saturated coexistence small and large black holes,and the second one measures that of the small black hole molecule number to the total molecule *** demonstrate that the first parameter can serve as an order parameter to characterize the first-order phase *** study also shows that the black hole state in the coexistence region is uniquely determined by these two introduced parameters bounded between 0 and *** results are quite significant in the analytical study of phase transition and the microscopic nature of black hole in the coexistence regions.

关键词： transition. state. thermodynamic

The Crystallization Behavior of L-Poly(lactic acid)/Polypropylene Blends:The Acceleration for Both L-Poly(lactic acid)and Polypropylene

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Chinese Journal of Polymer Science 2024年第6期42卷 775-786页

作者： Shuang-Cheng Li wei-Jia Zhou Wen-Jie Wu jun shao Shui-Liang Chen Hao-Qing Hou Sheng Xiang College of Chemistry&Chemical Engineering and Nanofiber Engineering Center of Jiangxi Province Jiangxi Normal UniversityNanchang330022China National Engineering Research Center for Carbohydrate Synthesis/Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022China Wenzhou Institute University of Chinese Academy of SciencesWenzhou325001China

For a polymer/polymer dismissible blend with two crystallizable components,the crystallization behavior of different components and the reciprocal influences between different crystals are interesting and important,but did not investigate in *** this study,the L-poly(lactic acid)/polypropylene(PLLA/PP)blends with different weight ratios were prepared by melt mixing and the crystallization behavior of the blends were *** showed that the crystalline structures of PLLA and PP were not altered by the *** the crystallization of PLLA,both the diffusion of chain segments and crystallization rate were enhanced under the existence of PP *** the crystallization of PP,its crystallization rate was depressed under the existence of amorphous PLLA molecular *** the PP crystallized from the existence of PLLA crystals,although the diffusion rate of PP was reduced by PLLA crystals,the nucleation positions were obviously enhanced,which accelerated the formation of PP *** investigation would supply more basic data for the application of PLLA/PP blend.

关键词： L-poly(lactic acid) Polypropylene Blends Crystalization behavior Crystallization acceleration

A GMM approach in coupling internal data and external summary information with heterogeneous data populations

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Science China Mathematics 2024年第5期67卷 1115-1132页

作者： jun shao Jinyi Wang Lei Wang Key Laboratory of Advanced Theory and Application in Statistics and Data Science(East China Normal University) Ministry of EducationShanghai 200062China School of Statistics East China Normal UniversityShanghai 200062China Department of Statistics University of Wisconsin-MadisonWI 53706USA School of Statistics and Data Science KLMDASRLEBPS and LPMCNankai UniversityTianjin 300071China

Because of advances in data collection and storage,statistical analysis in modern scientific research and practice now has opportunities to utilize external information such as summary statistics from similar studies.A likelihood approach based on a parametric model assumption has been developed in the literature to utilize external summary information when the populations for external and main internal data are assumed to be the *** this article,we instead consider the generalized estimation equation(GEE)approach for statistical inference,which is semiparametric or nonparametric,and show how to utilize external summary information even when internal and external data populations are not the *** approach is coupling the internal data and external summary information to form additional estimation equations and then applying the generalized method of moments(GMM).We show that the proposed GMM estimator is asymptotically normal and,under some conditions,is more efficient than the GEE estimator without using external summary *** of the asymptotic covariance matrix of the GMM estimators are also *** results are obtained to confirm our theory and quantify the improvements by utilizing external *** example is also included for illustration.

关键词： adjustment for heterogeneity constraint data integration generalized method of moments summarystatistic

A compact route for efficient production of high-purityβ-Ga_(2)O_(3) powder

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Rare Metals 2024年第9期43卷 4573-4584页

作者： Xiao-wei Zhou Gao-Jie Chen Liang Xu Zhi-jun shao Cheng Yang Yong-Pan Tian Zhuo Zhao School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032China Low-Carbon Research Institute Anhui University of TechnologyMa'anshan 243032China

The present study has proposed a compact process for the production of high-purityβ-Ga_(2)O_(3)powder by simply using gallium metal and water as the raw *** process basically consists of two essential steps including hydrothermal synthesis of Ga OOH and calcination of Ga OOH for the production of the target product ofβ-Ga_(2)O_(3).Thermodynamic evaluation and systematic experiments were conducted for process parameter optimization.X-ray diffractometer(XRD),scanning electron microscopy(SEM),thermogravimetryDdifferential scanning calorimetry(TG-DSC)and X-ray photoelectron spectroscopy(XPS)were utilized to clarify the reaction mechanisms of the hydrothermal synthesis and transformation of Ga OOH toβ-Ga_(2)O_(3)by *** analysis of the final product ofβ-Ga_(2)O_(3)obtained under the optimal conditions was carried out with inductively coupled plasma mass spectrometry(ICP-MS),and the results showed that the contents of the representative impurities such as Ni,Cu,In,Mn,Co,Zn and Cr are obviously lower than the requirement of 5Nβ-Ga_(2)O_(3)standard,exhibiting excellent application prospect of the proposed process to produce high-purityβ-Ga_(2)O_(3).

关键词： β-Ga_(2)O_(3) Hydrothermal synthesis Calcination Purity Reaction mechanism