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高分子链在微通道剪切流中的迁移机制及浓度的影响

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高分子学报 2015年第3期25卷 346-355页

作者：许少锋汪久根浙江大学宁波理工学院宁波31500 浙江大学机械工程学系杭州310027

提出了剪切流中高分子链在微通道内的迁移机制.该机制采用珠-簧链模型表示高分子链,高分子链受剪切作用而被拉伸,相邻珠子之间的流体力学相互作用产生了对称的扰动流场,由于在通道壁面附近对称的流场被破坏,壁面与高分子链间的流体力学... 详细信息

提出了剪切流中高分子链在微通道内的迁移机制.该机制采用珠-簧链模型表示高分子链,高分子链受剪切作用而被拉伸,相邻珠子之间的流体力学相互作用产生了对称的扰动流场,由于在通道壁面附近对称的流场被破坏,壁面与高分子链间的流体力学相互作用使高分子远离壁面,在强受限时,这种壁面诱导的流体力学相互作用会被屏蔽掉.利用耗散粒子动力学数值模拟了高分子链在微通道压力流中的迁移行为.数值模拟结果表明,在受限较弱时,高分子链向远离壁面的方向迁移,并随着流场增强,远离壁面的趋势越强;在受限较强时,高分子链不会发生远离壁面的行为.实验研究了长链高分子λ-DNA在壁面附近的迁移行为,实验结果及模拟结果与迁移机制预测的结果相吻合,验证了迁移机制的正确性.高分子链浓度会影响高分子链的迁移行为,当高分子链浓度较大时,高分子链在通道宽度方向不会发生迁移现象,意味着随着浓度的增大,壁面与高分子链间的流体力学相互作用会逐渐被屏蔽.

关键词：微通道高分子链迁移机制浓度

Study on Isomerous CAD Model Exchange Based on Feature

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武汉理工大学学报 2006年第S2期28卷 497-501页

作者： shao Xiaodong CHEN feng xu Chenguang (School of Mechano-electronic Engineering,Xidian Univ.,Xi’an 710071,China School of Mechano-electronic Engineering Xidian Univ.Xi'an 710071China

A model-exchange method based on feature between isomerous CAD systems is put forward in this *** this method,CAD model information is accessed at both feature and geometry levels and converted according to standard feature opera- *** feature information including feature tree,dimensions and constraints,which will be lost in traditional data conver- sion,as well as geometry are converted completely from source CAD system to destination *** the transferred model can be edit- ed through feature operation,which cannot be implemented by general model-exchange interface.

关键词： interface model exchange feature isomerous CAD standard

L-3-n-butylphthalide improves cognitive impairment in a transgenic AD mouse model

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L-3-n-butylphthalide improves cognitive impairment in a tran...

Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

中国神经科学学会第十届全国学术会议

作者： Ying PENG Yan-Li HU shao-feng xu Jiang Li Ling Wang Xiao-Liang Wang Institute of Materia Medica Chinese Academy of Medical Sciences & Peking Union Medical College

Alzheimer’s disease(AD) is an age-related and irreversibly progressive neurodegenerative disorder that occurs gradually and results in memory,behavior and personality changes.L-3-n-butylphthalide(L-NBP),an extract from seeds of Apium graveolens linn(Chinese celery),has been demonstrated to have neuroprotective effects on ischemic,vascular dementia and amyloid-B(AB)-infused animal models by inhibiting oxidative injury,neuronal apoptosis and glial activation,regulating APP processing and reducing A6 *** the current study,we examine the effect of L-NBP on learning and memory in amyloid precursor protein(APP) and presenilin 1(PS1)double-transgenic AD mouse model(APP/PSl) and the mechanisms of L-NBP in reducing A6 accumulation and tau ***-month old APP/PSl mice were given 15 mg/kg L-NBP by oral gavage for 3 months.L-NBP treatment significantly improved the spatial learning and memory deficits compared to the vehicle-treated APP/PSl mice,whereas L-NBP treatment had no effect on cerebral Aβ plaque deposition and Aβ levels in brain ***,we found a L-NBP-induced reduction of tau hyperphosphorylation at Serl99,Thr205,Ser396 and Ser404sites in APP/PSl *** the meantime,the expressions of cyclin-dependent kinase(CDK-5) and glycogen synthase kinase 3β(GSK-3β),the most important kinases involved in tau phosphorylation,were markedly decreased by L-NBP *** effects of L-NBP on decreasing tau phosphorylation and kinases activations were further confirmed in neuroblastoma SK-N-SH cells over-expressing WT human APP(SK-N-SH APPwt).L-NBP shows promising candidate of multi-target neuronal protective agent for the treatment of Alzheimer’s disease.

关键词： Alzheimer’s disease L-3-n-butylphthalide amyloid-β tau GSK-3β

来源： cnki会议评论

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Science China Chemistry 2025年第1期68卷 329-336页

作者： Yuzhu Li Yumeng Gao feng Tian Yu Wang Yuan Yao shaoliang Lin Xiang Ma Binbin xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

关键词： self-assembly conformation ordering alternating copolymer phosphorescence emission

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong Tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin xu Xiao Zhang Zongping shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

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校本作业体系的构建

宁波教育学院学报 2016年第6期18卷 95-97,103页

作者：邵旭峰宁波市江北外国语学校浙江宁波315020

从学生分级、作业分级、教学分级、评价分级及学校的保障措施等五个方面阐述了校本作业体系的创建,有利于学生各学科的均衡发展,提升学校整体教学质量。

关键词：作业体系教学分级评价分级

Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo xu Xiao feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe Sun Weilin xu Jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi Lin Ruian xu Lu Liu Yu Zhang feng Tian Jiao Jiao Li Jiajia xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

Copper homeostasis and neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3124-3143页

作者： Yuanyuan Wang Daidi Li Kaifei xu Guoqing Wang feng Zhang International Research Laboratory of Ethnomedicine of Ministry of Education Key Laboratory of Basic Pharmacology of Ministry of EducationLaboratory Animal Center and Key Laboratory of Basic Pharmacology of Guizhou ProvinceZunyi Medical UniversityZunyiGuizhou ProvinceChina

Copper,one of the most prolific transition metals in the body,is required for normal brain physiological activity and allows various functions to work normally through its range of *** homeostasis is meticulously maintained through a complex network of copper-dependent proteins,including copper transporters(CTR1 and CTR2),the two copper ion transporters the Cu-transporting ATPase 1(ATP7A)and Cu-transporting beta(ATP7B),and the three copper chaperones ATOX1,CCS,and *** in copper homeostasis can lead to either the deficiency or accumulation of copper in brain *** evidence suggests that abnormal copper metabolism or copper binding to various proteins,including ceruloplasmin and metallothionein,is involved in the pathogenesis of neurodegenerative ***,the exact mechanisms underlying these processes are not *** is a potent oxidant that increases reactive oxygen species production and promotes oxidative *** reactive oxygen species levels may further compromise mitochondrial integrity and cause mitochondrial *** oxygen species serve as key signaling molecules in copper-induced neuroinflammation,with elevated levels activating several critical inflammatory ***,copper can bind aberrantly to several neuronal proteins,including alphasynuclein,tau,superoxide dismutase 1,and huntingtin,thereby inducing neurotoxicity and ultimately cell *** study focuses on the latest literature evaluating the role of copper in neurodegenerative diseases,with a particular focus on copper-containing metalloenzymes and copper-binding proteins in the regulation of copper homeostasis and their involvement in neurodegenerative disease *** synthesizing the current findings on the functions of copper in oxidative stress,neuroinflammation,mitochondrial dysfunction,and protein misfolding,we aim to elucidate the mechanisms by which copper contributes to a wide range of heredit

关键词： Alzheimer's disease amyotrophic lateral sclerosis disease copper homeostasis copper toxicity Huntington's disease Menkes'disease multiple sclerosis neurodegenerative disease Parkinson's disease Wilson's disease